Transgenic overexpression of active calcineurin in β-cells results in decreased β-cell mass and hyperglycemia

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Bernal Mizrachi, Ernesto ^a   Cras Méneur, Corentin ^a   Ye, Bo Ra ^a   Johnson, James D ^b   Permutt, M Alan ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; INSULIN; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DEPOLARIZATION; DIABETES MELLITUS; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL SIZE; GENE EXPRESSION; GENETICS; MALE; METABOLISM; MUTATION; PATHOLOGY; PROMOTER REGION; RAT; SECRETION; TRANSGENE; TRANSGENIC MOUSE;

MUS;

ANIMALS; APOPTOSIS; CALCINEURIN; CELL LINE; CELL PROLIFERATION; CELL SIZE; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION; GLUCOSE; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, TRANSGENIC; MUTATION; PROMOTER REGIONS, GENETIC; RATS; TRANSGENES;

EID: 77957791965     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011969     Document Type: Article

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