Overstimulation and β-cell function

Diabetes

Volumn 50, Issue SUPPL. 1, 2001, Pages

  Grill, Valdemar ^a,b   Björklund, Anneli ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROINSULIN;

APOPTOSIS; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL STIMULATION; CONFERENCE PAPER; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; OSCILLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0035122490     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2007.s122     Document Type: Conference Paper

References (28)

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2. Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats
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4. The third phase of in vitro insulin secretion: Evidence for glucose insensitivity
5. Opposite effects of tolbutamide and diazoxide on the ATP-dependent potassium channel in mouse pancreatic B-cells
6. Beta-cell dysfunction with chronic hyperglycemia: "Overworked betacell" hypothesis
7. Cooling dissociates glucose-induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets
8. Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization
9. 2O of glucose-induced cyclic AMP accumulation in rat islets of Langerhans
10. i abnormalities in human pancreatic islets: Important role of overstimulation
11. Impaired β-cell functions induced by chronic exposure of cultured human islets to high glucose
12. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function
13. Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets
14. Increased proinsulin/insulin ratio in pancreatic extracts of hyperglycemic rats
15. Improvement of insulin secretion in diabetes after diazoxide
16. Beta-cell rest in type 2 diabetes: Effects on insulin secretion after diazoxide and insulin
17. Prolonged exposure of human B-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine
18. Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment
19. Glucose and tolbutamide induce apoptosis in pancreatic β cells
20. The role of calcium in the regulation of apoptosis
21. An early intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring noninsulin-dependent diabetes
22. Insulin administration enhances growth of the beta cell mass in streptozotocin-treated newborn rat
23. Duration of obesity increases the incidence of NIDDM
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25. Increase in insulin response after treatment of overt maturity-onset diabetes independent of the mode of treatment
26. Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial: A randomized, controlled trial
27. Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes