Calcineurin signaling regulates human islet β-cell survival

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 40050-40059

  Soleimanpour, Scott A ^a   Crutchlow, Michael F ^a   Ferrari, Alana M ^a   Raum, Jeffrey C ^a   Groff, David N ^a   Rankin, Matthew M ^b,c   Liu, Chengyang ^a   De León, Diva D ^b,c   Naji, Ali ^a   Kushner, Jake A ^b,c   Stoffers, Doris A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; CALCINEURIN; CALCINEURIN INHIBITORS; CELL APOPTOSIS; CELL REPLICATION; CELL SURVIVAL; ELEMENT-BINDING PROTEINS; HUMAN ISLETS; INSULIN RECEPTORS; MEDIATED SIGNALING PATHWAYS; NUCLEAR FACTOR OF ACTIVATED T-CELLS; TACROLIMUS;

CELL DEATH; MAMMALS; PHOSPHORYLATION; SIGNALING;

FETAL MONITORING;

CALCINEURIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EXENDIN 4; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REGULATOR PROTEIN; TACROLIMUS; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIVISION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; REGULATORY MECHANISM; RODENT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CALCINEURIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIC AMP; DIABETES MELLITUS; GENE EXPRESSION REGULATION; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOSUPPRESSIVE AGENTS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MICE; NFATC TRANSCRIPTION FACTORS; ORGAN TRANSPLANTATION; PEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; TACROLIMUS; VENOMS;

RODENTIA;

EID: 78650059541     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.154955     Document Type: Article

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