IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 1096-1100

  Olee, Tsaiwei ^a   Hashimoto, Sanshiro ^a   Quach, Jacqueline ^a   Lotz, Martin ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 18; INTERLEUKIN 6; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; STROMELYSIN;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CATABOLISM; CELL PROLIFERATION; DNA LIBRARY; ENZYME INDUCTION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEOGLYCAN SYNTHESIS; TISSUE METABOLISM;

ARTHRITIS; CARTILAGE, ARTICULAR; CELL DIVISION; CHONDROCYTES; GENE EXPRESSION REGULATION; GROWTH INHIBITORS; HUMANS; INTERLEUKIN-18; KNEE JOINT; NITRIC OXIDE; PROTEIN BIOSYNTHESIS; PROTEOGLYCANS; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033556175     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Arend, W. P., and J. M. Dayer. 1995 Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum. 38:151.
2. Feldmann, M., F. Brennan, E. Paleolog, P. Taylor, and R. N. Maini. 1997. Anti-tumor necrosis factor α therapy of rheumatoid arthritis: mechanism of action. Eur. Cytokine Netw. 8:297.
3. Ghivizzani, S. C., R. Kang, H. I. Georgescu, E. R. Lechman, D. Jaffurs, J. M. Engle, S. C. Watkins, M. H. Tindal, M. K. Suchanek, L. R. McKenzie, et al. 1997. Constitutive intra-articutar expression of human IL-1β following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis. J. Immunol. 159:3604.
4. Lotz, M., F. J. Blanco, J. von Kempis, J. Dudler, R. Maier, P. M. Villiger, and Y. Geng. 1995. Cytokine regulation of chondrocyte functions. J. Rheumatol. Suppl. 43:104.
5. Brinckerhoff, C. E. 1992. Regulation of metalloproteinase gene expression: implications for osteoarthritis. Crit. Rev. Eukaryot. Gene Expr. 2:145.
6. Reboul, P., J. P. Pelletier, G. Tardif, J. M. Cloutier, and J. Martel-Pelletier. 1996. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: a role in osteoarthritis. J. Clin, Invest. 97:2011.
7. Hamilton, J. A., P. H. Hart, T. Leizer, G. F. Vitti, and I. K. Campbell. 1991. Regulation of plasminogen activator activity in arthritic joints. J. Rheumatol. Suppl. 27:106.
8. Goldring, M. B., K. Fukuo, J. R. Birkhead, E. Dudek, and L. J. Sandell. 1994. Transcriptional suppression by interleukin-1 and interferon-γ of type II collagen gene expression in human chondrocytes. J. Cell. Biochem. 54:85.
9. Taskiran, D., M. Stefanovic-Racic, H. Georgescu, and C. Evans. 1994. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem. Biophys. Res. Commun. 200:142.
10. Geng, Y., F. J. Blanco, M. Cornelisson, and M. Lotz. 1995. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes. J. Immunol. 155:796.
11. Stadler, J., M. Stefanovic-Racic, T. R. Billiar, R. D. Curran, L. A. McIntyre, H. I. Georgescu, R. L. Simmons, and C. H. Evans. 1991. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J. Immunol. 147:3915.
12. Rediske, J., C. Koehne, B. Zhang, and M. Lotz. 1994. The inducible production of nitric oxide by articular cell types. Osteoarthritis Cartilage 2:199.
13. 2. Exp. Cell Res. 218:319.
14. Blanco, F. J., R. L. Ochs, H. Schwarz, and M. Lotz. 1995 Chondrocyte apoptosis induced by nitric oxide. Am. J. Pathol. 146:75.
15. Clancy, R. M., S. B. Abramson, C. Kohne, and J. Rediske. 1997. Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury. J. Cell. Physiol. 172:183.
16. Morales, T. I. 1992. Polypeptide regulators of matrix homeostasis in articular cartilage. In Articular Cartilage and Osteoarthritis. K. E. Kuettner, R. Schleyerbach, J. G. Peyron, and V. C. Hascall, eds. Raven Press, New York, pp. 265-280.
17. Poole, A. R. 1997. Cartilage in health and disease. In Arthritis and Allied Conditions. W. J. Koopman, ed. Williams & Wilkins. Baltimore, pp. 255-308.
18. Guerne, P. A., A. Sublet, and M. Lotz. 1994. Growth factor responsiveness of human articular chondrocytes: distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts. J. Cell. Physiol. 158:476.
19. Xu, C., B. O. Oyajobi, A. Frazer, L. D. Kozaci, R. G. Russell, and A. P. Hollander. 1996. Effects of growth factors and interleukin-1a on proteoglycan and type II collagen turnover in bovine nasal and articular chondrocyte pellet cultures. Endocrinology 137:3557.
20. Firestein, G. S. 1998. Rheumatoid arthritis and pannnus. In Rheumatology, Vol. I. J. H. Klippel and P. A. Dieppe, eds. Mosby, London, pp. 13.1-24.
21. Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
22. Gu, Y., K. Kuida, H. Tsutsui, G. Ku, K. Hsiao, M. A. Fleming, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, et al. 1997. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science 275:206.
23. Ghayur, T., S. Banerjee, M. Hugunin, D. Butler, L. Herzog, A. Carter, L. Quintal, L. Sekut, R. Talanian, M. Paskind, et al. 1997. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386:619.
24. Udagawa, N., N. J. Horwood, J. Elliolt, A. Mackay, J. Owens, H. Okamura, M. Kurimoto, T. J. Chambers, T. J. Martin, and M. T. Gillespie. 1997. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation. J. Exp. Med. 185:1005.
25. Conti, B., J. W. Jahng, C. Tinti, J. H. Son, and T. H. Joh. 1997. Induction of interferon-γ inducing factor in the adrenal cortex. J. Biol. Chem. 272:2035.
26. Ushio, S., M. Namba, T. Okura, K. Hattori, Y. Nukada, K. Akita, F. Tanabe, K. Konishi, M. Micallef, M. Fujii, et al. 1996. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156:4274.
27. Torigoe, K., S. Ushio, T. Okura, S. Kobayashi, M. Taniai, T. Kunikata, T. Murakami, O. Sanou, H. Kojima, M. Fujii, T. Ohta, M. Ikeda, H. Ikegami, and M. Kurimoto. 1997. Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem. 272:25737.
28. Pamet, P., K. E. Garka, T. P. Bonnert, S. K. Dower, and J. E. Sims. 1996. IL-1 Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J. Biol. Chem. 271:3967.
29. Goldberg, R. L., and L. M. Kolibas. 1990. An improved method for determining proteoglycans synthesized by chondrocytes in culture. Connect. Tissue Res. 24: 265.
30. Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095.
31. Yamamura, M., M. Kawashima, Y. Morita, H. Makino, T. Tanimoto, and M. Kurimoto. 1997. Increased production of interleukin-18 in synovium from patients with rheumatoid arthritis. Arthritis Rheum. 40:s274.
32. Stefanovic-Racic, M., T. I. Morales, D. Taskiran, L. A. McIntyre, and C. H. Evans. 1996. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J. Immunol. 156:1213.
33. Clancy, R. M., J. Rediske, X. Tang, N. Nijher, S. Frenkel, M. Philips, and S. B. Abramson. 1997. Outside-in signaling in the chondrocyte: nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. J. Clin. Invest. 100:1789.
34. Frenkel, S. R., R. M. Clancy, J. L. Ricci, P. E. Di Cesare, J. J. Rediske, and S. B. Abramson. 1996. Effects of nitric oxide on chondrocyte migration, adhesion, and cytoskeletal assembly. Arthritis Rheum. 39:1905.
35. Robinson, D. R. 1997. Eicosanoids and related compounds. In Arthritis and Allied Conditions. W. J. Koopman, ed. Williams & Wilkins, Baltimore, pp. 515-528.