메뉴 건너뛰기




Volumn 287, Issue 2 50-2, 2004, Pages

Pancreatic β-cell growth and survival in the onset of type 2 diabetes: A role for protein kinase B in the Akt?

Author keywords

Apoptosis; Insulin receptor substrate 2; Obesity; Protein kinase B substrates

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 2; PROTEIN KINASE B;

EID: 3242656480     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00031.2004     Document Type: Review
Times cited : (159)

References (62)
  • 1
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and beta-cell dysfunction
    • Boden G and Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32, Suppl 3: 14-23, 2002.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 3 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 2
    • 0033770540 scopus 로고    scopus 로고
    • Life and death of the pancreatic beta cells
    • Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab 11: 375-378, 2000.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 375-378
    • Bonner-Weir, S.1
  • 3
    • 0034457490 scopus 로고    scopus 로고
    • Perspective: Postnatal pancreatic beta cell growth
    • Bonner-Weir S. Perspective: postnatal pancreatic beta cell growth. Endocrinology 141: 1926-1929, 2000.
    • (2000) Endocrinology , vol.141 , pp. 1926-1929
    • Bonner-Weir, S.1
  • 4
    • 0037382719 scopus 로고    scopus 로고
    • Differential activation mechanisms of Erk-1/2 and p70S6K by glucose in pancreatic β-cells
    • Briaud I, Lingohr MK, Dickson L, Wrede C, and Rhodes CJ. Differential activation mechanisms of Erk-1/2 and p70S6K by glucose in pancreatic β-cells. Diabetes 52: 974-983, 2003.
    • (2003) Diabetes , vol.52 , pp. 974-983
    • Briaud, I.1    Lingohr, M.K.2    Dickson, L.3    Wrede, C.4    Rhodes, C.J.5
  • 5
    • 0035489990 scopus 로고    scopus 로고
    • Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation
    • Buteau J, Foisy S, Rhodes CJ, Carpenter L, Biden TJ, and Prentki M. Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes 50: 2237-2243, 2001.
    • (2001) Diabetes , vol.50 , pp. 2237-2243
    • Buteau, J.1    Foisy, S.2    Rhodes, C.J.3    Carpenter, L.4    Biden, T.J.5    Prentki, M.6
  • 6
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, and Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110, 2003.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 7
    • 0042822112 scopus 로고    scopus 로고
    • Increased beta cell apoptosis prevents adaptive increase in beta cell mass in a mouse model of type-2 diabetes; evidence for a role of islet amyloid formation rather than a direct action of amyloid
    • Butler AE, Janson J, Soeller WC, and Butler PC. Increased beta cell apoptosis prevents adaptive increase in beta cell mass in a mouse model of type-2 diabetes; evidence for a role of islet amyloid formation rather than a direct action of amyloid. Diabetes 52: 2304-2314, 2003.
    • (2003) Diabetes , vol.52 , pp. 2304-2314
    • Butler, A.E.1    Janson, J.2    Soeller, W.C.3    Butler, P.C.4
  • 9
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
    • Chan TO, Rittenhouse SE, and Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68: 965-1014, 1999.
    • (1999) Annu Rev Biochem , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 11
    • 0029793745 scopus 로고    scopus 로고
    • Cadherins regulate aggregation of pancreatic beta-cells in vivo
    • Dahl U, Sjodin A, and Semb H. Cadherins regulate aggregation of pancreatic beta-cells in vivo. Development 122: 2895-2902, 1996.
    • (1996) Development , vol.122 , pp. 2895-2902
    • Dahl, U.1    Sjodin, A.2    Semb, H.3
  • 13
    • 0035877778 scopus 로고    scopus 로고
    • Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1)
    • Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, and Rhodes CJ. Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 276: 21110-21120, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 21110-21120
    • Dickson, L.M.1    Lingohr, M.K.2    McCuaig, J.3    Hugl, S.R.4    Snow, L.5    Kahn, B.B.6    Myers Jr., M.G.7    Rhodes, C.J.8
  • 14
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, and Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12: 3499-3511, 1998.
    • (1998) Genes Dev , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 15
    • 0030001136 scopus 로고    scopus 로고
    • Insulin gene: Organisation, expression and regulation
    • Dumonteil E and Philippe J. Insulin gene: organisation, expression and regulation. Diabetes Metab 22: 164-173, 1996.
    • (1996) Diabetes Metab , vol.22 , pp. 164-173
    • Dumonteil, E.1    Philippe, J.2
  • 16
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • Gilley J, Coffer PJ, and Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162: 613-622, 2003.
    • (2003) J Cell Biol , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 17
    • 0023242545 scopus 로고
    • Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets
    • Halban PA, Powers SL, George KL, and Bonner-Weir S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 36: 783-790, 1987.
    • (1987) Diabetes , vol.36 , pp. 783-790
    • Halban, P.A.1    Powers, S.L.2    George, K.L.3    Bonner-Weir, S.4
  • 18
    • 0035704552 scopus 로고    scopus 로고
    • The thrifty phenotype hypothesis
    • Hales CN and Barker DJ. The thrifty phenotype hypothesis. Br Med Bull 60: 5-20, 2001.
    • (2001) Br Med Bull , vol.60 , pp. 5-20
    • Hales, C.N.1    Barker, D.J.2
  • 20
    • 0035195971 scopus 로고    scopus 로고
    • Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60%-partial pancreatectomy rats
    • Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, and Leahy JL. Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60%-partial pancreatectomy rats. Diabetologia 44: 2056-2065, 2001.
    • (2001) Diabetologia , vol.44 , pp. 2056-2065
    • Jetton, T.L.1    Liu, Y.Q.2    Trotman, W.E.3    Nevin, P.W.4    Sun, X.J.5    Leahy, J.L.6
  • 23
    • 0041856361 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells
    • Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, and Cobb MH. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. J Biol Chem 278: 32969-32977, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 32969-32977
    • Khoo, S.1    Griffen, S.C.2    Xia, Y.3    Baer, R.J.4    German, M.S.5    Cobb, M.H.6
  • 26
    • 1542365269 scopus 로고    scopus 로고
    • cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells
    • Kwon G, Pappan KL, Marshall CA, Schaffer JE, and McDaniel ML. cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells. J Biol Chem 279: 8938-8945, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 8938-8945
    • Kwon, G.1    Pappan, K.L.2    Marshall, C.A.3    Schaffer, J.E.4    McDaniel, M.L.5
  • 27
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
    • Li Y, Hansotia T, Yusta B, Ris F, Halban PA, and Drucker DJ. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278: 471-478, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3    Ris, F.4    Halban, P.A.5    Drucker, D.J.6
  • 29
    • 0036319371 scopus 로고    scopus 로고
    • Pancreatic beta-cell growth and survival - A role in obesity-linked type 2 diabetes?
    • Lingohr MK, Buettner R, and Rhodes CJ. Pancreatic beta-cell growth and survival - a role in obesity-linked type 2 diabetes? Trends Mol Med 8: 375-384, 2002.
    • (2002) Trends Mol Med , vol.8 , pp. 375-384
    • Lingohr, M.K.1    Buettner, R.2    Rhodes, C.J.3
  • 30
    • 0036224165 scopus 로고    scopus 로고
    • Activation of IRS-2 mediated signal transduction by IGF-1, but not TGF-a or EGF, augments pancreatic β-cell proliferation
    • Lingohr MK, Dickson LM, McCuaig JF, Hügl SR, Twardzik DR, and Rhodes CJ. Activation of IRS-2 mediated signal transduction by IGF-1, but not TGF-a or EGF, augments pancreatic β-cell proliferation. Diabetes 51: 966-976, 2002.
    • (2002) Diabetes , vol.51 , pp. 966-976
    • Lingohr, M.K.1    Dickson, L.M.2    McCuaig, J.F.3    Hügl, S.R.4    Twardzik, D.R.5    Rhodes, C.J.6
  • 32
    • 0242329748 scopus 로고    scopus 로고
    • Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression
    • Lingohr MK, Dickson LM, Wrede CE, Briaud I, McCuaig JF, Myers MG Jr, and Rhodes CJ. Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol 209: 17-31, 2003.
    • (2003) Mol Cell Endocrinol , vol.209 , pp. 17-31
    • Lingohr, M.K.1    Dickson, L.M.2    Wrede, C.E.3    Briaud, I.4    McCuaig, J.F.5    Myers Jr., M.G.6    Rhodes, C.J.7
  • 33
    • 0346880501 scopus 로고    scopus 로고
    • The inhibitors of apoptosis: There is more to life than Bcl2
    • Liston P, Fong WG, and Korneluk RG. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene 22: 8568-8580, 2003.
    • (2003) Oncogene , vol.22 , pp. 8568-8580
    • Liston, P.1    Fong, W.G.2    Korneluk, R.G.3
  • 34
    • 0037131246 scopus 로고    scopus 로고
    • β-cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
    • Liu YQ, Jetton TL, and Leahy JL. β-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem 277: 39163-39168, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 39163-39168
    • Liu, Y.Q.1    Jetton, T.L.2    Leahy, J.L.3
  • 35
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo LD and Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA 98: 11598-11603, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 36
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
    • McDaniel ML, Marshall CA, Pappan KL, and Kwon G. Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 51: 2877-2885, 2002.
    • (2002) Diabetes , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 38
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat
    • Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, and Polonsky KS. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47: 358-364, 1998.
    • (1998) Diabetes , vol.47 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Levisetti, M.4    Pugh, W.5    Bonner-Weir, S.6    Polonsky, K.S.7
  • 39
    • 25044456063 scopus 로고    scopus 로고
    • The X-linked inhibitor of apoptosis protein (XIAP) protects transformed β-cells from cytokine-mediated killing and prolongs murine islet allograft survival
    • Plesner A, Korneluk RG, Liston P, Tan R, and Verchere CB. The X-linked inhibitor of apoptosis protein (XIAP) protects transformed β-cells from cytokine-mediated killing and prolongs murine islet allograft survival (Abstract). Diabetes 51: A41, 2002.
    • (2002) Diabetes , vol.51
    • Plesner, A.1    Korneluk, R.G.2    Liston, P.3    Tan, R.4    Verchere, C.B.5
  • 40
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: Secondary beta-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxicity
    • Poitout V and Robertson RP. Minireview: Secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology 143: 339-342, 2002.
    • (2002) Endocrinology , vol.143 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 42
    • 0242280107 scopus 로고    scopus 로고
    • Cell cycle control and pancreatic β-cell proliferation
    • Rane SG and Reddy EP. Cell cycle control and pancreatic β-cell proliferation. Front Biosci 5: 1-19, 2000.
    • (2000) Front Biosci , vol.5 , pp. 1-19
    • Rane, S.G.1    Reddy, E.P.2
  • 43
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • Rena G, Guo S, Cichy SC, Unterman TG, and Cohan P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179-17183, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohan, P.5
  • 44
    • 0036615436 scopus 로고    scopus 로고
    • Molecular insights into insulin action and secretion
    • Rhodes CJ and White MF. Molecular insights into insulin action and secretion. Eur J Clin Invest 32, Suppl 3: 3-13, 2002.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 3 , pp. 3-13
    • Rhodes, C.J.1    White, M.F.2
  • 46
    • 0037155824 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
    • Rossig L, Badorff C, Holzmann Y, Zeiher AM, and Dimmeler S. Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 277: 9684-9689, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 9684-9689
    • Rossig, L.1    Badorff, C.2    Holzmann, Y.3    Zeiher, A.M.4    Dimmeler, S.5
  • 47
    • 0028845665 scopus 로고
    • Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas
    • Scaglia L, Smith FE, and Bonner-Weir S. Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology 136: 5461-5468, 1995.
    • (1995) Endocrinology , vol.136 , pp. 5461-5468
    • Scaglia, L.1    Smith, F.E.2    Bonner-Weir, S.3
  • 48
    • 0032763007 scopus 로고    scopus 로고
    • Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models
    • Shafrir E, Ziv E, and Mosthaf L. Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models. Ann NY Acad Sci 892: 223-246, 1999.
    • (1999) Ann NY Acad Sci , vol.892 , pp. 223-246
    • Shafrir, E.1    Ziv, E.2    Mosthaf, L.3
  • 49
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2: 731-737, 2001.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 50
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: Beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • Sorenson RL and Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29: 301-307, 1997.
    • (1997) Horm Metab Res , vol.29 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 51
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
    • Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 84: 5034-5037, 1987.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5034-5037
    • Staal, S.P.1
  • 52
    • 0035281991 scopus 로고    scopus 로고
    • Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation
    • Stratford S, DeWald DB, and Summers SA. Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation. Biochem J 354: 359-368, 2001.
    • (2001) Biochem J , vol.354 , pp. 359-368
    • Stratford, S.1    DeWald, D.B.2    Summers, S.A.3
  • 54
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: New perspective on obesity and related disorders
    • Unger RH and Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 15: 312-321, 2001.
    • (2001) FASEB J , vol.15 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 55
    • 1842855402 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    • Wang Q, Li L, Xu E, Wong V, Rhodes CJ, and Brubaker PL. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 47: 478-487, 2004.
    • (2004) Diabetologia , vol.47 , pp. 478-487
    • Wang, Q.1    Li, L.2    Xu, E.3    Wong, V.4    Rhodes, C.J.5    Brubaker, P.L.6
  • 56
    • 0142149134 scopus 로고    scopus 로고
    • Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet β-cells but not regulated via a positive feedback of secreted insulin
    • Wicksteed BL, Alarcón C, Briaud I, Lingohr MK, and Rhodes CJ. Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet β-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278: 42080-42090, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 42080-42090
    • Wicksteed, B.L.1    Alarcón, C.2    Briaud, I.3    Lingohr, M.K.4    Rhodes, C.J.5
  • 57
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, and White MF. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 23: 32-40, 1999.
    • (1999) Nat Genet , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 59
    • 0037668996 scopus 로고    scopus 로고
    • Modulation of mitogenic signaling pathways by conventional and novel protein kinase-C isoforms in pancreatic β-cells (INS-1)
    • Wrede C, Dickson LM, Lingohr MK, Briaud I, and Rhodes CJ. Modulation of mitogenic signaling pathways by conventional and novel protein kinase-C isoforms in pancreatic β-cells (INS-1). J Mol Endocrinol 30: 271-286, 2003.
    • (2003) J Mol Endocrinol , vol.30 , pp. 271-286
    • Wrede, C.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 60
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid induced apoptosis in pancreatic beta-cells (INS-1)
    • Wrede CE, Dickson LM, Lingohr MK, Briaud I, McCuaig JF, and Rhodes CJ. Protein kinase B/Akt prevents fatty acid induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 277: 49676-49684, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    McCuaig, J.F.5    Rhodes, C.J.6
  • 62
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KG, and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.