Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization

Cell Death and Differentiation

Volumn 13, Issue 2, 2006, Pages 236-249

  Yu, J W ^a   Wu, J ^a   Zhang, Z ^a   Datta, P ^a   Ibrahimi, I ^a   Taniguchi, S ^b   Sagara, J ^b   Fernandes Alnemri, T ^a   Alnemri, E S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

ASC; Caspase 1; Cryopyrin; Inflammasome; Inflammation; Interleukin 1 ; NF B; Pyrin

Indexed keywords

CELL PROTEIN; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN ASC; PYRIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MUTANT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

BACULOVIRIDAE; CARRIER PROTEINS; CASPASE 1; CELL LINE; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; MICROSCOPY, CONFOCAL; MUTATION; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY;

EID: 30844432876     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401734     Document Type: Article

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