IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB

Immunity

Volumn 7, Issue 4, 1997, Pages 571-581

  Robinson, Douglas ^a   Shibuya, Kazuko ^a   Mui, Alice ^a   Zonin, Francesca ^a   Murphy, Erin ^a   Sana, Theo ^a   Hartley, Suzanne B ^a   Menon, Satish ^a   Kastelein, Rob ^a   Bazan, Fernando ^a   O'Garra, Anne ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0030694235     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80378-7     Document Type: Article

References (69)

1. Abbas, A.K., Murphy, K.M., and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793.
2. Abrams, J. (1995). Immunometric assay of mouse and human cytokines using NIP-labelled anti-cytokine antibodies. Curr. Protocols Immunol. 13, 6.1-6.15.
3. Abrams, J.S., Roncarolo, M.-G., Yssel, H., Andersson, U., Gleich, G.J., and Silver, J.E. (1992). Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127, 5-24.
4. Bancroft, G.J., Sheehan, K.C.F., Schreiber, R.D., and Unanue, E.R. (1989). Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in SCID mice. J. Immunol. 143, 127-130.
5. Bazan, J.F., Timans, J.C., and Kastelein, R.A. (1996). A newly defined interleukin-1? Nature 379, 591.
6. Beebe, A.M., Mauze, S., Schork, N.J., and Coffman, R.L. (1997). Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity 6, 551-557.
7. - helper cells that secretes interleukin 2(IL-2), IL-3, IL-4 and interferon γ. J. Exp. Med. 174, 547-559.
8. Cao, Z., Henzel, W.J., and Gao, X. (1996). IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-1131.
9. Cherwinski, H.M., Schumacher, J.H., Brown, K.D., and Mosmann, T.R. (1987). Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166, 1229-1244.
10. D'Andrea, A., Rengaraju M., Valiante, N.M., Chemini, J., Kubin, M., Aste, M., Chan, S.H., Kobayashi, M., Young, D., Nickbarg, E., et al. (1992). Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176, 1387-1398.
11. Dighe, A.S., Campbell, D., Hsieh, C.-S., Clarke, S., Greaves, D.R., Gordon, S., Murphy, K.M., and Schreiber, R.D. (1995). Tissue-specific targeting of cytokine unresponsiveness in transgenic mice. Immunity 3, 657-666.
12. Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., et al. (1997). Caspase-1 processes IFN-γ inducing factor and regulates LPS-induced IFN-γ production. Nature 386, 619-623.
13. + Tcells: differential effects of IL-1 on helper and inflammatory T cells. J. Immunol. 140, 1555.
14. Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M.A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997). Activation of Interferon-γ inducing factor mediated by interleukin 1-β converting enzyme. Science 275, 206-209.
15. H1 cell development. Science 271, 984-987.
16. Guler, M.L., Jacobsen, N.G., Gubler, U., and Murphy, K.M. (1997). T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10. D2 T helper cell type 1 phenotype development. J. Immunol. 159, 1767-1775.
17. Hardiman, G., Rock, F.L., Balasubramanian, S., Kastelein, R.A., and Bazan, J.F. (1996). Molecular characterization and modular analysis of human MyD88. Oncogene 13, 2467-2475.
18. Haskins, K., Kobo, R., White, J., Pigeon, M., Kappler, J., and Marrack, P. (1983). The MHC-restricted antigen on T cells. I. Isolation of a monoclonal antibody. J. Exp. Med. 157, 1149-1169.
19. Heinzel, F.P., Sadick, M.D., Holaday, B.J., Coffman, R.L., and Locksley, R.M. (1989). Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. J. Exp. Med. 169, 59-72.
20. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
21. Hsieh, C.-S., Macatonia, S.E., O'Garra, A., and Murphy, K.M. (1995). T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181, 713-721.
22. Hunter, C.A., Timans, J., Pisacane, P., Menon, S., Cai, G., Chizzonitte, R., Bazan, J.F., and Kastelein, R.A. (1997). Comparison of the effects of interleukin-1α (IL-1α), IL-1β and IGIF (IL-1γ) on the production of interferon-gamma by NK cells. J. Immunol., in press.
23. Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E.J., and Murphy, K.M. (1995). Interleukin 12 signalling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181, 1755-1762.
24. Kaplan, M.H., Sun, Y.-L., Hoey, T., and Grusby, M.J. (1996). Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177.
25. Kohno, K., Kataoka, J., Ohtsuki, T., Suemoto, Y., Okamoto, I., Usui, M., Ikeda, M., and Kurimoto, M. (1997). IFN-g-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158, 1541-1550.
26. Lederer, J.A., Liou, J.S., Kim, S., Rice, N., and Lichtman, A.M. (1996). Regulation of NFκB activation in T helper 1 and T helper 2 cells. J. Immunol. 156, 56-63.
27. Lichtman, A.M., Chin, J., Schmidt, J.A., and Abbas, A.K. (1988). Role of interleukin 1 in the activation of T lymphocytes. Proc. Natl. Acad. Sci. USA 85, 9699-9703.
28. Locksley, R.M., and Scott, P. (1991). Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol. Today 12, 58-61.
29. Lohoff, M., Ferrick, D., Mittrucker, H.-W., Duncan, G.S., Bischof, S., Rollinghoff, M., and Mak, T.W. (1997). Interferon-regulatory-factor-1 is required for a T helper 1 immune response in vivo. Immunity 6, 681-689.
30. Macatonia, S.E., Taylor, P.M., Knight, S.C., and Askonas, B.A. (1989). Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J. Exp. Med. 169, 1255-1264.
31. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5, 1119-1128.
32. Magram, J., Connaughton, S.E., Warrier, R.R., Carvajal, D.M., Wu, C., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D.A., and Gately, M.K. (1996). IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses. Immunity 4, 471-481.
33. Malinin, N.L., Boldin, N.P., Kovalenko, A.V., and Wallach, D. (1997). MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385, 540-544.
34. Manetti, R., Parronchi, P., Guidizi, M.G., Piccinni, M.-P., Maggi, E., Trinchieri, G., and Romagnani, S. (1993). Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J. Exp. Med. 177, 1199-1204.
35. Mattner, F., Magram, J., Ferrante, J., Launois, P., Di Padova, K., Behin, R., Gately, M., and Louis, J., Alber, G. (1996). Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26, 1553-1559.
36. McArthur, J.G., and Raulet, D.H. (1993). CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med. 178, 1645-1653.
37. Medzhitov, R., Preston-Hulburt, P., and Janeway, C.A. (1997). A human homologue of the DrosophilaToll protein signals activation of adaptive immunity. Nature 388, 394-397.
38. Metlay, J.P., Witmer-Pack., Agger, R., Crowley, M.T., Lawless, D., and Steinman, R.M. (1990). The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171, 1753-1771.
39. Micallef, M.J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigo, K., Fujii, M., Ikeda, M., et al. (1996). Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for IFN-γ production. Eur. J. Immunol. 26, 1647-1651.
40. Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A., and Coffman, R.L. (1986). Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
41. Mui, A.L., Miyajima, A., Harada, N., O'Farrell, A.M., and Wakao, H. (1995). Interleukin 3, granulocyte-macrophage colony stimulating factor and interleukin 5, transduce signals through two Stat5 homologs. EMBO J. 14, 1166-1175.
42. Murphy, E.E., Terres, G., Macatonia, S.E., Hsieh, C.-S., Mattson, J., Lanier, L., Wysocka, M., Trinchieri, G., Murphy, K., and O'Garra, A. (1994). B7 and interleukin-12 cooperate for proliferation and IFN-γ production by mouse Th1 clones that are unresponsive to B7 co-stimulation. J. Exp. Med. 180, 223-231.
43. + T cell populations. J. Exp. Med. 183, 901-913.
44. + TCR-lo thymocytes in vivo. Science 250, 1720-1722.
45. O'Garra, A., and Murphy, K. (1994). Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6, 458-466.
46. Ohara, J., and Paul, W.E. (1985). Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315, 333-336.
47. Okamura, H., Tsutsul, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Mukuda, Y., Hattori, K., et al. (1995). Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378, 88-91.
48. Openshaw, P., Murphy, E., Hosken, N.A., Maino, V., Davis, K., Murphy, K., and O'Garra, A. (1995). Heterogeneity of Intracellular cytokine synthesis at the single cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182, 1357-1367.
49. Ozmen, L., Pericin, M., Hakimi, J., Chizzonite, R.A., Wysocka, M., Trinchieri, G., Gately, M., and Garotta, G. (1994). Interleukin 12, interferon-γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med. 180, 907-915.
50. Paul, W.E., and Seder, R.A. (1994). Lymphocyte responses and cytokines. Cell 76, 241-251.
51. Regnier, C.H., Yeong Song, H., Gao, X., Goeddel, D.V., Cao, Z., and Rothe, M. (1997). Identification and characterization of an IκB kinase. Cell 90, 373-383.
52. Roberts, L.J., Baldwin, T.M., Curtis, J.M., Handman, E., and Foote, S.J. (1997). Resistance to Leishmania major is linked to the H-2 region on chromosome 17 and to chromosome 9. J. Exp. Med. 185, 1705-1710.
53. H2 subsets: doubt no more, Immunol. Today 12, 256-257.
54. Romagnani, S. (1994). Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12, 227-257.
55. + T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178, 567-577.
56. Schoenhaut, D.S., Chua, A.O., Wolitzky, A.G., Quinn, P.M., Dwyer, C.M., McComas, W., Familletti, P.C., Gately, M.K., and Gubler, U. (1992). Cloning and expression of IL-12. J. Immunol. 148, 3433-3440.
57. Scott, P., Natovitz, P., Coffman, R.L., Pearce, E., and Sher, A. (1988). Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168, 1675-1684.
58. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90, 10188-10192.
59. Sher, A., and Coffman, R.L. (1992). Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10, 385-409.
60. Slade, S.J., and Langhorne, J. (1989). Production of interferon-gamma during infection of mice with plasmodium chabaudi. Immunobiology 179, 353-365.
61. Swain, S.L., Bradley, L.M., Croft, M., Tonkonogy, S., Atkins, G., Weinberg, A.D., Duncan, D.D., Hedrick, S.M., Dutton, R.W., and Huston, G. (1991). Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123, 115-144.
62. Szabo, S.J., Jacobson, N.G., Dighe, A.S., Gubler, U., and Murphy, K.M. (1995). Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2, 665-675.
63. Szabo, S., Dighe, A.S., Gubler, U., and Murphy, K.M. (1997). Regulation of the interleukin (IL)-12β2 subunit expression in developing T helper 1 (Th1) and Th2 Cells. J. Exp. Med. 185, 817-824.
64. Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., Taniguchi, T., and Asano, Y. (1997). Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6, 673-679.
65. Thierfelder, W.E., van Deursen, J.M., Yamamoto, K., Tripp, R.A., Sarawar, S.R., Carson, R.T., Sangster, M.Y., Vignali, D.A.A., Doherty, P.C., Grosveld, G.G., et al. (1996). Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171-174.
66. Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., et al. (1996). Cloning of the cDNA for human IFN-γ inducing factor, expression in Escherichia coli, and studies on the biological activites of the protein. J. Immunol. 156, 4274-4279.
67. Weaver, C.T., Hawrylowicz, C.M., and Unanue, E.R. (1988). T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 85, 8181-8185.
68. Wilson, I., Vogel, J., and Somerville, S. (1997). Signaling pathways: a common theme in plants and animals? Curr. Biol. 7, 175-178.
69. Young, H.A. (1996). Regulation of Interferon-γ gene expression. J. Interferon Cytokine Res. 16, 563-568.