Visfatin: A protein secreted by visceral fat that Mimics the effects of insulin

Science

Volumn 307, Issue 5708, 2005, Pages 426-430

  Fukuhara, Atsunori ^a,b   Matsuda, Morihiro ^a   Nishizawa, Masako ^c   Segawa, Katsumori ^a   Tanaka, Masaki ^a   Kishimoto, Kae ^c   Matsuki, Yasushi ^c   Murakami, Mirei ^d   Ichisaka, Tomoko ^d   Murakami, Hiroko ^c   Watanabe, Eijiro ^c   Takagi, Toshiyuki ^a   Akiyoshi, Megumi ^c   Ohtsubo, Tsuguteru ^c   Kihara, Shinji ^e   Yamashita, Shizuya ^e   Makishima, Makoto ^a   Funahashi, Tohru ^e   Yamanaka, Shinya ^d   Hiramatsu, Ryuji ^c   Matsuzawa, Yuji ^f   Shimomura, Iichiro ^a,e,g   more..

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f SUMITOMO HOSPITAL   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; GLUCOSE; HUMAN ENGINEERING; METABOLISM; PLASMA THEORY; TISSUE;

FAT TISSUES; PLASMA GLUCOSE; PRE-B CELL COLONY-ENHANCING FACTORS (PBEF); VISCERAL FAT;

PROTEINS;

CYTOKINE; GLUCOSE; INSULIN; INTERLEUKIN 7; UNCLASSIFIED DRUG; VISFATIN;

MEDICINE;

ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE MUTATION; GLUCOSE HOMEOSTASIS; HETEROZYGOSITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; RECEPTOR BINDING;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BINDING SITES; BLOOD GLUCOSE; CELL LINE; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR MIMICRY; MUSCLE CELLS; PHOSPHORYLATION; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SUBCUTANEOUS TISSUE; VISCERA;

EID: 19944433652     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1097243     Document Type: Article

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19. We thank the members of the Shimomura laboratory for helpful discussions, D. Accili and S. Takahashi for the IGF-IR expression vector, and H. Kondo for the visfatin-producing adenovirus. Supported by the 21st Century Center of Excellence Program; the Japan Research Foundation for Clinical Pharmacology; the Ministry of Health, Labor and Welfare, Japan; and the Ministry of Education, Culture, Sports, Science and Technology, Japan.