FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

Cell Metabolism

Volumn 2, Issue 3, 2005, Pages 153-163

  Kitamura, Yukari Ido ^a   Kitamura, Tadahiro ^a   Kruse, Jan Philipp ^b,c   Raum, Jeffrey C ^d   Stein, Roland ^d   Gu, Wei ^c   Accili, Domenico ^a  

^a NewYork Presbyterian Hospital   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NONE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH FACTOR RECEPTOR; INSULIN; NEUROGENIC DIFFERENTIATION FACTOR; NUCLEAR PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN MAFA; SIRTUIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FOXO; UBIQUITIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BETA GALACTOSIDASE; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; HYDROGEN PEROXIDE; LUCIFERASE; MAFA PROTEIN, MOUSE; MESSENGER RNA; NERVE PROTEIN; PML PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR MAF; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME REPRESSION; HYPERGLYCEMIA; IN VIVO STUDY; MOLECULAR MECHANICS; MOUSE; MUTANT; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSGENICS; ADENOVIRUS; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENT ANTIBODY TECHNIQUE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; POINT MUTATION; PROMOTER REGION; TRANSGENIC MOUSE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALIA;

ACETYLATION; ADENOVIRIDAE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DIABETES MELLITUS, TYPE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; LUCIFERASES; MAF TRANSCRIPTION FACTORS, LARGE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; POINT MUTATION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIRTUINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 27744518040     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2005.08.004     Document Type: Article

References (52)

1. D. Accili Lilly lecture 2003: The struggle for mastery in insulin action: From triumvirate to republic Diabetes 53 2004 1633-1642
2. D. Accili K.C. Arden FoxOs at the crossroads of cellular metabolism, differentiation, and transformation Cell 117 2004 421-426
3. G.I. Bell K.S. Polonsky Diabetes mellitus and genetically programmed defects in beta-cell function Nature 414 2001 788-791
4. C.L. Brooks W. Gu Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation Curr. Opin. Cell Biol. 15 2003 164-171
5. A. Brunet A. Bonni M.J. Zigmond M.Z. Lin P. Juo L.S. Hu M.J. Anderson K.C. Arden J. Blenis M.E. Greenberg Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor Cell 96 1999 857-868
6. A. Brunet L.B. Sweeney J.F. Sturgill K.F. Chua P.L. Greer Y. Lin H. Tran S.E. Ross R. Mostoslavsky H.Y. Cohen et. al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011-2015
7. Q.M. Chen J. Liu J.B. Merrett Apoptosis or senescence-like growth arrest: Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts Biochem. J. 347 2000 543-551
8. H. Daitoku M. Hatta H. Matsuzaki S. Aratani T. Ohshima M. Miyagishi T. Nakajima A. Fukamizu Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proc. Natl. Acad. Sci. USA 101 2004 10042-10047
9. G.P. Dimri X. Lee G. Basile M. Acosta G. Scott C. Roskelley E.E. Medrano M. Linskens I. Rubelj O. Pereira-Smith et. al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc. Natl. Acad. Sci. USA 92 1995 9363-9367
10. V. Doucas M. Tini D.A. Egan R.M. Evans Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling Proc. Natl. Acad. Sci. USA 96 1999 2627-2632
11. C. Frippiat Q.M. Chen S. Zdanov J.P. Magalhaes J. Remacle O. Toussaint Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts J. Biol. Chem. 276 2001 2531-2537
12. W. Gu X.L. Shi R.G. Roeder Synergistic activation of transcription by CBP and p53 Nature 387 1997 819-823
13. A. Guo P. Salomoni J. Luo A. Shih S. Zhong W. Gu P. Paolo Pandolfi The function of PML in p53-dependent apoptosis Nat. Cell Biol. 2 2000 730-736
14. M.C. Harbeck D.C. Louie J. Howland B.A. Wolf P.L. Rothenberg Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells Diabetes 45 1996 711-717
15. H.P. Huang M. Liu H.M. El-Hodiri K. Chu M. Jamrich M.J. Tsai Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3 Mol. Cell. Biol. 20 2000 3292-3307
16. H.P. Huang K. Chu E. Nemoz-Gaillard D. Elberg M.J. Tsai Neogenesis of beta-cells in adult BETA2/NeuroD-deficient mice Mol. Endocrinol. 16 2002 541-551
17. A. Ito Y. Kawaguchi C.H. Lai J.J. Kovacs Y. Higashimoto E. Appella T.P. Yao MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation EMBO J. 21 2002 6236-6245
18. J. Jensen R.S. Heller T. Funder-Nielsen E.E. Pedersen C. Lindsell G. Weinmaster O.D. Madsen P. Serup Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation Diabetes 49 2000 163-176
19. J.W. Jeong M.K. Bae M.Y. Ahn S.H. Kim T.K. Sohn M.H. Bae M.A. Yoo E.J. Song K.J. Lee K.W. Kim Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation Cell 111 2002 709-720
20. T. Kitamura J. Nakae Y. Kitamura Y. Kido W.H. Biggs 3rd C.V. Wright M.F. White K.C. Arden D. Accili The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth J. Clin. Invest. 110 2002 1839-1847
21. T. Kitamura Y. Kitamura J. Nakae A. Giordano S. Cinti C.R. Kahn A. Efstratiadis D. Accili Mosaic analysis of insulin receptor function J. Clin. Invest. 113 2004 209-219
22. G.J. Kops B.M. Burgering Forkhead transcription factors: New insights into protein kinase B (c- akt) signaling J. Mol. Med. 77 1999 656-665
23. S. Lenzen J. Drinkgern M. Tiedge Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues Free Radic. Biol. Med. 20 1996 463-466
24. M. Li J. Luo C.L. Brooks W. Gu Acetylation of p53 inhibits its ubiquitination by Mdm2 J. Biol. Chem. 277 2002 50607-50611
25. M. Li C.L. Brooks F. Wu-Baer D. Chen R. Baer W. Gu Mono- versus polyubiquitination: Differential control of p53 fate by Mdm2 Science 302 2003 1972-1975
26. J. Luo A.Y. Nikolaev S. Imai D. Chen F. Su A. Shiloh L. Guarente W. Gu Negative control of p53 by Sir2alpha promotes cell survival under stress Cell 107 2001 137-148
27. J. Luo M. Li Y. Tang M. Laszkowska R.G. Roeder W. Gu Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo Proc. Natl. Acad. Sci. USA 101 2004 2259-2264
28. T.A. Matsuoka L. Zhao I. Artner H.W. Jarrett D. Friedman A. Means R. Stein Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells Mol. Cell. Biol. 23 2003 6049-6062
29. T.A. Matsuoka I. Artner E. Henderson A. Means M. Sander R. Stein The MafA transcription factor appears to be responsible for tissue-specific expression of insulin Proc. Natl. Acad. Sci. USA 101 2004 2930-2933
30. R.H. Medema G.J. Kops J.L. Bos B.M. Burgering AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 Nature 404 2000 782-787
31. T. Miyata T. Maeda J.E. Lee NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus Genes Dev. 13 1999 1647-1652
32. M.C. Motta N. Divecha M. Lemieux C. Kamel D. Chen W. Gu Y. Bultsma M. McBurney L. Guarente Mammalian SIRT1 represses forkhead transcription factors Cell 116 2004 551-563
33. J. Nakae T. Kitamura D.L. Silver D. Accili The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression J. Clin. Invest. 108 2001 1359-1367
34. J. Nakae W.H. Biggs T. Kitamura W.K. Cavenee C.V. Wright K.C. Arden D. Accili Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 Nat. Genet. 32 2002 245-253
35. J. Nakae T. Kitamura Y. Kitamura W.H. Biggs K.C. Arden D. Accili The forkhead transcription factor foxo1 regulates adipocyte differentiation Dev. Cell 4 2003 119-129
36. F.J. Naya H.P. Huang Y. Qiu H. Mutoh F.J. DeMayo A.B. Leiter M.J. Tsai Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice Genes Dev. 11 1997 2323-2334
37. H. Okamoto J. Nakae T. Kitamura B.C. Park I. Dragatsis D. Accili Transgenic rescue of insulin receptor-deficient mice J. Clin. Invest. 114 2004 214-223
38. M. Olbrot J. Rud L.G. Moss A. Sharma Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA Proc. Natl. Acad. Sci. USA 99 2002 6737-6742
39. M. Pearson P.G. Pelicci PML interaction with p53 and its role in apoptosis and replicative senescence Oncogene 20 2001 7250-7256
40. V. Poitout L.K. Olson R.P. Robertson Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator J. Clin. Invest. 97 1996 1041-1046
41. F. Quignon F. De Bels M. Koken J. Feunteun J.C. Ameisen H. de The PML induces a novel caspase-independent death process Nat. Genet. 20 1998 259-265
42. R.P. Robertson J. Harmon P.O. Tran Y. Tanaka H. Takahashi Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection Diabetes 52 2003 581-587
43. M. Sandri C. Sandri A. Gilbert C. Skurk E. Calabria A. Picard K. Walsh S. Schiaffino S.H. Lecker A.L. Goldberg Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy Cell 117 2004 399-412
44. V.M. Schwitzgebel D.W. Scheel J.R. Conners J. Kalamaras J.E. Lee D.J. Anderson L. Sussel J.D. Johnson M.S. German Expression of neurogenin3 reveals an islet cell precursor population in the pancreas Development 127 2000 3533-3542
45. A. Sharma L.K. Olson R.P. Robertson R. Stein The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression Mol. Endocrinol. 9 1995 1127-1134
46. T.N. Stitt D. Drujan B.A. Clarke F. Panaro Y. Timofeyva W.O. Kline M. Gonzalez G.D. Yancopoulos D.J. Glass The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors Mol. Cell 14 2004 395-403
47. A. van der Horst L.G. Tertoolen L.M. de Vries-Smits R.A. Frye R.H. Medema B.M. Burgering FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) J. Biol. Chem. 279 2004 28873-28879
48. H. Vaziri S.K. Dessain E. Ng Eaton S.I. Imai R.A. Frye T.K. Pandita L. Guarente R.A. Weinberg hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 2001 149-159
49. N. Welsh B. Margulis L.A. Borg H.J. Wiklund J. Saldeen M. Flodstrom M.A. Mello A. Andersson D.G. Pipeleers C. Hellerstrom et. al. Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus Mol. Med. 1 1995 806-820
50. D.J. Withers J. Sanchez-Gutierrez H. Towery D.J. Burks J.-M. Ren S. Previs Y. Zhang D. Bernal S. Pons G.I. Shulman et. al. Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900-904
51. L. Zhao M. Guo T.A. Matsuoka D.K. Hagman S.D. Parazzoli V. Poitout R. Stein The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription J. Biol. Chem. 280 2005 11887-11894
52. S. Zhong P. Hu T.Z. Ye R. Stan N.A. Ellis P.P. Pandolfi A role for PML and the nuclear body in genomic stability Oncogene 18 1999 7941-7947