Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 5, 2003, Pages 2300-2308

  Yoon, Kun Ho ^a,e   Ko, Seung Hyun ^f   Cho, Jae Hyoung ^a   Lee, Jung Min ^f   Ahn, Yu Bae ^f   Song, Ki Ho ^f   Yoo, Soon Jib ^f   Kang, Moo Il ^f   Cha, Bong Yun ^f   Lee, Kwang Woo ^f   Son, Ho Young ^f   Kang, Sung Koo ^f   Kim, Hee Seung ^b   Lee, In Kyu ^c   Bonner Weir, Susan ^d  

^a The Catholic University of Korea   (South Korea)

^b Seoul Metropolitan Government Seobuk Hospital   (South Korea)

^c Dongsan Medical Center   (South Korea)

^d JOSLIN DIABETES CENTER   (United States)

^e The Catholic University of Korea   (South Korea)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; CELL FRACTIONATION; CELL VOLUME; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; KOREA; MALE; MORPHOMETRICS; NON INSULIN DEPENDENT DIABETES MELLITUS; ORGAN DONOR; PANCREAS; PANCREAS ISLET; PANCREAS ISLET CELL; PANCREAS RESECTION; PANCREAS TUMOR; PATIENT; PRIORITY JOURNAL; SURGICAL TECHNIQUE;

ADULT; AGED; BODY MASS INDEX; CELL SIZE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN; ISLETS OF LANGERHANS; KOREA; MALE; MIDDLE AGED; PANCREATECTOMY; PANCREATIC NEOPLASMS; TISSUE DONORS;

EID: 0038707331     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020735     Document Type: Article

References (43)

1. Welsh M, Mares J, Oberg C, Karlsson T 1993 Genetic factors of importance for β-cell proliferation. Diabetes Metab Rev 9:25-36
2. Leahy JL, Bonner-Weir S, Weir GC 1992 Beta cell dysfunction induced by chronic hyperglycemia. Diabetes Care 15:442-455
3. Sempoux C, Guiot Y, Dubois D, Moulin P, Rahier J 2001 Morphological evidence for abnormal β-cell function. Diabetes 50(Suppl 1):S172-S177
4. Clark A, Jones LC, de Koning E, Hansen BC, Matthews DR 2001 Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function? Diabetes 50(Suppl 1):S169-S171
5. Gepts W, Lecompte PM 1981 The pancreatic islets in diabetes. Am J Med 70:105-115
6. Ken S, Nobuhisa Y, Tohru T 1979 Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects. Tohoku J Exp Med 129:273-283
7. Kloppel G, Lohr M, Habich K, Oberholzer M, Heitz P 1985 Islet pathology and pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Path Res 4:110-125
8. Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJ, Holman RR, Turner RC 1988 Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res Clin Pract 4:151-159
9. Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH 1982 Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 31:694-700
10. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S 2002 Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islets of Japanese type II diabetic patients. Diabetologia 45:85-96
11. O'Reilly LA, Gu D, Sarvetnick N, Edlund H, Phillips JM, Fulford T, Cooke A 1997 α-cell neogenesis in an animal model of IDDM. Diabetes 46:599-606
12. Li Z, Karlsson FA, Sandler S 2000 Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice. J Endocrinol 165:93-99
13. Rahier J, Goebbels RM, Henquin JC 1983 Cellular composition of the human diabetic pancreas. Diabetologia 24:366-371
14. Montanya E, Nacher V, Biarnes M, Soler J 2000 Linear correlation between β-cell mass and body weight throughout the lifespan in Lewis rats: role of β-cell hyperplasia and hypertrophy. Diabetes 49:1341-1346
15. Park YS, Lee KU, Kim CH, Kim HK, Hong SK, Park KS, Lee HK, Min HK 1997 Past and current obesity in Koreans with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 35:49-56
16. Kim DJ, Lee MS, Kim KW, Lee MK 2001 Insulin secretory dysfunction and insulin resistance in the pathogenesis of Korean type 2 diabetes mellitus. Metabolism 50:590-593
17. Lu WG, Pipeleers DG, Kloppel G, Bouwens L 1996 Comparative immunocytochemical study of MHC class II expression in human donor pancreas and isolated islets. Virchows Arch 429:205-211
18. Weibel ER 1978 Stereologic methods. In: Practical methods for biologic morphometry, vol 1. London: Academic Press; 101-161
19. Montana E, Bonner-Weir S, Weir GC 1993 β-Cell mass and growth after syngeneic islet cell transplantation in normal and streptozotocin diabetic C57BL/6mice. J Clin Invest 91:780-787
20. Montana E, Bonner-Weir S, Weir GC 1994 Transplanted β cell response to increased metabolic demand: changes in β cell replication and mass. J Clin Invest 93:1577-1582
21. Bouwens L, Pipeleers DG 1998 Extra-insular β cells associated with ductules are frequent in adult human pancreas. Diabetologia 41:629-633
22. Bonner-Weir S 2001 β-Cell turnover: its assessment and implications. Diabetes 50(Suppl 1):S20-S24
23. Bonner-Weir S 2000 Islet growth and development in the adult. J Mol Endocrinol 24:297-302
24. Bonner-Weir S 1994 Regulation of pancreatic β-cell mass in vivo. Recent Prog Horm Res 49:91-104
25. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS 1998 Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell degects in the male Zucker diabetic fatty rat. Diabetes 47:358-364
26. Bernard-Kargar C, Ktorza A 2001 Endocrine pancreas plasticity under physiological and pathological conditions. Diabetes 50(Suppl 1):S30-S35
27. Bernard C, Berthault MF, Saulnier C, Ktorza A 1999 Neogenesis vs. apoptosis as main components of pancreatic β cell mass changes in glucose-infused normal and mildly diabetic adult rats. FASEB J 13:1195-1205
28. Vinik A, Pittenger G, Rafaeloff R, Rosenberg L, Duguid W 1996 Determinants of pancreatic islet cell mass: a balance between neogenesis and senescence/apoptosis. Diabetes Rev 4:235-263
29. Corbett J, Serup P, Bonner-Weir S, Nielsen JH 1997 Beta-cell ontogeny: growth and death. Diabetologia 40:B27-B32
30. Bonner-Weir S, Deery D, Leahy JL, Weir GC 1989 Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion. Diabetes 38:49-53
31. Parsons JA, Brelje TC, Sorenson RL 1992 Adaptation of islet to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130:1459-1466
32. Parsons JA, Bartke A, Sorenson RL 1995 Number and islet size of islets of Langerhans in pregnant human growth hormone-expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormones. Endocrinology 136:2013-2021
33. Scaglia L, Smith FE, Bonner-Weir S 1995 Apoptosis contributes to the involution of β cell mass in the post partum rat pancreas. Endocrinology 136:5461-5468
34. Marynissen G, Malaisse WJ, Van Assche FA 1987 Influence of lactation on morphometric and secretory variables in pancreatic β-cell of mildly diabetic rats. Diabetes 36:883-891
35. Milburn Jr JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, Beltrandel-Rio H, Newgard CB, Johnson JH, Unger RH 1995 Pancreatic β-cells in obesity: evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 270:1295-1299
36. Saito K, Takahashi T, Yaginuma N, Iwama N 1978 Islet morphometry in the diabetic pancreas of man. Tohoku J Exp Med 125:185-197
37. Wittingen J, Frey CF 1974 Islet concentration in the head, body, tail and uncinate process of the pancreas. Ann Surg 412-414
38. Baetens D, Malaisse LF, Perrelet A, Orci L 1979 Endocrine pancreas: three dimensional reconstruction shows two types of islets of Langerhans. Science 206:1323-1325
39. Orci L, Malaisse-Lagae F, Amherdt M, Ravazzola M, Weisswange A, Dobbs R, Perrelet A, Unger R 1975 Cell contacts in human islets of Langerhans. J Clin Endocrinol Metab 41:841-844
40. Westermark P 1994 Amyloid and polypeptide hormones: what is their interrelationship? Int J Exp Clin Invest 1:47-60
41. Bouwens L, Kloppel G 1996 Islet cell neogenesis in the pancreas. Virchows Arch 427:553-560
42. Bouwens L 1998 Transdifferentiation versus stem cell hypothesis for the regeneration of islet β-cells in the pancreas. Microsc Res Tech 43:332-336
43. Rosenberg L 1995 In vivo transformation: neogenesis of β cells from pancreatic ductal cells. Cell Transplant 4:371-383