-
1
-
-
33746921690
-
Caspase-containing complexes in the regulation of cell death and inflammation
-
Festjens, N., et al. 2006. Caspase-containing complexes in the regulation of cell death and inflammation. Biol Chem 387:1005-16.
-
(2006)
Biol Chem
, vol.387
, pp. 1005-1016
-
-
Festjens, N.1
-
2
-
-
33845483887
-
Caspases in cell survival, proliferation and differentiation
-
Lamkanfi, M., et al. 2007. Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 44-55.
-
(2007)
Cell Death Differ
, vol.14
, pp. 44-55
-
-
Lamkanfi, M.1
-
3
-
-
0036312069
-
Alice in caspase land. A phylogenetic analysis of caspases from worm to man
-
Lamkanfi, M., et al. 2002. Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ 9:358-61.
-
(2002)
Cell Death Differ
, vol.9
, pp. 358-361
-
-
Lamkanfi, M.1
-
4
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright, K. M., et al. 2003. A unified model for apical caspase activation. Mol Cell 11:529-41.
-
(2003)
Mol Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
-
5
-
-
0026517239
-
Molecular cloning of the interleukin-1 beta converting enzyme
-
Cerretti, D. P., et al. 1992. Molecular cloning of the interleukin-1 beta converting enzyme. Science 256:97-100.
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
-
6
-
-
0031004174
-
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
-
Ghayur, T., et al. 1997. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 386:619-23.
-
(1997)
Nature
, vol.386
, pp. 619-623
-
-
Ghayur, T.1
-
7
-
-
27744446058
-
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
-
Schmitz, J., et al. 2005. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23:479-90.
-
(2005)
Immunity
, vol.23
, pp. 479-490
-
-
Schmitz, J.1
-
8
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
-
Thornberry, N. A., et al. 1992. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:763-74.
-
(1992)
Nature
, vol.356
, pp. 763-774
-
-
Thornberry, N.A.1
-
9
-
-
0028920863
-
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
-
Kuida, K., et al. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267: 2000-3.
-
(1995)
Science
, vol.267
, pp. 2000-2003
-
-
Kuida, K.1
-
10
-
-
0028984948
-
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
-
Li, P., et al. 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401-11.
-
(1995)
Cell
, vol.80
, pp. 401-411
-
-
Li, P.1
-
11
-
-
33845497181
-
Inflammatory caspases and inflammasomes: Master switches of inflammation
-
Martinon, F., and Tschopp, J. 2007. Inflammatory caspases and inflammasomes: Master switches of inflammation. Cell Death Differ 14: 10-22.
-
(2007)
Cell Death Differ
, vol.14
, pp. 10-22
-
-
Martinon, F.1
Tschopp, J.2
-
12
-
-
1642285783
-
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
-
Agostini, L., et al. 2004. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319-25.
-
(2004)
Immunity
, vol.20
, pp. 319-325
-
-
Agostini, L.1
-
13
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon, F., Burns, K., and Tschopp, J. 2002. The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-26.
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
14
-
-
33846024748
-
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
-
Amer, A., et al. 2006. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 281: 35217-23.
-
(2006)
J Biol Chem
, vol.281
, pp. 35217-35223
-
-
Amer, A.1
-
15
-
-
31744441475
-
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
-
Boyden, E. D., and Dietrich, W. F. 2006. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38: 240-4.
-
(2006)
Nat Genet
, vol.38
, pp. 240-244
-
-
Boyden, E.D.1
Dietrich, W.F.2
-
16
-
-
33744464740
-
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
-
Franchi, L., et al. 2006. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol 7: 576-82.
-
(2006)
Nat Immunol
, vol.7
, pp. 576-582
-
-
Franchi, L.1
-
17
-
-
33846014297
-
Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
-
Kanneganti, T. D., et al. 2006. Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 281: 36560-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 36560-36568
-
-
Kanneganti, T.D.1
-
18
-
-
32944462834
-
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
-
Kanneganti, T. D., et al. 2006. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440:233-6.
-
(2006)
Nature
, vol.440
, pp. 233-236
-
-
Kanneganti, T.D.1
-
19
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan, S., et al. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-32.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
-
20
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon, F., et al. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-41.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
-
21
-
-
33744493091
-
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
-
Miao, E. A., et al. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 7:569-75.
-
(2006)
Nat Immunol
, vol.7
, pp. 569-575
-
-
Miao, E.A.1
-
22
-
-
22444433175
-
NLRs join TLRs as innate sensors of pathogens
-
Martinon, F., and Tschopp, J. 2005. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26:447-54.
-
(2005)
Trends Immunol
, vol.26
, pp. 447-454
-
-
Martinon, F.1
Tschopp, J.2
-
23
-
-
3142654767
-
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
-
Mariathasan, S., et al. 2004. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-8.
-
(2004)
Nature
, vol.430
, pp. 213-218
-
-
Mariathasan, S.1
-
24
-
-
17644396670
-
CATERPILLER: A novel gene family important in immunity, cell death, and diseases
-
Ting, J. P., and Davis, B. K. 2005. CATERPILLER: A novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol 23:387-414.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 387-414
-
-
Ting, J.P.1
Davis, B.K.2
-
25
-
-
0033514959
-
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells
-
Puren, A. J., Fantuzzi, G., and Dinarello, C. A. 1999. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc Natl Acad Sci USA 96: 2256-61.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2256-2261
-
-
Puren, A.J.1
Fantuzzi, G.2
Dinarello, C.A.3
-
26
-
-
34247118826
-
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
-
Kanneganti, T. D., et al. 2007. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 26:433-43.
-
(2007)
Immunity
, vol.26
, pp. 433-443
-
-
Kanneganti, T.D.1
-
27
-
-
0029979369
-
Biologic basis for interleukin-1 in disease
-
Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87: 2095-147.
-
(1996)
Blood
, vol.87
, pp. 2095-2147
-
-
Dinarello, C.A.1
-
28
-
-
0031831906
-
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist
-
Dinarello, C. A. 1998. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 16:457-99.
-
(1998)
Int Rev Immunol
, vol.16
, pp. 457-499
-
-
Dinarello, C.A.1
-
29
-
-
0037328007
-
A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers
-
Bergman, M. R., et al. 2003. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Biochem J 369:485-96.
-
(2003)
Biochem J
, vol.369
, pp. 485-496
-
-
Bergman, M.R.1
-
30
-
-
0030958529
-
Interleukin 1-induced calcium signalling in chondrocytes requires focal adhesions
-
Luo, L., Cruz, T., and McCulloch, C. 1997. Interleukin 1-induced calcium signalling in chondrocytes requires focal adhesions. Biochem J 324 (Pt 2):653-8.
-
(1997)
Biochem J
, vol.324
, pp. 653-658
-
-
Luo, L.1
Cruz, T.2
McCulloch, C.3
-
31
-
-
0032867864
-
Distinct roles for p42/p44 and p38 mitogenactivated protein kinases in the induction of IL-2 by IL-1
-
Matthews, J. S., and O’Neill, L. A. 1999. Distinct roles for p42/p44 and p38 mitogenactivated protein kinases in the induction of IL-2 by IL-1. Cytokine 11: 643-55.
-
(1999)
Cytokine
, vol.11
, pp. 643-655
-
-
Matthews, J.S.1
O’Neill, L.A.2
-
32
-
-
0034677894
-
Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1
-
Palsson, E. M., et al. 2000. Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1. J Biol Chem 275:7818-25.
-
(2000)
J Biol Chem
, vol.275
, pp. 7818-7825
-
-
Palsson, E.M.1
-
33
-
-
0024564514
-
Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein
-
Shirakawa, F., et al. 1989. Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein. Mol Cell Biol 9:959-64.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 959-964
-
-
Shirakawa, F.1
-
34
-
-
0024355977
-
In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C
-
Shirakawa, F., and Mizel, S. B. 1989. In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9:2424-30.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 2424-2430
-
-
Shirakawa, F.1
Mizel, S.B.2
-
35
-
-
0032030721
-
Regulation of interleukin 1 signalling through integrin binding and actin reorganization: Disparate effects on NF-kappaB and stress kinase pathways
-
Zhu, P., et al. 1998. Regulation of interleukin 1 signalling through integrin binding and actin reorganization: Disparate effects on NF-kappaB and stress kinase pathways. Biochem J 330 (Pt 2):975-81.
-
(1998)
Biochem J
, vol.330
, pp. 975-981
-
-
Zhu, P.1
-
36
-
-
37749030247
-
A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins
-
Kersse, K., et al. 2007. A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins. Biochem Soc Trans 35:1508-11.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1508-1511
-
-
Kersse, K.1
-
37
-
-
0034743434
-
Regulation of IL-1beta generation by pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
-
Druilhe, A., et al. 2001. Regulation of IL-1beta generation by pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ 8:649-57.
-
(2001)
Cell Death Differ
, vol.8
, pp. 649-657
-
-
Druilhe, A.1
-
38
-
-
0034730325
-
ICEBERG: A novel inhibitor of interleukin-1beta generation
-
Humke, E. W., et al. 2000. ICEBERG: A novel inhibitor of interleukin-1beta generation. Cell 103:99-111.
-
(2000)
Cell
, vol.103
, pp. 99-111
-
-
Humke, E.W.1
-
39
-
-
10644270650
-
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation
-
Lamkanfi, M., et al. 2004. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. J Biol Chem 279: 51729-38.
-
(2004)
J Biol Chem
, vol.279
, pp. 51729-51738
-
-
Lamkanfi, M.1
-
40
-
-
0035860780
-
Cop, a caspase recruitment domaincontaining protein and inhibitor of caspase-1 activation processing
-
Lee, S. H., Stehlik, C., and Reed, J. C. 2001. Cop, a caspase recruitment domaincontaining protein and inhibitor of caspase-1 activation processing. J Biol Chem 276: 34495-500.
-
(2001)
J Biol Chem
, vol.276
, pp. 34495-34500
-
-
Lee, S.H.1
Stehlik, C.2
Reed, J.C.3
-
41
-
-
0027181936
-
Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4
-
Colotta, F., et al. 1993. Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4. Science 261:472-5.
-
(1993)
Science
, vol.261
, pp. 472-475
-
-
Colotta, F.1
-
42
-
-
0032534729
-
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: A novel mechanism of regulation of IL-1 responsiveness
-
Lang, D., et al. 1998. The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: A novel mechanism of regulation of IL-1 responsiveness. J Immunol 161:6871-7.
-
(1998)
J Immunol
, vol.161
, pp. 6871-6877
-
-
Lang, D.1
-
43
-
-
0027988175
-
Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses
-
Giri, J. G., et al. 1994. Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. J Immunol 153:5862-9.
-
(1994)
J Immunol
, vol.153
, pp. 5862-5869
-
-
Giri, J.G.1
-
44
-
-
0037237908
-
The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
-
Smith, D. E., et al. 2003. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity 18:87-96.
-
(2003)
Immunity
, vol.18
, pp. 87-96
-
-
Smith, D.E.1
-
45
-
-
0025321201
-
Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein
-
Carter, D. B., et al. 1990. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344: 633-8.
-
(1990)
Nature
, vol.344
, pp. 633-638
-
-
Carter, D.B.1
-
46
-
-
0025713953
-
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
-
Hannum, C. H., et al. 1990. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343:336-40.
-
(1990)
Nature
, vol.343
, pp. 336-340
-
-
Hannum, C.H.1
-
47
-
-
0032169511
-
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells
-
Dao, T., Mehal, W. Z., and Crispe, I. N. 1998. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. J Immunol 161:2217-22.
-
(1998)
J Immunol
, vol.161
, pp. 2217-2222
-
-
Dao, T.1
Mehal, W.Z.2
Crispe, I.N.3
-
48
-
-
8944226108
-
Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production
-
Micallef, M. J., et al. 1996. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production. Eur J Immunol 26:1647-51.
-
(1996)
Eur J Immunol
, vol.26
, pp. 1647-1651
-
-
Micallef, M.J.1
-
49
-
-
0028845730
-
Cloning of a new cytokine that induces IFN-gamma production by T cells
-
Okamura, H., et al. 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378:88-91.
-
(1995)
Nature
, vol.378
, pp. 88-91
-
-
Okamura, H.1
-
50
-
-
0032193770
-
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production
-
Yoshimoto, T., et al. 1998. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production. J Immunol 161:3400-7.
-
(1998)
J Immunol
, vol.161
, pp. 3400-3407
-
-
Yoshimoto, T.1
-
51
-
-
0032005857
-
Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor
-
Horwood, N. J., et al. 1998. Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor. J Clin Invest 101:595-603.
-
(1998)
J Clin Invest
, vol.101
, pp. 595-603
-
-
Horwood, N.J.1
-
52
-
-
0033556175
-
IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
-
Olee, T., et al. 1999. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J Immunol 162:1096-100.
-
(1999)
J Immunol
, vol.162
, pp. 1096-1100
-
-
Olee, T.1
-
53
-
-
0033136775
-
Cutting edge: Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
-
Hoshino, K., et al. 1999. Cutting edge: Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol 162:5041-4.
-
(1999)
J Immunol
, vol.162
, pp. 5041-5044
-
-
Hoshino, K.1
-
54
-
-
0029989325
-
IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
-
Parnet, P., et al. 1996. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem 271:3967-70.
-
(1996)
J Biol Chem
, vol.271
, pp. 3967-3970
-
-
Parnet, P.1
-
55
-
-
0030851728
-
Purification and characterization of the human interleukin-18 receptor
-
Torigoe, K., et al. 1997. Purification and characterization of the human interleukin-18 receptor. J Biol Chem 272:25737-42.
-
(1997)
J Biol Chem
, vol.272
, pp. 25737-25742
-
-
Torigoe, K.1
-
56
-
-
0032521933
-
IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes
-
Barbulescu, K., et al. 1998. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes. J Immunol 160:3642-7.
-
(1998)
J Immunol
, vol.160
, pp. 3642-3647
-
-
Barbulescu, K.1
-
57
-
-
0034254194
-
IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21
-
Kalina, U., et al. 2000. IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J Immunol 165:1307-13.
-
(2000)
J Immunol
, vol.165
, pp. 1307-1313
-
-
Kalina, U.1
-
58
-
-
0031578229
-
Interleukin-18 activates NF-kappaB in murine T helper type 1 cells
-
Matsumoto, S., et al. 1997. Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem Biophys Res Commun 234:454-7.
-
(1997)
Biochem Biophys Res Commun
, vol.234
, pp. 454-457
-
-
Matsumoto, S.1
-
59
-
-
0036467440
-
Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1
-
Nakahira, M., et al. 2002. Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1. J Immunol 168:1146-53.
-
(2002)
J Immunol
, vol.168
, pp. 1146-1153
-
-
Nakahira, M.1
-
60
-
-
0030694235
-
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB
-
Robinson, D., et al. 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. Immunity 7:571-81.
-
(1997)
Immunity
, vol.7
, pp. 571-581
-
-
Robinson, D.1
-
61
-
-
36249006497
-
The activity of caspase-1 is increased in lesional psoriatic epidermis
-
Johansen, C., et al. 2007. The activity of caspase-1 is increased in lesional psoriatic epidermis. J Invest Dermatol 127:2857-64.
-
(2007)
J Invest Dermatol
, vol.127
, pp. 2857-2864
-
-
Johansen, C.1
-
62
-
-
22544457464
-
The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes
-
Niyonsaba, F., et al. 2005. The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes. J Immunol 175:1776-84.
-
(2005)
J Immunol
, vol.175
, pp. 1776-1784
-
-
Niyonsaba, F.1
-
63
-
-
0033012676
-
Cloning and expression of interleukin-18 binding protein
-
Aizawa, Y., et al. 1999. Cloning and expression of interleukin-18 binding protein. FEBS Lett 445:338-42.
-
(1999)
FEBS Lett
, vol.445
, pp. 338-342
-
-
Aizawa, Y.1
-
64
-
-
0032983336
-
Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
-
Novick, D., et al. 1999. Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response. Immunity 10:127-36.
-
(1999)
Immunity
, vol.10
, pp. 127-136
-
-
Novick, D.1
-
65
-
-
0037192869
-
Identification of amino acid residues critical for biological activity in human interleukin-18
-
Kim, S. H., et al. 2002. Identification of amino acid residues critical for biological activity in human interleukin-18. J Biol Chem 277:10998-1003.
-
(2002)
J Biol Chem
, vol.277
, pp. 10998-11003
-
-
Kim, S.H.1
-
66
-
-
0033974776
-
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
-
Kim, S. H., et al. 2000. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci USA 97:1190-5.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1190-1195
-
-
Kim, S.H.1
-
67
-
-
0031968825
-
Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States
-
Lawrence, R. C., et al. 1998. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41:778-99.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 778-799
-
-
Lawrence, R.C.1
-
68
-
-
33344467770
-
Clinical practice. Osteoarthritis of the knee
-
Felson, D. T. 2006. Clinical practice. Osteoarthritis of the knee. N Engl J Med 354:841-8.
-
(2006)
N Engl J Med
, vol.354
, pp. 841-848
-
-
Felson, D.T.1
-
69
-
-
0036286667
-
The role of cytokines in osteoarthritis pathophysiology
-
Fernandes, J. C., Martel-Pelletier, J., and Pelletier, J. P. 2002. The role of cytokines in osteoarthritis pathophysiology. Biorheology 39:237-46.
-
(2002)
Biorheology
, vol.39
, pp. 237-246
-
-
Fernandes, J.C.1
Martel-Pelletier, J.2
Pelletier, J.P.3
-
70
-
-
0032990777
-
The role of cytokines as inflammatory mediators in osteoarthritis: Lessons from animal models
-
Goldring, M. B. 1999. The role of cytokines as inflammatory mediators in osteoarthritis: Lessons from animal models. Connect Tissue Res 40:1-11.
-
(1999)
Connect Tissue Res
, vol.40
, pp. 1-11
-
-
Goldring, M.B.1
-
71
-
-
0034564348
-
Osteoarthritis and cartilage: The role of cytokines
-
Goldring, M. B. 2000. Osteoarthritis and cartilage: The role of cytokines. Curr Rheumatol Rep 2:459-65.
-
(2000)
Curr Rheumatol Rep
, vol.2
, pp. 459-465
-
-
Goldring, M.B.1
-
72
-
-
0028950175
-
Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process
-
Pelletier, J. P., et al. 1995. Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol Suppl 43:109-14.
-
(1995)
J Rheumatol
, pp. 109-114
-
-
Pelletier, J.P.1
-
73
-
-
0036012888
-
Effects of TNFalpha-antagonists on nitric oxide production in human cartilage
-
Vuolteenaho, K., et al. 2002. Effects of TNFalpha-antagonists on nitric oxide production in human cartilage. Osteoarthritis Cartilage 10:327-32.
-
(2002)
Osteoarthritis Cartilage
, vol.10
, pp. 327-332
-
-
Vuolteenaho, K.1
-
74
-
-
15644369352
-
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
-
Gu, Y., et al. 1997. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 275:206-9.
-
(1997)
Science
, vol.275
, pp. 206-209
-
-
Gu, Y.1
-
75
-
-
0033238104
-
Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: Localization and role in the maturation of interleukin-1beta and interleukin-18
-
Saha, N., et al. 1999. Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: Localization and role in the maturation of interleukin-1beta and interleukin-18. Arthritis Rheum 42:1577-87.
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1577-1587
-
-
Saha, N.1
-
76
-
-
18344374479
-
Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: A potential therapeutic target of cartilage degradation
-
Futani, H., et al. 2002. Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: A potential therapeutic target of cartilage degradation. J Immunother 25 (Suppl 1):561-4.
-
(2002)
J Immunother
, vol.25
, pp. 561-564
-
-
Futani, H.1
-
77
-
-
0021358538
-
Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids
-
Nouri, A. M., Panayi, G. S., and Goodman, S. M. 1984. Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol 55:295-302.
-
(1984)
Clin Exp Immunol
, vol.55
, pp. 295-302
-
-
Nouri, A.M.1
Panayi, G.S.2
Goodman, S.M.3
-
78
-
-
0141727395
-
Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis
-
Rudolphi, K., et al. 2003. Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage 11:738-46.
-
(2003)
Osteoarthritis Cartilage
, vol.11
, pp. 738-746
-
-
Rudolphi, K.1
-
79
-
-
0029814957
-
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression
-
Caron, J. P., et al. 1996. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 39:1535-44.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 1535-1544
-
-
Caron, J.P.1
-
80
-
-
22244474585
-
Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: A multicenter study
-
Chevalier, X., et al. 2005. Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: A multicenter study. J Rheumatol 32:1317-23.
-
(2005)
J Rheumatol
, vol.32
, pp. 1317-1323
-
-
Chevalier, X.1
-
81
-
-
1342285045
-
Osteoarthritis gene therapy
-
Evans, C. H., et al. 2004. Osteoarthritis gene therapy. Gene Ther 11:379-89.
-
(2004)
Gene Ther
, vol.11
, pp. 379-389
-
-
Evans, C.H.1
-
82
-
-
2342505985
-
A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer
-
Gouze, J. N., et al. 2003. A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer. Arthritis Res Ther 5:R301-9.
-
(2003)
Arthritis Res Ther
, vol.5
, pp. R301-R309
-
-
Gouze, J.N.1
-
83
-
-
34249309953
-
Treatment of osteoarthritis with anakinra
-
Iqbal, I., and Fleischmann, R. 2007. Treatment of osteoarthritis with anakinra. Curr Rheumatol Rep 9:31-5.
-
(2007)
Curr Rheumatol Rep
, vol.9
, pp. 31-35
-
-
Iqbal, I.1
Fleischmann, R.2
-
84
-
-
2942555576
-
Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10
-
Zhang, X., Mao, Z., and Yu, C. 2004. Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J Orthop Res 22:742-50.
-
(2004)
J Orthop Res
, vol.22
, pp. 742-750
-
-
Zhang, X.1
Mao, Z.2
Yu, C.3
-
85
-
-
0038011833
-
Evolving concepts of rheumatoid arthritis
-
Firestein, G. S. 2003. Evolving concepts of rheumatoid arthritis. Nature 423:356-61.
-
(2003)
Nature
, vol.423
, pp. 356-361
-
-
Firestein, G.S.1
-
86
-
-
35148873270
-
The pathogenesis of rheumatoid arthritis
-
Koch, A. E. 2007. The pathogenesis of rheumatoid arthritis. Am J Orthop 36:5-8.
-
(2007)
Am J Orthop
, vol.36
, pp. 5-8
-
-
Koch, A.E.1
-
87
-
-
0035012803
-
The epidemiology of rheumatoid arthritis
-
Gabriel, S. E. 2001. The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27:269-81.
-
(2001)
Rheum Dis Clin North Am
, vol.27
, pp. 269-281
-
-
Gabriel, S.E.1
-
88
-
-
34948849235
-
Clinical practice. Osteoarthritis of the hip
-
Lane, N. E. 2007. Clinical practice. Osteoarthritis of the hip. N Engl J Med 357: 1413-21.
-
(2007)
N Engl J Med
, vol.357
, pp. 1413-1421
-
-
Lane, N.E.1
-
89
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
McInnes, I. B., and Schett, G. 2007. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-42.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
90
-
-
33748657833
-
Is IL-1 a good therapeutic target in the treatment of arthritis?
-
Burger, D., et al. 2006. Is IL-1 a good therapeutic target in the treatment of arthritis? Best Pract Res Clin Rheumatol 20:879-96.
-
(2006)
Best Pract Res Clin Rheumatol
, vol.20
, pp. 879-896
-
-
Burger, D.1
-
91
-
-
16644365071
-
The role of interleukin-1 in the pathogenesis of rheumatoid arthritis
-
Oxford
-
Kay, J., and Calabrese, L. 2004. The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 43(Suppl 3):iii2-iii9.
-
(2004)
Rheumatology
, vol.43
, pp. iii2-iii9
-
-
Kay, J.1
Calabrese, L.2
-
92
-
-
0025120445
-
Synovial fluid concentration of five different cytokines in rheumatic diseases
-
Westacott, C. I., et al. 1990. Synovial fluid concentration of five different cytokines in rheumatic diseases. Ann Rheum Dis 49:676-81.
-
(1990)
Ann Rheum Dis
, vol.49
, pp. 676-681
-
-
Westacott, C.I.1
-
93
-
-
17644375193
-
Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium
-
Rosengren, S., et al. 2005. Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium. Ann Rheum Dis 64:708-14.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 708-714
-
-
Rosengren, S.1
-
94
-
-
0035097986
-
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: A possible role in the resolution of arthritis
-
Gabay, C., et al. 2001. Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis. Arthritis Rheum 44:451-62.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 451-462
-
-
Gabay, C.1
-
95
-
-
0028810316
-
Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice
-
Van Lent, P. L., et al. 1995. Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. J Rheumatol 22:2250-8.
-
(1995)
J Rheumatol
, vol.22
, pp. 2250-2258
-
-
Lent, V.P.L.1
-
96
-
-
0032705651
-
Role of tumour necrosis factor alpha in experimental arthritis: Separate activity of interleukin 1beta in chronicity and cartilage destruction
-
van den Berg, W. B., et al. 1999. Role of tumour necrosis factor alpha in experimental arthritis: Separate activity of interleukin 1beta in chronicity and cartilage destruction. Ann Rheum Dis 58(Suppl 1):140-8.
-
(1999)
Ann Rheum Dis
, vol.58
, pp. 140-148
-
-
van den Berg, W.B.1
-
97
-
-
21044444039
-
Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases
-
Milner, J. M., and Cawston, T. E. 2005. Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases. Curr Drug Targets Inflamm Allergy 4:363-75.
-
(2005)
Curr Drug Targets Inflamm Allergy
, vol.4
, pp. 363-375
-
-
Milner, J.M.1
Cawston, T.E.2
-
98
-
-
0031695366
-
Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist
-
Ma, Y., et al. 1998. Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist. Arthritis Rheum 41:1798-865.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1798-1865
-
-
Ma, Y.1
-
99
-
-
0035399950
-
IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells
-
Nakae, S., et al. 2001. IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells. J Immunol 167:90-7.
-
(2001)
J Immunol
, vol.167
, pp. 90-97
-
-
Nakae, S.1
-
100
-
-
0032743708
-
A proinflammatory role for IL-18 in rheumatoid arthritis
-
Gracie, J. A., et al. 1999. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 104:1393-401.
-
(1999)
J Clin Invest
, vol.104
, pp. 1393-1401
-
-
Gracie, J.A.1
-
101
-
-
0037331297
-
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis
-
Joosten, L. A., et al. 2003. Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 48:339-47.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 339-347
-
-
Joosten, L.A.1
-
102
-
-
7244255884
-
Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis
-
Rooney, T., et al. 2004. Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis. Ann Rheum Dis 63:1393-8.
-
(2004)
Ann Rheum Dis
, vol.63
, pp. 1393-1398
-
-
Rooney, T.1
-
103
-
-
0035097068
-
Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis
-
Yamamura, M., et al. 2001. Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis. Arthritis Rheum 44:275-85.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 275-285
-
-
Yamamura, M.1
-
104
-
-
33746488770
-
Clinical significance of IL-18, IL-15, IL-12 and TNF-alpha measurement in rheumatoid arthritis
-
Petrovic-Rackov, L., and Pejnovic, N. 2006. Clinical significance of IL-18, IL-15, IL-12 and TNF-alpha measurement in rheumatoid arthritis. Clin Rheumatol 25:448-52.
-
(2006)
Clin Rheumatol
, vol.25
, pp. 448-452
-
-
Petrovic-Rackov, L.1
Pejnovic, N.2
-
105
-
-
0035173776
-
Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
-
Wei, X. Q., et al. 2001. Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18. J Immunol 166:517-21.
-
(2001)
J Immunol
, vol.166
, pp. 517-521
-
-
Wei, X.Q.1
-
106
-
-
0034541175
-
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
-
Joosten, L. A., et al. 2000. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis. J Immunol 165:6553-8.
-
(2000)
J Immunol
, vol.165
, pp. 6553-6558
-
-
Joosten, L.A.1
-
107
-
-
0035997487
-
Anti-tumour necrosis factor (TNF) alpha treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13
-
Pittoni, V., et al. 2002. Anti-tumour necrosis factor (TNF) alpha treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13. Ann Rheum Dis 61:723-5.
-
(2002)
Ann Rheum Dis
, vol.61
, pp. 723-725
-
-
Pittoni, V.1
-
108
-
-
0034909059
-
Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells
-
Tanaka, M., et al. 2001. Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells. J Rheumatol 28:1779-87.
-
(2001)
J Rheumatol
, vol.28
, pp. 1779-1787
-
-
Tanaka, M.1
-
109
-
-
35348977471
-
Cellular targets of interleukin-18 in rheumatoid arthritis
-
Dai, S. M., et al. 2007. Cellular targets of interleukin-18 in rheumatoid arthritis. Ann Rheum Dis 66:1411-8.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 1411-1418
-
-
Dai, S.M.1
-
110
-
-
33748670160
-
Clinical effects of pralnacasan (PRAL), an orally-active interleukin-1β converting enzyme (ICE) inhibitor, in a 285 patient PhII trial in rheumatoid arthritis (RA)
-
Pavelka, K., et al. 2002. Clinical effects of pralnacasan (PRAL), an orally-active interleukin-1β converting enzyme (ICE) inhibitor, in a 285 patient PhII trial in rheumatoid arthritis (RA). Arthritis Rheum 46:LB02.
-
(2002)
Arthritis Rheum
, vol.46
, pp. LB02
-
-
Pavelka, K.1
-
111
-
-
34247219224
-
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3, 3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R, 3S)-2-ethoxy-5-oxotetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18
-
Wannamaker, W., et al. 2007. (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3, 3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R, 3S)-2-ethoxy-5-oxotetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. J Pharmacol Exp Ther 321:509-16.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 509-516
-
-
Wannamaker, W.1
-
112
-
-
4244001994
-
Selective interleukin-1beta-converting enzyme (ICE/CASPASE-1) inhibition with pralnacasan (HMR 3480/VX-740) reduces inflammation and joint destruction in murine type II collegenase-induced arthritis
-
Ku, G., Ford, P., and Raybuck, S. A. 2002. Selective interleukin-1beta-converting enzyme (ICE/CASPASE-1) inhibition with pralnacasan (HMR 3480/VX-740) reduces inflammation and joint destruction in murine type II collegenase-induced arthritis. Arthritis Rheum 44:5241.
-
(2002)
Arthritis Rheum
, vol.44
, pp. 5241
-
-
Ku, G.1
Ford, P.2
Raybuck, S.A.3
-
113
-
-
0029064447
-
Interleukin-1 receptor antagonist inhibits proteoglycan breakdown in antigen induced but not polycation induced arthritis in the rabbit
-
Arner, E. C., et al. 1995. Interleukin-1 receptor antagonist inhibits proteoglycan breakdown in antigen induced but not polycation induced arthritis in the rabbit. J Rheumatol 22:1338-46.
-
(1995)
J Rheumatol
, vol.22
, pp. 1338-1346
-
-
Arner, E.C.1
-
114
-
-
0032752705
-
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation
-
Joosten, L. A., et al. 1999. IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol 163:5049-55.
-
(1999)
J Immunol
, vol.163
, pp. 5049-5055
-
-
Joosten, L.A.1
-
115
-
-
0029875804
-
Anticytokine treatment of established type II collageninduced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra
-
Joosten, L. A., et al. 1996. Anticytokine treatment of established type II collageninduced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra. Arthritis Rheum 39:797-809.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 797-809
-
-
Joosten, L.A.1
-
116
-
-
34447272928
-
[Anakinra, a recombinant human IL-1 receptor antagonist, in clinical practice. Outcome in 60 patients with severe rheumatoid arthritis]
-
Botsios, C., et al. 2007. [Anakinra, a recombinant human IL-1 receptor antagonist, in clinical practice. Outcome in 60 patients with severe rheumatoid arthritis]. Reumatismo 59:32-7.
-
(2007)
Reumatismo
, vol.59
, pp. 32-37
-
-
Botsios, C.1
-
117
-
-
17444394445
-
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
-
Bresnihan, B., et al. 1998. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41:2196-204.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 2196-2204
-
-
Bresnihan, B.1
-
118
-
-
0036190776
-
Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
-
Cohen, S., et al. 2002. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46:614-24.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 614-624
-
-
Cohen, S.1
-
119
-
-
0037309790
-
Interleukin 1 receptor antagonist anakinra improves functional status in patients with rheumatoid arthritis
-
Cohen, S. B., Woolley, J. M., and Chan, W. 2003. Interleukin 1 receptor antagonist anakinra improves functional status in patients with rheumatoid arthritis. J Rheumatol 30:225-31.
-
(2003)
J Rheumatol
, vol.30
, pp. 225-231
-
-
Cohen, S.B.1
Woolley, J.M.2
Chan, W.3
-
120
-
-
0034083128
-
A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of Genant and Larsen scores
-
Jiang, Y., et al. 2000. A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 43:1001-9.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 1001-1009
-
-
Jiang, Y.1
-
121
-
-
34447318083
-
The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: A metaanalysis and adjusted indirect comparisons
-
Oxford
-
Nixon, R., Bansback, N., and Brennan, A. 2007. The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: A metaanalysis and adjusted indirect comparisons. Rheumatology (Oxford), 46:1146-7.
-
(2007)
Rheumatology
, vol.46
, pp. 1146-1147
-
-
Nixon, R.1
Bansback, N.2
Brennan, A.3
-
122
-
-
3342980733
-
Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation
-
Dinarello, C. A. 2004. Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation. Curr Opin Pharmacol 4:378-85.
-
(2004)
Curr Opin Pharmacol
, vol.4
, pp. 378-385
-
-
Dinarello, C.A.1
-
123
-
-
34548648099
-
The use of TNF-alpha blocking agents in rheumatoid arthritis: An update
-
Toussirot, E., and Wendling, D. 2007. The use of TNF-alpha blocking agents in rheumatoid arthritis: An update. Expert Opin Pharmacother 8:2089-107.
-
(2007)
Expert Opin Pharmacother
, vol.8
, pp. 2089-2107
-
-
Toussirot, E.1
Wendling, D.2
-
124
-
-
0035664487
-
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
-
Plater-Zyberk, C., et al. 2001. Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. J Clin Invest 108:1825-32.
-
(2001)
J Clin Invest
, vol.108
, pp. 1825-1832
-
-
Plater-Zyberk, C.1
-
125
-
-
33646703978
-
New insights into gout epidemiology
-
Mikuls, T. R., and Saag, K. G. 2006. New insights into gout epidemiology. Curr Opin Rheumatol 18:199-203.
-
(2006)
Curr Opin Rheumatol
, vol.18
, pp. 199-203
-
-
Mikuls, T.R.1
Saag, K.G.2
-
126
-
-
3442899325
-
Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population
-
Wallace, K. L., et al. 2004. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J Rheumatol 31:1582-7.
-
(2004)
J Rheumatol
, vol.31
, pp. 1582-1587
-
-
Wallace, K.L.1
-
127
-
-
24344502740
-
Mechanisms of inflammation in gout
-
Oxford
-
Dalbeth, N., and Haskard, D. O. 2005. Mechanisms of inflammation in gout. Rheumatology (Oxford) 44:1090-6.
-
(2005)
Rheumatology
, vol.44
, pp. 1090-1096
-
-
Dalbeth, N.1
Haskard, D.O.2
-
128
-
-
0024392731
-
Urate oxidase: Primary structure and evolutionary implications
-
Wu, X. W., et al. 1989. Urate oxidase: Primary structure and evolutionary implications. Proc Natl Acad Sci USA 86:4412-6.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 4412-4416
-
-
Wu, X.W.1
-
129
-
-
17644371344
-
Obesity, weight change, hypertension, diuretic use, and risk of gout in men: The health professionals follow-up study
-
Choi, H. K., et al. 2005. Obesity, weight change, hypertension, diuretic use, and risk of gout in men: The health professionals follow-up study. Arch Intern Med 165:742-8.
-
(2005)
Arch Intern Med
, vol.165
, pp. 742-748
-
-
Choi, H.K.1
-
130
-
-
18144370736
-
Gout: Epidemiology and lifestyle choices
-
Choi, H. K., and Curhan, G. 2005. Gout: Epidemiology and lifestyle choices. Curr Opin Rheumatol 17:341-5.
-
(2005)
Curr Opin Rheumatol
, vol.17
, pp. 341-345
-
-
Choi, H.K.1
Curhan, G.2
-
131
-
-
0031812793
-
Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro
-
Derfus, B., et al. 1998. Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro. Calcif Tissue Int 63:258-62.
-
(1998)
Calcif Tissue Int
, vol.63
, pp. 258-262
-
-
Derfus, B.1
-
132
-
-
0141560729
-
Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: New developments relevant to the clinician
-
Pay, S., and Terkeltaub, R. 2003. Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: New developments relevant to the clinician. Curr Rheumatol Rep 5:235-43.
-
(2003)
Curr Rheumatol Rep
, vol.5
, pp. 235-243
-
-
Pay, S.1
Terkeltaub, R.2
-
133
-
-
0023898228
-
Calcium pyrophosphate crystal deposition in hyaline cartilage. Ultrastructural analysis and implications for pathogenesis
-
Pritzker, K. P., Cheng, P. T., and Renlund, R. C. 1988. Calcium pyrophosphate crystal deposition in hyaline cartilage. Ultrastructural analysis and implications for pathogenesis. J Rheumatol 15:828-35.
-
(1988)
J Rheumatol
, vol.15
, pp. 828-835
-
-
Pritzker, K.P.1
Cheng, P.T.2
Renlund, R.C.3
-
134
-
-
27744451970
-
Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage
-
Johnson, K., and Terkeltaub, R. 2005. Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage. Front Biosci 10:988-97.
-
(2005)
Front Biosci
, vol.10
, pp. 988-997
-
-
Johnson, K.1
Terkeltaub, R.2
-
135
-
-
0023178197
-
Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1
-
Di Giovine, F. S., et al. 1987. Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J Immunol 138:3213-8.
-
(1987)
J Immunol
, vol.138
, pp. 3213-3218
-
-
Giovine, D.F.S.1
-
136
-
-
32344438251
-
Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18
-
Inokuchi, T., et al. 2006. Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Cytokine 33:21-7.
-
(2006)
Cytokine
, vol.33
, pp. 21-27
-
-
Inokuchi, T.1
-
137
-
-
34047174085
-
A pilot study of IL-1 inhibition by anakinra in acute gout
-
So, A., et al. 2007. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 9:1228.
-
(2007)
Arthritis Res Ther
, vol.9
, pp. 1228
-
-
So, A.1
-
138
-
-
33645458522
-
Familial Mediterranean fever and the other autoinflammatory syndromes: Evaluation of the patient with recurrent fever
-
Samuels, J., and Ozen, S. 2006. Familial Mediterranean fever and the other autoinflammatory syndromes: Evaluation of the patient with recurrent fever. Curr Opin Rheumatol 18:108-17.
-
(2006)
Curr Opin Rheumatol
, vol.18
, pp. 108-117
-
-
Samuels, J.1
Ozen, S.2
-
139
-
-
37349036932
-
Cryopyrin-associated periodic syndromes and autoinflammation
-
Shinkai, K., McCalmont, T. H., and Leslie, K. S. 2007. Cryopyrin-associated periodic syndromes and autoinflammation. Clin Exp Dermatol 33:1-9.
-
(2007)
Clin Exp Dermatol
, vol.33
, pp. 1-9
-
-
Shinkai, K.1
McCalmont, T.H.2
Leslie, K.S.3
-
140
-
-
33846139340
-
Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes
-
Simon, A., and van der Meer, J. W. 2007. Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes. Am J Physiol Regul Integr Comp Physiol 292:R86-98.
-
(2007)
Am J Physiol Regul Integr Comp Physiol
, vol.292
, pp. R86-R98
-
-
Simon, A.1
van der Meer, J.W.2
-
141
-
-
0036899758
-
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrinassociated autoinflammatory diseases
-
Aksentijevich, I., et al. 2002. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrinassociated autoinflammatory diseases. Arthritis Rheum 46:3340-8.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 3340-3348
-
-
Aksentijevich, I.1
-
142
-
-
18344385660
-
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: A novel mutation underlies both syndromes
-
Dode, C., et al. 2002. New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: A novel mutation underlies both syndromes. Am J Hum Genet 70:1498-506.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 1498-1506
-
-
Dode, C.1
-
143
-
-
0036302235
-
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
-
Feldmann, J., et al. 2002. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet 71:198-203.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 198-203
-
-
Feldmann, J.1
-
144
-
-
0035179970
-
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
Hoffman, H. M., et al. 2001. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29:301-5.
-
(2001)
Nat Genet
, vol.29
, pp. 301-305
-
-
Hoffman, H.M.1
-
145
-
-
34249774571
-
Cryopyrin-associated autoinflammatory syndrome: A new mutation
-
Zeft, A., and Bohnsack, J. F. 2007. Cryopyrin-associated autoinflammatory syndrome: A new mutation. Ann Rheum Dis 66:843-4.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 843-844
-
-
Zeft, A.1
Bohnsack, J.F.2
-
146
-
-
4143125654
-
Infevers: An evolving mutation database for auto-inflammatory syndromes
-
Touitou, I., et al. 2004. Infevers: An evolving mutation database for auto-inflammatory syndromes. Hum Mutat 24:194-8.
-
(2004)
Hum Mutat
, vol.24
, pp. 194-198
-
-
Touitou, I.1
-
147
-
-
34047103840
-
Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia
-
Rosengren, S., et al. 2007. Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J Allergy Clin Immunol 119:991-6.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 991-996
-
-
Rosengren, S.1
-
148
-
-
0037792866
-
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome
-
Hawkins, P. N., Lachmann, H. J., and McDermott, M. F. 2003. Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med 348:2583-4.
-
(2003)
N Engl J Med
, vol.348
, pp. 2583-2584
-
-
Hawkins, P.N.1
Lachmann, H.J.2
McDermott, M.F.3
-
149
-
-
34249941913
-
Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling
-
Duncan, J. A., et al. 2007. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc Natl Acad Sci USA 104:8041-6.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8041-8046
-
-
Duncan, J.A.1
-
150
-
-
33745478448
-
Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation
-
Tameling, W. I., et al. 2006. Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation. Plant Physiol 140:1233-45.
-
(2006)
Plant Physiol
, vol.140
, pp. 1233-1245
-
-
Tameling, W.I.1
-
151
-
-
34848875155
-
Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
-
Gattorno, M., et al. 2007. Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations. Arthritis Rheum 56:3138-48.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 3138-3148
-
-
Gattorno, M.1
-
152
-
-
33847364065
-
Successful treatment of renal amyloidosis due to familial cold autoinflammatory syndrome using an interleukin-1 receptor antagonist
-
Thornton, B. D., et al. 2007. Successful treatment of renal amyloidosis due to familial cold autoinflammatory syndrome using an interleukin-1 receptor antagonist. Am J Kidney Dis 49:477-81.
-
(2007)
Am J Kidney Dis
, vol.49
, pp. 477-481
-
-
Thornton, B.D.1
-
153
-
-
10444241090
-
Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene
-
Arostegui, J. I., et al. 2004. Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene. Arthritis Rheum 50:4045-50.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 4045-4050
-
-
Arostegui, J.I.1
-
154
-
-
33645561945
-
Neonatal-onset multisystem inflammatory disease (NOMID) due to a novel S331R mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatment
-
Boschan, C., et al. 2006. Neonatal-onset multisystem inflammatory disease (NOMID) due to a novel S331R mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatment. Am J Med Genet A 140:883-6.
-
(2006)
Am J Med Genet A
, vol.140
, pp. 883-886
-
-
Boschan, C.1
-
155
-
-
33847379803
-
Clinical and genetic characterization of Italian patients affected by CINCA syndrome
-
Oxford
-
Caroli, F., et al. 2007. Clinical and genetic characterization of Italian patients affected by CINCA syndrome. Rheumatology (Oxford) 46:473-8.
-
(2007)
Rheumatology
, vol.46
, pp. 473-478
-
-
Caroli, F.1
-
156
-
-
33746876396
-
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition
-
Goldbach-Mansky, R., et al. 2006. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med 355:581-92.
-
(2006)
N Engl J Med
, vol.355
, pp. 581-592
-
-
Goldbach-Mansky, R.1
-
157
-
-
4043104941
-
Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease
-
Hawkins, P. N., et al. 2004. Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease. Arthritis Rheum 50:2708-9.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2708-2709
-
-
Hawkins, P.N.1
-
158
-
-
1042290321
-
Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra
-
Hawkins, P. N., et al. 2004. Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 50:607-12.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 607-612
-
-
Hawkins, P.N.1
-
159
-
-
8444225132
-
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
-
Hoffman, H. M., et al. 2004. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364:1779-85.
-
(2004)
Lancet
, vol.364
, pp. 1779-1785
-
-
Hoffman, H.M.1
-
160
-
-
33845686908
-
Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations
-
Leslie, K. S., et al. 2006. Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations. Arch Dermatol 142:1591-7.
-
(2006)
Arch Dermatol
, vol.142
, pp. 1591-1597
-
-
Leslie, K.S.1
-
161
-
-
24944528385
-
Positive clinical and biochemical responses to anakinra in a 3-yr-old patient with cryopyrin-associated periodic syndrome (CAPS)
-
Oxford
-
Ramos, E., et al. 2005. Positive clinical and biochemical responses to anakinra in a 3-yr-old patient with cryopyrin-associated periodic syndrome (CAPS). Rheumatology (Oxford) 44:1072-3.
-
(2005)
Rheumatology
, vol.44
, pp. 1072-1073
-
-
Ramos, E.1
-
162
-
-
23444439667
-
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients
-
Stack, J. H., et al. 2005. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol 175:2630-V.
-
(2005)
J Immunol
, vol.175
, pp. 2630
-
-
Stack, J.H.1
-
163
-
-
33645359493
-
Familial Mediterranean fever
-
Onen, F. 2006. Familial Mediterranean fever. Rheumatol Int 26:489-96.
-
(2006)
Rheumatol Int
, vol.26
, pp. 489-496
-
-
Onen, F.1
-
164
-
-
34548186724
-
Population genetics of familial Mediterranean fever: A review
-
Yepiskoposyan, L., and Harutyunyan, A. 2007. Population genetics of familial Mediterranean fever: A review. Eur J Hum Genet 15:911-6.
-
(2007)
Eur J Hum Genet
, vol.15
, pp. 911-916
-
-
Yepiskoposyan, L.1
Harutyunyan, A.2
-
165
-
-
0035091156
-
Episodic evolution of pyrin in primates: Human mutations recapitulate ancestral amino acid states
-
Schaner, P., et al. 2001. Episodic evolution of pyrin in primates: Human mutations recapitulate ancestral amino acid states. Nat Genet 27:318-21.
-
(2001)
Nat Genet
, vol.27
, pp. 318-321
-
-
Schaner, P.1
-
166
-
-
0037349294
-
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis
-
Chae, J. J., et al. 2003. Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell 11:591-604.
-
(2003)
Mol Cell
, vol.11
, pp. 591-604
-
-
Chae, J.J.1
-
167
-
-
33745631232
-
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production
-
Chae, J. J., et al. 2006. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci USA 103:9982-7.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9982-9987
-
-
Chae, J.J.1
-
168
-
-
34547138176
-
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing
-
Papin, S., et al. 2007. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ 14:1457-66.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1457-1466
-
-
Papin, S.1
-
169
-
-
30844432876
-
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization
-
Yu, J. W., et al. 2006. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ 13:236-49.
-
(2006)
Cell Death Differ
, vol.13
, pp. 236-249
-
-
Yu, J.W.1
-
170
-
-
33645288545
-
Structural and functional insights into the B30.2/SPRY domain
-
Woo, J. S., et al. 2006. Structural and functional insights into the B30.2/SPRY domain. EMBO J 25:1353-63.
-
(2006)
EMBO J
, vol.25
, pp. 1353-1363
-
-
Woo, J.S.1
-
171
-
-
35948942144
-
The efficacy of anakinra in an adolescent with colchicineresistant familial Mediterranean fever
-
Calligaris, L., et al. 2007. The efficacy of anakinra in an adolescent with colchicineresistant familial Mediterranean fever. Eur J Pediatr. 167:645-696.
-
(2007)
Eur J Pediatr
, vol.167
, pp. 645-696
-
-
Calligaris, L.1
-
172
-
-
0030804743
-
A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome
-
Lindor, N. M., et al. 1997. A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. Mayo Clin Proc 72:611-5.
-
(1997)
Mayo Clin Proc
, vol.72
, pp. 611-615
-
-
Lindor, N.M.1
-
173
-
-
33749621794
-
Peculiarities of PAPA syndrome
-
Oxford
-
Tallon, B., and Corkill, M. 2006. Peculiarities of PAPA syndrome. Rheumatology (Oxford) 45:1140-3.
-
(2006)
Rheumatology
, vol.45
, pp. 1140-1143
-
-
Tallon, B.1
Corkill, M.2
-
174
-
-
0030872948
-
PSTPIP: A tyrosine phosphorylated cleavage furrowassociated protein that is a substrate for a PEST tyrosine phosphatase
-
Spencer, S., et al. 1997. PSTPIP: A tyrosine phosphorylated cleavage furrowassociated protein that is a substrate for a PEST tyrosine phosphatase. J Cell Biol 138:845-60.
-
(1997)
J Cell Biol
, vol.138
, pp. 845-860
-
-
Spencer, S.1
-
175
-
-
0037091012
-
Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder
-
Wise, C. A., et al. 2002. Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Hum Mol Genet 11:961-9.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 961-969
-
-
Wise, C.A.1
-
176
-
-
0344823965
-
Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway
-
Shoham, N. G., et al. 2003. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci USA 100:13501-6.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 13501-13506
-
-
Shoham, N.G.1
-
177
-
-
35348934890
-
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
-
Yu, J. W., et al. 2007. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell 28:214-27.
-
(2007)
Mol Cell
, vol.28
, pp. 214-227
-
-
Yu, J.W.1
-
178
-
-
34548031870
-
The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
-
Fernandes-Alnemri, T., et al. 2007. The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14:1590-604.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1590-1604
-
-
Fernandes-Alnemri, T.1
-
179
-
-
14944380059
-
Anakinra for flares of pyogenic arthritis in PAPA syndrome
-
Oxford
-
Dierselhuis, M. P., et al. 2005. Anakinra for flares of pyogenic arthritis in PAPA syndrome. Rheumatology (Oxford) 44:406-8.
-
(2005)
Rheumatology
, vol.44
, pp. 406-408
-
-
Dierselhuis, M.P.1
-
180
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky, D. K. 2002. Inflammatory bowel disease. N Engl J Med 347:417-29.
-
(2002)
N Engl J Med
, vol.347
, pp. 417-429
-
-
Podolsky, D.K.1
-
181
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier, R. J., and Podolsky, D. K. 2007. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448:427-34.
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
182
-
-
33745775434
-
Mechanisms of disease: Pathogenesis of Crohn’s disease and ulcerative colitis
-
Sartor, R. B. 2006. Mechanisms of disease: Pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390-407.
-
(2006)
Nat Clin Pract Gastroenterol Hepatol
, vol.3
, pp. 390-407
-
-
Sartor, R.B.1
-
183
-
-
33750609696
-
Recent trends in the epidemiology of inflammatory bowel diseases: Up or down?
-
Lakatos, P. L. 2006. Recent trends in the epidemiology of inflammatory bowel diseases: Up or down? World J Gastroenterol 12:6102-8.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 6102-6108
-
-
Lakatos, P.L.1
-
184
-
-
33745473236
-
Family and twin studies in inflammatory bowel disease
-
Halme, L., et al. 2006. Family and twin studies in inflammatory bowel disease. World J Gastroenterol 12:3668-72.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 3668-3672
-
-
Halme, L.1
-
185
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr, R. H., et al. 2006. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461-3.
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
-
186
-
-
37249034766
-
Systematic association mapping identifies NELL1 as a novel IBD disease gene
-
Franke, A., et al. 2007. Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS ONE 2:c691.
-
(2007)
PLoS ONE
, vol.2
, pp. c691
-
-
Franke, A.1
-
187
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNP’s identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe, J., et al. 2007. A genome-wide association scan of nonsynonymous SNP’s identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39:207-11.
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
-
188
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease
-
Hugot, J. P., et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411:599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
189
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease
-
Ogura, Y., et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411:603-6.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
190
-
-
2442585704
-
Functional variants of OCTN cation transporter genes are associated with Crohn’s disease
-
Peltekova, V. D., et al. 2004. Functional variants of OCTN cation transporter genes are associated with Crohn’s disease. Nat Genet 36.
-
(2004)
Nat Genet
, pp. 36
-
-
Peltekova, V.D.1
-
191
-
-
2442519456
-
Genetic variation in DLG5 is associated with inflammatory bowel disease
-
Stoll, M., et al. 2004. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 36:471-5.
-
(2004)
Nat Genet
, vol.36
, pp. 471-475
-
-
Stoll, M.1
-
192
-
-
35348932070
-
Intracellular NOD-like receptors in host defense and disease
-
Kanneganti, T. D., Lamkanfi, M., and Nunez, G. 2007. Intracellular NOD-like receptors in host defense and disease. Immunity 27:549-59.
-
(2007)
Immunity
, vol.27
, pp. 549-559
-
-
Kanneganti, T.D.1
Lamkanfi, M.2
Nunez, G.3
-
193
-
-
22244465576
-
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-kB activation in muramyl dipeptide recognition
-
Barnich, N., et al. 2005. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-kB activation in muramyl dipeptide recognition. J Cell Biol 170:21-6.
-
(2005)
J Cell Biol
, vol.170
, pp. 21-26
-
-
Barnich, N.1
-
194
-
-
34447504037
-
The NOD2-RICK complex signals from the plasma membrane
-
Lecine, P., et al. 2007. The NOD2-RICK complex signals from the plasma membrane. J Biol Chem 282:15197-207.
-
(2007)
J Biol Chem
, vol.282
, pp. 15197-15207
-
-
Lecine, P.1
-
195
-
-
0012722659
-
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
-
Girardin, S. E., et al. 2003. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278:8869-72.
-
(2003)
J Biol Chem
, vol.278
, pp. 8869-8872
-
-
Girardin, S.E.1
-
196
-
-
0142180157
-
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
-
Girardin, S. E., et al. 2003. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 278:41702-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 41702-41708
-
-
Girardin, S.E.1
-
197
-
-
0037458665
-
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease
-
Inohara, N., et al. 2003. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease. J Biol Chem 278:5509-12.
-
(2003)
J Biol Chem
, vol.278
, pp. 5509-5512
-
-
Inohara, N.1
-
198
-
-
0035895992
-
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
-
Ogura, Y., et al. 2001. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-18.
-
(2001)
J Biol Chem
, vol.276
, pp. 4812-4818
-
-
Ogura, Y.1
-
199
-
-
77951073629
-
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis
-
Ferwerda, G., et al. 2005. NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog, 1:279-85.
-
(2005)
PLoS Pathog
, vol.1
, pp. 279-285
-
-
Ferwerda, G.1
-
200
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi, K. S., et al. 2005. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307:731-4.
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
-
201
-
-
4344699028
-
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae
-
Opitz, B., et al. 2004. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem 279:36426-32.
-
(2004)
J Biol Chem
, vol.279
, pp. 36426-36432
-
-
Opitz, B.1
-
202
-
-
33846469538
-
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
-
Hsu, Y. M., et al. 2007. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8:198-205.
-
(2007)
Nat Immunol
, vol.8
, pp. 198-205
-
-
Hsu, Y.M.1
-
203
-
-
33846936219
-
RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs
-
Park, J. H., et al. 2007. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol 178:2380-6.
-
(2007)
J Immunol
, vol.178
, pp. 2380-2386
-
-
Park, J.H.1
-
204
-
-
37548999003
-
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2
-
Yang, Y., et al. 2007. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem. 282:36223-9.
-
(2007)
J Biol Chem
, vol.282
, pp. 36223-36229
-
-
Yang, Y.1
-
205
-
-
33846469539
-
A pair of 9s: It’s in the CARDs
-
Underhill, D. M., and Shimada, T. 2007. A pair of 9s: It’s in the CARDs. Nat Immunol 8:122-4.
-
(2007)
Nat Immunol
, vol.8
, pp. 122-124
-
-
Underhill, D.M.1
Shimada, T.2
-
206
-
-
33847381116
-
The fundamental basis of inflammatory bowel disease
-
Strober, W., Fuss, I., and Mannon, P. 2007. The fundamental basis of inflammatory bowel disease. J Clin Invest 117:514-21.
-
(2007)
J Clin Invest
, vol.117
, pp. 514-521
-
-
Strober, W.1
Fuss, I.2
Mannon, P.3
-
207
-
-
4444332518
-
Regulation of IL-8 and IL-1beta expression in Crohn’s disease associated NOD2/CARD15 mutations
-
Li, J., et al. 2004. Regulation of IL-8 and IL-1beta expression in Crohn’s disease associated NOD2/CARD15 mutations. Hum Mol Genet 13:1715-25.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1715-1725
-
-
Li, J.1
-
208
-
-
3242664636
-
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
-
Rakoff-Nahoum, S., et al. 2004. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229-41.
-
(2004)
Cell
, vol.118
, pp. 229-241
-
-
Rakoff-Nahoum, S.1
-
209
-
-
37649013801
-
Chronic stimulation of Nod2 mediates tolerance to bacterial products
-
Hedl, M., et al. 2007. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci USA 104:19440-5.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19440-19445
-
-
Hedl, M.1
-
210
-
-
34247239745
-
Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
-
Uehara, A., et al. 2007. Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol 44:3100-11.
-
(2007)
Mol Immunol
, vol.44
, pp. 3100-3111
-
-
Uehara, A.1
-
211
-
-
35648995482
-
NOD2 transgenic mice exhibit enhanced MDP-mediated downregulation of TLR2 responses and resistance to colitis induction
-
Yang, Z., et al. 2007. NOD2 transgenic mice exhibit enhanced MDP-mediated downregulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133:1510-12.
-
(2007)
Gastroenterology
, vol.133
, pp. 1510-1512
-
-
Yang, Z.1
-
212
-
-
13244277880
-
Nod 2 mutation in Crohn’s disease potentiates NF-kappaB activity and IL-1beta processing
-
Maeda, S., et al. 2005. Nod 2 mutation in Crohn’s disease potentiates NF-kappaB activity and IL-1beta processing. Science 307:734-8.
-
(2005)
Science
, vol.307
, pp. 734-738
-
-
Maeda, S.1
-
213
-
-
3142674847
-
Heterotypic interactions among NACHT domains: Implications for regulation of innate immune responses
-
Damiano, J. S., et al. 2004. Heterotypic interactions among NACHT domains: Implications for regulation of innate immune responses. Biochem J 381:213-9.
-
(2004)
Biochem J
, vol.381
, pp. 213-219
-
-
Damiano, J.S.1
-
214
-
-
34347382756
-
MDP-induced interleukin-1beta processing requires Nod 2 and CIAS1/NALP3
-
Pan, Q., et al. 2007. MDP-induced interleukin-1beta processing requires Nod 2 and CIAS1/NALP3. J Leukoc Biol 82:177-83.
-
(2007)
J Leukoc Biol
, vol.82
, pp. 177-183
-
-
Pan, Q.1
-
215
-
-
33748493563
-
Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis
-
Watanabe, T., et al. 2006. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25:473-85.
-
(2006)
Immunity
, vol.25
, pp. 473-485
-
-
Watanabe, T.1
-
216
-
-
26044460479
-
NOD2 3020insC mutation and the pathogenesis of Crohn’s disease: Impaired IL-1beta production points to a loss-of-function phenotype
-
Netea, M. G., et al. 2005. NOD2 3020insC mutation and the pathogenesis of Crohn’s disease: Impaired IL-1beta production points to a loss-of-function phenotype. Neth J Med 63:305-8.
-
(2005)
Neth J Med
, vol.63
, pp. 305-308
-
-
Netea, M.G.1
-
217
-
-
21144468350
-
Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn’s disease
-
van Heel, D. A., et al. 2005. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn’s disease. Lancet 365:1794-6.
-
(2005)
Lancet
, vol.365
, pp. 1794-1796
-
-
van Heel, D.A.1
-
218
-
-
0036628565
-
Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation
-
Siegmund, B. 2002. Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation. Biochem Pharmacol 64:1-8.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1-8
-
-
Siegmund, B.1
-
219
-
-
0035818549
-
IL-1 beta-converting enzyme (caspase-1) in intestinal inflammation
-
Siegmund, B., et al. 2001. IL-1 beta-converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci USA 98:13249-54.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13249-13254
-
-
Siegmund, B.1
-
220
-
-
0033168120
-
Bioactive IL-18 expression is up-regulated in Crohn’s disease
-
Monteleone, G., et al. 1999. Bioactive IL-18 expression is up-regulated in Crohn’s disease. J Immunol 163:143-7.
-
(1999)
J Immunol
, vol.163
, pp. 143-147
-
-
Monteleone, G.1
-
221
-
-
0035072423
-
Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn’s disease lesions
-
Pages, F., et al. 2001. Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn’s disease lesions. Eur Cytokine Netw 12:97-104.
-
(2001)
Eur Cytokine Netw
, vol.12
, pp. 97-104
-
-
Pages, F.1
-
222
-
-
0033152023
-
IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: Expression and localization in intestinal mucosal cells
-
Pizarro, T. T., et al. 1999. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: Expression and localization in intestinal mucosal cells. J Immunol 162:6829-35.
-
(1999)
J Immunol
, vol.162
, pp. 6829-6835
-
-
Pizarro, T.T.1
-
223
-
-
0032923019
-
Investigation of the expression of IL-1beta converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages
-
McAlindon, M. E., et al. 1999. Investigation of the expression of IL-1beta converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages. Clin Exp Immunol 116:251-7.
-
(1999)
Clin Exp Immunol
, vol.116
, pp. 251-257
-
-
McAlindon, M.E.1
-
224
-
-
0031921472
-
Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease
-
McAlindon, M. E., Hawkey, C. J., and Mahida, Y. R. 1998. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut 42:214-9.
-
(1998)
Gut
, vol.42
, pp. 214-219
-
-
McAlindon, M.E.1
Hawkey, C.J.2
Mahida, Y.R.3
-
225
-
-
0043074846
-
Crohn disease worsened by anakinra administration
-
Carter, J. D., Valeriano, J., and Vasey, F. B. 2003. Crohn disease worsened by anakinra administration. J Clin Rheumatol 9:276-7.
-
(2003)
J Clin Rheumatol
, vol.9
, pp. 276-277
-
-
Carter, J.D.1
Valeriano, J.2
Vasey, F.B.3
-
226
-
-
34249913692
-
The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression
-
Bauer, C., et al. 2007. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression. Dig Dis Sci 52:1642-52.
-
(2007)
Dig Dis Sci
, vol.52
, pp. 1642-1652
-
-
Bauer, C.1
-
227
-
-
9144222968
-
The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation
-
Loher, F., et al. 2004. The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation. J Pharmacol Exp Ther 308:583-90.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 583-590
-
-
Loher, F.1
-
228
-
-
0026710191
-
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
-
Bone, R. C., et al. 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-55.
-
(1992)
Chest
, vol.101
, pp. 1644-1655
-
-
Bone, R.C.1
-
229
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss, R. S., and Karl, I. E. 2003. The pathophysiology and treatment of sepsis. N Engl J Med 348:138-50.
-
(2003)
N Engl J Med
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
230
-
-
0037396875
-
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
-
Levy, M. M., et al. 2003. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530-8.
-
(2003)
Intensive Care Med
, vol.29
, pp. 530-538
-
-
Levy, M.M.1
-
231
-
-
31344461826
-
Sepsis in European intensive care units: Results of the SOAP study
-
Vincent, J. L., et al. 2006. Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 34:344-53.
-
(2006)
Crit Care Med
, vol.34
, pp. 344-353
-
-
Vincent, J.L.1
-
232
-
-
33750580090
-
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18
-
Sarkar, A., et al. 2006. Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med 174:1003-10.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 1003-1010
-
-
Sarkar, A.1
-
233
-
-
0030008326
-
Effect of endotoxin in IL-1 beta-deficient mice
-
Fantuzzi, G., et al. 1996. Effect of endotoxin in IL-1 beta-deficient mice. J Immunol 157:291-6.
-
(1996)
J Immunol
, vol.157
, pp. 291-296
-
-
Fantuzzi, G.1
-
234
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
Hotchkiss, R. S., and Nicholson, D. W. 2006. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6:813-22.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
235
-
-
0028018567
-
Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebo-controlled multicenter trial
-
Fisher, C. J., Jr., et al. 1994. Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebo-controlled multicenter trial. Crit Care Med 22:12-21.
-
(1994)
Crit Care Med
, vol.22
, pp. 12-21
-
-
Fisher, C.J.1
-
236
-
-
0030746482
-
Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
-
Zeni, F., Freeman, B., and Natanson, C. 1997. Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment. Crit Care Med 25:1095-100.
-
(1997)
Crit Care Med
, vol.25
, pp. 1095-1100
-
-
Zeni, F.1
Freeman, B.2
Natanson, C.3
-
237
-
-
35349016235
-
Recognition of microorganisms and activation of the immune response
-
Medzhitov, R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449:819-26.
-
(2007)
Nature
, vol.449
, pp. 819-826
-
-
Medzhitov, R.1
-
238
-
-
1542615639
-
Immune surveillance in the skin: Mechanisms and clinical consequences
-
Kupper, T. S., and Fuhlbrigge, R. C. 2004. Immune surveillance in the skin: Mechanisms and clinical consequences. Nat Rev Immunol 4:211-22.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 211-222
-
-
Kupper, T.S.1
Fuhlbrigge, R.C.2
-
239
-
-
6344259982
-
Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions
-
Companjen, A., et al. 2004. Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions. Eur Cytokine Netw 15:210-6.
-
(2004)
Eur Cytokine Netw
, vol.15
, pp. 210-216
-
-
Companjen, A.1
-
240
-
-
0031569196
-
The IL-1 system in psoriatic skin: IL-1 antagonist sphere of influence in lesional psoriatic epidermis
-
Debets, R., et al. 1997. The IL-1 system in psoriatic skin: IL-1 antagonist sphere of influence in lesional psoriatic epidermis. J Immunol 158:2955-63.
-
(1997)
J Immunol
, vol.158
, pp. 2955-2963
-
-
Debets, R.1
-
241
-
-
34547671041
-
The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: Dominance of innate immune responses in psoriasis
-
Mee, J. B., et al. 2007. The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: Dominance of innate immune responses in psoriasis. Am J Pathol 171:32-42.
-
(2007)
Am J Pathol
, vol.171
, pp. 32-42
-
-
Mee, J.B.1
-
242
-
-
33644838268
-
Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1, 25-dihydroxyvitamin D3 in primary keratinocytes
-
Kong, J., Grando, S. A., and Li, Y. C. 2006. Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1, 25-dihydroxyvitamin D3 in primary keratinocytes. J Immunol 176:3780-7.
-
(2006)
J Immunol
, vol.176
, pp. 3780-3787
-
-
Kong, J.1
Grando, S.A.2
Li, Y.C.3
-
243
-
-
1842689976
-
Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist
-
Shepherd, J., Little, M. C., and Nicklin, M. J. 2004. Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist. J Invest Dermatol 122:665-9.
-
(2004)
J Invest Dermatol
, vol.122
, pp. 665-669
-
-
Shepherd, J.1
Little, M.C.2
Nicklin, M.J.3
-
244
-
-
0035869399
-
Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice
-
Antonopoulos, C., et al. 2001. Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice. J Immunol 166:3672-7.
-
(2001)
J Immunol
, vol.166
, pp. 3672-3677
-
-
Antonopoulos, C.1
-
245
-
-
34250792190
-
Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity
-
Watanabe, H., et al. 2007. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 127:1956-63.
-
(2007)
J Invest Dermatol
, vol.127
, pp. 1956-1963
-
-
Watanabe, H.1
-
246
-
-
85133982127
-
IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis
-
Antonopoulos, C., et al. 2007. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol. 83.
-
(2007)
J Leukoc Biol
, pp. 83
-
-
Antonopoulos, C.1
-
247
-
-
33947497237
-
NALP1 in vitiligo-associated multiple autoimmune disease
-
Jin, Y., et al. 2007. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med 356:1216-25.
-
(2007)
N Engl J Med
, vol.356
, pp. 1216-1225
-
-
Jin, Y.1
-
248
-
-
23444441962
-
Interleukin-1 and neuronal injury
-
Allan, S. M., Tyrrell, P. J., and Rothwell, N. J. 2005. Interleukin-1 and neuronal injury. Nat Rev Immunol 5:629-40.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 629-640
-
-
Allan, S.M.1
Tyrrell, P.J.2
Rothwell, N.J.3
-
249
-
-
36749012006
-
Interleukin-1 and inflammatory neurodegeneration
-
Simi, A., et al. 2007. Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans 35:1122-6.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1122-1126
-
-
Simi, A.1
-
250
-
-
30444459031
-
The role of inflammation in CNS injury and disease
-
Lucas, S. M., Rothwell, N. J., and Gibson, R. M. 2006. The role of inflammation in CNS injury and disease. Br J Pharmacol 147(Suppl 1):5232-40.
-
(2006)
Br J Pharmacol
, vol.147
, pp. 5232-5240
-
-
Lucas, S.M.1
Rothwell, N.J.2
Gibson, R.M.3
-
251
-
-
23944524535
-
IL-18: A key player in neuroinflammation and neurodegeneration?
-
Felderhoff-Mueser, U., et al. 2005. IL-18: A key player in neuroinflammation and neurodegeneration? Trends Neurosci 28:487-93.
-
(2005)
Trends Neurosci
, vol.28
, pp. 487-493
-
-
Felderhoff-Mueser, U.1
-
252
-
-
0028220499
-
Proinflammatory cytokines in serum of patients with acute cerebral ischemia: Kinetics of secretion and relation to the extent of brain damage and outcome of disease
-
Fassbender, K., et al. 1994. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: Kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci 122:135-9.
-
(1994)
J Neurol Sci
, vol.122
, pp. 135-139
-
-
Fassbender, K.1
-
253
-
-
0029132696
-
Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke
-
Tarkowski, E., et al. 1995. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke 26:1393-8.
-
(1995)
Stroke
, vol.26
, pp. 1393-1398
-
-
Tarkowski, E.1
-
254
-
-
8044252166
-
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury
-
Friedlander, R. M., et al. 1997. Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med 185:933-40.
-
(1997)
J Exp Med
, vol.185
, pp. 933-940
-
-
Friedlander, R.M.1
-
255
-
-
0030972543
-
Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein
-
Hara, H., et al. 1997. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J Cereb Blood Flow Metab 17:370-5.
-
(1997)
J Cereb Blood Flow Metab
, vol.17
, pp. 370-375
-
-
Hara, H.1
-
256
-
-
0031894316
-
Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice
-
Schielke, G. P., et al. 1998. Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice. J Cereb Blood Flow Metab 18:180-5.
-
(1998)
J Cereb Blood Flow Metab
, vol.18
, pp. 180-185
-
-
Schielke, G.P.1
-
257
-
-
0034660250
-
Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines
-
Rabuffetti, M., et al. 2000. Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. J Neurosci 20:4398-404.
-
(2000)
J Neurosci
, vol.20
, pp. 4398-4404
-
-
Rabuffetti, M.1
-
258
-
-
0142153881
-
Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat
-
Mulcahy, N. J., et al. 2003. Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br J Pharmacol 140:471-6.
-
(2003)
Br J Pharmacol
, vol.140
, pp. 471-476
-
-
Mulcahy, N.J.1
-
259
-
-
38549127374
-
Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations
-
Clark, S. R., et al. 2007. Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. J Cereb Blood Flow Metab 28:387-94.
-
(2007)
J Cereb Blood Flow Metab
, vol.28
, pp. 387-394
-
-
Clark, S.R.1
-
260
-
-
39849105534
-
Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage
-
Gueorguieva, I., et al. 2007. Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol 65:317-25.
-
(2007)
Br J Clin Pharmacol
, vol.65
, pp. 317-325
-
-
Gueorguieva, I.1
-
261
-
-
0028556463
-
Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier
-
Gutierrez, E. G., Banks, W. A., and Kastin, A. J. 1994. Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier. J Neuroimmunol 55:153-60.
-
(1994)
J Neuroimmunol
, vol.55
, pp. 153-160
-
-
Gutierrez, E.G.1
Banks, W.A.2
Kastin, A.J.3
-
262
-
-
0033387565
-
Potential mechanisms of interleukin-1 involvement in cerebral ischaemia
-
Touzani, O., et al. 1999. Potential mechanisms of interleukin-1 involvement in cerebral ischaemia. J Neuroimmunol 100:203-15.
-
(1999)
J Neuroimmunol
, vol.100
, pp. 203-215
-
-
Touzani, O.1
-
263
-
-
25444517949
-
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
-
Emsley, H. C., et al. 2005. A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J Neurol Neurosurg Psychiatry 76:1366-72.
-
(2005)
J Neurol Neurosurg Psychiatry
, vol.76
, pp. 1366-1372
-
-
Emsley, H.C.1
-
264
-
-
34848849121
-
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat
-
Ross, J., et al. 2007. A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Neuropharmacology 53:638-42.
-
(2007)
Neuropharmacology
, vol.53
, pp. 638-642
-
-
Ross, J.1
-
266
-
-
0034773521
-
Epidemiology of severe brain injuries: A prospective population-based study
-
Masson, F., et al. 2001. Epidemiology of severe brain injuries: A prospective population-based study. J Trauma 51:481-9.
-
(2001)
J Trauma
, vol.51
, pp. 481-489
-
-
Masson, F.1
-
267
-
-
1342285210
-
Neuropathological and biochemical features of traumatic injury in the developing brain
-
Bittigau, P., et al. 2003. Neuropathological and biochemical features of traumatic injury in the developing brain. Neurotoxicol Res 5:475-90.
-
(2003)
Neurotoxicol Res
, vol.5
, pp. 475-490
-
-
Bittigau, P.1
-
268
-
-
0028661078
-
SOD-1 transgenic mice as a model for studies of neuroprotection in stroke and brain trauma
-
Chan, P. H., et al. 1994. SOD-1 transgenic mice as a model for studies of neuroprotection in stroke and brain trauma. Ann NY Acad Sci 738:93-103.
-
(1994)
Ann NY Acad Sci
, vol.738
, pp. 93-103
-
-
Chan, P.H.1
-
269
-
-
0029973612
-
An experimental model of closed head injury in mice: Pathophysiology, histopathology, and cognitive deficits
-
Chen, Y., et al. 1996. An experimental model of closed head injury in mice: Pathophysiology, histopathology, and cognitive deficits. J Neurotrauma 13:557-68.
-
(1996)
J Neurotrauma
, vol.13
, pp. 557-568
-
-
Chen, Y.1
-
270
-
-
3042794144
-
A detrimental role for nitric oxide synthase-2 in the pathology resulting from acute cerebral injury
-
Jones, N. C., et al. 2004. A detrimental role for nitric oxide synthase-2 in the pathology resulting from acute cerebral injury. J Neuropathol Exp Neurol 63:708-20.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 708-720
-
-
Jones, N.C.1
-
271
-
-
0032708427
-
Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade
-
Fink, K. B., et al. 1999. Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade. Neuroscience 94:1213-8.
-
(1999)
Neuroscience
, vol.94
, pp. 1213-1218
-
-
Fink, K.B.1
-
272
-
-
23044498470
-
Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes
-
Jones, N. C., et al. 2005. Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes. Eur J Neurosci 22:72-8.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 72-78
-
-
Jones, N.C.1
-
273
-
-
0036675515
-
Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist
-
Tehranian, R., et al. 2002. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma 19:939-51.
-
(2002)
J Neurotrauma
, vol.19
, pp. 939-951
-
-
Tehranian, R.1
-
274
-
-
0036326050
-
Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury
-
Yatsiv, I., et al. 2002. Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab 22:971-8.
-
(2002)
J Cereb Blood Flow Metab
, vol.22
, pp. 971-978
-
-
Yatsiv, I.1
-
275
-
-
0345491863
-
Prognostic value of interleukin-1 beta levels after acute brain injury
-
Tasci, A., et al. 2003. Prognostic value of interleukin-1 beta levels after acute brain injury. Neurol Res 25:871-4.
-
(2003)
Neurol Res
, vol.25
, pp. 871-874
-
-
Tasci, A.1
-
276
-
-
33847283652
-
Activation of caspase-1 dependent interleukins in developmental brain trauma
-
Sifringer, M., et al. 2007. Activation of caspase-1 dependent interleukins in developmental brain trauma. Neurobiol Dis 25:614-22.
-
(2007)
Neurobiol Dis
, vol.25
, pp. 614-622
-
-
Sifringer, M.1
-
277
-
-
33644625777
-
Brain inflammation in epilepsy: Experimental and clinical evidence
-
Vezzani, A., and Granata, T. 2005. Brain inflammation in epilepsy: Experimental and clinical evidence. Epilepsia 46:1724-43.
-
(2005)
Epilepsia
, vol.46
, pp. 1724-1743
-
-
Vezzani, A.1
Granata, T.2
-
278
-
-
0019882992
-
Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy
-
Nadler, J. V. 1981. Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 29:2031-42.
-
(1981)
Life Sci
, vol.29
, pp. 2031-2042
-
-
Nadler, J.V.1
-
279
-
-
0016230519
-
Kainic acid: A powerful neurotoxic analogue of glutamate
-
Olney, J. W., Rhee, V., and Ho, O. L. 1974. Kainic acid: A powerful neurotoxic analogue of glutamate. Brain Res 77:507-12.
-
(1974)
Brain Res
, vol.77
, pp. 507-512
-
-
Olney, J.W.1
Rhee, V.2
Ho, O.L.3
-
280
-
-
33746145901
-
Inactivation of caspase-1 in rodent brain: A novel anticonvulsive strategy
-
Ravizza, T., et al. 2006. Inactivation of caspase-1 in rodent brain: A novel anticonvulsive strategy. Epilepsia 47:1160-8.
-
(2006)
Epilepsia
, vol.47
, pp. 1160-1168
-
-
Ravizza, T.1
-
281
-
-
0033943296
-
Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
-
De Simoni, M. G., et al. 2000. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur J Neurosci 12:2623-33.
-
(2000)
Eur J Neurosci
, vol.12
, pp. 2623-2633
-
-
Simoni, D.M.G.1
-
282
-
-
12944273495
-
Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice
-
Vezzani, A., et al. 2000. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc Natl Acad Sci USA 97:11534-9.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11534-11539
-
-
Vezzani, A.1
-
283
-
-
0036337913
-
Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis
-
Vezzani, A., et al. 2002. Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia 43(Suppl 5):30-5.
-
(2002)
Epilepsia
, vol.43
, pp. 30-35
-
-
Vezzani, A.1
-
284
-
-
0021256895
-
Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner, G. G., and Wong, C. W. 1984. Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-90.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
285
-
-
0001360461
-
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
-
Griffin, W. S., et al. 1989. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 86:7611-5.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 7611-7615
-
-
Griffin, W.S.1
-
286
-
-
58249125300
-
Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients
-
Ojala, J., et al. 2007. Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients. Neurobiol Aging.
-
(2007)
Neurobiol Aging
-
-
Ojala, J.1
-
287
-
-
33748471099
-
Inflammation in Alzheimer’s disease: Driving force, bystander or beneficial response?
-
Wyss-Coray, T. 2006. Inflammation in Alzheimer’s disease: Driving force, bystander or beneficial response? Nat Med 12:1005-15.
-
(2006)
Nat Med
, vol.12
, pp. 1005-1015
-
-
Wyss-Coray, T.1
-
288
-
-
0032588231
-
Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease
-
Zhu, S. G., et al. 1999. Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease. J Neuropathol Exp Neurol 58:582-7.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 582-587
-
-
Zhu, S.G.1
-
289
-
-
0025801468
-
Is amyloidogenesis during Alzheimer’s disease due to an IL-1-/IL-6-mediated “acute phase response” in the brain?
-
Vandenabeele, P., and Fiers, W. 1991. Is amyloidogenesis during Alzheimer’s disease due to an IL-1-/IL-6-mediated “acute phase response” in the brain? Immunol Today 12:217-9.
-
(1991)
Immunol Today
, vol.12
, pp. 217-219
-
-
Vandenabeele, P.1
Fiers, W.2
-
290
-
-
34249899174
-
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
-
Shaftel, S. S., et al. 2007. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117:1595-604.
-
(2007)
J Clin Invest
, vol.117
, pp. 1595-1604
-
-
Shaftel, S.S.1
-
291
-
-
0038727936
-
Description of Parkinson’s disease as a clinical syndrome
-
Fahn, S. 2003. Description of Parkinson’s disease as a clinical syndrome. Ann NY Acad Sci 991:1-14.
-
(2003)
Ann NY Acad Sci
, vol.991
, pp. 1-14
-
-
Fahn, S.1
-
292
-
-
0032497504
-
Parkinson’s disease. First of two parts
-
Lang, A. E., and Lozano, A. M. 1998. Parkinson’s disease. First of two parts. N Engl J Med 339:1044-53.
-
(1998)
N Engl J Med
, vol.339
, pp. 1044-1053
-
-
Lang, A.E.1
Lozano, A.M.2
-
293
-
-
0032497504
-
Parkinson’s disease. Second of two parts
-
Lang, A. E., and Lozano, A. M. 1998. Parkinson’s disease. Second of two parts. N Engl J Med 339:1130-43.
-
(1998)
N Engl J Med
, vol.339
, pp. 1130-1143
-
-
Lang, A.E.1
Lozano, A.M.2
-
294
-
-
20744435383
-
Molecular pathophysiology of Parkinson’s disease
-
Moore, D. J., et al. 2005. Molecular pathophysiology of Parkinson’s disease. Annu Rev Neurosci 28:57-87.
-
(2005)
Annu Rev Neurosci
, vol.28
, pp. 57-87
-
-
Moore, D.J.1
-
295
-
-
0021864241
-
Parkinson’s disease: Loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions
-
Uhl, G. R., Hedreen, J. C., and Price, D. L. 1985. Parkinson’s disease: Loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions. Neurology 35:1215-8.
-
(1985)
Neurology
, vol.35
, pp. 1215-1218
-
-
Uhl, G.R.1
Hedreen, J.C.2
Price, D.L.3
-
296
-
-
35348966882
-
Neuroinflammatory mechanisms in Parkinson’s disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
-
Tansey, M. G., McCoy, M. K., and Frank-Cannon, T. C. 2007. Neuroinflammatory mechanisms in Parkinson’s disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol 208:1-25.
-
(2007)
Exp Neurol
, vol.208
, pp. 1-25
-
-
Tansey, M.G.1
McCoy, M.K.2
Frank-Cannon, T.C.3
-
297
-
-
0029417080
-
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients
-
Blum-Degen, D., et al. 1995. Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients. Neurosci Lett 202:17-20.
-
(1995)
Neurosci Lett
, vol.202
, pp. 17-20
-
-
Blum-Degen, D.1
-
298
-
-
0028171374
-
Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
-
Mogi, M., et al. 1994. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett 180:147-50.
-
(1994)
Neurosci Lett
, vol.180
, pp. 147-150
-
-
Mogi, M.1
-
299
-
-
33748973074
-
Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra
-
Ferrari, C. C., et al. 2006 Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol Dis 24: 183-193.
-
(2006)
Neurobiol Dis
, vol.24
, pp. 183-193
-
-
Ferrari, C.C.1
-
300
-
-
0034023082
-
Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain
-
Mogi, M., et al. 2000. Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain. J Neural Transm 107:335-41.
-
(2000)
J Neural Transm
, vol.107
, pp. 335-341
-
-
Mogi, M.1
-
301
-
-
0038607606
-
Caspase-1 and caspase-8 cleave and inactivate cellular parkin
-
Kahns, S., et al. 2003. Caspase-1 and caspase-8 cleave and inactivate cellular parkin. J Biol Chem 278:23376-80.
-
(2003)
J Biol Chem
, vol.278
, pp. 23376-23380
-
-
Kahns, S.1
-
302
-
-
0342368772
-
Association between early-onset Parkinson’s disease and mutations in the parkin gene
-
Lucking, C. B., et al. 2000. Association between early-onset Parkinson’s disease and mutations in the parkin gene. N Engl J Med 342:1560-7.
-
(2000)
N Engl J Med
, vol.342
, pp. 1560-1567
-
-
Lucking, C.B.1
-
303
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura, H., et al. 2000. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25:302-5.
-
(2000)
Nat Genet
, vol.25
, pp. 302-305
-
-
Shimura, H.1
-
304
-
-
0035807904
-
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease
-
Du, Y., et al. 2001. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease. Proc Natl Acad Sci USA 98:14669-74.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14669-14674
-
-
Du, Y.1
-
305
-
-
34548133584
-
Multiple sclerosis: A complicated picture of autoimmunity
-
McFarland, H. F., and Martin, R. 2007. Multiple sclerosis: A complicated picture of autoimmunity. Nat Immunol 8:913-9.
-
(2007)
Nat Immunol
, vol.8
, pp. 913-919
-
-
McFarland, H.F.1
Martin, R.2
-
306
-
-
0033600078
-
Progress in determining the causes and treatment of multiple sclerosis
-
Noseworthy, J. H. 1999. Progress in determining the causes and treatment of multiple sclerosis. Nature 399:A40-7.
-
(1999)
Nature
, vol.399
, pp. A40-A47
-
-
Noseworthy, J.H.1
-
307
-
-
0036432013
-
Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of “depression due to multiple sclerosis.”
-
Pollak, Y., et al. 2002. Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of “depression due to multiple sclerosis.” Brain Behav Immun 16:533-43.
-
(2002)
Brain Behav Immun
, vol.16
, pp. 533-543
-
-
Pollak, Y.1
-
308
-
-
0028990468
-
Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
-
Olsson, T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 144:245-68.
-
(1995)
Immunol Rev
, vol.144
, pp. 245-268
-
-
Olsson, T.1
-
309
-
-
0027331778
-
Demonstration of interleukin-1 beta in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level
-
Bauer, J., et al. 1993. Demonstration of interleukin-1 beta in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level. J Neuroimmunol 48:13-21.
-
(1993)
J Neuroimmunol
, vol.48
, pp. 13-21
-
-
Bauer, J.1
-
310
-
-
85134000134
-
Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species
-
Brosnan, C. F., et al. 1995. Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species. Neurology 45:516-21.
-
(1995)
Neurology
, vol.45
, pp. 516-521
-
-
Brosnan, C.F.1
-
311
-
-
0034853483
-
IL-18 in patients with multiple sclerosis
-
Losy, J., and Niezgoda, A. 2001. IL-18 in patients with multiple sclerosis. Acta Neurol Scand 104:171-3.
-
(2001)
Acta Neurol Scand
, vol.104
, pp. 171-173
-
-
Losy, J.1
Niezgoda, A.2
-
312
-
-
0026066932
-
Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis
-
Maimone, D., et al. 1991. Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol 32:67-74.
-
(1991)
J Neuroimmunol
, vol.32
, pp. 67-74
-
-
Maimone, D.1
-
313
-
-
0035943088
-
Increased serum levels of interleukin-18 in patients with multiple sclerosis
-
Nicoletti, F., et al. 2001. Increased serum levels of interleukin-18 in patients with multiple sclerosis. Neurology 57:342-4.
-
(2001)
Neurology
, vol.57
, pp. 342-344
-
-
Nicoletti, F.1
-
314
-
-
0030034011
-
Myelin-induced experimental allergic encephalomyelitis in Lewis rats: Tumor necrosis factor alpha levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord
-
Villarroya, H., et al. 1996. Myelin-induced experimental allergic encephalomyelitis in Lewis rats: Tumor necrosis factor alpha levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord. J Neuroimmunol 64:55-61.
-
(1996)
J Neuroimmunol
, vol.64
, pp. 55-61
-
-
Villarroya, H.1
-
315
-
-
0033198269
-
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination
-
Furlan, R., et al. 1999. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 163:2403-9.
-
(1999)
J Immunol
, vol.163
, pp. 2403-2409
-
-
Furlan, R.1
-
316
-
-
0037094037
-
Caspase-1 expression in multiple sclerosis plaques and cultured glial cells
-
Ming, X., et al. 2002. Caspase-1 expression in multiple sclerosis plaques and cultured glial cells. J Neurol Sci 197:9-18.
-
(2002)
J Neurol Sci
, vol.197
, pp. 9-18
-
-
Ming, X.1
-
317
-
-
0032077870
-
Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells
-
Badovinac, V., et al. 1998. Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells. J Neuroimmunol 85:87-95.
-
(1998)
J Neuroimmunol
, vol.85
, pp. 87-95
-
-
Badovinac, V.1
-
318
-
-
0028828583
-
Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats
-
Martin, D., and Near, S. L. 1995. Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. J Neuroimmunol 61:241-5.
-
(1995)
J Neuroimmunol
, vol.61
, pp. 241-245
-
-
Martin, D.1
Near, S.L.2
-
319
-
-
0345268747
-
The EAE-associated behavioral syndrome. II. Modulation by anti-inflammatory treatments
-
Pollak, Y., et al. 2003. The EAE-associated behavioral syndrome. II. Modulation by anti-inflammatory treatments. J Neuroimmunol 137:100-8.
-
(2003)
J Neuroimmunol
, vol.137
, pp. 100-108
-
-
Pollak, Y.1
-
320
-
-
0034028453
-
The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor
-
Schiffenbauer, J., et al. 2000. The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor. Clin Immunol 95:117-23.
-
(2000)
Clin Immunol
, vol.95
, pp. 117-123
-
-
Schiffenbauer, J.1
-
321
-
-
0032005559
-
Combined treatment of acute EAE in Lewis rats with TNFbinding protein and interleukin-1 receptor antagonist
-
Wiemann, B., et al. 1998. Combined treatment of acute EAE in Lewis rats with TNFbinding protein and interleukin-1 receptor antagonist. Exp Neurol 149:455-63.
-
(1998)
Exp Neurol
, vol.149
, pp. 455-463
-
-
Wiemann, B.1
-
322
-
-
0032400918
-
Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis
-
Wildbaum, G., et al. 1998. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J Immunol 161:6368-74.
-
(1998)
J Immunol
, vol.161
, pp. 6368-6374
-
-
Wildbaum, G.1
-
323
-
-
33845647322
-
HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG(35-55)-induced experimental autoimmune encephalomyelitis in C57BL/6 mice
-
Furlan, R., et al. 2007. HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG(35-55)-induced experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther 14:93-8.
-
(2007)
Gene Ther
, vol.14
, pp. 93-98
-
-
Furlan, R.1
-
324
-
-
0031724091
-
Diagnosis of amyotrophic lateral sclerosis
-
Rowland, L. P. 1998. Diagnosis of amyotrophic lateral sclerosis. J Neurol Sci 160(Suppl 1): 56-24.
-
(1998)
J Neurol Sci
, vol.160
, pp. 24-56
-
-
Rowland, L.P.1
-
325
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
-
Gurney, M. E., et al. 1994. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 264:1772-5.
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
-
326
-
-
0028888945
-
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
-
Ripps, M. E., et al. 1995. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 92:689-93.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 689-693
-
-
Ripps, M.E.1
-
327
-
-
0029053881
-
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
Wong, P. C., et al. 1995. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14:1105-16.
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
-
328
-
-
0034647003
-
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
-
Li, M., et al. 2000. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288:335-9.
-
(2000)
Science
, vol.288
, pp. 335-339
-
-
Li, M.1
-
329
-
-
0036269810
-
Differential expression of inflammation- and apoptosisrelated genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
-
Yoshihara, T., et al. 2002. Differential expression of inflammation- and apoptosisrelated genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 80:158-67.
-
(2002)
J Neurochem
, vol.80
, pp. 158-167
-
-
Yoshihara, T.1
-
330
-
-
0032430185
-
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
-
Pasinelli, P., et al. 1998. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc Natl Acad Sci USA 95:15763-8.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15763-15768
-
-
Pasinelli, P.1
-
331
-
-
0034610328
-
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
-
Pasinelli, P., et al. 2000. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 97:13901-6.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13901-13906
-
-
Pasinelli, P.1
-
332
-
-
0034744513
-
Interleukin-1beta converting enzyme/caspase-1 (ICE/caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients
-
Ilzecka, J., Stelmasiak, Z., and Dobosz, B. 2001. Interleukin-1beta converting enzyme/caspase-1 (ICE/caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients. Acta Neurol Scand 103:255-8.
-
(2001)
Acta Neurol Scand
, vol.103
, pp. 255-258
-
-
Ilzecka, J.1
Stelmasiak, Z.2
Dobosz, B.3
-
333
-
-
0033630642
-
Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death [Review]
-
Martin, L. J., et al. 2000. Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death [Review]. Int J Mol Med 5:3-13.
-
(2000)
Int J Mol Med
, vol.5
, pp. 3-13
-
-
Martin, L.J.1
-
334
-
-
0345049629
-
Inhibition of ICE slows ALS in mice
-
Friedlander, R. M., et al. 1997. Inhibition of ICE slows ALS in mice. Nature 388:31.
-
(1997)
Nature
, vol.388
, pp. 31
-
-
Friedlander, R.M.1
|