메뉴 건너뛰기




Volumn 105, Issue 6, 2000, Pages 731-740

Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INSULIN; MESSENGER RNA; SOMATOMEDIN B;

EID: 0034063375     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5656     Document Type: Article
Times cited : (140)

References (59)
  • 3
    • 0031587697 scopus 로고    scopus 로고
    • Insulin-like growth factors
    • Le Roith, D. 1997. Insulin-like growth factors. N. Engl. J. Med. 336:633-640.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 633-640
    • Le Roith, D.1
  • 4
    • 0023857378 scopus 로고
    • Expression of somaromedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: Identification, characterization, and tissue distribution
    • Han, V.K., Lund, P.K., Lee, D.C., and D'Ercole, A.J. 1988. Expression of somaromedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterization, and tissue distribution. J. Clin. Endocrinol. Metab. 66:422-429.
    • (1988) J. Clin. Endocrinol. Metab. , vol.66 , pp. 422-429
    • Han, V.K.1    Lund, P.K.2    Lee, D.C.3    D'Ercole, A.J.4
  • 5
    • 0027451064 scopus 로고
    • Interactions of nutrients, insulin-like growth factors (IGFs) and IGF-binding proteins in the regulation of DNA synthesis by isolated fetal rat islets of Langerhans
    • Hogg, J., Han, V.K.M., Clemmons, D.H., and Hill, D.J. 1993. Interactions of nutrients, insulin-like growth factors (IGFs) and IGF-binding proteins in the regulation of DNA synthesis by isolated fetal rat islets of Langerhans. J. Endocrinol. 138:401-412.
    • (1993) J. Endocrinol. , vol.138 , pp. 401-412
    • Hogg, J.1    Han, V.K.M.2    Clemmons, D.H.3    Hill, D.J.4
  • 6
    • 0020067003 scopus 로고
    • Insulin and multiplication stimulating activity (an insulin-like growth factor) stimulate islet beta-cell replication in neonatal rat pancreatic monolayer cultures
    • Rabinovitch, A., Quigley, C., Russell, T., Patel, Y., and Mintz, D.H. 1982. Insulin and multiplication stimulating activity (an insulin-like growth factor) stimulate islet beta-cell replication in neonatal rat pancreatic monolayer cultures. Diabetes. 31:160-164.
    • (1982) Diabetes , vol.31 , pp. 160-164
    • Rabinovitch, A.1    Quigley, C.2    Russell, T.3    Patel, Y.4    Mintz, D.H.5
  • 7
    • 0027250196 scopus 로고
    • Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones
    • Maake, C., and Reinecke, M. 1993. Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones. Cell Tissue Res. 273:249-259.
    • (1993) Cell Tissue Res. , vol.273 , pp. 249-259
    • Maake, C.1    Reinecke, M.2
  • 8
    • 9344234447 scopus 로고    scopus 로고
    • Increased amounts of a high molecular weight insulin-like growth factor II (IGF-II) peptide and IGF-II messenger ribonucleic acid in pancreatic islets of diabetic Goto-Kakizaki rats
    • Hoog, A., et al. 1996. Increased amounts of a high molecular weight insulin-like growth factor II (IGF-II) peptide and IGF-II messenger ribonucleic acid in pancreatic islets of diabetic Goto-Kakizaki rats. Endocrinology. 137:2415-2423.
    • (1996) Endocrinology , vol.137 , pp. 2415-2423
    • Hoog, A.1
  • 9
    • 0030883227 scopus 로고    scopus 로고
    • Ultrastructural localization of insulin-like growth factor-2 (IGF-2) to the secretory granules of insulin cells: A study in normal and diabetic (GK) rats
    • Hoog, A., et al. 1997. Ultrastructural localization of insulin-like growth factor-2 (IGF-2) to the secretory granules of insulin cells: a study in normal and diabetic (GK) rats. Ultrastruct. Pathol. 21:457-466.
    • (1997) Ultrastruct. Pathol. , vol.21 , pp. 457-466
    • Hoog, A.1
  • 10
    • 0030596338 scopus 로고    scopus 로고
    • Non-insulin-dependent diabetes mellitus: A genetically programmed failure of the beta cell to compensate for insulin resistance
    • Polonsky, K.S., Sturis, J., and Bell, G.I. 1996. Non-insulin-dependent diabetes mellitus: a genetically programmed failure of the beta cell to compensate for insulin resistance. N. Engl. J. Med. 334:777-783.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 777-783
    • Polonsky, K.S.1    Sturis, J.2    Bell, G.I.3
  • 11
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetic genes
    • De Fronzo, R.A. 1997. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetic genes. Diabetes Reviews. 5:177-269.
    • (1997) Diabetes Reviews , vol.5 , pp. 177-269
    • De Fronzo, R.A.1
  • 12
    • 0026468362 scopus 로고
    • What if minkowski had been ageusic? An alternative angle on diabetes
    • McGarry, J.D. 1992. What if Minkowski had been ageusic? An alternative angle on diabetes. Science. 258:766-770.
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 13
    • 0026048186 scopus 로고
    • Exaggerated early insulin release and insulin resistance in a diabetes-prone population: A metabolic comparison of Pima Indians and Caucasians
    • Lillioja, S., et al. 1991. Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. J. Clin. Endocrinol. Metab. 73:866-876.
    • (1991) J. Clin. Endocrinol. Metab. , vol.73 , pp. 866-876
    • Lillioja, S.1
  • 14
    • 0028213750 scopus 로고
    • Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity
    • Le Stunff, C., and Bougneres, P. 1992. Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes. 43:696-702.
    • (1992) Diabetes , vol.43 , pp. 696-702
    • Le Stunff, C.1    Bougneres, P.2
  • 15
    • 0028506528 scopus 로고
    • Central nervous system and peripheral abnormalities: Clues to the understanding of obesity and NIDDM
    • Jeanrenaud, B. 1994. Central nervous system and peripheral abnormalities: clues to the understanding of obesity and NIDDM Diabetologia. 37(Suppl. 2):S170-S178.
    • (1994) Diabetologia , vol.37 , Issue.SUPPL. 2
    • Jeanrenaud, B.1
  • 16
    • 0026546176 scopus 로고
    • Muscle insulin resistance may not be a primary etiological factor in the genetically obese fa/fa rat
    • Zarjevski, N., Doyle, P., and Jeanrenaud, B. 1992. Muscle insulin resistance may not be a primary etiological factor in the genetically obese fa/fa rat. Endocrinology. 130:1564-1570.
    • (1992) Endocrinology , vol.130 , pp. 1564-1570
    • Zarjevski, N.1    Doyle, P.2    Jeanrenaud, B.3
  • 17
    • 0028314008 scopus 로고
    • Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus
    • Kanery, H., Moshe, S., Shafrir, E., Lunenfeld, B., and Karasik, A. 1994. Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA. 91:1853-1857.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1853-1857
    • Kanery, H.1    Moshe, S.2    Shafrir, E.3    Lunenfeld, B.4    Karasik, A.5
  • 18
    • 0028147131 scopus 로고
    • Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man
    • Del Prato, S., et al. 1994. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia. 37:1025-1035.
    • (1994) Diabetologia , vol.37 , pp. 1025-1035
    • Del Prato, S.1
  • 19
    • 0026601859 scopus 로고
    • Patients with insulinoma show insulin resistance in the absence of arterial hypertension
    • Pontiroli, A.E., Alberetto, M., and Pozza, G. 1992. Patients with insulinoma show insulin resistance in the absence of arterial hypertension. Diabetalogia. 35:294-295.
    • (1992) Diabetalogia , vol.35 , pp. 294-295
    • Pontiroli, A.E.1    Alberetto, M.2    Pozza, G.3
  • 20
    • 0029856092 scopus 로고    scopus 로고
    • Comparison of insulin sensitivity in patients with insulinoma and obese type 2 diabetes mellitus
    • Skrha, J., Sindelka, G., Haas, T., Hilgertova, J., and Justova, V. 1996. Comparison of insulin sensitivity in patients with insulinoma and obese Type 2 diabetes mellitus. Horm. Metab. Res. 28:595-598.
    • (1996) Horm. Metab. Res. , vol.28 , pp. 595-598
    • Skrha, J.1    Sindelka, G.2    Haas, T.3    Hilgertova, J.4    Justova, V.5
  • 21
    • 0024457316 scopus 로고
    • Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene
    • Marban, S.L., DeLoia, J.A., and Gearhart, J.D. 1989. Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene. Dev. Genet. 10:356-364.
    • (1989) Dev. Genet. , vol.10 , pp. 356-364
    • Marban, S.L.1    DeLoia, J.A.2    Gearhart, J.D.3
  • 22
    • 0001044371 scopus 로고
    • Hyperinsulinemia precedes insulin resistance in transgenic mouse model of type II diabetes
    • Abstr.
    • Marban, S.L. 1992. Hyperinsulinemia precedes insulin resistance in transgenic mouse model of type II diabetes. Diabetes. 41(Suppl.):145A. (Abstr.)
    • (1992) Diabetes , vol.41 , Issue.SUPPL.
    • Marban, S.L.1
  • 23
    • 0023030927 scopus 로고
    • Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor
    • Stempien, M.M., Fong, N.M., Rall, L.B., and Bell, G.I. 1986. Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 5:357-361.
    • (1986) DNA , vol.5 , pp. 357-361
    • Stempien, M.M.1    Fong, N.M.2    Rall, L.B.3    Bell, G.I.4
  • 24
    • 0028073946 scopus 로고
    • Expression of Glut-2 antisense RNA in β-cells of transgenic mice leads to diabetes
    • Valera, A., et al. 1994. Expression of Glut-2 antisense RNA in β-cells of transgenic mice leads to diabetes. J. Biol. Chem. 269:28543-28546.
    • (1994) J. Biol. Chem. , vol.269 , pp. 28543-28546
    • Valera, A.1
  • 26
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases
    • Chirgwin, J.M., Przybyla, A.W., McDonald, R.J., and Rutter, W.J. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases. Biochemistry. 18:5294-5299.
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.W.2    McDonald, R.J.3    Rutter, W.J.4
  • 27
    • 0014042613 scopus 로고
    • Method for the isolation of intact islets of Langerhans from the rat pancreas
    • Lacy, P.E., and Kostianousky, M. 1967. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 16:35-39.
    • (1967) Diabetes , vol.16 , pp. 35-39
    • Lacy, P.E.1    Kostianousky, M.2
  • 29
    • 0029889265 scopus 로고    scopus 로고
    • Functional active receptors for insulin-like growth factor-1 (IGF-I) and IGH-II on insulin-glucagon-, and somatostatin-producing cells
    • Fehmann, H.C., Jehle, P., Markus, U., and Goke, B. 1996. Functional active receptors for insulin-like growth factor-1 (IGF-I) and IGH-II on insulin-glucagon-, and somatostatin-producing cells. Metabolism. 45:759-766.
    • (1996) Metabolism , vol.45 , pp. 759-766
    • Fehmann, H.C.1    Jehle, P.2    Markus, U.3    Goke, B.4
  • 30
    • 0028874383 scopus 로고
    • Involution of β-cell dysfunction in the male Zucker diaberic fatty rat
    • Tokuyama, Y., et al. 1995. Involution of β-cell dysfunction in the male Zucker diaberic fatty rat. Diabetes, 44:1447-1457.
    • (1995) Diabetes , vol.44 , pp. 1447-1457
    • Tokuyama, Y.1
  • 31
    • 0028997729 scopus 로고
    • The β-cell in diabetes: From molecular genetics to clinical research
    • Polonsky, K.S. 1995. The β-cell in diabetes: from molecular genetics to clinical research. Diabetes. 44:705-717.
    • (1995) Diabetes , vol.44 , pp. 705-717
    • Polonsky, K.S.1
  • 32
    • 0017686819 scopus 로고
    • Changes in the islets of Langerhans in the obese Zucker rat
    • Larsson, L.I., Boder, G.B., and Shaw, W.N. 1977. Changes in the islets of Langerhans in the obese Zucker rat. Lab. Invest. 36:593-598.
    • (1977) Lab. Invest. , vol.36 , pp. 593-598
    • Larsson, L.I.1    Boder, G.B.2    Shaw, W.N.3
  • 33
    • 0015901279 scopus 로고
    • Structural changes of pancreatic islets in genetically obese rats
    • Shino, A., Matsueo, T., Iwatsuka, H., and Zizuki, Z. 1973. Structural changes of pancreatic islets in genetically obese rats. Diabetologia. 9:413-421.
    • (1973) Diabetologia , vol.9 , pp. 413-421
    • Shino, A.1    Matsueo, T.2    Iwatsuka, H.3    Zizuki, Z.4
  • 34
    • 0014799716 scopus 로고
    • Studies in the diabetic mutant mouse: Electron microscopy of pancreatic islets
    • Like, A.A., and Chick, W.L. 1970. Studies in the diabetic mutant mouse: electron microscopy of pancreatic islets. Diabetologia. 6:216-242.
    • (1970) Diabetologia , vol.6 , pp. 216-242
    • Like, A.A.1    Chick, W.L.2
  • 35
    • 0023547895 scopus 로고
    • Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells
    • Van Schravendijk, C.F.H., Foriers, A., Van den Brande, J.L., and Pipeleers, D.G. 1987. Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells. Endocrinology. 121:1784-1788.
    • (1987) Endocrinology , vol.121 , pp. 1784-1788
    • Van Schravendijk, C.F.H.1    Foriers, A.2    Van Den Brande, J.L.3    Pipeleers, D.G.4
  • 36
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling
    • Withers, D.J., et al. 1999. Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling. Nat. Genet. 23:32-40.
    • (1999) Nat. Genet. , vol.23 , pp. 32-40
    • Withers, D.J.1
  • 37
    • 0015864927 scopus 로고
    • The influence of genetic background on the expression of the obese (ob) gene in the mouse
    • Coleman, D.L., and Hummel, K.P. 1973. The influence of genetic background on the expression of the obese (ob) gene in the mouse. Diabetologia. 9:287-293.
    • (1973) Diabetologia , vol.9 , pp. 287-293
    • Coleman, D.L.1    Hummel, K.P.2
  • 38
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    • Bruning, J.C., et al. 1997. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell. 21:561-572.
    • (1997) Cell , vol.21 , pp. 561-572
    • Bruning, J.C.1
  • 39
    • 0024508097 scopus 로고
    • Compensatory growth of pancreatic B-cells in adult rats after short term glucose infusion
    • Bonner-Weir, S., Deery, D., Leahy, J.L. and Weir, G.C. 1989. Compensatory growth of pancreatic B-cells in adult rats after short term glucose infusion. Diabetes. 38:49 -53.
    • (1989) Diabetes , vol.38 , pp. 49-53
    • Bonner-Weir, S.1    Deery, D.2    Leahy, J.L.3    Weir, G.C.4
  • 40
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • Araki, E., et al. 1994. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 372:186-190.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1
  • 41
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • Tamemoto, H., et al. 1994. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature. 372:182-186.
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1
  • 42
    • 0343939275 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes
    • Withers, D.J., et al. 1998. Disruption of IRS-2 causes type 2 diabetes. Nature. 391:300-903.
    • (1998) Nature , vol.391 , pp. 300-903
    • Withers, D.J.1
  • 43
    • 0027944978 scopus 로고
    • The insulin-like growth factor-1 receptor. Structure, ligand-binding mechanism and signal transduction
    • De Meyts, P., et al. 1994. The insulin-like growth factor-1 receptor. Structure, ligand-binding mechanism and signal transduction. Horm. Res. 42:152-169.
    • (1994) Horm. Res. , vol.42 , pp. 152-169
    • De Meyts, P.1
  • 44
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor 1 receptor
    • LeRoith, D., Werner, H., Beitner-Johnson, D., and Roberts, C.T. 1995. Molecular and cellular aspects of the insulin-like growth factor 1 receptor. Endocr. Rev. 16:143-163.
    • (1995) Endocr. Rev. , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts, C.T.4
  • 45
    • 0021688886 scopus 로고
    • The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells
    • Mottola, C., and Czech, M.P. 1984. The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells. J. Biol. Chem. 259:12705-12713.
    • (1984) J. Biol. Chem. , vol.259 , pp. 12705-12713
    • Mottola, C.1    Czech, M.P.2
  • 46
    • 0026036288 scopus 로고
    • Genomic imprinting and the strange case of the insulin-like growth factor II receptor
    • Haig, D., and Graham, C. 1991. Genomic imprinting and the strange case of the insulin-like growth factor II receptor. Cell. 64:1045-1046.
    • (1991) Cell , vol.64 , pp. 1045-1046
    • Haig, D.1    Graham, C.2
  • 47
    • 0026635880 scopus 로고
    • Genetic analysis of genomic imprinting: An imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus
    • Forejt, J., and Gregorova, S. 1992. Genetic analysis of genomic imprinting: an imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Cell. 70:443-450.
    • (1992) Cell , vol.70 , pp. 443-450
    • Forejt, J.1    Gregorova, S.2
  • 48
    • 0030976615 scopus 로고    scopus 로고
    • Insulin-like growth factor II stimulates cell proliferation through the insulin receptor
    • Morrione, A., et al. 1997. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc. Natl. Acad. Sci. USA. 94:3777-3782.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3777-3782
    • Morrione, A.1
  • 49
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni, R.N., et al. 1999. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96:329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1
  • 50
    • 0027231548 scopus 로고
    • Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone gene
    • Valera, A., et al. 1993. Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone gene. FASEB J. 7:791-800.
    • (1993) FASEB J. , vol.7 , pp. 791-800
    • Valera, A.1
  • 51
    • 0033323812 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hiperplasia
    • Petrik, J., et al. 1999. Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hiperplasia. Endocrinology. 140:2353-2363.
    • (1999) Endocrinology , vol.140 , pp. 2353-2363
    • Petrik, J.1
  • 52
    • 0026463439 scopus 로고
    • Insulin-like growth factors (IGFs): Implications for aging
    • Cohen, P., et al. 1992. Insulin-like growth factors (IGFs): implications for aging. Psyconeuroendocrinology. 17:335-342.
    • (1992) Psyconeuroendocrinology , vol.17 , pp. 335-342
    • Cohen, P.1
  • 53
    • 0028318189 scopus 로고
    • Altered body composition and increased frequency of diverse malignancies in insulin-like growth factos-II transgenic mice
    • Rogler, C.E., et al. 1994. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factos-II transgenic mice. J. Biol. Chem. 269:13779-13784.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13779-13784
    • Rogler, C.E.1
  • 54
    • 0030022827 scopus 로고    scopus 로고
    • Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice
    • Rossetti, L., et al. 1996. Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice. J. Biol. Chem. 271:203-208.
    • (1996) J. Biol. Chem. , vol.271 , pp. 203-208
    • Rossetti, L.1
  • 55
    • 0025218963 scopus 로고
    • Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion
    • Leahy J.L., and Vandekerkhove, K.M. 1990. Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion. Endocrinology. 126:1593-1598.
    • (1990) Endocrinology , vol.126 , pp. 1593-1598
    • Leahy, J.L.1    Vandekerkhove, K.M.2
  • 56
    • 0029969719 scopus 로고    scopus 로고
    • Effects of insulin-like growth factors (IGF) on pancreatic islet function in IGF binding protein-1 transgenic mice
    • Dheen, S.T., Kajkumar, K., and Murphy, L.J. 1996. Effects of insulin-like growth factors (IGF) on pancreatic islet function in IGF binding protein-1 transgenic mice. Diabetologia. 39:1249-1254.
    • (1996) Diabetologia , vol.39 , pp. 1249-1254
    • Dheen, S.T.1    Kajkumar, K.2    Murphy, L.J.3
  • 57
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
    • Unger, R.H. 1995. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes. 44:863-870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 58
    • 0027947379 scopus 로고
    • β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
    • Lee, Y., et al. 1994. β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc. Natl. Acad. Sci. USA. 91:10878-10882.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10878-10882
    • Lee, Y.1
  • 59
    • 0028985060 scopus 로고
    • Pancreatic β-cell in obesity
    • Milburn, J.L., et al. 1995. Pancreatic β-cell in obesity. J. Biol. Chem. 270:1295-1299.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1295-1299
    • Milburn, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.