SOCS proteins: Negative regulators of cytokine signaling

Stem Cells

Volumn 19, Issue 5, 2001, Pages 378-387

  Krebs, Danielle L ^a   Hilton, Douglas J ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Cytokine; JAK; Signal transduction; SOCS; STAT

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; GAMMA INTERFERON; JANUS KINASE; PROTEASOME; STAT PROTEIN; SUPPRESSOR FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING; UNCLASSIFIED DRUG;

BINDING SITE; CELL DIFFERENTIATION; CELL SURFACE; CYTOKINE RELEASE; ENZYME INACTIVATION; EXTRAMEDULLARY HEMATOPOIESIS; GENE OVEREXPRESSION; GENE TARGETING; NEGATIVE FEEDBACK; PROTEIN ANALYSIS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

JANUS;

EID: 0034801684     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.19-5-378     Document Type: Review

References (70)

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7. A new protein containing an SH2 domain that inhibits JAK kinases
8. Twenty proteins containing a C-terminal SOCS box form five structural classes
9. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
10. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
11. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs
12. SWiP-1: Novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development
13. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
14. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
15. Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
16. STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver
17. A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons
18. Identification of SOCS-3 as a potential mediator of central leptin resistance
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20. The role of SOCS-3 in leptin signaling and leptin resistance
21. Interleukin-10 inhibits expression of both interferon alpha- and interferon gammainduced genes by suppressing tyrosine phosphorylation of STAT1
22. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma
23. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
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27. Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS-3 promoter
28. SOCS-3 is an insulin-induced negative regulator of insulin signaling
29. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1
30. SOCS3 is essential in the regulation of fetal liver erythropoiesis
31. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
32. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
33. Mechanism of STAT3 activation by insulin-like growth factor I receptor
34. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice
35. Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction
36. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
37. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
38. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
39. Interferon induces peripheral lymphadenopathy in mice
40. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
41. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts
42. Gigantism in mice lacking suppressor of cytokine signalling-2
43. Transgenic models of growth hormone action
44. Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads
45. Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice
46. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
47. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
48. Cloning and characterization of novel CIS family genes
49. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells
50. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
51. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
52. Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone
53. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
54. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein
55. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
56. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
57. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
58. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
59. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
60. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
61. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
62. SOCS-1 is a potent inhibitor of IL-4 signal transduction
63. CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling
64. Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
65. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not S2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
66. Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction
67. Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor
68. Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells
69. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
70. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor receptor