Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

Nature Genetics

Volumn 38, Issue 2, 2006, Pages 240-244

  Boyden, Eric D ^a   Dietrich, William F ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; INTERLEUKIN 1BETA CONVERTING ENZYME;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; EMBRYO; ENZYME ACTIVATION; GENE; GENE FUNCTION; GENE LOCUS; GENE NALP 1B; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ALLELES; ANIMALS; ANTIGENS, BACTERIAL; APOPTOSIS REGULATORY PROTEINS; BACTERIAL TOXINS; BASE SEQUENCE; CASPASE 1; CELL SURVIVAL; DISEASE SUSCEPTIBILITY; EXONS; MACROPHAGES; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; RNA, MESSENGER;

ANIMALIA; BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS);

EID: 31744441475     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1724     Document Type: Article

References (30)

1. Stephen, J. Anthrax toxin. Pharmacol. Ther. 12, 501-513 (1981).
2. Collier, R.J. & Young, J.A. Anthrax toxin. Annu. Rev. Cell Dev. Biol. 19, 45-70 (2003).
3. Friedlander, A.M. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261, 7123-7126 (1986).
4. Hanna, P.C., Kochi, S. & Collier, R.J. Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells. Mol. Biol. Cell 3, 1269-1277 (1992).
5. Hanna, P.C., Acosta, D. & Collier, R.J. On the role of macrophages in anthrax. Proc. Natl. Acad. Sci. USA 90, 10198-10201 (1993).
6. Friedlander, A.M., Bhatnagar, R., Leppla, S.H., Johnson, L. & Singh, Y. Characterization of macrophage sensitivity and resistance to anthrax lethal toxin. Infect. Immun. 61, 245-252 (1993).
7. Roberts, J.E., Watters, J.W., Ballard, J.D. & Dietrich, W.F. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol. Microbiol. 29, 581-591 (1998).
8. Watters, J.W. & Dietrich, W.F. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics 73, 223-231 (2001).
9. Watters, J.W., Dewar, K., Lehoczky, J., Boyartchuk, V. & Dietrich, W.F. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr. Biol. 11, 1503-1511 (2001).
10. Summerton, J. & Weller, D. Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic Acid Drug Dev. 7, 187-195 (1997).
11. Draper, B.W., Morcos, P.A. & Kimmel, C.B. Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown. Genesis 30, 154-156 (2001).
12. Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426 (2002).
13. Cordoba-Rodriguez, R., Fang, H., Lankford, C.S. & Frucht, D.M. Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1β and IL-18. J. Biol. Chem. 279, 20563-20566 (2004).
14. Tschopp, J., Martinon, F. & Burns, K. Nalps: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4, 95-104 (2003).
15. Martinon, F., Hofmann, K. & Tschopp, J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr. Biol. 11, R118-R120 (2001).
16. Geddes, B.J. et al. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem. Biophys. Res. Commun. 284, 77-82 (2001).
17. Poyet, J.-L. et al. Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276, 28309-28313 (2001).
18. Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218 (2004).
19. Brennan, M.A. & Cookson, B.T. Salmonella induces macrophage death by caspase-1-dependent necrosis. Mol. Microbiol. 38, 31-40 (2000).
20. Jesenberger, V., Procyk, K.J., Yuan, J., Reipert, S. & Baccarini, M. Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis. J. Exp. Med. 192, 1035-1045 (2000).
21. Klimpel, K.R., Arora, N. & Leppla, S.H. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol. Microbiol. 13, 1093-1100 (1994).
22. Vitale, G., Bernardi, L., Napolitani, G., Mock, M. & Montecucco, C. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem. J. 352, 739-745 (2000).
23. Pellizzari, R., Guidi-Rontani, C., Vitale, G., Mock, M. & Montecucco, C. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits LPS/IFNγ-induced release of NO and TNFα FEBS Lett. 462, 199-204 (1999).
24. Kim, S.O. et al. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-α. J. Biol. Chem. 278, 7413-7421 (2003).
25. Menard, A., Papini, E., Mock, M. & Montecucco, C. The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Biochem. J. 320, 687-691 (1996).
26. Growney, J.D. & Dietrich, W.F. High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Genome Res. 10, 1158-1171 (2000).
27. Yui, M.A. et al. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm. Genome 7, 331-334 (1996).
28. Reifsnyder, P.C. et al. Genotypic and phenotypic characterization of six new recombinant congenic strains derived from NOD/Shi and CBA/J genomes. Mamm. Genome 10, 161-167 (1999).
29. Svenson, K.L. et al. Strain distribution pattern for SSLP markers in the SWXJ recombinant inbred strain set: chromosomes 1 to 6. Mamm. Genome 6, 867-872 (1995).
30. Shultz, K.L., Svenson, K.L., Cheah, Y.-C., Paigen, B. & Beamer, W.G. Strain distribution pattern for SSLP markers in the SWXJ recombinant inbred strain set: chromosomes 7 to X. Mamm. Genome 7, 526-532 (1996).