메뉴 건너뛰기




Volumn 18, Issue 19, 1999, Pages 5310-5320

Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1)

Author keywords

Cyclin D; Cyclin E; Myc; p21(Cip1); p27(Kip1)

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE; CYCLIN E; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN P21; PROTEIN P27;

EID: 0033214995     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.19.5310     Document Type: Article
Times cited : (287)

References (71)
  • 2
    • 0026665523 scopus 로고
    • Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max
    • Amati, B., Dalton, S., Brooks, M.W., Littlewood, T.D., Evan, G.I. and Land, H. (1992) Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature, 359, 423-426.
    • (1992) Nature , vol.359 , pp. 423-426
    • Amati, B.1    Dalton, S.2    Brooks, M.W.3    Littlewood, T.D.4    Evan, G.I.5    Land, H.6
  • 3
    • 0027533679 scopus 로고
    • Oncogenic activity of the c-Myc protein requires dimerization with Max
    • Amati, B., Brooks, M.W., Levy, N., Littlewood, T.D., Evan, G.I. and Land, H. (1993a) Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell. 72, 233-245.
    • (1993) Cell. , vol.72 , pp. 233-245
    • Amati, B.1    Brooks, M.W.2    Levy, N.3    Littlewood, T.D.4    Evan, G.I.5    Land, H.6
  • 4
    • 0027364326 scopus 로고
    • The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max
    • Amati, B., Littlewood, T.D., Evan, G.I. and Land, H. (1993b) The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J., 12, 5083-5087.
    • (1993) EMBO J. , vol.12 , pp. 5083-5087
    • Amati, B.1    Littlewood, T.D.2    Evan, G.I.3    Land, H.4
  • 7
    • 0028879873 scopus 로고
    • Myc but not fos rescue of PDGF signalling block caused by kinase-inactive Src
    • Barone, M.V. and Courtneidge, S.A. (1995) Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature, 378, 509-512.
    • (1995) Nature , vol.378 , pp. 509-512
    • Barone, M.V.1    Courtneidge, S.A.2
  • 8
    • 0030986411 scopus 로고    scopus 로고
    • 1 arrest through reduction of cyclin E-CDK2 kinase activity
    • 1 arrest through reduction of cyclin E-CDK2 kinase activity. Oncogene. 15, 1347-1356.
    • (1997) Oncogene. , vol.15 , pp. 1347-1356
    • Berns, K.1    Hijmans, E.M.2    Bernards, R.3
  • 10
    • 0025763419 scopus 로고
    • Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
    • Blackwood, E.M. and Eisenman, R.N. (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science, 251, 1211-1217.
    • (1991) Science , vol.251 , pp. 1211-1217
    • Blackwood, E.M.1    Eisenman, R.N.2
  • 11
    • 0033214080 scopus 로고    scopus 로고
    • Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
    • Bouchard, C. et al. (1999) Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J., 18, 5321-5333.
    • (1999) EMBO J. , vol.18 , pp. 5321-5333
    • Bouchard, C.1
  • 12
    • 0027465481 scopus 로고
    • A selective transcriptional induction system for mammalian cells based on Ga14-estrogen receptor fusion proteins
    • Braselmann, S., Graninger, P. and Busslinger, M. (1993) A selective transcriptional induction system for mammalian cells based on Ga14-estrogen receptor fusion proteins. Proc. Natl Acad. Sci. USA, 90, 1657-1661.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 1657-1661
    • Braselmann, S.1    Graninger, P.2    Busslinger, M.3
  • 13
    • 0032535177 scopus 로고    scopus 로고
    • c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets
    • Bush, A., Mateyak, M., Dugan, K., Obaya, A., Adachi, S., Sedivy, J. and Cole, M. (1998) c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes Dev., 12, 3797-37802.
    • (1998) Genes Dev. , vol.12 , pp. 3797-37802
    • Bush, A.1    Mateyak, M.2    Dugan, K.3    Obaya, A.4    Adachi, S.5    Sedivy, J.6    Cole, M.7
  • 15
    • 0032905924 scopus 로고    scopus 로고
    • c-Myc target genes involved in cell growth, apoptosis and metabolism
    • Dang, C.V. (1999) c-Myc target genes involved in cell growth, apoptosis and metabolism. Mol. Cell. Biol., 19, 1-11.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 16
    • 0030657477 scopus 로고    scopus 로고
    • A dominant-negative cyclin d1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase
    • Diehl, J.A. and Sherr, C.J. (1997) A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase. Mol. Cell. Biol., 17, 7362-7374.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7362-7374
    • Diehl, J.A.1    Sherr, C.J.2
  • 18
    • 0026099022 scopus 로고
    • The MYC protein activates transcription of the α-prothymosin gene
    • Eilers, M., Schirm, S. and Bishop, J.M. (1991) The MYC protein activates transcription of the α-prothymosin gene. EMBO J., 10, 133-141.
    • (1991) EMBO J. , vol.10 , pp. 133-141
    • Eilers, M.1    Schirm, S.2    Bishop, J.M.3
  • 19
    • 0022340978 scopus 로고
    • Isolation of monoclonal antibodies specific for the human c-myc protooncogene product
    • Evan, G., Lewis, G., Ramsay, G. and Bishop, J. (1985) Isolation of monoclonal antibodies specific for the human c-myc protooncogene product. Mol. Cell. Biol., 5, 3610-3616.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 3610-3616
    • Evan, G.1    Lewis, G.2    Ramsay, G.3    Bishop, J.4
  • 21
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl, V., Stamp, G., Andrews, A., Rosewell, I. and Dickson, C. (1995) Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev., 9, 2364-2372.
    • (1995) Genes Dev. , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 23
    • 0028168242 scopus 로고
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature, 371, 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 24
    • 0028263811 scopus 로고
    • c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington, E.A., Bennett, M.R., Fanidi, A. and Evan, G.I. (1994) c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J., 13, 3286-3295.
    • (1994) EMBO J. , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 25
    • 0029686266 scopus 로고    scopus 로고
    • Proteins of the Myc network: Essential regulators of cell growth and differentiation
    • Henriksson, M. and Lüscher, B. (1996) Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv. Cancer Res., 68, 109-182.
    • (1996) Adv. Cancer Res. , vol.68 , pp. 109-182
    • Henriksson, M.1    Lüscher, B.2
  • 27
    • 0022584344 scopus 로고
    • The regulation and expression of c-myc in normal and malignant cells
    • Kelly, K. and Siebenlist, U. (1986) The regulation and expression of c-myc in normal and malignant cells. Annu. Rev. Immunol., 4, 317-338.
    • (1986) Annu. Rev. Immunol. , vol.4 , pp. 317-338
    • Kelly, K.1    Siebenlist, U.2
  • 28
    • 0028358931 scopus 로고
    • Cyclin E controls S phase progression and its down-regulation during Drusophila embryogenesis is required for the arrest of cell proliferation
    • Knoblich, J.A., Sauer, K., Jones, L., Richardson, H., Saint, R. and Lehner, C.F. (1994) Cyclin E controls S phase progression and its down-regulation during Drusophila embryogenesis is required for the arrest of cell proliferation. Cell, 77, 107-120.
    • (1994) Cell , vol.77 , pp. 107-120
    • Knoblich, J.A.1    Sauer, K.2    Jones, L.3    Richardson, H.4    Saint, R.5    Lehner, C.F.6
  • 29
    • 0026737875 scopus 로고
    • Myc and Max proteins possess distinct transcriptional activities
    • Kretzner, L., Blackwood, E.M. and Eisenman, R.N. (1992) Myc and Max proteins possess distinct transcriptional activities. Nature, 359, 426-429.
    • (1992) Nature , vol.359 , pp. 426-429
    • Kretzner, L.1    Blackwood, E.M.2    Eisenman, R.N.3
  • 31
    • 0029092265 scopus 로고
    • Transformation of primary rat embryo cells
    • Land, H. (1995) Transformation of primary rat embryo cells. Methods Enzymol., 254, 37-41.
    • (1995) Methods Enzymol. , vol.254 , pp. 37-41
    • Land, H.1
  • 32
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood, T.D., Hancock, D.C., Danielian, P.S., Parker, M.G. and Evan, G.I. (1995) A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res., 23, 1686-1690.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 34
    • 0030849451 scopus 로고    scopus 로고
    • Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
    • Mateyak, M.K., Obaya, A.J., Adachi, S. and Sedivy, J.M. (1997) Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ., 8, 1039-1048.
    • (1997) Cell Growth Differ. , vol.8 , pp. 1039-1048
    • Mateyak, M.K.1    Obaya, A.J.2    Adachi, S.3    Sedivy, J.M.4
  • 35
    • 0032981481 scopus 로고    scopus 로고
    • INK4a inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
    • INK4a inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol. Cell. Biol., 19, 1981-1989.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1981-1989
    • McConnell, B.B.1    Gregory, F.J.2    Stott, F.J.3    Hara, E.4    Peters, G.5
  • 36
    • 0032493894 scopus 로고    scopus 로고
    • The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
    • McMahon, S.B., Van, B.H., Dugan, K.A., Copeland, T.D. and Cole, M.D. (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell, 94, 363-374.
    • (1998) Cell , vol.94 , pp. 363-374
    • McMahon, S.B.1    Van, B.H.2    Dugan, K.A.3    Copeland, T.D.4    Cole, M.D.5
  • 37
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan, D.O. (1995) Principles of CDK regulation. Nature, 374, 131-134.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 38
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
    • Morgenstern, J.P. and Land, H. (1990) Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res., 18, 3587-3596.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 39
    • 0021178906 scopus 로고
    • Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture
    • Mougneau, E., Lemieux, L., Rassoulzadegan, M. and Cuzin, F. (1984) Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture. Proc. Natl Acad. Sci. USA, 81, 5758-5762.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 5758-5762
    • Mougneau, E.1    Lemieux, L.2    Rassoulzadegan, M.3    Cuzin, F.4
  • 43
    • 0027236954 scopus 로고
    • Production of high-titer helper-free retroviruses by transient transfection
    • Pear, W.S., Nolan, G.P., Scott, M.L. and Baltimore, D. (1993) Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl Acad. Sci. USA, 90, 8392-8396.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8392-8396
    • Pear, W.S.1    Nolan, G.P.2    Scott, M.L.3    Baltimore, D.4
  • 45
    • 0030927929 scopus 로고    scopus 로고
    • Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
    • Planas-Silva, M. and Weinberg, R.A. (1997) Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol. Cell. Biol., 17, 4059-4069.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4059-4069
    • Planas-Silva, M.1    Weinberg, R.A.2
  • 47
    • 0029145975 scopus 로고
    • Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
    • Poon, R.Y., Toyoshima, H. and Hunter, T. (1995) Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell, 6, 1197-1213.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1197-1213
    • Poon, R.Y.1    Toyoshima, H.2    Hunter, T.3
  • 48
    • 0025981310 scopus 로고
    • Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region
    • Prendergast, G.C. and Ziff, E.B. (1991) Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region. Science, 251, 186-189.
    • (1991) Science , vol.251 , pp. 186-189
    • Prendergast, G.C.1    Ziff, E.B.2
  • 49
    • 0025829169 scopus 로고
    • Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation
    • Prendergast, G.C., Lawe, D. and Ziff, E.B. (1991) Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell, 65, 395-407.
    • (1991) Cell , vol.65 , pp. 395-407
    • Prendergast, G.C.1    Lawe, D.2    Ziff, E.B.3
  • 52
    • 0028173667 scopus 로고
    • 1/S phase transition by expression of cyclins D1 and E with an inducible system
    • 1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol., 14, 1669-1679.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1669-1679
    • Resnitzky, D.1    Gossen, M.2    Bujard, H.3    Reed, S.I.4
  • 53
    • 0030614715 scopus 로고    scopus 로고
    • Kipl coordinate their inhibitory interactions with cdk4 and cdk2
    • Kipl coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev., 11, 492-503.
    • (1997) Genes Dev. , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 54
    • 0029153609 scopus 로고
    • Kip-Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • Reynisdottir, I., Polyak, K., Iavarone, A. and Massague, J. (1995) Kip-Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev., 9, 1831-1845.
    • (1995) Genes Dev. , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 55
    • 0025861901 scopus 로고
    • Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling
    • Roussel, M.F., Cleveland, J.L., Shurtleff, S.A. and Sherr, C.J. (1991) Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling. Nature, 353, 361-363.
    • (1991) Nature , vol.353 , pp. 361-363
    • Roussel, M.F.1    Cleveland, J.L.2    Shurtleff, S.A.3    Sherr, C.J.4
  • 56
    • 0029888119 scopus 로고    scopus 로고
    • Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis
    • Rudolph, B., Saffrich, R., Zwicker, J., Henglein, B., Muller, R., Ansorge, W. and Eilers, M. (1996) Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. EMBO J., 15, 3065-3076.
    • (1996) EMBO J. , vol.15 , pp. 3065-3076
    • Rudolph, B.1    Saffrich, R.2    Zwicker, J.3    Henglein, B.4    Muller, R.5    Ansorge, W.6    Eilers, M.7
  • 60
    • 0028171292 scopus 로고
    • 1 phase progression: Cycling on cue
    • 1 phase progression: cycling on cue. Cell, 79, 551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 62
    • 10544256183 scopus 로고    scopus 로고
    • Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    • Sicinski, P. et al. (1996) Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature, 384, 470-474.
    • (1996) Nature , vol.384 , pp. 470-474
    • Sicinski, P.1
  • 63
    • 0028845977 scopus 로고
    • Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts
    • Solomon, D.L., Philipp, A., Land, H. and Eilers, M. (1995) Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts. Oncogene, 11, 1893-1897.
    • (1995) Oncogene , vol.11 , pp. 1893-1897
    • Solomon, D.L.1    Philipp, A.2    Land, H.3    Eilers, M.4
  • 64
    • 9044232147 scopus 로고    scopus 로고
    • Formation of p27-CDK complexes during the human mitotic cell cycle
    • Soos, T.J. et al. (1996) Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ., 7, 135-146.
    • (1996) Cell Growth Differ. , vol.7 , pp. 135-146
    • Soos, T.J.1
  • 66
    • 0028363519 scopus 로고
    • 1 cyclin-Cdk protein kinase activity, is related to p21
    • 1 cyclin-Cdk protein kinase activity, is related to p21. Cell, 78, 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 68
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach, J., Hennecke, S. and Amati, B. (1997) Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J., 16, 5334-5344.
    • (1997) EMBO J. , vol.16 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 70
    • 0032535253 scopus 로고    scopus 로고
    • Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis
    • Xiao, Q., Claassen, G., Shi, J., Adachi, S., Sedivy, J. and Hann, S.R. (1998) Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. Genes Dev., 12, 3803-3808.
    • (1998) Genes Dev. , vol.12 , pp. 3803-3808
    • Xiao, Q.1    Claassen, G.2    Shi, J.3    Adachi, S.4    Sedivy, J.5    Hann, S.R.6
  • 71
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy, F., Eischen, C.M., Randle, D.H., Kamijo, T., Cleveland, J.L., Sherr, C.J. and Roussel, M.F. (1998) Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev., 12, 2424-2433.
    • (1998) Genes Dev. , vol.12 , pp. 2424-2433
    • Zindy, F.1    Eischen, C.M.2    Randle, D.H.3    Kamijo, T.4    Cleveland, J.L.5    Sherr, C.J.6    Roussel, M.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.