Targeted deletion of the PRL receptor: Effects on islet development, insulin production, and glucose tolerance

Endocrinology

Volumn 143, Issue 4, 2002, Pages 1378-1385

  Freemark, Michael ^a   Avril, Isabelle ^c   Fleenor, D O N ^a   Driscoll, Phyllis ^a   Petro, A N N ^a   Opara, Emmanuel ^a   Kendall, Will ^a   Oden, J O N ^a   Bridges, Spencer ^a   Binart, Nadine ^b   Breant, Bernadette ^c   Kelly, Paul A ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; MESSENGER RNA; PLACENTA LACTOGEN; PROLACTIN; PROLACTIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; GENE DELETION; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; INSULIN METABOLISM; INSULIN RELEASE; INSULINOMA; MORPHOMETRICS; MOUSE; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; WEANING; WILD TYPE;

EID: 18344382724     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.4.8722     Document Type: Article

References (34)

1. Relative effects of pregnancy, human placental lactogen and prednisolone on carbohydrate tolerance in normal and subclinical diabetic subjects
2. Effects of placental lactogen and progesterone on insulin stimulated glucose metabolism in rat muscles in vitro
3. Role of gestational hormones in the induction of insulin resistance
4. Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: Implications for pregnancy
5. Effects of steroid and lactogenic hormones on islets of Langerhans: A new hypothesis for the role of pregnancy and steroids in the adaptation of islets to pregnancy
6. Effects of homologous placental lactogens, prolactins and growth hormones on islet β cell division and insulin secretion in rat, mouse and human islets: Implication for placental lactogen regulation of islet function during pregnancy
7. Prolactin induction of insulin gene expression: The roles of glucose and glucose transporter-2
8. Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: Mechanisms for long term up-regulation of islets
9. Constitutive expression of placental lactogen in pancreatic β cells: Effects on cell morphology, growth and gene expression
10. Prolactin induction of insulin gene transcription: The roles of glucose and STAT5
11. Targeted expression of placental lactogen in the β cells of transgenic mice results in β cell proliferation, islet mass augmentation, and hypoglycemia
12. Effects of hyperprolactinemia on plasma glucose and prolactin in rats exposed to ether stress
13. Blood glucose and prolactin in hyperprolactinemic rats exposed to restraint and surgical stress
14. Effects of hyperprolactinemia on glucose tolerance and insulin release in male and female rats
15. Serum lipids, postheparin plasma lipase activities, and glucose tolerance in patients with prolactinoma
16. Direct relationship between elevated free testosterone and insulin resistance in hyperprolactinemic women
17. Peripheral glucose metabolism in human hyperprolactinemia
18. Effects of glucose load and/or arginine on insulin and growth hormone secretion in hyperprolactinemia and obesity
19. Acute elevation of endogenous prolactin does not influence glucose homeostasis in healthy men
20. Lack of effect of hyperprolactinemia on glucose disposal and insulin secretion in patients with prolactinomas
21. Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: Effect of lactogenic hormones
22. Effects of hypophysectomy and growth hormone on cultured islets of Langerhans of the rat
23. Morphological changes in the islets of Langerhans of the pituitary dwarf mice during induced growth
24. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
25. Osteoblasts are a new target for prolactin: Analysis of bone formation in prolactin receptor knockout mice
26. Rescue of preimplantation egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration
27. β cell mass and proliferation following late fetal and early postnatal malnutrition in the rat
28. Characterization and control of pulsatile secretion of insulin and glucagon
29. The prolactin receptor in the fetal rat: Cellular localization of messenger RNA, immunoreactive protein and ligand binding activity and induction of expression in late gestation
30. Ontogenesis of prolactin receptors in the human fetus in early gestation: Implications for tissue differentiation and development
31. β cell proliferation and growth factors
32. Using β cell growth factors to enhance human pancreatic islet transplantation
33. Early diabetes and abnormal postnatal pancreatic development in mice lacking Glut-2
34. Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis