메뉴 건너뛰기




Volumn 113, Issue 10, 2004, Pages 1398-1407

Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; E2F1 PROTEIN, MOUSE; E2F2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F;

EID: 2942596505     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200418879     Document Type: Article
Times cited : (87)

References (46)
  • 1
    • 0032825860 scopus 로고    scopus 로고
    • Identification of target genes of oncogenic transcription factors
    • Boyd, K.E., and Farnham, P.J. 1999. Identification of target genes of oncogenic transcription factors. Proc. Soc. Exp. Biol. Med. 222:9-28.
    • (1999) Proc. Soc. Exp. Biol. Med. , vol.222 , pp. 9-28
    • Boyd, K.E.1    Farnham, P.J.2
  • 2
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRb-family proteins
    • Dyson, N. 1998. The regulation of E2F by pRb-family proteins. Genes Dev. 12:2245-2262.
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 3
    • 0031886093 scopus 로고    scopus 로고
    • Regulation of cell proliferation by the E2F transcription factors
    • Helin, K. 1998. Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8:28-35.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 28-35
    • Helin, K.1
  • 4
    • 0037150731 scopus 로고    scopus 로고
    • The genetics of the E2F family of transcription factors: Shared functions and unique roles
    • DeGregori, J. 2002. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim. Biophys. Acta. 1602:131-150.
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 131-150
    • DeGregori, J.1
  • 5
    • 0034949169 scopus 로고    scopus 로고
    • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis
    • Ishida, S., et al. 2001. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol. Cell. Biol. 21:4684-4699.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4684-4699
    • Ishida, S.1
  • 6
    • 0035252592 scopus 로고    scopus 로고
    • E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
    • Müller, H., et al. 2001. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15:267-285.
    • (2001) Genes Dev. , vol.15 , pp. 267-285
    • Müller, H.1
  • 7
    • 0037080483 scopus 로고    scopus 로고
    • E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints
    • Ren, B., et al. 2002. E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints. Genes Dev. 16:245-256.
    • (2002) Genes Dev. , vol.16 , pp. 245-256
    • Ren, B.1
  • 8
    • 0037080674 scopus 로고    scopus 로고
    • Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis
    • Weinmann, A.S., Yan, P.S., Oberley, M.J., Huang, T.H., and Farnham, P.J. 2002. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 16:235-244.
    • (2002) Genes Dev. , vol.16 , pp. 235-244
    • Weinmann, A.S.1    Yan, P.S.2    Oberley, M.J.3    Huang, T.H.4    Farnham, P.J.5
  • 9
    • 0034175616 scopus 로고    scopus 로고
    • Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
    • Takahashi, Y., Rayman, J.B., and Dynlacht, B.D. 2000. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 14:804-816.
    • (2000) Genes Dev. , vol.14 , pp. 804-816
    • Takahashi, Y.1    Rayman, J.B.2    Dynlacht, B.D.3
  • 10
    • 0033857983 scopus 로고    scopus 로고
    • Target gene specificity of E2F and pocket protein family members in living cells
    • Wells, J., Boyd, K.E., Fry, C.J., Bartley, S.M., and Farnham, P.J. 2000. Target gene specificity of E2F and pocket protein family members in living cells. Mol. Cell. Biol. 20:5797-5807.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5797-5807
    • Wells, J.1    Boyd, K.E.2    Fry, C.J.3    Bartley, S.M.4    Farnham, P.J.5
  • 11
    • 0029949784 scopus 로고    scopus 로고
    • E2F1 functions in mice to promote apoptosis and suppress proliferation
    • Field, S.J., et al. 1996. E2F1 functions in mice to promote apoptosis and suppress proliferation. Cell. 85:549-561.
    • (1996) Cell , vol.85 , pp. 549-561
    • Field, S.J.1
  • 12
    • 0029888359 scopus 로고    scopus 로고
    • Tumor induction and tissue atrophy in mice lacking E2F-1
    • Yamasaki, L., et al. 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 85:537-548.
    • (1996) Cell , vol.85 , pp. 537-548
    • Yamasaki, L.1
  • 13
    • 0033450933 scopus 로고    scopus 로고
    • A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection
    • Zhu, J.W., DeRyckere, D., Li, F.X., Wan, Y.Y., and DeGregori, J. 1999. A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection. Cell Growth Differ. 10:829-838.
    • (1999) Cell Growth Differ. , vol.10 , pp. 829-838
    • Zhu, J.W.1    DeRyckere, D.2    Li, F.X.3    Wan, Y.Y.4    DeGregori, J.5
  • 14
    • 0034056483 scopus 로고    scopus 로고
    • A role for E2F1 in the induction of apoptosis during thymic negative selection
    • Garcia, I., Murga, M., Vicario, A., Field, S.J., and Zubiaga, A.M. 2000. A role for E2F1 in the induction of apoptosis during thymic negative selection. Cell Growth Differ. 11:91-98.
    • (2000) Cell Growth Differ. , vol.11 , pp. 91-98
    • Garcia, I.1    Murga, M.2    Vicario, A.3    Field, S.J.4    Zubiaga, A.M.5
  • 15
    • 18244409134 scopus 로고    scopus 로고
    • Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity
    • Murga, M., et al. 2001. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 15:959-970.
    • (2001) Immunity , vol.15 , pp. 959-970
    • Murga, M.1
  • 16
    • 0035197922 scopus 로고    scopus 로고
    • E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis
    • Zhu, J.W., et al. 2001. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol. Cell. Biol. 21:8547-8564.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8547-8564
    • Zhu, J.W.1
  • 17
    • 0034654105 scopus 로고    scopus 로고
    • E2F3 is critical for normal cellular proliferation
    • Humbert, P.O., et al. 2000. E2F3 is critical for normal cellular proliferation. Genes Dev. 14:690-703.
    • (2000) Genes Dev. , vol.14 , pp. 690-703
    • Humbert, P.O.1
  • 18
    • 0348191246 scopus 로고    scopus 로고
    • E2F4 is essential for normal erythrocyte maturation and neonatal viability
    • Humbert, P.O., et al. 2000. E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol. Cell. 6:281-291.
    • (2000) Mol. Cell , vol.6 , pp. 281-291
    • Humbert, P.O.1
  • 19
    • 0346930623 scopus 로고    scopus 로고
    • Loss of E2F4 activity leads to abnormal development of multiple cellular lineages
    • Rempel, R.E., et al. 2000. Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol. Cell. 6:293-306.
    • (2000) Mol. Cell , vol.6 , pp. 293-306
    • Rempel, R.E.1
  • 20
    • 0032522452 scopus 로고    scopus 로고
    • A specific, nonproliferative role for E2F-5 in choroids plexus function revealed by gene targeting
    • Lindeman, G.J., et al. 1998. A specific, nonproliferative role for E2F-5 in choroids plexus function revealed by gene targeting. Genes Dev. 12:1092-1098.
    • (1998) Genes Dev. , vol.12 , pp. 1092-1098
    • Lindeman, G.J.1
  • 22
    • 0036205327 scopus 로고    scopus 로고
    • Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo
    • Cloud, J.E., et al. 2002. Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Mol. Cell Biol. 22:2663-2672.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 2663-2672
    • Cloud, J.E.1
  • 23
    • 0035936113 scopus 로고    scopus 로고
    • The E2F1-3 transcription factors are essential for cellular proliferation
    • Wu, L., et al. 2001. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 414:457-462.
    • (2001) Nature , vol.414 , pp. 457-462
    • Wu, L.1
  • 24
    • 0035407269 scopus 로고    scopus 로고
    • Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas
    • Heller, R.S., et al. 2001. Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes. 50:1553-1561.
    • (2001) Diabetes , vol.50 , pp. 1553-1561
    • Heller, R.S.1
  • 25
    • 0033637617 scopus 로고    scopus 로고
    • Sodium fusidate ameliorates the course of diabetes induced in mice by multiple low doses of streptozotocin
    • Nicoletti, F., et al. 2000. Sodium fusidate ameliorates the course of diabetes induced in mice by multiple low doses of streptozotocin. J. Autoimmun. 15:395-405.
    • (2000) J. Autoimmun. , vol.15 , pp. 395-405
    • Nicoletti, F.1
  • 26
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
    • Rane, S.G., et al. 1999. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat. Genet. 22:44-52.
    • (1999) Nat. Genet. , vol.22 , pp. 44-52
    • Rane, S.G.1
  • 27
    • 85047693348 scopus 로고    scopus 로고
    • Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
    • doi:10.1172/JCI20031688S
    • Garofalo, R.S., et al. 2003. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ. J. Clin. Invest. 112:197-208. doi:10.1172/JCI20031688S.
    • (2003) J. Clin. Invest. , vol.112 , pp. 197-208
    • Garofalo, R.S.1
  • 28
    • 0033867321 scopus 로고    scopus 로고
    • Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis
    • Suzuki, A., and Hemmati-Brivanlou, A. 2000. Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis. Mol. Cell. 5:217-229.
    • (2000) Mol. Cell , vol.5 , pp. 217-229
    • Suzuki, A.1    Hemmati-Brivanlou, A.2
  • 29
    • 0031738115 scopus 로고    scopus 로고
    • Transcribing pancreas
    • Edlund, H. 1998. Transcribing pancreas. Diabetes. 47:1817-1823.
    • (1998) Diabetes , vol.47 , pp. 1817-1823
    • Edlund, H.1
  • 30
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi, Y., et al. 2002. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 32:128-134.
    • (2002) Nat. Genet. , vol.32 , pp. 128-134
    • Kawaguchi, Y.1
  • 31
    • 0036162954 scopus 로고    scopus 로고
    • Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability
    • Sidorova, J.M., and Breeden, L.L. Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability. Genetics. 160:123-136.
    • Genetics , vol.160 , pp. 123-136
    • Sidorova, J.M.1    Breeden, L.L.2
  • 32
    • 0036545865 scopus 로고    scopus 로고
    • Involvement of Rad9-dependent damage checkpoint control in arrest of cell cycle, induction of cell death, and chromosome instability caused by defects in origin recognition complex in Saccharomyces cerevisiae
    • Watanabe, K., Morishita, J., Umezu, K., Shirahige, K., and Maki, H. 2002. Involvement of Rad9-dependent damage checkpoint control in arrest of cell cycle, induction of cell death, and chromosome instability caused by defects in origin recognition complex in Saccharomyces cerevisiae. Eukaryot. Cell. 1:200-212.
    • (2002) Eukaryot. Cell , vol.1 , pp. 200-212
    • Watanabe, K.1    Morishita, J.2    Umezu, K.3    Shirahige, K.4    Maki, H.5
  • 33
    • 0038641807 scopus 로고    scopus 로고
    • Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice
    • Li, F.X., Zhu, J.W., Hogan, C.J., and DeGregori, J. Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol. Cell. Biol. 23:3607-3622.
    • Mol. Cell. Biol. , vol.23 , pp. 3607-3622
    • Li, F.X.1    Zhu, J.W.2    Hogan, C.J.3    DeGregori, J.4
  • 34
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • Rozenblum, E., et al. 1997. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57:1731-1734.
    • (1997) Cancer Res. , vol.57 , pp. 1731-1734
    • Rozenblum, E.1
  • 35
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy, N., and DePinho, R.A. 2002. Pancreatic cancer biology and genetics. Nat. Rev. Cancer. 2:897-909.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 36
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D.G., Schwarz, J.K., Cress, W.D., and Nevins, J.R. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature. 365:349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 37
    • 0027362625 scopus 로고
    • The retinoblastoma protein binds to a family of E2F transcription factors
    • Lees, J.A., et al. 1993. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 13:7813-7825.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7813-7825
    • Lees, J.A.1
  • 38
    • 0030053130 scopus 로고    scopus 로고
    • Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
    • Lukas, J., Petersen, B.O., Holm, K., Bartek, J., and Helin, K. 1996. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16:1047-1057.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1047-1057
    • Lukas, J.1    Petersen, B.O.2    Holm, K.3    Bartek, J.4    Helin, K.5
  • 39
    • 0034306996 scopus 로고    scopus 로고
    • The Rb/E2F pathway: Expanding roles and emerging paradigms
    • Harbour, J.W., and Dean, D.C. 2000. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14:2393-2409.
    • (2000) Genes Dev. , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2
  • 40
    • 0035553388 scopus 로고    scopus 로고
    • Hereditary pancreatitis: A model for understanding the genetic basis of acute and chronic pancreatitis
    • Whitcomb, D.C. 2001. Hereditary pancreatitis: a model for understanding the genetic basis of acute and chronic pancreatitis. Pancreatology. 1:565-570.
    • (2001) Pancreatology , vol.1 , pp. 565-570
    • Whitcomb, D.C.1
  • 41
    • 0033744530 scopus 로고    scopus 로고
    • Comparison of reg I and reg III levels during acute pancreatitis in the rat
    • Zenilman, M.E., Tuchman, D., Zheng, Q., Levine, J., and Delany, H. 2000. Comparison of reg I and reg III levels during acute pancreatitis in the rat. Ann. Surg. 232:646-652.
    • (2000) Ann. Surg. , vol.232 , pp. 646-652
    • Zenilman, M.E.1    Tuchman, D.2    Zheng, Q.3    Levine, J.4    Delany, H.5
  • 42
    • 0036068097 scopus 로고    scopus 로고
    • Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis
    • Graf, R., Schiesser, M., Lussi, A., Went, P., Scheele, G.A., and Bimmler, D. 2002. Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis. J. Surg. Res. 105:136-144.
    • (2002) J. Surg. Res. , vol.105 , pp. 136-144
    • Graf, R.1    Schiesser, M.2    Lussi, A.3    Went, P.4    Scheele, G.A.5    Bimmler, D.6
  • 43
    • 0036222095 scopus 로고    scopus 로고
    • Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells
    • Fishman, M.P., and Melton, D.A. 2002. Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int. J. Dev. Biol. 46:201-207.
    • (2002) Int. J. Dev. Biol. , vol.46 , pp. 201-207
    • Fishman, M.P.1    Melton, D.A.2
  • 44
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir, S., and Shama, A. 2002. Pancreatic stem cells. J. Pathol. 197:519-526.
    • (2002) J. Pathol. , vol.197 , pp. 519-526
    • Bonner-Weir, S.1    Shama, A.2
  • 45
    • 0028147867 scopus 로고
    • Normal human pancreas cultures display functional ductal characteristics
    • Vilá, M.R., Lloreta, J., and Real, F.X. 1994. Normal human pancreas cultures display functional ductal characteristics. Lab. Invest. 71:423-431.
    • (1994) Lab. Invest. , vol.71 , pp. 423-431
    • Vilá, M.R.1    Lloreta, J.2    Real, F.X.3
  • 46
    • 0242300080 scopus 로고    scopus 로고
    • The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss
    • Li, F.X., et al. 2003. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc. Natl. Acad. Sci. U.S.A. 100:12935-12940.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 12935-12940
    • Li, F.X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.