Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia

Journal of Biological Chemistry

Volumn 271, Issue 2, 1996, Pages 1200-1208

  Vasavada, Rupangi C ^a,b   Cavaliere, Christi ^a,b   D'Ercole, A Joseph ^d   Dann, Pamela ^a   Burtis, William J ^a,b   Madlener, Alex L ^b   Zawalich, Kathleen ^c   Zawalich, Walter ^c   Philbrick, William ^a   Stewart, Andrew F ^a,b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF NURSING   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL CELL; ARTICLE; CELL HYPERPLASIA; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GLUCOSE HOMEOSTASIS; HORMONAL REGULATION; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN RELEASE; MORPHOMETRICS; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALS; GENE EXPRESSION; HYPERINSULINISM; HYPERPLASIA; HYPOGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN BIOSYNTHESIS; PROTEINS; RATS;

EID: 13344270898     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.2.1200     Document Type: Article

References (38)

1. Stewart, A. F., Insogna K. L., and Broadus, A. E. (1995) in Endocrinology (DeGroot, L., ed) 3rd Ed., pp. 1061-1074, W. B. Saunders, Philadelphia
2. Stewart, A. F. (1993) in The American Society for Bone and Mineral Research Primer on Metabolic Bone Diseases and Disorders of Mineral Metabolism (Favus, M., ed) 2nd Ed., pp. 169-173, Raven Press, New York
3. Nissenson, E. A., and Halloran, B. (eds) (1992) Parathyroid Hormone-related Protein , CRC Press, Boca Raton, FL
4. Broadus, A. E., and Stewart, A. F. (1994) in The Parathyroids: Basic and Clinical Concepts (Bilezikian, J. P., Levine, M. A., and Marcus, R., eds) pp. 259-294, Raven Press, New York
5. Orloff, J. J., Reddy, D., dePapp, A. E., Yang, K. H., Soifer, N. S., and Stewart, A. F. (1994) Endocrine Rev. 15, 40-60
6. dePapp, A. E., and Stewart, A. F. (1993) Trends Endocrinol. Metab. 4, 181-187
7. Drucker, D. J., Asa, S. L., Henderson, J., and Goltzman, D. (1989) Mol. Endocrinol. 3, 1589-1595
8. Asa, S. L., Henderson, J., Goltzman, D., and Drucker, D. (1990) J. Clin. Endocrinol. Metab. 71, 1112-1118
9. Stewart, A. F., Insogna, K. L., Burtis, W. J., Aminiafshar, A., Wu, T., and Broadus, A. E. (1986) J. Bone Miner. Res. 1, 267-276
10. Jüppner, H., Abou-Samra, A.-B., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H., and Segre, G. V. (1991) Science 254, 1024-1026
11. Kaiser, S. M., Laneuville, P., Bernier, S. M., Rhims, J. S., Kremer, R., and Goltzman, D. (1992) J. Biol. Chem. 267, 13623-13628
12. Karaplis, A. C. Henderson, J. E., Amizuka, N., Lanske, B. K. M., Biasotto, D., and Goltzman, D. (1994) J. Bone Min. Res. 9, (Suppl. 1), S121
13. Philbrick, W. M., Wysolmerski, J. J., Galbraith, S., Holt, E., Orloff, J. J., Yang, K. H., Vasavada, R. C., Weir, E. C., Broadus, A. E., and Stewart. A. F. (1996) Physiol. Rev., in press
14. Wysolmerski, J. J., Carucci, J. M., Broadus, A. E., and Philbrick, W. M. (1994) J. Bone Miner. Res. 9, (Suppl. 1), S121
15. Wysolmerski, J. J., Broadus, A. E., Zhou, J., Fuchs, E., Milstone, L. M., and Philbrick, W. M. (1994) Proc. Natl. Acad. Sci U. S. A. 91, 1133-1137
16. Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., and Mulligan, R. C. (1994) Genes & Dev. 8, 277-289
17. Lanske, B., Karaplis, A., Luz, A., Mulligan, R., and Kronenberg, H. (1994) J. Bone Miner. Res. 9, (Suppl. 1), S121
18. Gaich, G., Orloff, J. J., Atillasoy, E. J., Burtis, W. J., Ganz, M. B., and Stewart, A. F. (1993) Endocrinology 132, 1402-1409
19. Hanahan, D. (1985) Nature 315, 115-122
20. Efrat, S., Linde, S., Kofod, H., Spector, D., Dellannoy, M., Grant, S., Hanahan, D., and Baekkeskov, S. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 9037-9041
21. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., and Rutter, W. J. (1979) Biochemistry 18, 5294-5299
22. Thiede, M. A., Daifotis, A. G., Weir, E. C., Brines, M. L., Burtis, W. J., Ikeda, K., Dreyer, B. E., Garfield, R. E., and Broadus. A. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6969-6973
23. Stewart, A. F., Insogna, K. L., Goltzman, D., and Broadus. A. E. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 1454-1458
24. Zawalich, W. S., Zawalich, K. C., Ganesan, S., Calle, R., and Rasmussen, H. (1991) Biochem. J. 278, 49-56
25. Gaich, G., and Burtis, W. J. (1990) Endocrinology 127, 1444-1449
26. Burtis, W. J., Brady, T. G., Orloff, J. J., Ersbak, J. B., Warrell, R. P., Olson, B. R., Wu, T. L., Mitnick, M. A., Broadus, A. E., and Stewart, A. F. (1990) N. Engl. J. Med. 322, 1106-1112
27. Behringer, R. R., Lewin, T. M., Quaife, C. J., Palmiter, R. D., Brinster, R. L., and D'Ercole, A. J. (1990) Endocrinology 127, 1033-1040
28. Soifer, N. E., Van Why, S. K., Ganz, M. B., Kashgarian, M., Seigel, N. J., and Stewart, A. F. (1993) J. Clin. Invest. 92, 2850-2857
29. Stewart, A. F., Vignery, A., Silvergate, A., Ravin, N. D., LiVolsi, V., Broadus, A. E., and Baron, R. (1982) J. Clin. Endocrinol. Metab. 55, 219-227
30. Zawalich, W. S., Zawalich, K. C., Cline, G., Shulman, G., and Rasmussen, H. (1993) Diabetes 42, 843-850
31. Epstein, P. N., Boschero, A. C., Atwater, I., Cai, Xingang, and Overbeek, P. A. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 12038-12041
32. Kato, I., Suzuki, Y., Akabane, A., Yonekura, H., Tanaka, O., Kondo, H., Takasawa, S., Yoshimoto, T., and Okamoto, H. (1994) J. Biol. Chem. 269, 21223-21228
33. Ma, Y. H., Landis, C., Tchao, N., Wang, J., Rodd, G., Hanahan, D., Bourne, H. R., and Grodsky, G. M. (1994) Endocrinology 134, 42-47
34. Picarella, D., Kratz, A., Li, C.-B., Ruddle, N., and Flavell, R. A. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10036-10040
35. Lo, D., Burkly, L. C., Widera, G., Cowing, C., Flavell, R. A., Palmiter, R. D., and Brinster, R. L. Cell 53, 159-168
36. Parsons, J. A., Bartke, A., and Sorenson, R. L. (1995) Endocrinology 136, 2013-2021
37. Boden, G., Murer, E., and Mozzoli, M. (1994) Ann. Int. Med. 121, 109-112
38. Streuker, C., and Drucker, D. J. (1991) Mol. Endocrinol. 5, 703-708