-
1
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238, 2000
-
(2000)
N Engl J Med
, vol.343
, pp. 230-238
-
-
Shapiro, A.M.J.1
Lakey, J.R.T.2
Ryan, E.A.3
Korbutt, G.S.4
Toth, E.5
Warnock, G.L.6
Kneteman, N.M.7
Rajotte, R.V.8
-
2
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian W, Auger JA, Poumain-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA: Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346:1692-1698, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumain-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
3
-
-
0033954474
-
Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass and induces mild hypoglycemia
-
Garcia-Ocaña A, Takane K, Syed MA, Philbrick WM, Vasavada RC, Stewart AF: Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass and induces mild hypoglycemia, J Biol Chem 275:1226-1232, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 1226-1232
-
-
Garcia-Ocaña, A.1
Takane, K.2
Syed, M.A.3
Philbrick, W.M.4
Vasavada, R.C.5
Stewart, A.F.6
-
4
-
-
0034686028
-
Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia
-
Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann PS, Ogren L, Talamantes F, Stewart AF: Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem 275:15399-15406, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 15399-15406
-
-
Vasavada, R.C.1
Garcia-Ocaña, A.2
Zawalich, W.S.3
Sorenson, R.L.4
Dann, P.S.5
Ogren, L.6
Talamantes, F.7
Stewart, A.F.8
-
6
-
-
2342510386
-
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46, 2004
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
7
-
-
0021885273
-
Glucose-stimulated DNA replication in the pancreatic islets during the development of the rat fetus
-
Swenne I: Glucose-stimulated DNA replication in the pancreatic islets during the development of the rat fetus. Diabetes 34:803-807, 1985
-
(1985)
Diabetes
, vol.34
, pp. 803-807
-
-
Swenne, I.1
-
8
-
-
0028987251
-
Dynamics of β-cell mass in the growing rat pancreas: Estimation with a simple mathematical model
-
Finegood DT, Scaglia L, Bonner-Weir S: Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44:249-256, 1995
-
(1995)
Diabetes
, vol.44
, pp. 249-256
-
-
Finegood, D.T.1
Scaglia, L.2
Bonner-Weir, S.3
-
9
-
-
0030953998
-
Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation
-
Ptasznik A, Beattie GM, Mally MI, Cirulli V, Lopez A, Hayek A: Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation. J Cell Biol 137:1127-1136, 1997
-
(1997)
J Cell Biol
, vol.137
, pp. 1127-1136
-
-
Ptasznik, A.1
Beattie, G.M.2
Mally, M.I.3
Cirulli, V.4
Lopez, A.5
Hayek, A.6
-
10
-
-
0030825432
-
Adaptation of islets of Langerhans to pregnancy: Beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
-
Sorenson RL, Brelje TC: Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29:301-307, 1997
-
(1997)
Horm Metab Res
, vol.29
, pp. 301-307
-
-
Sorenson, R.L.1
Brelje, T.C.2
-
11
-
-
0028937476
-
Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin
-
Harvey M, Vogel H, Lee EY-P, Bradley A, Donehower LA: Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res 55:1146-1151, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 1146-1151
-
-
Harvey, M.1
Vogel, H.2
Lee, E.Y.-P.3
Bradley, A.4
Donehower, L.A.5
-
12
-
-
0028136594
-
Cooperative tumorigenic effects of germline mutations in Rb and p53
-
Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T: Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet 7:480-484, 1994
-
(1994)
Nat Genet
, vol.7
, pp. 480-484
-
-
Williams, B.O.1
Remington, L.2
Albert, D.M.3
Mukai, S.4
Bronson, R.T.5
Jacks, T.6
-
13
-
-
0021888904
-
Heritable formation of pancreatic β-cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
-
Hanahan D: Heritable formation of pancreatic β-cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115-122, 1985
-
(1985)
Nature
, vol.315
, pp. 115-122
-
-
Hanahan, D.1
-
14
-
-
0034534019
-
Overexpression of cyclin D1 occurs frequently in human pancreatic endocrine tumors
-
Chung DC, Brown SB, Grahme-Cooke F, Seto M, Warshaw AL, Jensen RT, Arnold A: Overexpression of cyclin D1 occurs frequently in human pancreatic endocrine tumors. J Clin Endocrinol Metab 85:4373-4378, 2000
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 4373-4378
-
-
Chung, D.C.1
Brown, S.B.2
Grahme-Cooke, F.3
Seto, M.4
Warshaw, A.L.5
Jensen, R.T.6
Arnold, A.7
-
15
-
-
14644422601
-
Overexpression of cyclin D1 in pancreatic β-cells in vivo results in islet hyperplasia without hypoglycemia
-
Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC: Overexpression of cyclin D1 in pancreatic β-cells in vivo results in islet hyperplasia without hypoglycemia. Diabetes 54:712-719, 2005
-
(2005)
Diabetes
, vol.54
, pp. 712-719
-
-
Zhang, X.1
Gaspard, J.P.2
Mizukami, Y.3
Li, J.4
Graeme-Cook, F.5
Chung, D.C.6
-
16
-
-
9644266753
-
β-Cell replication is the primary mechanism for maintaining postnatal beta cell mass
-
Georgia S, Bhushan A: β-Cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114:963-968, 2004
-
(2004)
J Clin Invest
, vol.114
, pp. 963-968
-
-
Georgia, S.1
Bhushan, A.2
-
17
-
-
17644387563
-
Cyclins D2 and D1 are essential for postnatal pancreatic beta cell growth
-
Kushner J, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF: Cyclins D2 and D1 are essential for postnatal pancreatic beta cell growth. Mol Cell Biol 25:3752-3762, 2005
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3752-3762
-
-
Kushner, J.1
Ciemerych, M.A.2
Sicinska, E.3
Wartschow, L.M.4
Teta, M.5
Long, S.Y.6
Sicinski, P.7
White, M.F.8
-
18
-
-
85047690318
-
Impaired pancreatic growth, β cell mass and β cell function in E2F1-/- mice
-
Fajas L, Annicotte J-S, Miard S, Sarruf D, Watanabe M, Auwerx J: Impaired pancreatic growth, β cell mass and β cell function in E2F1-/- mice. J Clin Invest 113:1288-1295, 2004
-
(2004)
J Clin Invest
, vol.113
, pp. 1288-1295
-
-
Fajas, L.1
Annicotte, J.-S.2
Miard, S.3
Sarruf, D.4
Watanabe, M.5
Auwerx, J.6
-
19
-
-
2942596505
-
Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double mutant mice
-
Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Field SJ, Real FX, Zubiaga AM: Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double mutant mice. J Clin Invest 113:1398-1407, 2004
-
(2004)
J Clin Invest
, vol.113
, pp. 1398-1407
-
-
Iglesias, A.1
Murga, M.2
Laresgoiti, U.3
Skoudy, A.4
Bernales, I.5
Fullaondo, A.6
Moreno, B.7
Lloreta, J.8
Field, S.J.9
Real, F.X.10
Zubiaga, A.M.11
-
20
-
-
0032937751
-
Loss of expression of cdk4 causes insulin-deficient diabetes and cdk4 activation results in beta cell hyperplasia
-
Rane S, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M: Loss of expression of cdk4 causes insulin-deficient diabetes and cdk4 activation results in beta cell hyperplasia. Nat Genet 22:44-52, 1999
-
(1999)
Nat Genet
, vol.22
, pp. 44-52
-
-
Rane, S.1
Dubus, P.2
Mettus, R.V.3
Galbreath, E.J.4
Boden, G.5
Reddy, E.P.6
Barbacid, M.7
-
21
-
-
0032849353
-
Targeted disruption of cdk4 delays cell cycle entry with enhanced p27-kip activity
-
Tsutsui T, Hesabi B, Moons D, Pandolfi PP, Hansel KS, Koff A, Kiyokawa H: Targeted disruption of cdk4 delays cell cycle entry with enhanced p27-kip activity. Mol Cell Biol 19:7011-7019, 1999
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7011-7019
-
-
Tsutsui, T.1
Hesabi, B.2
Moons, D.3
Pandolfi, P.P.4
Hansel, K.S.5
Koff, A.6
Kiyokawa, H.7
-
22
-
-
0033304945
-
The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
-
Pestell RG, Albanese C, Reutens AT, Segall JE, Lee RJ, Arnold A: The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20:501-534, 1999
-
(1999)
Endocr Rev
, vol.20
, pp. 501-534
-
-
Pestell, R.G.1
Albanese, C.2
Reutens, A.T.3
Segall, J.E.4
Lee, R.J.5
Arnold, A.6
-
23
-
-
9444236895
-
Cyclin D1: Normal and abnormal functions
-
Fu M, Wang C, Li Z, Sakamaki T, Pestell RG: Cyclin D1: normal and abnormal functions. Endocrinology 145:5439-5447, 2004
-
(2004)
Endocrinology
, vol.145
, pp. 5439-5447
-
-
Fu, M.1
Wang, C.2
Li, Z.3
Sakamaki, T.4
Pestell, R.G.5
-
24
-
-
4444350468
-
Wagging the dogma: Tissue-specific cell cycle control in the mouse embryo
-
Pagano M, Jackson PK: Wagging the dogma: tissue-specific cell cycle control in the mouse embryo. Cell 118:535-538, 2004
-
(2004)
Cell
, vol.118
, pp. 535-538
-
-
Pagano, M.1
Jackson, P.K.2
-
25
-
-
20044380925
-
Deletion of cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
-
Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M: Deletion of cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 11:175-182, 2005
-
(2005)
Nat Med
, vol.11
, pp. 175-182
-
-
Uchida, T.1
Nakamura, T.2
Hashimoto, N.3
Matsuda, T.4
Kotani, K.5
Sakaue, H.6
Kido, Y.7
Hayashi, Y.8
Nakayama, K.I.9
White, M.F.10
Kasuga, M.11
-
26
-
-
13344270898
-
Overexpression of PTHrP in the pancreatic islets of transgenic mice causes hypoglycemia, hyperinsulinemia and islet hyperplasia
-
Vasavada R, Cavaliere C, D'Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick WM, Stewart AF: Overexpression of PTHrP in the pancreatic islets of transgenic mice causes hypoglycemia, hyperinsulinemia and islet hyperplasia. J Biol Chem 271:1200-1208, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 1200-1208
-
-
Vasavada, R.1
Cavaliere, C.2
D'Ercole, A.J.3
Dann, P.4
Burtis, W.J.5
Madlener, A.L.6
Zawalich, K.7
Zawalich, W.8
Philbrick, W.M.9
Stewart, A.F.10
-
27
-
-
0035650568
-
Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes
-
Garcia-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, Lopez-Talavera J-C, Stewart AF: Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes. Diabetes 50:2752-2762, 2001
-
(2001)
Diabetes
, vol.50
, pp. 2752-2762
-
-
Garcia-Ocaña, A.1
Vasavada, R.C.2
Cebrian, A.3
Reddy, V.4
Takane, K.K.5
Lopez-Talavera, J.-C.6
Stewart, A.F.7
-
28
-
-
9444254643
-
Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen
-
Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC: Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen. Diabetes 53:3120-3130, 2004
-
(2004)
Diabetes
, vol.53
, pp. 3120-3130
-
-
Fujinaka, Y.1
Sipula, D.2
Garcia-Ocaña, A.3
Vasavada, R.C.4
-
29
-
-
0029097759
-
Radiation induced cell cycle arrest compromised by p21 deficiency
-
Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ: Radiation induced cell cycle arrest compromised by p21 deficiency. Nature 377:552-557, 1995
-
(1995)
Nature
, vol.377
, pp. 552-557
-
-
Brugarolas, J.1
Chandrasekaran, C.2
Gordon, J.I.3
Beach, D.4
Jacks, T.5
Hannon, G.J.6
-
30
-
-
0042856301
-
Genetic rescue of cdk-4-null mice restores pancreatic beta cell proliferation but not homeostatic cell number
-
Martin J, Hunt SL, Dubus P, Sotillo R, Nehme-Pelluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M: Genetic rescue of cdk-4-null mice restores pancreatic beta cell proliferation but not homeostatic cell number. Oncogene 22:5261-5269, 2003
-
(2003)
Oncogene
, vol.22
, pp. 5261-5269
-
-
Martin, J.1
Hunt, S.L.2
Dubus, P.3
Sotillo, R.4
Nehme-Pelluard, F.5
Magnuson, M.A.6
Parlow, A.F.7
Malumbres, M.8
Ortega, S.9
Barbacid, M.10
-
32
-
-
0030903830
-
Prolactin regulation of islet-derived INS-1 cells: Characteristics and immunocytochemical analysis of STAT5 translocation
-
Stout LE, Svensson AM, Sorenson RL: Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation. Endocrinology 138:1592-1603, 1997
-
(1997)
Endocrinology
, vol.138
, pp. 1592-1603
-
-
Stout, L.E.1
Svensson, A.M.2
Sorenson, R.L.3
-
33
-
-
33644764291
-
Double transgenic overexpression of PTHrP and HGF in the pancreatic islet: Effects on β-cell growth and function
-
Garcia-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane K, Lopez-Talavera J-C, Stewart AFS: Double transgenic overexpression of PTHrP and HGF in the pancreatic islet: effects on β-cell growth and function. Diabetes 50 (Suppl. 2):A525, 2001
-
(2001)
Diabetes
, vol.50
, Issue.2 SUPPL.
-
-
Garcia-Ocaña, A.1
Vasavada, R.C.2
Cebrian, A.3
Reddy, V.4
Takane, K.5
Lopez-Talavera, J.-C.6
Stewart, A.F.S.7
-
34
-
-
0033637086
-
Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
-
Sage J, Mulligan GJ, Attardi LD, Miller A, Chen SQ, Williams B, Theodorou E, Jacks T: Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization. Genes Dev 14:3037-3050, 2000
-
(2000)
Genes Dev
, vol.14
, pp. 3037-3050
-
-
Sage, J.1
Mulligan, G.J.2
Attardi, L.D.3
Miller, A.4
Chen, S.Q.5
Williams, B.6
Theodorou, E.7
Jacks, T.8
-
35
-
-
0030922363
-
The retinoblastoma gene family is differentially expressed during embryogenesis
-
Jiang Z, Zacksenhaus E, Gallie BL, Phillips RA: The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene 14:1789-1797, 1997
-
(1997)
Oncogene
, vol.14
, pp. 1789-1797
-
-
Jiang, Z.1
Zacksenhaus, E.2
Gallie, B.L.3
Phillips, R.A.4
-
36
-
-
0032840013
-
Oxidative stress induces p21 expression in pancreatic isla cells: Possible implication in beta cell dysfunction
-
Kaneto H, Kajimoto Y, Fujitani Y, Matsuoka T, Sakamoto K, Matsuhisa M, Yamasaki Y, Hori M: Oxidative stress induces p21 expression in pancreatic isla cells: possible implication in beta cell dysfunction. Diabetologia 42:1093-1097, 1999
-
(1999)
Diabetologia
, vol.42
, pp. 1093-1097
-
-
Kaneto, H.1
Kajimoto, Y.2
Fujitani, Y.3
Matsuoka, T.4
Sakamoto, K.5
Matsuhisa, M.6
Yamasaki, Y.7
Hori, M.8
-
38
-
-
0347364774
-
ZGlobal expression analysis of well differentiatred pancreatic endocrtine neoplasms using oligonucleotide microarrays
-
Maitra A, Hansel DE, Afgani P, Ashfaq R, Rahman A, Naji A, Deng S, Geradts J, Hawthorne LA, House MG, Yeo CJ: ZGlobal expression analysis of well differentiatred pancreatic endocrtine neoplasms using oligonucleotide microarrays. Clin Cancer Res 9:5988-5995, 2003
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5988-5995
-
-
Maitra, A.1
Hansel, D.E.2
Afgani, P.3
Ashfaq, R.4
Rahman, A.5
Naji, A.6
Deng, S.7
Geradts, J.8
Hawthorne, L.A.9
House, M.G.10
Yeo, C.J.11
-
39
-
-
0032553485
-
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, Walkman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B: Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501, 1998
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Walkman, T.4
Zhou, S.5
Brown, J.P.6
Sedivy, J.M.7
Kinzler, K.W.8
Vogelstein, B.9
-
41
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512, 1999
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
42
-
-
0033559264
-
kip cdk 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
-
kip cdk 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18:1571-1583, 1999
-
(1999)
EMBO J
, vol.18
, pp. 1571-1583
-
-
Cheng, M.1
Olivier, P.2
Diehl, J.A.3
Fero, M.4
Roussel, M.F.5
Roberts, J.M.6
Sherr, C.J.7
|