Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

Nature Immunology

Volumn 7, Issue 6, 2006, Pages 576-582

  Franchi, Luigi ^a   Amer, Amal ^a   Body Malapel, Mathilde ^a   Kanneganti, Thirumala Devi ^a   Özören, Nesrin ^a   Jagirdar, Rajesh ^a   Inohara, Naohiro ^a   Vandenabeele, Peter ^b   Bertin, John ^c,d   Coyle, Anthony ^c,d,e   Grant, Ethan P ^c,d   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b GHENT UNIVERSITY   (Belgium)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

^d Synta Pharmaceuticals Corp   (United States)

^e MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MUTANT PROTEIN; PATTERN RECOGNITION RECEPTOR; PROTEIN IPAF; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOSOL; ENZYME ACTIVATION; EXPOSURE; EXTRACELLULAR SPACE; FEMALE; MACROPHAGE; MALE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SALMONELLA; SALMONELLOSIS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CASPASE 1; CYTOSOL; ENZYME ACTIVATION; FLAGELLIN; INTERLEUKIN-1; MACROPHAGES; MICE; MICE, MUTANT STRAINS; NF-KAPPA B; PROTEIN TRANSPORT; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; TOLL-LIKE RECEPTOR 5;

EID: 33744464740     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1346     Document Type: Article

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