메뉴 건너뛰기




Volumn 5, Issue 8, 2005, Pages 629-640

Interleukin-1 and neuronal injury

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA CHEMOKINE; C REACTIVE PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; N METHYL DEXTRO ASPARTIC ACID; RECOMBINANT INTERLEUKIN 1; RECOMBINANT PROTEIN;

EID: 23444441962     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1664     Document Type: Review
Times cited : (872)

References (111)
  • 1
    • 0842324557 scopus 로고    scopus 로고
    • The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish
    • Huising, M. O., Stet, R. J., Savelkoul, H. F. & Verburg-van Kemenade, B. M. The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish. Dev. Comp. Immunol. 28, 395-413 (2004).
    • (2004) Dev. Comp. Immunol. , vol.28 , pp. 395-413
    • Huising, M.O.1    Stet, R.J.2    Savelkoul, H.F.3    Verburg-Van Kemenade, B.M.4
  • 2
    • 0022364132 scopus 로고
    • Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
    • March, C. J. et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315, 641-647 (1985).
    • (1985) Nature , vol.315 , pp. 641-647
    • March, C.J.1
  • 3
    • 0026507126 scopus 로고
    • A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes
    • Thornberry, N. A. et al. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356, 768-774 (1992). A key paper that identified the enzyme that is responsible for cleavage of inactive pro-IL-1β to the mature biologically active protein.
    • (1992) Nature , vol.356 , pp. 768-774
    • Thornberry, N.A.1
  • 4
    • 0023683844 scopus 로고
    • cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily
    • Sims, J. E. et al. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241, 585-589 (1988).
    • (1988) Science , vol.241 , pp. 585-589
    • Sims, J.E.1
  • 5
    • 0031013038 scopus 로고    scopus 로고
    • A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling
    • Korherr, C., Hofmeister, R., Wesche, H. & Falk, W. A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. Eur. J. Immunol. 27, 262-267 (1997). An important paper that shows that recruitment of an accessory protein to the IL-1-IL-1R1 complex is essential for signal transduction to take place.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 262-267
    • Korherr, C.1    Hofmeister, R.2    Wesche, H.3    Falk, W.4
  • 7
    • 0025713953 scopus 로고
    • Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
    • Hannum, C. H. et al. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343, 336-340 (1990).
    • (1990) Nature , vol.343 , pp. 336-340
    • Hannum, C.H.1
  • 8
    • 0032529388 scopus 로고    scopus 로고
    • The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes
    • Malyak, M., Smith, M. F. Jr, Abel, A. A., Hance, K. R. & Arend, W. P. The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes. J. Immunol. 161, 2004-2010 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 2004-2010
    • Malyak, M.1    Smith Jr., M.F.2    Abel, A.A.3    Hance, K.R.4    Arend, W.P.5
  • 9
    • 0031749136 scopus 로고    scopus 로고
    • Overview of interleukin-18: More than an interferon-γ inducing factor
    • Dinarello, C. A. et al. Overview of interleukin-18: more than an interferon-γ inducing factor. J. Leukoc. Biol. 63, 658-664 (1998).
    • (1998) J. Leukoc. Biol. , vol.63 , pp. 658-664
    • Dinarello, C.A.1
  • 10
    • 0037465251 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
    • Dunne, A. & O'Neill, L. A. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci. STKE [online] 2003, RE3 (2003). A valuable updated review of the receptors of the IL-1-receptor and TLR family, and their signalling pathways.
    • (2003) Sci. STKE [Online] , vol.2003
    • Dunne, A.1    O'Neill, L.A.2
  • 11
    • 0035471572 scopus 로고    scopus 로고
    • A new nomenclature for IL-1-family genes
    • Sims, J. E. et al. A new nomenclature for IL-1-family genes. Trends Immunol. 22, 536-537 (2001).
    • (2001) Trends Immunol. , vol.22 , pp. 536-537
    • Sims, J.E.1
  • 12
    • 0036467389 scopus 로고    scopus 로고
    • IL-1 and IL-18 receptors, and their extended family
    • Sims, J. E. IL-1 and IL-18 receptors, and their extended family. Curr. Opin. Immunol. 14, 117-122 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 117-122
    • Sims, J.E.1
  • 13
    • 0033983153 scopus 로고    scopus 로고
    • 'Inflammatory' cytokines: Neuromodulators in normal brain?
    • Vitkovic, L., Bockaert, J. & Jacque, C. 'Inflammatory' cytokines: neuromodulators in normal brain? J. Neurochem. 74, 457-471 (2000).
    • (2000) J. Neurochem. , vol.74 , pp. 457-471
    • Vitkovic, L.1    Bockaert, J.2    Jacque, C.3
  • 14
    • 0033603199 scopus 로고    scopus 로고
    • Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologists
    • Watkins, L. R., Hansen, M. K., Nguyen, K. T., Lee, J. E. & Maier, S. F. Dynamic regulation of the proinflammatory cytokine, interleukin-1β: molecular biology for non-molecular biologists. Life Sci. 65, 449-481 (1999).
    • (1999) Life Sci. , vol.65 , pp. 449-481
    • Watkins, L.R.1    Hansen, M.K.2    Nguyen, K.T.3    Lee, J.E.4    Maier, S.F.5
  • 15
    • 0037151057 scopus 로고    scopus 로고
    • Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    • Hsu, H. Y. & Wen, M. H. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J. Biol. Chem. 277, 22131-22139 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 22131-22139
    • Hsu, H.Y.1    Wen, M.H.2
  • 16
    • 0037087422 scopus 로고    scopus 로고
    • Antimicrobial peptides initiate IL-1β posttranslational processing: A novel role beyond innate immunity
    • Perregaux, D. G., Bhavsar, K., Contillo, L., Shi, J. & Gabel, C. A. Antimicrobial peptides initiate IL-1β posttranslational processing: a novel role beyond innate immunity. J. Immunol. 168, 3024-3032 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3024-3032
    • Perregaux, D.G.1    Bhavsar, K.2    Contillo, L.3    Shi, J.4    Gabel, C.A.5
  • 17
    • 0034656403 scopus 로고    scopus 로고
    • Increased expression of mRNA encoding interleukin-1β and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration
    • Eriksson, C., Tehranian, R., Iverfeldt, K., Winblad, B. & Schultzberg, M. Increased expression of mRNA encoding interleukin-1β and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration. J. Neurosci. Res. 60, 266-279 (2000).
    • (2000) J. Neurosci. Res. , vol.60 , pp. 266-279
    • Eriksson, C.1    Tehranian, R.2    Iverfeldt, K.3    Winblad, B.4    Schultzberg, M.5
  • 18
    • 13244269959 scopus 로고    scopus 로고
    • S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors
    • Liu, L., Li, Y, Van Eldik, L. J., Griffin, W. S. & Barger, S. W. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. J. Neurochem. 92, 546-553 (2005).
    • (2005) J. Neurochem. , vol.92 , pp. 546-553
    • Liu, L.1    Li, Y.2    Van Eldik, L.J.3    Griffin, W.S.4    Barger, S.W.5
  • 19
    • 0025820423 scopus 로고
    • Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain
    • Relton, J. K. et al. Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. J. Exp. Med. 174, 305-310 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 305-310
    • Relton, J.K.1
  • 20
    • 0031065115 scopus 로고    scopus 로고
    • The 3′ untranslated region of IL-1β regulates protein production
    • Kern, J. A., Warnock, L. J. & McCafferty, J. D. The 3′ untranslated region of IL-1β regulates protein production. J. Immunol. 158, 1187-1193 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 1187-1193
    • Kern, J.A.1    Warnock, L.J.2    McCafferty, J.D.3
  • 22
    • 0028175838 scopus 로고
    • Interleukin-1β maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity
    • Perregaux, D. & Gabel, C. A. Interleukin-1β maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J. Biol. Chem. 269, 15195-15203 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 15195-15203
    • Perregaux, D.1    Gabel, C.A.2
  • 23
    • 0036479134 scopus 로고    scopus 로고
    • Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production
    • Le Feuvre, R. A., Brough, D., Iwakura, Y., Takeda, K. & Rothwell, N. J. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J. Biol. Chem. 277, 3210-3218 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 3210-3218
    • Le Feuvre, R.A.1    Brough, D.2    Iwakura, Y.3    Takeda, K.4    Rothwell, N.J.5
  • 24
    • 0037443542 scopus 로고    scopus 로고
    • 2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages
    • 2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages. J. Immunol. 170, 3029-3036 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3029-3036
    • Brough, D.1
  • 25
    • 3042800587 scopus 로고    scopus 로고
    • Phospholipases C and A2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes
    • Andrei, C. et al. Phospholipases C and A2 control lysosome-mediated IL-1β secretion: implications for inflammatory processes. Proc. Natl Acad. Sci. USA 101, 9745-9750 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 9745-9750
    • Andrei, C.1
  • 26
    • 0028989337 scopus 로고
    • Potassium-inhibited processing of IL-1β in human monocytes
    • Walev, I., Reske, K., Palmer, M., Valeva, A. & Bhakdi, S. Potassium-inhibited processing of IL-1β in human monocytes. EMBO J. 14, 1607-1614 (1995).
    • (1995) EMBO J. , vol.14 , pp. 1607-1614
    • Walev, I.1    Reske, K.2    Palmer, M.3    Valeva, A.4    Bhakdi, S.5
  • 27
    • 0033051323 scopus 로고    scopus 로고
    • P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death
    • Ferrari, D. et al. P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death. FEBS Lett. 447, 71-75 (1999).
    • (1999) FEBS Lett. , vol.447 , pp. 71-75
    • Ferrari, D.1
  • 28
    • 1842581655 scopus 로고    scopus 로고
    • A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1β processing and release
    • Elssner, A., Duncan, M., Gavrilin, M. & Wewers, M. D. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1β processing and release. J. Immunol. 172, 4987-4994 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4987-4994
    • Elssner, A.1    Duncan, M.2    Gavrilin, M.3    Wewers, M.D.4
  • 29
    • 0034813135 scopus 로고    scopus 로고
    • Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors
    • Perregaux, D. G. et al. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J. Pharmacol. Exp. Ther. 299, 187-197 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 187-197
    • Perregaux, D.G.1
  • 30
    • 0037930829 scopus 로고    scopus 로고
    • Glutathione S-transferase ω 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing
    • Laliberte, R. E. et al. Glutathione S-transferase ω 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J. Biol. Chem. 278, 16567-16578 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 16567-16578
    • Laliberte, R.E.1
  • 31
    • 0346121529 scopus 로고    scopus 로고
    • Glutathione S-transferase ω-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    • Li, Y. J. et al. Glutathione S-transferase ω-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum. Mol. Genet. 12, 3259-3267 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 3259-3267
    • Li, Y.J.1
  • 32
    • 0032560554 scopus 로고    scopus 로고
    • A neuromodulatory role of interleukin-1β in the hippocampus
    • Schneider, H. et al. A neuromodulatory role of interleukin-1β in the hippocampus. Proc. Natl Acad. Sci. USA 95, 7778-7783 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7778-7783
    • Schneider, H.1
  • 33
    • 0037293972 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior
    • Kelley, K. W. et al. Cytokine-induced sickness behavior. Brain Behav. Immun. 17, S112-S118 (2003).
    • (2003) Brain Behav. Immun. , vol.17
    • Kelley, K.W.1
  • 34
    • 0023231717 scopus 로고
    • Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1
    • Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F. & Besedovsky, H. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238, 524-526 (1987).
    • (1987) Science , vol.238 , pp. 524-526
    • Berkenbosch, F.1    Van Oers, J.2    Del Rey, A.3    Tilders, F.4    Besedovsky, H.5
  • 35
    • 0041784703 scopus 로고    scopus 로고
    • The expanding interleukin-1 family and its receptors: Do alternative IL-1 receptor/signaling pathways exist in the brain?
    • Boutin, H., Kimber, I., Rothwell, N. J. & Pinteaux, E. The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Mol. Neurobiol. 27, 239-248 (2003).
    • (2003) Mol. Neurobiol. , vol.27 , pp. 239-248
    • Boutin, H.1    Kimber, I.2    Rothwell, N.J.3    Pinteaux, E.4
  • 36
    • 0035422660 scopus 로고    scopus 로고
    • Two novel IL-1 family members, IL-1δ and IL-1ε, function as an antagonist and agonist of NF-κB activation through the orphan IL-1 receptor-related protein 2
    • Debets, R. et al. Two novel IL-1 family members, IL-1δ and IL-1ε, function as an antagonist and agonist of NF-κB activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 167, 1440-1446 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1440-1446
    • Debets, R.1
  • 37
    • 0030298213 scopus 로고    scopus 로고
    • Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)
    • Lovenberg, T. W. et al. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2). J. Neuroimmunol. 70, 113-122 (1996).
    • (1996) J. Neuroimmunol. , vol.70 , pp. 113-122
    • Lovenberg, T.W.1
  • 38
    • 0038546741 scopus 로고    scopus 로고
    • IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells
    • Berglof, E. et al. IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. J. Neuroimmunol. 139, 36-43 (2003).
    • (2003) J. Neuroimmunol. , vol.139 , pp. 36-43
    • Berglof, E.1
  • 39
    • 14644446054 scopus 로고    scopus 로고
    • The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1β signalling responses
    • Wang, P. et al. The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1β signalling responses. Cytokine 29, 245-250 (2005).
    • (2005) Cytokine , vol.29 , pp. 245-250
    • Wang, P.1
  • 40
    • 12344285047 scopus 로고    scopus 로고
    • IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system
    • Ching, S., He, L., Lai, W. & Quan, N. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav. Immun. 19, 127-137 (2005).
    • (2005) Brain Behav. Immun. , vol.19 , pp. 127-137
    • Ching, S.1    He, L.2    Lai, W.3    Quan, N.4
  • 41
    • 0030957283 scopus 로고    scopus 로고
    • Endogenous interleukin-1 receptor antagonist is neuroprotective
    • Loddick, S. A. et al. Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem. Biophys. Res. Commun. 234, 211-215 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.234 , pp. 211-215
    • Loddick, S.A.1
  • 42
    • 17844406433 scopus 로고    scopus 로고
    • Intra-parenchymal injection of tumor necrosis factor-α and interleukin 1-β produces dopamine neuron loss in the rat
    • Carvey, P. M. et al. Intra-parenchymal injection of tumor necrosis factor-α and interleukin 1-β produces dopamine neuron loss in the rat. J. Neural Transm. 112, 601-612 (2005). One of the few papers to show direct neurotoxic effects of IL-1.
    • (2005) J. Neural Transm. , vol.112 , pp. 601-612
    • Carvey, P.M.1
  • 43
    • 0031595870 scopus 로고    scopus 로고
    • Interleukin-1β and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat
    • Lawrence, C. B., Allan, S. M. & Rothwell, N. J. Interleukin-1β and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur. J. Neurosci. 10, 1188-1195 (1998).
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 1188-1195
    • Lawrence, C.B.1    Allan, S.M.2    Rothwell, N.J.3
  • 44
    • 0029620390 scopus 로고
    • Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors
    • Chao, C. C., Hu, S., Ehrlich, L. & Peterson, P. K. Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain. Behav. Immun. 9, 355-365 (1995).
    • (1995) Brain. Behav. Immun. , vol.9 , pp. 355-365
    • Chao, C.C.1    Hu, S.2    Ehrlich, L.3    Peterson, P.K.4
  • 45
    • 0030974030 scopus 로고    scopus 로고
    • Cytokine-mediated neuronal apoptosis
    • Hu, S., Peterson, P. K. & Chao, C. C. Cytokine-mediated neuronal apoptosis. Neurochem. Int. 30, 427-431 (1997).
    • (1997) Neurochem. Int. , vol.30 , pp. 427-431
    • Hu, S.1    Peterson, P.K.2    Chao, C.C.3
  • 46
    • 0033230204 scopus 로고    scopus 로고
    • Neuronal death in cytokine-activated primary human brain cell culture: Role of tumor necrosis factor-α
    • Downen, M., Amaral, T. D., Hua, L. L., Zhao, M. L. & Lee, S. C. Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-α. Glia 28, 114-127 (1999).
    • (1999) Glia , vol.28 , pp. 114-127
    • Downen, M.1    Amaral, T.D.2    Hua, L.L.3    Zhao, M.L.4    Lee, S.C.5
  • 47
    • 0028958354 scopus 로고
    • Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats
    • Yamasaki, Y. et al. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 26, 676-681 (1995). The first study to show that administration of exogenous IL-1 can exacerbate experimental neuronal injury.
    • (1995) Stroke , vol.26 , pp. 676-681
    • Yamasaki, Y.1
  • 48
    • 0026656192 scopus 로고
    • Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat
    • Relton, J. K. & Rothwell, N. J. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull. 29, 243-246 (1992). The first paper to report the neuroprotective effects of IL-1RA in neuronal injury.
    • (1992) Brain Res. Bull. , vol.29 , pp. 243-246
    • Relton, J.K.1    Rothwell, N.J.2
  • 49
    • 0037410074 scopus 로고    scopus 로고
    • Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential
    • Rothwell, N. Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav. Immun. 17, 152-157 (2003).
    • (2003) Brain Behav. Immun. , vol.17 , pp. 152-157
    • Rothwell, N.1
  • 50
    • 12944273495 scopus 로고    scopus 로고
    • Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice
    • Vezzani, A. et al. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl Acad. Sci. USA 97, 11534-11539 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11534-11539
    • Vezzani, A.1
  • 51
    • 0029036329 scopus 로고
    • Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats
    • Lin, M. T., Kao, T. Y., Jin, Y. T. & Chen, C. F. Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats. Brain Res. Bull. 37, 595-598 (1995).
    • (1995) Brain Res. Bull. , vol.37 , pp. 595-598
    • Lin, M.T.1    Kao, T.Y.2    Jin, Y.T.3    Chen, C.F.4
  • 52
    • 0037376813 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor
    • Loscher, C. E., Mills, K. H. & Lynch, M. A. Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor. J. Neuroimmunol. 137, 117-124 (2003).
    • (2003) J. Neuroimmunol. , vol.137 , pp. 117-124
    • Loscher, C.E.1    Mills, K.H.2    Lynch, M.A.3
  • 53
    • 0030614952 scopus 로고    scopus 로고
    • Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
    • Hara, H. et al. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl Acad. Sci. USA 94, 2007-2012 (1997). The first paper to show that inhibition of the enzyme responsible for production of the mature, active IL-1β protein provides neuroprotection.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2007-2012
    • Hara, H.1
  • 54
    • 0035413361 scopus 로고    scopus 로고
    • Role of IL-1α and IL-1β in ischemic brain damage
    • Boutin, H. et al. Role of IL-1α and IL-1β in ischemic brain damage. J. Neurosci. 21, 5528-5534 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 5528-5534
    • Boutin, H.1
  • 56
    • 0029047891 scopus 로고
    • Interleukin-1β attenuates excitatory amino acid-induced neurodegeneration in vitro: Involvement of nerve growth factor
    • Strijbos, P. J. & Rothwell, N. J. Interleukin-1β attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci. 15, 3468-3474 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 3468-3474
    • Strijbos, P.J.1    Rothwell, N.J.2
  • 57
    • 0033215124 scopus 로고    scopus 로고
    • Inflammatory cytokines IL-1α, IL-1β, IL-6, and TNF-α impart neuroprotection to an excitotoxin through distinct pathways
    • Carlson, N. G. et al. Inflammatory cytokines IL-1α, IL-1β, IL-6, and TNF-α impart neuroprotection to an excitotoxin through distinct pathways. J. Immunol. 163, 3963-3968 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 3963-3968
    • Carlson, N.G.1
  • 58
    • 0141535180 scopus 로고    scopus 로고
    • Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
    • Viviani, B. et al. Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci. 23, 8692-8700 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 8692-8700
    • Viviani, B.1
  • 59
    • 0035827446 scopus 로고    scopus 로고
    • Interleukin-1β exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures
    • Pringle, A. K., Niyadurupola, N., Johns, P., Anthony, D. C. & Iannotti, F. Interleukin-1β exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures. Neurosci. Lett. 305, 29-32 (2001).
    • (2001) Neurosci. Lett. , vol.305 , pp. 29-32
    • Pringle, A.K.1    Niyadurupola, N.2    Johns, P.3    Anthony, D.C.4    Iannotti, F.5
  • 60
    • 0023554153 scopus 로고
    • Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury
    • Busto, R. et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J. Cereb. Blood Flow Metab. 7, 729-738 (1987).
    • (1987) J. Cereb. Blood Flow Metab. , vol.7 , pp. 729-738
    • Busto, R.1
  • 61
    • 0028879709 scopus 로고
    • Fever in acute stroke worsens prognosis. A prospective study
    • Azzimondi, G. et al. Fever in acute stroke worsens prognosis. A prospective study. Stroke 26, 2040-2043 (1995).
    • (1995) Stroke , vol.26 , pp. 2040-2043
    • Azzimondi, G.1
  • 63
    • 0142213823 scopus 로고    scopus 로고
    • Interleukin-1β and adverse effects on cerebral blood flow during long-term global hypoperfusion
    • Maher, C. O., Anderson, R. E., Martin, H. S., McClelland, R. L. & Meyer, F. B. Interleukin-1β and adverse effects on cerebral blood flow during long-term global hypoperfusion. J. Neurosurg. 99, 907-912 (2003).
    • (2003) J. Neurosurg. , vol.99 , pp. 907-912
    • Maher, C.O.1    Anderson, R.E.2    Martin, H.S.3    McClelland, R.L.4    Meyer, F.B.5
  • 64
    • 0028337568 scopus 로고
    • Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome
    • Fassbender, K., Schmidt, R., Mossner, R., Daffertshofer, M. & Hennerici, M. Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke 25, 1105-1108 (1994).
    • (1994) Stroke , vol.25 , pp. 1105-1108
    • Fassbender, K.1    Schmidt, R.2    Mossner, R.3    Daffertshofer, M.4    Hennerici, M.5
  • 65
    • 3242781549 scopus 로고    scopus 로고
    • Cell type-specific interleukin-1β signaling in the CNS
    • Srinivasan, D., Yen, J. H., Joseph, D. J. & Friedman, W. Cell type-specific interleukin-1β signaling in the CNS. J. Neurosci. 24, 6482-6488 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 6482-6488
    • Srinivasan, D.1    Yen, J.H.2    Joseph, D.J.3    Friedman, W.4
  • 66
    • 0036138936 scopus 로고    scopus 로고
    • Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor
    • Touzani, O. et al. Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J. Neurosci. 22, 38-43 (2002). The first report that IL-1β has effects in the CNS that are not mediated through binding IL-1R1, the classical IL-1 signalling receptor.
    • (2002) J. Neurosci. , vol.22 , pp. 38-43
    • Touzani, O.1
  • 67
    • 11844254511 scopus 로고    scopus 로고
    • Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury
    • Basu, A. et al. Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J. Cereb. Blood Flow Metab. 25, 17-29 (2005).
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 17-29
    • Basu, A.1
  • 68
    • 0036273683 scopus 로고    scopus 로고
    • IL-1β signalling in glial cells in wildtype and IL-1R1 deficient mice
    • Parker, L. C., Luheshi, G. N., Rothwell, N. J. & Pinteaux, E. IL-1β signalling in glial cells in wildtype and IL-1R1 deficient mice. Br. J. Pharmacol. 136, 312-320 (2002).
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 312-320
    • Parker, L.C.1    Luheshi, G.N.2    Rothwell, N.J.3    Pinteaux, E.4
  • 69
    • 0035487313 scopus 로고    scopus 로고
    • Cytokines and acute neurodegeneration
    • Allan, S. M. & Rothwell, N. J. Cytokines and acute neurodegeneration. Nature Rev. Neurosci. 2, 734-744 (2001).
    • (2001) Nature Rev. Neurosci. , vol.2 , pp. 734-744
    • Allan, S.M.1    Rothwell, N.J.2
  • 70
    • 0033563321 scopus 로고    scopus 로고
    • Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures
    • Vezzani, A. et al. Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J. Neurosci. 19, 5054-5065 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 5054-5065
    • Vezzani, A.1
  • 72
    • 13244269848 scopus 로고    scopus 로고
    • IL-1-regulated responses in astrocytes: Relevance to injury and recovery
    • John, G. R., Lee, S. C., Song, X., Rivieccio, M. & Brosnan, C. F. IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia 49, 161-176 (2005).
    • (2005) Glia , vol.49 , pp. 161-176
    • John, G.R.1    Lee, S.C.2    Song, X.3    Rivieccio, M.4    Brosnan, C.F.5
  • 73
    • 4744352557 scopus 로고    scopus 로고
    • Interleukin-1: A master regulator of neuroinflammation
    • Basu, A., Krady, J. K. & Levison, S. W. Interleukin-1: a master regulator of neuroinflammation. J. Neurosci. Res. 78, 151-156 (2004).
    • (2004) J. Neurosci. Res. , vol.78 , pp. 151-156
    • Basu, A.1    Krady, J.K.2    Levison, S.W.3
  • 74
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi, F. Immune function of microglia. Glia 36, 165-179 (2001).
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 75
    • 0036847165 scopus 로고    scopus 로고
    • Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells
    • Pinteaux, E., Parker, L. C., Rothwell, N. J. & Luheshi, G. N. Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J. Neurochem. 83, 754-763 (2002).
    • (2002) J. Neurochem. , vol.83 , pp. 754-763
    • Pinteaux, E.1    Parker, L.C.2    Rothwell, N.J.3    Luheshi, G.N.4
  • 76
    • 0036353262 scopus 로고    scopus 로고
    • Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    • Vela, J. M., Molina-Holgado, E., Arevalo-Martin, A., Almazan, G. & Guaza, C. Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol. Cell. Neurosci. 20, 489-502 (2002).
    • (2002) Mol. Cell. Neurosci. , vol.20 , pp. 489-502
    • Vela, J.M.1    Molina-Holgado, E.2    Arevalo-Martin, A.3    Almazan, G.4    Guaza, C.5
  • 78
    • 1642319121 scopus 로고    scopus 로고
    • Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli
    • Konsman, J. P., Vigues, S., Mackerlova, L., Bristow, A. & Blomqvist, A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J. Comp. Neurol. 472, 113-129 (2004).
    • (2004) J. Comp. Neurol. , vol.472 , pp. 113-129
    • Konsman, J.P.1    Vigues, S.2    Mackerlova, L.3    Bristow, A.4    Blomqvist, A.5
  • 79
    • 0037025054 scopus 로고    scopus 로고
    • Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation
    • Proescholdt, M. G. et al. Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation. Neuroscience 112, 731-749 (2002).
    • (2002) Neuroscience , vol.112 , pp. 731-749
    • Proescholdt, M.G.1
  • 80
    • 0034840589 scopus 로고    scopus 로고
    • Recruitment of neutrophils across the blood-brain barrier: The role of E- and P-selectins
    • Bernardes-Silva, M., Anthony, D. C., Issekutz, A. C. & Perry, V. H. Recruitment of neutrophils across the blood-brain barrier: the role of E- and P-selectins. J. Cereb. Blood Flow Metab. 21, 1115-1124 (2001).
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 1115-1124
    • Bernardes-Silva, M.1    Anthony, D.C.2    Issekutz, A.C.3    Perry, V.H.4
  • 81
    • 13144254202 scopus 로고    scopus 로고
    • CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown
    • Anthony, D. et al. CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown. Curr. Biol. 8, 923-926 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 923-926
    • Anthony, D.1
  • 82
    • 3142692415 scopus 로고    scopus 로고
    • Different cytokine levels in thrombolysis patients as predictors for clinical outcome
    • Mazzotta, G. et al. Different cytokine levels in thrombolysis patients as predictors for clinical outcome. Eur. J. Neurol. 11, 377-381 (2004).
    • (2004) Eur. J. Neurol. , vol.11 , pp. 377-381
    • Mazzotta, G.1
  • 83
    • 0028220499 scopus 로고
    • Proinflammatory cytokines in serum of patients with acute cerebral ischemia: Kinetics of secretion and relation to the extent of brain damage and outcome of disease
    • Fassbender, K. et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J. Neurol. Sci. 122, 135-139 (1994).
    • (1994) J. Neurol. Sci. , vol.122 , pp. 135-139
    • Fassbender, K.1
  • 84
    • 0029132696 scopus 로고
    • Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke
    • Tarkowski, E. et al. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke 26, 1393-1398 (1995). One of the earliest studies to show that concentrations of IL-1β are increased in patients who have suffered a clinical stroke.
    • (1995) Stroke , vol.26 , pp. 1393-1398
    • Tarkowski, E.1
  • 85
    • 0032589394 scopus 로고    scopus 로고
    • Increased IL-1β, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study
    • Kostulas, N., Pelidou, S. H., Kivisakk, P., Kostulas, V. & Link, H. Increased IL-1β, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. Stroke 30, 2174-2179 (1999).
    • (1999) Stroke , vol.30 , pp. 2174-2179
    • Kostulas, N.1    Pelidou, S.H.2    Kivisakk, P.3    Kostulas, V.4    Link, H.5
  • 86
    • 0029076766 scopus 로고
    • Interleukin-6 and interleukin-1 receptor antagonist in acute stroke
    • Beamer, N. B., Coull, B. M., Clark, W. M., Hazel, J. S. & Silberger, J. R. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann. Neurol. 37, 800-805 (1995).
    • (1995) Ann. Neurol. , vol.37 , pp. 800-805
    • Beamer, N.B.1    Coull, B.M.2    Clark, W.M.3    Hazel, J.S.4    Silberger, J.R.5
  • 87
    • 0035056594 scopus 로고    scopus 로고
    • Inflammatory cytokines in subarachnoid haemorrhage: Association with abnormal blood flow velocities in basal cerebral arteries
    • Fassbender, K. et al. Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J. Neurol. Neurosurg. Psychiatry 70, 534-537 (2001).
    • (2001) J. Neurol. Neurosurg. Psychiatry , vol.70 , pp. 534-537
    • Fassbender, K.1
  • 88
    • 0030833671 scopus 로고    scopus 로고
    • Cerebrospinal fluid interleukin-1 receptor antagonist and tumor necrosis factor-α following subarachnoid hemorrhage
    • Mathiesen, T., Edner, G., Ulfarsson, E. & Andersson, B. Cerebrospinal fluid interleukin-1 receptor antagonist and tumor necrosis factor-α following subarachnoid hemorrhage. J. Neurosurg. 87, 215-220 (1997).
    • (1997) J. Neurosurg. , vol.87 , pp. 215-220
    • Mathiesen, T.1    Edner, G.2    Ulfarsson, E.3    Andersson, B.4
  • 89
    • 0036330007 scopus 로고    scopus 로고
    • Toward wisdom from failure: Lessons from neuroprotective stroke trials and new therapeutic directions
    • Gladstone, D. J., Black, S. E. & Hakim, A. M. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33, 2123-2136 (2002).
    • (2002) Stroke , vol.33 , pp. 2123-2136
    • Gladstone, D.J.1    Black, S.E.2    Hakim, A.M.3
  • 90
    • 0035303568 scopus 로고    scopus 로고
    • The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis
    • Bresnihan, B. The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin. Arthritis Rheum. 30, 17-20 (2001).
    • (2001) Semin. Arthritis Rheum. , vol.30 , pp. 17-20
    • Bresnihan, B.1
  • 91
    • 0028018567 scopus 로고
    • Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebo-controlled multicenter trial
    • The IL-1RA Sepsis Syndrome Study Group
    • Fisher, C. J. Jr. et al. Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial. The IL-1RA Sepsis Syndrome Study Group. Crit. Care Med. 22, 12-21 (1994).
    • (1994) Crit. Care Med. , vol.22 , pp. 12-21
    • Fisher Jr., C.J.1
  • 92
    • 0030877935 scopus 로고    scopus 로고
    • Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A Phase III, randomized, double-blind, placebo-controlled, multicenter trial
    • The Interleukin-1 Receptor Antagonist Sepsis Investigator Group
    • Opal, S. M. et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a Phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit. Care Med. 25, 1115-1124 (1997).
    • (1997) Crit. Care Med. , vol.25 , pp. 1115-1124
    • Opal, S.M.1
  • 93
    • 0034943173 scopus 로고    scopus 로고
    • Recommendations for clinical trial evaluation of acute stroke therapies
    • Stroke Therapy Academic Industry Roundtable II. Recommendations for clinical trial evaluation of acute stroke therapies. Stroke 32, 1598-1606 (2001).
    • (2001) Stroke , vol.32 , pp. 1598-1606
  • 94
    • 25444517949 scopus 로고    scopus 로고
    • A randomised Phase II study of interleukin-1 receptor antagonist in acute stroke patients
    • in the press
    • Emsley, H. C. et al. A randomised Phase II study of interleukin-1 receptor antagonist in acute stroke patients. J. Neurol. Neurosurg. Psychiatry (in the press). The findings of the first clinical trial of IL-1RA for the treatment of patients who have suffered an acute stroke.
    • J. Neurol. Neurosurg. Psychiatry
    • Emsley, H.C.1
  • 95
    • 14844351846 scopus 로고    scopus 로고
    • Trends in monitoring patients with aneurysmal subarachnoid haemorrhage
    • Springborg, J. B., Frederiksen, H. J., Eskesen, V. & Olsen, N. V. Trends in monitoring patients with aneurysmal subarachnoid haemorrhage. Br. J. Anaesth. 94, 259-270 (2005).
    • (2005) Br. J. Anaesth. , vol.94 , pp. 259-270
    • Springborg, J.B.1    Frederiksen, H.J.2    Eskesen, V.3    Olsen, N.V.4
  • 96
    • 0038380461 scopus 로고    scopus 로고
    • CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury
    • Campbell, S. J. et al. CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury. FASEB J. 17, 1168-1170 (2003).
    • (2003) FASEB J. , vol.17 , pp. 1168-1170
    • Campbell, S.J.1
  • 97
    • 0025163697 scopus 로고
    • Interleukin 1α and an interleukin 1β fragment are somnogenic
    • Obal, F. Jr. et al. Interleukin 1α and an interleukin 1β fragment are somnogenic. Am. J. Physiol. 259, R439-R446 (1990).
    • (1990) Am. J. Physiol. , vol.259
    • Obal Jr., F.1
  • 98
    • 0031945485 scopus 로고    scopus 로고
    • Effects of interleukin-1β on sleep are mediated by the type I receptor
    • Fang, J., Wang, Y. & Krueger, J. M. Effects of interleukin-1β on sleep are mediated by the type I receptor. Am. J. Physiol. 274, R655-R660 (1998).
    • (1998) Am. J. Physiol. , vol.274
    • Fang, J.1    Wang, Y.2    Krueger, J.M.3
  • 99
    • 0142172107 scopus 로고    scopus 로고
    • Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
    • Avital, A. et al. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 13, 826-834 (2003).
    • (2003) Hippocampus , vol.13 , pp. 826-834
    • Avital, A.1
  • 100
    • 0036773030 scopus 로고    scopus 로고
    • Genetic control of IL-1β bioactivity through differential regulation of the IL-1 receptor antagonist
    • Vamvakopoulos, J., Green, C. & Metcalfe, S. Genetic control of IL-1β bioactivity through differential regulation of the IL-1 receptor antagonist. Eur. J. Immunol. 32, 2988-2996 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2988-2996
    • Vamvakopoulos, J.1    Green, C.2    Metcalfe, S.3
  • 101
    • 0033596657 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease
    • Francis, S. E. et al. Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease. Circulation 99, 861-866 (1999).
    • (1999) Circulation , vol.99 , pp. 861-866
    • Francis, S.E.1
  • 102
    • 0037335985 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis
    • Worrall, B. B. et al. Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis. Stroke 34, 790-793 (2003).
    • (2003) Stroke , vol.34 , pp. 790-793
    • Worrall, B.B.1
  • 103
    • 0036323332 scopus 로고    scopus 로고
    • Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α
    • Dominici, R. et al. Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α. Immunogenetics 54, 82-86 (2002).
    • (2002) Immunogenetics , vol.54 , pp. 82-86
    • Dominici, R.1
  • 104
    • 0038749478 scopus 로고    scopus 로고
    • Association of interleukin-1α gene polymorphism with cerebral infarction
    • Um, J. Y. et al. Association of interleukin-1α gene polymorphism with cerebral infarction. Brain Res. Mol. Brain Res. 115, 50-54 (2003).
    • (2003) Brain Res. Mol. Brain Res. , vol.115 , pp. 50-54
    • Um, J.Y.1
  • 105
    • 0037269189 scopus 로고    scopus 로고
    • Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke
    • Seripa, D. et al. Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke. Cerebrovasc. Dis. 15, 276-281 (2003).
    • (2003) Cerebrovasc. Dis. , vol.15 , pp. 276-281
    • Seripa, D.1
  • 106
    • 10744224902 scopus 로고    scopus 로고
    • Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-α genes, but not the interleukin-1β gene
    • Lee, B. C. et al. Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-α genes, but not the interleukin-1β gene. Neurosci. Lett. 357, 33-36 (2004).
    • (2004) Neurosci. Lett. , vol.357 , pp. 33-36
    • Lee, B.C.1
  • 107
    • 19944427889 scopus 로고    scopus 로고
    • Polymorphisms of the interleukin-1β gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro
    • Iacoviello, L. et al. Polymorphisms of the interleukin-1β gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro. Arterioscler. Thromb. Vasc. Biol. 25, 222-227 (2005).
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 222-227
    • Iacoviello, L.1
  • 108
    • 3543035297 scopus 로고    scopus 로고
    • Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals
    • Cullup, H., Middleton, P. G., Duggan, G., Conn, J. S. & Dickinson, A. M. Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals. Clin. Exp. Immunol. 137, 351-358 (2004).
    • (2004) Clin. Exp. Immunol. , vol.137 , pp. 351-358
    • Cullup, H.1    Middleton, P.G.2    Duggan, G.3    Conn, J.S.4    Dickinson, A.M.5
  • 111
    • 0041842648 scopus 로고    scopus 로고
    • Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia
    • Molina-Holgado, F. et al. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J. Neurosci. 23, 6470-6474 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 6470-6474
    • Molina-Holgado, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.