Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis

Epilepsia

Volumn 43, Issue SUPPL. 5, 2002, Pages 30-35

  Vezzani, Annamaria ^a   Moneta, Daniela ^a   Richichi, Cristina ^a   Aliprandi, Marisa ^a   Burrows, Stephanie J ^a   Ravizza, Teresa ^a   Perego, Carlo ^a   Grazia De Simoni, M ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Anticonvulsant; Glia; IL 1 receptor antagonist; Interleukin (IL); Limbic system

Indexed keywords

ANTICONVULSIVE AGENT; ANTIINFLAMMATORY AGENT; BICUCULLINE METHIODIDE; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAINIC ACID; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; COMPLEX PARTIAL SEIZURE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ELECTROSTIMULATION; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TRANSGENIC MOUSE;

ANIMALS; CYTOKINES; EPILEPSY; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; LIMBIC SYSTEM; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SIALOGLYCOPROTEINS;

EID: 0036337913     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.43.s.5.14.x     Document Type: Conference Paper

References (30)

1. Gene expression and function of interteukin-1, interleukin-6 and tumor necrosis factor in the brain
2. Inflammatory cytokines within the central nervous system: Sources, function and mechanism of action
3. Cytokines in neuronal cell types
4. Cytokines and the nervous system, I: Expression and recognition
5. Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain
6. In situ hybridization study of interleukin-1β mRNA induced by kainic acid in the rat brain
7. Interleukin-1β in the brain is induced by audiogenic seizure
8. Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain
9. Kindling modulates the IL-1β system, TNF-α, TGF-β1 and neuropeptide mRNA in specific brain regions
10. Release of TNF in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage
11. Increased neuronal β-amyloid precursor protein expression in human temporal lobe epilepsy: Association with interleukin-1α immunoreactivity
12. Interleukin(IL)- 1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy
13. Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist
14. Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures
15. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
16. Somatostatin, neuropeptide Y, neurokinin B and cholecystokinin immunoreactivity in two chronic models of temporal lobe epilepsy
17. Self-sustaining limbic status epilepticus induced by continuous hippocampal stimulation: Electrographic and behavioral characteristics
18. Modification of seizure activity by electrical stimulation, II: Motor seizure
19. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice
20. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
21. The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases
22. Role of pro- and anti-inflammatory cytokines during inflammation: Experimental and clinical findings
23. Cytokine modulation of glial glutamate uptake: A possible involvement of nitric oxide
24. Interleukin-1β does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the rat in vitro
25. Interleukin-1 beta inhibits gamma-aminobutyric acid type A (GABAA) receptor current in cultured hippocampal neurons
26. Functions and mechanisms of interleukin 1 in the brain
27. Interleukin-1beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices
28. Interleukin-1beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus
29. Interleukin- 1beta (IL-1beta) and tumor necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
30. Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1β