Reduced ischemic brain injury in interleukin-1β converting enzyme- deficient mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 2, 1998, Pages 180-185

  Schielke, Gerald P ^a,b,d   Yang, Guo Yuan ^b   Shivers, Brenda D ^a   Betz, A Lorris ^b,c  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d NONE   (United States)

Author keywords

Cerebral ischemia; Converting Enzyme; Edema; Interleukin 1

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; INFLAMMATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STROKE;

EID: 0031894316     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199802000-00009     Document Type: Article

References (43)

1. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR (1995) Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol 37:800-805
2. Betz AL, Iannotti F (1983) Simultaneous determination of regional cerebral blood flow and blood-brain glucose transport kinetics in the gerbil. J Cereb Blood Flow Metab 3:193-199
3. Betz AL, Schielke GP, Yang GY (1996) Interleukin-1 in cerebral ischemia. Keio J Med 45:230-238
4. Betz AL, Yang GY, Davidson BL (1995) Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. J Cereb Blood Flow Metab 15:547-551
5. Bhat RV, DiRocco R, Marcy VR, Flood DG, Zhu Y, Dobrzanski P, Siman R, Scott R, Contreras PC, Miller M (1996) Increased expression of IL-1β converting enzyme in hippocampus after ischemia: selective localization in microglia. J Neurosci 16:4146-4154
6. Buttini M, Sauter A, Boddeke HW (1994) Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat. Brain Res Mol Brain Res 23:126-134
7. Chopp M, Zhang RL, Chen H, Li Y, Jiang N, Rusche FR (1994) Postischemic administration of an anti-mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke 25:869-876
8. Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87:2095-2147
9. Enari M, Hug H, Nagata S (1995) Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78-81
10. Friedlander RM, Gagliardini V, Hara H, Fink K, Li W, MacDonald G, Fishman MC, Greenberg AH, Moskowitz MA, Yuan J (1997) Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med 185:993-940
11. Friedlander RM, Gagliardini V, Rotello RJ, Yuan J (1996) Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis. J Exp Med 184:717-724
12. Garcia JH, Liu KF, Relton JK (1995) Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion. Am J Pathol 147:1477-1486
13. Gehrmann J, Banati RB, Wiessner C, Hossmann KA, Kreutzberg GW (1995) Reactive microglia in cerebral ischaemia: an early mediator of tissue damage? Neuropathol Appl Neurobiol 21:277-289
14. Gehrmann J, Bonnekoh P, Miyazawa T, Oschlies U, Dux E, Hossmann KA, Kreutzberg GW (1992) The microglial reaction in the rat hippocampus following global ischemia: immuno-electron microscopy. Acta Neuropathol 84:588-595
15. Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, Kurimoto M, Tanimoto T, Flavell RA, Sato V, Harding MW, Livingston DJ, Su MS-S (1997) Activation of Interferon-γ inducing factor by interleukin-1ß converting enzyme. Science 275:206-209
16. Hallenbeck JM (1996) Significance of the inflammatory response in brain ischemia. Acta Neurochir Suppl Wien 66:27-31
17. Hara H, Fink K, Endres M, Friedlander RM, Gagliardini V, Yuan J, Moskowitz MA (1997a) Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J Cereb Blood Flow Metab 17:370-375
18. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Haung Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA (1997b) Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 94:2007-2012
19. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neural nitric oxide synthase. Science 265:1883-1885
20. Klir JJ, McClellan JL, Kluger MJ (1994) Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats. Am J Physiol 266:R1845-R1848
21. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267: 2000-2003
22. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, et al. (1995a) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401-411
23. Li Y, Chopp M, Jiang N, Yao F, Zaloga C (1995b) Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397
24. Linnik MD, Zobrist RH, Hatfield MD (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2009
25. Liu T, McDonnell PC, Young PR, White RF, Siren AL, Hallenbeck JM, Barone FC, Feurestein GZ (1993) Interleukin-1 beta mRNA expression in ischemic rat cortex. Stroke 24:1746-1750
26. Loddick SA, Rothwell NJ (1996) Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab 16:932-940
27. Lynch T, Vasilakos J, Raser K, Keane K, Shivers B (1997) Inhibition of the interleukin-1β converting enzyme family rescues neurons from apoptotic death. Mol Psychiatr 2:227-238
28. Milligan CE, Prevette D, Yaginuma H, Homma S, Cardwell C, Fritz LC, Tomaselli KJ, Oppenheim RW, Schwartz LM (1995) Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron 15:385-393
29. Minami M, Kuraishi Y, Yabuuchi K, Yamazaki A, Satoh M (1992) Induction of interleukin 1β mRNA in rat brain after transient forebrain ischemia. J Neurochem 58:390-392
30. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653-660
31. Obrenovitch TP, Clayton CB, Strong AJ (1987) A double-radionuclide autoradiographic method using N-isopropyl-iodoamphetamine for sequential measurements of local cerebral blood flow. J Cereb Blood Flow Metab 7:356-365
32. Relton JK, Martin D, Thompson RC, Russell DA (1996) Peripheral administration of Interleukin-1 Receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat. Exp Neurol 138: 206-213
33. Relton JK, Rothwell NJ (1992) Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull 29:243-246
34. Rothwell NJ, Hopkins SJ (1995) Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci 18:130-136
35. Smith BK, Kluger MJ (1992) Human IL-1 receptor antagonist partially suppresses LPS fever but not plasma levels of IL-6 in Fischer rats. Am J Physiol 263:R653-R655
36. Szaflarski J, Burtrum D, Silverstein F (1995) Cerebral hypoxiaischemia stimulates cytokine gene expressin in perinatal rats. Stroke 26:1093-1100
37. van Lockeren Campagne M, Gill R (1996) Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat. Neurosci Lett 213:111-114
38. Van Uitert RL, Levy DE (1978) Regional brain blood flow in the conscious gerbil. Stroke 9:67-72
39. Vasilakos JP, Ghayur T, Carroll RT, Giegel DA, Saunders JM, Quintal L, Keane KM, Shivers BD (1995) IL-1 beta converting enzyme (ICE) is not required for apoptosis induced by lymphokine deprivation in an IL-2-dependent T cell line. J Immunol 155:3433-3442
40. Wang X, Yue TL, Barone FC, White RF, Gagnon RC, Feuerstein GZ (1994) Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia. Mol Chem Neuropathol 23:103-114
41. Yamasaki Y, Matsuura N, Shozuhara H, Onodera H, Itoyama Y, Kogure K (1995) Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 26:676-681
42. Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, Kamii H (1994) Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after local cerebral ischemia. Stroke 25:165-170
43. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75:641-652