Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 80, Issue 1, 2002, Pages 158-167

  Yoshihara, Tsuyoshi ^a   Ishigaki, Shinsuke ^a   Yamamoto, Masahiko ^a   Liang, Yideng ^a   Niwa, Jun Ichi ^a   Takeuchi, Hideyuki ^a   Doyu, Manabu ^a   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amyotrophic lateral sclerosis (ALS); Copper zinc superoxide dismutase (SOD1); Inflammation; Microarray; Neurodegeneration; Spinal cord

Indexed keywords

COMPLEMENTARY DNA; COPPER ZINC SUPEROXIDE DISMUTASE; INTERLEUKIN 1BETA CONVERTING ENZYME; MUTANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; DNA DETERMINATION; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GLIA CELL; HUMAN; HUMAN TISSUE; INFLAMMATION; MALE; MOTOR NEURON DISEASE; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; SPINAL CORD;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; MICE; MICE, TRANSGENIC; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD; SUPEROXIDE DISMUTASE;

ANIMALIA; MUS MUSCULUS;

EID: 0036269810     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00683.x     Document Type: Article

References (41)

1. Increased expression of the pro-inflammatory enzyme, cyclooxygenase-2 in amytrophic lateral sclerosis
2. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
3. Identification of macrophage populations expressing tumor necrosis factor-alpha mRNA in acute multiple sclerosis
4. Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice
5. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis
6. Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia
7. XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage
8. X-linked IAP is a direct inhibitor of cell-death proteases
9. Reduction of background problems in nonradioactive northern and southern blot analyses enables higher sensitivity than 32P-based hybridizations
10. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
11. Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia
12. Neuronal apoptosis in Creutzfeidt-Jakob disease
13. Neuronal apoptosis in human immunodeficiency virus infection
14. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
15. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
16. Natural history of amyotrophic lateral sclerosis in a database population: Validation of a scoring system and a model for survival prediction
17. Regional heterogeneity in the response of astrocytes following traumatic brain injury in the adult rat
18. Serial analysis of gene expression in a microglial cell line
19. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells
20. Induction of junD mRNA after transient forebrain ischemia in the rat. Effect of hypothermia
21. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
22. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
23. Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury
24. Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays
25. Microglia as effector cells in brain damage and repair. Focus on prostanoids and nitric oxide
26. Expression of GDNF receptor (RET and GDNFR-α) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis
27. Diagnosis and progression of ALS
28. Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia
29. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
30. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
31. Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
32. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
33. Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): Implications for neuron-glia interactions during neurodegeneration
34. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
35. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
36. Soluble TNF receptors partially protect injured motoneurons in the postnatal CNS
37. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions
38. Induction of thymosin beta(4) mRNA following focal brain ischemia
39. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
40. Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: An immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062
41. m for hydrogen peroxide