Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 595-603

  Horwood, Nicole J ^a   Udagawa, Nobuyuki ^b   Elliott, Jan ^a   Grail, Dianne ^c   Okamura, Haruki ^d   Kurimoto, Masashi ^e   Dunn, Ashley R ^c   Martin, T John ^a   Gillespie, Matthew T ^a,f  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b SHOWA UNIVERSITY   (Japan)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

^e HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

^f ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Bone development; Cytokines; Osteoblasts; Spleen; T lymphocyte subsets

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; BONE REMODELING; CELL DIFFERENTIATION; HELPER CELL; KUPFFER CELL; MONONUCLEAR CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; SPLEEN CELL; STEM CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0032005857     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1333     Document Type: Article

References (25)

1. Suda, T., N. Takahashi, and T.J. Martin. 1995. Modulation of osteoclast differentiation: update. In Endocrine Rev. Monographs. Vol. 4. D.D. Bikle and A. Negrovilar, editors. Endocrine Society, Bethesda, MD. 266-270.
2. Martin, T.J., and K.W. Ng. 1994. Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. J. Cell. Biochem. 56:357-366.
3. Takahashi, N., T. Akatsu, N. Udagawa, T. Sasaki, A. Yamaguchi, J.M. Moseley, T.J. Martin, and T. Suda. 1988. Osteoblastic cells are involved in osteoclast formation. Endocrinology. 123:2600-2602.
4. Rosen, C.J., K. Usiskin, M. Owens, C.O. Barlascini, M. Belsky, and R.A. Adler. 1990. T lymphocyte surface antigen markers in osteoporosis. J. Bone Miner. Res. 5:851-855.
5. Abrahamsen, B., K. Bendtzen, and H. Beck-Nielsen. 1997. Cytokines and T-lymphocyte subsets in healthy post-menopausal women: estrogen retards bone loss without affecting the release of IL-1 or IL-1ra. Bone. 20:251-258.
6. Hustmyer, F.G., E. Walker, X.-P. Yu, G. Girasole, Y. Sakagami, M. Peacock, and S.C. Manolagas. 1993. Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis. J. Bone Miner. Res. 8:51-59.
7. Buchinsky, F.J., Y. Ma, G.N. Mann, B. Rucinski, H.P. Bryer, D.F. Romero, W.S.S. Jee, and S. Epstein. 1996. T lymphocytes play a crucial role in the development of cyclosporin A-induced osteopenia. Endocrinology. 137: 2278-2285.
8. John, V., J.M. Hock, L.L. Short, A.L. Glasebrook, and R.J. Sells Galvin. 1996. A role for CD8+ T lymphocytes in osteoclast differentiation in vitro. Endocrinology. 137:2457-2463.
9. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature. 378:88-91.
10. Ushio, S., M. Namba, T. Okura, K. Hattori, Y. Nukada, K. Akita, F. Tanabe, K. Konishi, M. Micallef, M. Fujii, et al. 1996 Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156:4274-4279.
11. Micallef, M.J., O. Takashi, K. Kohno, F. Tanabe, S. Ushio, M. Namba, T. Tanimoto, K. Torigoe, M. Fujii, M. Ikeda, et al. 1996. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for Interferon-γ production. Eur. J. Immunol. 26: 1647-1651.
12. Yoshimoto, T., H. Okamura, Y.-I. Tagawa, Y. Iwakura, and K. Nakanishi. 1997. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc. Natl. Acad. Sci. USA. 94:3948-3953.
13. Udagawa, N., N.J. Horwood, J. Elliott, A. Mackay, J. Owens, H. Okamura, M. Kurimoto, T.J. Chambers, T.J. Martin, and M.T. Gillespie. 1997. Interleukin 18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte-macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation. J. Exp. Med. 185:1005-1012.
14. Stanley, E., G.J. Lieschke, D. Grail, D. Metcalf, G. Hodgson, J.A.M. Gall, D.W. Maher, J. Cebon, V. Sinickas, and A.R. Dunn. 1994. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc. Natl. Acad. Sci. USA. 91:5592-5596.
15. Robb, L., C.C. Drinkwater, D. Metcalf, R. Li, F. Kontgen, N.A. Nicola, and C.G. Begley. 1995. Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc. Natl. Acad. Sci. USA. 92:9565-9569.
16. Udagawa, N., N. Takahashi, T. Akatsu, T. Sasaki, A. Yamaguchi, H. Kodama, T.J. Martin, and T. Suda. 1989. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like coll differentiation in cocultures with mouse spleen cells. Endocrinology. 125:1805-1813.
17. Chambers, T.J., P.A. Revell, K. Fuller, and N.A. Athanasou. 1984. Resorption of bone by isolated rabbit osteoclasts. J. Cell Sci. 66:383-399.
18. Metcalf, D., and N.A. Nicola. 1992. The clonal proliferation of normal mouse hematopoietic cells: enhancement and suppression by colony-stimulating factor combinations. Blood. 79:2861-2866.
19. Matsumoto, S., K. Tsuji-Takayama, Y. Aizawa, K. Koide, M. Takeuchi, T. Ohta, and M. Kurimoto. 1997. Interleukin-18 activates NF-κB in murine T helper type 1 cells. Biochem. Biophys. Res. Commun. 234:454-457.
20. Movsowitz, C., S. Epstein, M. Fallon, M. Ismail, and F. Thomas. 1988. Cyclosporin A in vivo produces severe osteopenia in the rat: effect of dose and duration of administration. Endocrinology. 123:2571-2577.
21. Buchinsky, F.J., Y. Ma, G.N. Mann, B. Rucinski, H.P. Bryer, B.V. Paynton, W.S.S. Jee, G.N. Hendy, and S. Epstein. 1995. Bone mineral metabolism in T lymphocyte-deficient and -replete strains of rat. J. Bone. Miner. Res. 10:1556-1565.
22. Serrano, S., M.L. Marinoso, J.C. Soriano, J. Rubies-Prat, J. Aubia, J. Coll, J. Bosch, L. Del Rio, J. Vila, A. Goday, and M. Nacher. 1995. Bone remodelling in human immunodeficiency virus-1-infected patients. A histomorphometric study. Bone. 16:185-191.
23. Consolini, R., P. Cini, B. Cei, and E. Bottone. 1987. Thymic dysfunction in histiocytosis-X. Am. J. Ped. Hematol. Oncol. 9:146-148.
24. Cline, M. 1994. Histiocytes and histiocytosis. Blood. 84:2840-2863.
25. Li, P., H. Allen, S. Banerjee, and T. Seshadri. 1997. Characterization of mice deficient in interleukin-1β converting enzyme. J. Cell. Biochem. 64:27-32.