Inverse Relationship between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

Diabetes

Volumn 50, Issue 8, 2001, Pages 1771-1777

  Cnop, Miriam ^a   Hannaert, Jean Claude ^a   Hoorens, Anne ^a   Eizirik, Décio L ^a   Pipeleers, Daniel G ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; ENZYME INHIBITOR; EPOXIDE; ETOMOXIR; FATTY ACID; OLEIC ACID; PALMITIC ACID; PALMITIC ACID DERIVATIVE; TRIACYLGLYCEROL;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; CYTOPLASM; DRUG ANTAGONISM; DRUG EFFECT; KINETICS; MALE; METABOLISM; PANCREAS ISLET; RAT; TIME; WISTAR RAT;

ANIMALS; APOPTOSIS; CARNITINE O-PALMITOYLTRANSFERASE; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASM; ENZYME INHIBITORS; EPOXY COMPOUNDS; FATTY ACIDS, NONESTERIFIED; ISLETS OF LANGERHANS; KINETICS; MALE; OLEIC ACID; PALMITIC ACID; PALMITIC ACIDS; RATS; RATS, WISTAR; TIME FACTORS; TRIGLYCERIDES;

EID: 0035430782     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.8.1771     Document Type: Article

References (45)

1. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E: A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38:1213-1217, 1995
2. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789, 1963
3. Lillioja S, Bogardus C, Mott D, Kennedy LA, Knowler WC, Howard BV: Relationship between insulin-mediated glucose disposal and lipid metabolism in man. J Clin Invest 75:1106-1115, 1985
4. Ferrannini E, Barrett EJ, Bevilacqua S, De Fronzo RA: Effect of fatty acids on glucose production and utilizalion in man. J Clin Invest 72:1737-1747, 1983
5. Waldhausl WK, Roden M: The effects of free fatty acids on glucose transport and phosphorylation in human skeletal muscle. Curr Opin Endocrinol Diabetes 7:211-216, 2000
6. Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ: Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101:1094-1101, 1998
7. Zhou Y, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
8. Zhou Y, Grill VE: Long term exposure to fatty acids and ketones inhibits β-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584-1500, 1995
9. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci U S A 91:10878-10882, 1994
10. Lee Y, Hirose H, Zhou Y, Esser V, McGarry JD, Unger RH: Increased lipogenic capacity of the islets of obese rats. Diabetes 46:408-413, 1997
11. Shimabukuro M, Zhou Y, Levi M, Unger RH: Fatty acid-induced β cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 95:2498-2502, 1998
12. Hoorens A, Pipeleers DG: Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia 42:55-59, 1999
13. Hoorens A, Stangé G, Pavlovic D, Pipeleers D: Distinction between interleukin-1-induced necrosis and apoptosis of islet cells. Diabetes 50: 551-557, 2001
14. Hoorens A, Van de Casteele M, Klöppel G, Pipeleers DG: Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574, 1996
15. Pipeleers DG, in't Veld PA, Van De Winkel M, Maes E, Schuit FC, Gepts W: A new in vitro model for the study of pancreatic α and β cells. Endocrinology 117:806-816, 1985
16. Ling Z, Hannaert JC, Pipeleers DG: Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture. Diabetologia 37:15-21, 1994
17. Spector AA, Fletcher JE, Ashbrook JD: Analysis of long-chair free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants. Biochemistry 10:3229-3232, 1971
18. Richieri GV, Anel A, Kleinfeld AM: Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32:7574-7580, 1993
19. 15N]nitrate in biological fluids. Anal Biochem 126:131-138, 1982
20. Flodström M, Chen MC, Smismans A, Schuit F, Pipeleers DG, Eizirik DL: Interleukin 1β increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic β cells. Cytokine 11:400-407, 1999
21. Pipeleers DG, Van De Winkel M: Pancreatic β cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci U S A 83:5267-5271, 1986
22. Wallenstein S, Zucker CL, Fleiss JL: Some statistical methods useful in circulation research. Circ Res 47:1-9, 1980
23. Richieri GV, Ogata RT, Kleinfeld AM: A fluorescently labeled intestinal fatty acid binding protein. J Biol Chem 267:23495-23501, 1992
24. Cistola DP, Hamilton JA, Jackson D, Small DM: Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule. Biochemistry 27:1881-1888, 1988
25. Stocker R, Bowry VW: Tocopherol-mediated peroxidation of lipoprotein lipids and its inhibition by co-antioxidants. In Handbook of Antioxidants. Cadenas E, Packer L, Eds. New York, Marcel Dekker, 1996, p. 27-41
26. Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD: More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling. Diabetes 43:878-883, 1994
27. Shimabukuro M, Ohneda M, Lee Y, Unger RH: Role of nitric oxide in obesity-induced β cell disease. J Clin Invest 100:290-295, 1997
28. Unger RH, Zhou Y, Orci L: Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A 96:2327-2332, 1999
29. Milburn JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH: Pancreatic β-cells in obesity. J Biol Chem 270:1295-1299, 1995
30. Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH: Defective fatty acid-mediated β-cell compensation in Zucker diabetic fatty rats. J Biol Chem 271:5633-5637, 1996
31. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE: Malonyl-CoA and long-chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion J Biol Chem 267:5802-5810, 1992
32. Liu YQ, Tornheim K, Leahy JL: Fatty acid-induced β cell hypersensitivity to glucose. J Clin Invest 101:1870-1875, 1998
33. Warnotte C, Gilon P, Nenqnin M, Henquin JC: Mechanisms of the stimulation of insulin release by saturated fatty acids. Diabetes 43:703-711, 1994
34. Gordon GB: Saturated free fatty acid toxicity, Exp Mol Pathol 27:262-276, 1977
35. de Vries JE, Vork MM, Roemen THM, de Jong YF, Cleutjens JPM, van der Vusse GJ, van Bilsen M: Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J Lipid Res 38:1384-1394, 1997
36. Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA: Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proc Natl Acad Sci U S A 89:10930-10934, 1992
37. Oakes ND, Kjellstedt A, Forsberg GB, Clementz T, Camejo G, Furler SM, Kraegen EW, Olwegard-Halvarsson M, Jenkins AB, Ljung B: Development and initial evaluation of a novel method for assessing tissue-specific plasma free fatty acid utilization in vivo using (R)-2-bromopalmitate tracer. J Lipid Res 40:1155-1169, 1999
38. Chase JFA, Tubbs PK: Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters. Biochem J 129:55-65, 1972
39. Declercq PE, Falck JR, Kuwajima M, Tyminski H, Foster DW, McGarry JD: Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. J Biol Chem 262:9812-9821, 1987
40. Luxon BA: Inhibition of binding to fatty acid binding protein reduces the intracellular transport of fatty acids. Am J Physiol 271:G113-G120, 1996
41. Paumen MB, Ishida Y, Muramatsu M, Yamamoto M, Honjo T: Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272:3324-3329, 1997
42. Luiken JJFP, van Nieuwenhoven FA, America G, van der Vusse GJ, Glatz JFC: Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: involvement of sarcolemmal proteins. J Lipid Res 38:745-758, 1997
43. Carlsson C, Borg LAH, Welsh N: Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140:3422-3428, 1999
44. Zhou Y, Ling Z, Grill VE: Inhibitory effects of fatty acids on glucose-regulated β-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism 45:981-986, 1996
45. Berne C: The metabolism of lipids in mouse pancreatic islets: the oxidation of fatty acids and ketone bodies. Biochem J 152:661-666, 1975