A proinflammatory role for IL-18 in rheumatoid arthritis

Journal of Clinical Investigation

Volumn 104, Issue 10, 1999, Pages 1393-1401

  Gracie, J Alastair ^a   Forsey, Rosalyn J ^a   Chan, Woon Ling ^b   Gilmour, Ashley ^a   Leung, Bernard P ^a   Greer, Morag R ^a   Kennedy, Kirsty ^a   Carter, Robert ^b   Wei, Xiao Qing ^a   Xu, Damo ^a   Field, Max ^a   Foulis, Alan ^a   Liew, Foo Y ^a   McInnes, Iain B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM;

EID: 0032743708     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7317     Document Type: Article

References (43)

1. Mauri, C., Williams, R.O., Walmsley, M., and Feldmann, M. 1996. Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen induced arthritis. Eur. J. Immunol. 26:1511-1518.
2. Racke, M.K., et al. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease J. Exp. Med, 180:1961-1966.
3. Katz, J.D., Benoist, C., and Mathis, D. 1995. T helper cell subsets in insulin dependent diabetes. Science. 268:1185-1188.
4. Mosmann, T.R., and Sad, S. 1996. The expanding universe of T cell subsets: Th1, Th2 and more. Immunol. Today. 17:13-17.
5. Ulfgren, A.-K., Lindblad, S., Klareskog, L., Andersson, J., and Andersson, U. 1995. Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis. Ann. Rheum. Dis. 54:654-661.
6. Miltenburg, A.M.M., van Laar, J.M, De Kuiper, R., Daha, M.R., and Breedveld, F.C. 1992. T cells cloned from human rheumatoid synovial membrane functionally represent the Th1 subset. Scand. J. Immunol. 35:603-610.
7. Dolhain, R.J.E.M., Heiden, A.N., Haar, N.T., Breedveld, F.C., and Miltenburg, A.M.M. 1996. Shift towards T lymphocytes with a T helper 1 cytokine secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum. 39:1961-1969.
8. Ronnelid, J., et al. 1998. Production of T cell cytokines at the single cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood. Br. J. Rheum. 37:7-14.
9. Gately, M.K., et al. 1998. The interleukin-12/interleukin-12 receptor system. Ann. Rev. Immunol. 16:495-521.
10. Morita, Y., et al. 1998. Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis. Arthritis Rheum. 41:306-314.
11. Feldmann, F., Brennan, F.M., and Maini, R.N. 1996. Role of cytokines in rheumatoid arthritis. Ann. Rev. Immunol. 14:397-440.
12. Ushio, S., et al. 1996. Cloning of the cDNA for human IFNγ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156:4274-4279.
13. Gu, Y., et al. 1997. Activation of interferon-gamma inducing factor mediated by interleukin-1β converting enzyme. Science. 275:206-209.
14. Okamura, H., Kashiwamura, S., Tsutsui, H., Yoshimoto, T., and Nakanishi, K. 1998. Regulation of interferon-γ production by IL-12 and IL-18. Curr. Opin. Immunol. 10:259-264.
15. Kohno, K., and Kurimoto, M. 1998. Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both. Clin. Immunol. Immunopathol. 86:11-15.
16. Takeda, K., et al. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8:383-390.
17. Udagawa, N., et al. 1997. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J. Exp. Med. 185:1005-1012.
18. Olee, T., Hashimoto, S., Quach, J., and Lotz, M. 1999. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J Immunol. 162:1096-1100.
19. Rothe, H., Jenkins, N., Copeland, N., and Kolb, H. 1997. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J. Clim. Invest. 99:469-474.
20. Kawakami, K., et al. 1997. IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-γ production. J. Immunol. 159:5528-5534.
21. Bohn, E., et al. 1998. IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol 160:299-307.
22. Chan, W.L., and Mitchison, N.A. 1982. Use of somatic cell hybrids for production of monospecific viral antibodies. Lab. Res. Methods Biol. Med. 15:125-141.
23. Arnett, F.C., Edworthy, S.M., and Block, D.A. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-324.
24. McInnes, I.B., et al. 1997. Production of nitric oxide in the synovial mem-brane of rheumatoid and osteoarthritis patients. J. Exp. Med. 184:1519-1524.
25. Ruchatz, H., Leung, B.P., Wei, X.-Q., McInnes, I.B., Liew, F.Y. 1998. Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J. Immunol. 160:5654-5660.
26. Puren, A.J., Fantuzzi, G., and Dinarello, C.A. 1999. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. USA. 96:2256-2261.
27. Dinarello, C.A., et al. 1998. Overview of interleukin-18: more than an interferon-gamma inducing factor. J. Leukoc. Biol. 63:658-664.
28. McInnes, I.B., et al. 1996. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat. Med. 2:175-182.
29. McInnes, I.B., and Liew, F.Y. 1998. Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis. Immunol Today. 19:75-79.
30. Firestein, G.S., and Zvaifler, N.J. 1987. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis, II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum. 30:864-871.
31. Feldmann, M., Charles, P., Taylor, P., and Maini, R.N. 1998. Biological insights from clinical trials with anti-TNF therapy. Springer Semin. Immunopathol. 20:21-28.
32. McInnes, I.B., and Liew, F.Y. 1998. Nitric oxide and immune response. In Nitric oxide and bone disease. M. Hukkanen, J.M. Polak, and S.P.F. Hughes, editors. Cambridge University Press. Cambridge, United Kingdom. 8-20.
33. Loetscher, P., et al. 1998 CCR5 is characteristic of Th1 lymphocytes. Nature. 391:344-345.
34. van der Graaff, W.L., Prins, A.P., Dijkmans, B.A., and van Lier, R.A. 1998. Prognostic value of Th1/Th2 ratio in rheumatoid arthritis. Lancet. 351:1931.
35. Novick, D., et al. 1999. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 10:127-136.
36. Xu, D., et al. 1998. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med. 188:1485-1492.
37. Barbulescu, K., et al. 1998. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes, J. Immunol 160:3642-3647.
38. McInnes, I.B., Leung, B.P., Sturrock, R.D., Field, M., and Liew, F.Y. 1997. Interleukin-15 mediates T cell-dependent regulation of tumour necrosis factor-alpha production in rheumatoid arthritis. Nat. Med. 3:189-195.
39. Williams, R.O., Feldmann, M., and Maini, R.N. 1994. Anti-tumour necrosis factor ameliorates joint disease in munne collagen induced arthritis. Proc. Natl. Acad. Sci. USA. 89:9784-9788.
40. 3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production and responsiveness to contact with activated T cells. J. Immunol. 149:2040-2046.
41. Puren, A.J., Fantuzzi, G., Gu, V., Su, M.S., and Dinarello, C.A. 1998. Interleukin-18 (IFNγ-inducing factor) induces IL-8 and IL-1β via TNF-α production from non-CD14+ human blood mononuclear cells. J. Clin. Invest. 101:711-721.
42. Kim, Y.M., Talanian, R.V., Li, J., and Billiar, T.R. 1998. Nitric oxide prevents IL-1β and 1FN - inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1β-converting enzyme). J. Immunol. 161:122-128.
43. Ku, G., Faust, T., Lauffer, L.L., Livingston, D.J., and Harding, M.W. 1996, Interleukin-1β converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine. 8:377-386.