Neogenesis vs. apoptosis as main components of pancreatic β cell mass changes in glucose-infused normal and mildly diabetic adult rats

FASEB Journal

Volumn 13, Issue 10, 1999, Pages 1195-1205

  Bernard, Catherine ^a   Berthault, Marie France ^a   Saulnier, Catherine ^a   Ktorza, Alain ^a  

^a EUROPEAN SPACE AGENCY   (France)

Author keywords

Chronic hyperglycemia; Pancreas plasticity; Streptozotocin

Indexed keywords

GLUCOSE; INSULIN; STREPTOZOCIN;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOCRINE CELL; GLUCOSE INFUSION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PLASTICITY; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALIA;

EID: 0032999544     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.10.1195     Document Type: Article

References (32)

1. Marynissen, G., Aerts, L., and Van Assche, F. A. (1983) The endocrine pancreas during pregnancy and lactation in the rat. J. Dev. Physiol. 5, 373-381
2. Hellerström, C., Andersson, A., Swenne, I., Welsh, N., and Sjoholm, A. (1988) Replication of B cells in the normal and diabetic pancreas. In The Pathology of the Endocrine Pancreas in Diabetes (Lefebvre, P., and Pipeleers, D., eds) pp. 141-170, Springer-Verlag, Heidelberg, Germany
3. Parsons, J. A., Brelje, T. C., and Sorenson, R. L. (1992) Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130, 1459-1466
4. Bonner-Weir, S., and Smith, F. (1994) Islet cell growth and the growth factors involved. Trends Endocrinol. Metab. 5, 60-64
5. Finegood, D. T., Scaglia, L., and Bonner-Weir, S. (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44, 249-256
6. Swenne, I. (1983) Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat. Diabetes 32, 14-19
7. Westermark, P., and Willander, E. (1978) The influence of amyloid deposits on the islet volume in maturity-onset diabetes mellitus. Diabetologia, 15, 417-421
8. Gepts, W., and Lecompte, P. (1981) The pancreatic islets in diabetes. Am. J. Med. 70, 105-114
9. Klöppel, G., Löhr, M., Habich, K., Oberholzer, M., and Heitz, P. (1985) Islet pathology and pathogenesis of Type 1 and Type 2 diabetes mellitus revisited. Surv. Synth. Path. Res. 4, 110-125
10. Clark, A., Wells, C. A., Buley, I. D., Cruickshank, J. K., Vanhegan, R. I., Matthews, D. R., Cooper, G. J., Holman, R. R., and Turner, R. C. (1988) Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res. 9, 151-159
11. Bernard, C., Thibault, C., Berthault, M. F., Magnan, C., Saulnier, C., Portha, B., Pralong, W. F., Pénicaud, L., and Ktorza, A. (1998) Pancreatic beta-cell regeneration after 48 h glucose infusion in mildly diabetic rats is not correlated with functional improvement. Diabetes 47, 1058-1065
12. Thibault, C., Guettet, C., Laury, M. C., N'Guyen, J. M., Tormo, M. A., Bailbé, D., Portha, B., Pénicaud, L., and Ktorza, A. (1993) In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48 h hyperglycaemic period. Diabetologia 36, 589-595
13. Ktorza, A., Girard, J., Kinebanyan, M. F., and Picon, L. (1981) Hyperglycemia induced by glucose infusion in the unrestrained pregnant rat during the last three days of gestation: metabolic and hormonal changes in the mother and the fetuses. Diabetologia 21, 569-574
14. Montana, E., Bonner-Weir, S., and Weir, G. C. (1993) Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. J. Clin. Invest. 91, 780-787
15. Movassat, J., Saulnier, C., and Portha, B. (1997) Insulin administration enhances growth of the beta-cell mass in streptozotocin-treated newborn rats. Diabetes 46, 1445-1452
16. Swenne, I. (1982) The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. Diabetes 31, 754-760
17. Coles, H., Burne, J., and Raff, M. (1993) Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 118, 777-784
18. Rosenberg, L., Brown, R. A., and Duguid, W. P. (1983) A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J. Surg. Res. 35, 63-72
19. Rosenberg, L., Duguid, W. P., Healy, M., Clas, D., and Vinik, A. I. (1992) Reversal of diabetes by the induction of islet cell neogenesis. Transplant. Proc. 24, 1027-1028
20. Wang, R. N., Klöppel, G., and Bouwens, L. (1995) Duct to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38, 1405-1411
21. Bonner-Weir, S., Trent, D. F., Zmachinski, C. J., Clore, E. T., and Weir, G. C. (1981) Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone. Metabolism 30, 914-918
22. Bonner-Weir, S., Trent, D. F., and Weir, G. C. (1983) Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin. Invest. 71, 1544-1553
23. Cantenys, D., Portha, B., Dutrillaux, M. C., Hollande, E., Roz, C., and Picon, L. (1981) Histogenesis of the endocrine pancreas in newborn rats after destruction by streptozotocin. An immuno-cytochemical study. Virchows Arch. 35, 109-122
24. Lipsett, M., Dhatt, N., and Finegood, D. T. (1998) Pancreatic ductule formation induced by glucose infusion in adult rats. 47 (Suppl. 1), A257 (abstr.)
25. Bonner-Weir, S., Deery, D., Leahy, J. L., and Weir, G. C. (1989) Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 38, 49-53
26. Susini, S., Roche, E., Prentki, M., and Schlegel, W. (1998) Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta (INS-1) cells. FASEB J. 12, 1173-1182
27. Höörens, A., Van de Casteele, M., Klöppel, G., and Pipeleers, D. (1996) Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J. Clin. Invest. 98, 1568-1574
28. Gu, D., and Sarvetnick, N. (1993) Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development 118, 33-46
29. Cecil, R. (1911) On hypertrophy and regeneration of islands of Langerhans. J. Exp. Med. 14, 500-519
30. Scaglia, L., Smith, F. E., and Bonner-Weir, S. (1995) Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology 136, 5461-5468
31. Laybutt, D., Chisholm, D., and Kreagen, E. (1997) Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats. Am. J. Physiol. 273, E1-E9
32. Pick, A., Clark, J., Kubstrup, C., Levisetti, M., Pugh, W., Bonner-Weir, S., and Polonsky, K. S. (1998) Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47, 358-364