Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

Journal of Experimental Medicine

Volumn 185, Issue 5, 1997, Pages 933-940

  Friedlander, Robert M ^a,b   Gagliardini, Valeria ^a   Hara, Hideaki ^c   Fink, Klaus B ^c   Li, Weiwei ^a   MacDonald, Glen ^d   Fishman, Mark C ^a   Greenberg, Arnold H ^d   Moskowitz, Michael A ^c   Yuan, Junying ^a,e  

^a Cardiovascular Research Center   (United States)

^b Neurosurgical Service   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF MANITOBA   (Canada)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; NEUROTROPHIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CHICK EMBRYO; CONTROLLED STUDY; GENE MUTATION; GENETIC MANIPULATION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL GANGLION;

ANIMALS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CASPASE 1; CELL COUNT; CENTRAL NERVOUS SYSTEM; CEREBRAL ARTERIES; CHICK EMBRYO; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; FACIAL NERVE; GANGLIA, SPINAL; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 8044252166     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.5.933     Document Type: Article

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