IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients

Journal of Immunology

Volumn 175, Issue 4, 2005, Pages 2630-2634

  Stack, Jeffrey H ^a   Beaumont, Kevin ^a   Larsen, Paul D ^a   Straley, Kimberly S ^a   Henkel, Greg W ^a   Randle, John C R ^a   Hoffman, Hal M ^b  

^a VERTEX PHARMACEUTICALS   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CASPASE INHIBITOR; CYTOKINE; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; VX 765;

ADULT; AGED; ARTICLE; CIAS1 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; FAMILIAL COLD AUTOINFLAMMATORY SYNDROME; FEMALE; GENE; GENE MUTATION; HUMAN; HYPERSENSITIVITY; INFLAMMATORY DISEASE; MALE; MUCKLE WELLS SYNDROME; PRIORITY JOURNAL; WELLS SYNDROME;

EID: 23444439667     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.4.2630     Document Type: Article

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