Intracellular NOD-like Receptors in Host Defense and Disease

Immunity

Volumn 27, Issue 4, 2007, Pages 549-559

  Kanneganti, Thirumala Devi ^a   Lamkanfi, Mohamed ^a   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MURAMYL DIPEPTIDE; PEPTIDOGLYCAN; RECEPTOR PROTEIN; TOLL LIKE RECEPTOR;

COMPLEX FORMATION; CYTOSOL; DISEASE PREDISPOSITION; ENZYME ACTIVATION; FRANCISELLA; GENE FUNCTION; GENE MUTATION; GENETIC VARIABILITY; HOST RESISTANCE; HUMAN; INFLAMMATORY DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; BACTERIAL INFECTIONS; HUMANS; IMMUNITY, NATURAL; MICE; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; SIGNAL TRANSDUCTION;

EID: 35348932070     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2007.10.002     Document Type: Review

References (104)

1. Abbott D.W., Wilkins A., Asara J.M., and Cantley L.C. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14 (2004) 2217-2227
2. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., and Akey C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell 9 (2002) 423-432
3. Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., and Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20 (2004) 319-325
4. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
5. Amer A., Franchi L., Kanneganti T.D., Body-Malapel M., Ozoren N., Brady G., Meshinchi S., Jagirdar R., Gewirtz A., Akira S., and Nunez G. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J. Biol. Chem. 281 (2006) 35217-35223
6. Boughan P.K., Argent R.H., Body-Malapel M., Park J.H., Ewings K.E., Bowie A.G., Ong S.J., Cook S.J., Sorensen O.E., Manzo B.A., et al. Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. J. Biol. Chem. 281 (2006) 11637-11648
7. Boyden E.D., and Dietrich W.F. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet. 38 (2006) 240-244
8. Bruey J.M., Bruey-Sedano N., Luciano F., Zhai D., Balpai R., Xu C., Kress C.L., Bailly-Maitre B., Li X., Osterman A., et al. Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129 (2007) 45-56
9. Burns K., Martinon F., and Tschopp J. New insights into the mechanism of IL-1beta maturation. Curr. Opin. Immunol. 15 (2003) 26-30
10. Chamaillard M., Hashimoto M., Horie Y., Masumoto J., Qiu S., Saab L., Ogura Y., Kawasaki A., Fukase K., Kusumoto S., et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 4 (2003) 702-707
11. Chamaillard M., Philpott D., Girardin S.E., Zouali H., Lesage S., Chareyre F., Bui T.H., Giovannini M., Zaehringer U., Penard-Lacronique V., et al. Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc. Natl. Acad. Sci. USA 100 (2003) 3455-3460
12. Coers J., Vance R.E., Fontana M.F., and Dietrich W.F. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell. Microbiol. 9 (2007) 2344-2357
13. Diez E., Lee S.H., Gauthier S., Yaraghi Z., Tremblay M., Vidal S., and Gros P. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nat. Genet. 33 (2003) 55-60
14. Dowds T.A., Masumoto J., Zhu L., Inohara N., and Nunez G. Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J. Biol. Chem. 279 (2004) 21924-21928
15. Duncan J.A., Bergstralh D.T., Wang Y., Willingham S.B., Ye Z., Zimmermann A.G., and Ting J.P. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc. Natl. Acad. Sci. USA 104 (2007) 8041-8046
16. Elmaagacli A.H., Koldehoff M., Hindahl H., Steckel N.K., Trenschel R., Peceny R., Ottinger H., Rath P.M., Ross R.S., Roggendorf M., et al. Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation. Transplantation 81 (2006) 247-254
17. Ezzell J.W., Ivins B.E., and Leppla S.H. Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin. Infect. Immun. 45 (1984) 761-767
18. Faustin B., Lartigue L., Bruey J.M., Luciano F., Sergienko E., Bailly-Maitre B., Volkmann N., Hanein D., Rouiller I., and Reed J.C. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol. Cell 25 (2007) 713-724
19. Ferwerda G., Girardin S.E., Kullberg B.J., Le Bourhis L., de Jong D.J., Langenberg D.M., van Crevel R., Adema G.J., Ottenhoff T.H., Van der Meer J.W., and Netea M.G. NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog. 1 (2005) 279-285
20. Fortier A., Diez E., and Gros P. Naip5/Birc1e and susceptibility to Legionella pneumophila. Trends Microbiol. 13 (2005) 328-335
21. Fortier A., de Chastellier C., Balor S., and Gros P. Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. Cell. Microbiol. 9 (2006) 910-923
22. Franchi L., Am A., Body-Malapel M., Kanneganti T.D., Ozoren N., Jagirdar R., Inohara N., Vandenabeele P., Bertin J., Coyle A., et al. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7 (2006) 576-582
23. + for caspase-1 activation induced by intracellular and extracellular bacteria. J. Biol. Chem. 282 (2007) 18810-18818
24. Friedlander A.M. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261 (1986) 7123-7126
25. Fritz J.H., Girardin S.E., Fitting C., Werts C., Mengin-Lecreulx D., Caroff M., Cavaillon J.M., Philpott D.J., and Adib-Conquy M. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur. J. Immunol. 35 (2005) 2459-2470
26. Fritz J.H., Le Bourhis L., Sellge G., Magalhaes J.G., Fsihi H., Kufer T.A., Collins C., Viala J., Ferrero R.L., Girardin S.E., and Philpott D.J. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 26 (2007) 445-459
27. Gavrilin M.A., Bouakl I.J., Knatz N.L., Duncan M.D., Hall M.W., Gunn J.S., and Wewers M.D. Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release. Proc. Natl. Acad. Sci. USA 103 (2006) 141-146
28. Girardin S.E., Tournebize R., Mavris M., Page A.L., Li X., Stark G.R., Bertin J., DiStefano P.S., Yaniv M., Sansonetti P.J., and Philpott D.J. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep. 2 (2001) 736-742
29. Girardin S.E., Boneca I.G., Carneiro L.A., Antignac A., Jehanno M., Viala J., Tedin K., Taha M.K., Labigne A., Zahringer U., et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300 (2003) 1584-1587
30. Girardin S.E., Boneca I.G., Viala J., Chamaillard M., Labigne A., Thomas G., Philpott D.J., and Sansonetti P.J. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278 (2003) 8869-8872
31. Granell M., Urbano-Ispizua A., Arostegui J.I., Fernandez-Aviles F., Martinez C., Rovira M., Rius J., Plaza S., Gaya A., Navarro A., et al. Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation. Haematologica 91 (2006) 1372-1376
32. Harton J.A., Linhoff M.W., Zhang J., and Ting J.P. Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J. Immunol. 169 (2002) 4088-4093
33. Hasegawa M., Yang K., Hashimoto M., Park J.H., Kim Y.G., Fujimoto Y., Nunez G., Fukase K., and Inohara N. Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. J. Biol. Chem. 281 (2006) 29054-29063
34. Henry T., Brotcke A., Weiss D.S., Thompson L.J., and Monack D.M. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J. Exp. Med. 204 (2007) 987-994
35. Hoffmann J.A. The immune response of Drosophila. Nature 426 (2003) 33-38
36. Hoffman H.M., Rosengren S., Boyle D.L., Cho J.Y., Nayar J., Mueller J.L., Anderson J.P., Wanderer A.A., and Firestein G.S. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364 (2004) 1779-1785
37. Holler E., Rogler G., Herfarth H., Brenmoehl J., Wild P.J., Hahn J., Eissner G., Scholmerich J., and Andreesen R. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104 (2004) 889-894
38. Holt P.G., and Sly P.D. Interactions between respiratory tract infections and atopy in the aetiology of asthma. Eur. Respir. J. 19 (2002) 538-545
39. Hsu Y.M., Zhang Y., You Y., Wang D., Li H., Duramad O., Qin X.F., Dong C., and Lin X. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8 (2007) 198-205
40. Hugot J.P., Chamaillard M., Zouali H., Lesage S., Cezard J.P., Belaiche J., Almer S., Tysk C., O'Morain C.A., Gassull M., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 (2001) 599-603
41. Hysi P., Kabesch M., Moffatt M.F., Schedel M., Carr D., Zhang Y., Boardman B., von Mutius E., Weiland S.K., Leupold W., et al. NOD1 variation, immunoglobulin E and asthma. Hum. Mol. Genet. 14 (2005) 935-941
42. Inohara N., and Nunez G. The NOD: a signaling module that regulates apoptosis and host defense against pathogens. Oncogene 20 (2001) 6473-6481
43. Inohara N., and Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3 (2003) 371-382
44. Inohara N., Koseki T., del Peso L., Hu Y., Yee C., Chen S., Carrio R., Merino J., Liu D., Ni J., and Nunez G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem. 274 (1999) 14560-14567
45. Inohara N., Ogura Y., and Nunez G. Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr. Opin. Microbiol. 5 (2002) 76-80
46. Inohara N., Ogura Y., Fontalba A., Gutierrez O., Pons F., Crespo J., Fukase K., Inamura S., Kusumoto S., Hashimoto M., et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278 (2003) 5509-5512
47. Inohara N., Chamaillard M., McDonald C., and Nunez G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu. Rev. Biochem. 74 (2005) 355-383
48. + release. Am. J. Physiol. Cell Physiol. 286 (2004) C1100-C1108
49. Kanazawa N., Okafuji I., Kambe N., Nishikomori R., Nakata-Hizume M., Nagai S., Fuji A., Yuasa T., Manki A., Sakurai Y., et al. Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. Blood 105 (2005) 1195-1197
50. Kanneganti T.D., Body-Malapel M., Am A., Park J.H., Whitfield J., Franchi L., Taraporewala Z.F., Miller D., Patton J.T., Inohara N., and Nunez G. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281 (2006) 36560-36568
51. Kanneganti T.D., Ozoren N., Body-Malapel M., Am A., Park J.H., Franchi L., Whitfield J., Barchet W., Colonna M., Vandenabeele P., et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440 (2006) 233-236
52. Kanneganti T.D., Lamkanfi M., Kim Y.G., Chen G., Park J.H., Franchi L., Vandenabeele P., and Nunez G. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 26 (2007) 433-443
53. Kawai T., and Akira S. TLR signaling. Cell Death Differ. 13 (2006) 816-825
54. Kim J.G., Lee S.J., and Kagnoff M.F. Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infect. Immun. 72 (2004) 1487-1495
55. Kobayashi K., Inohara N., Hernandez L.D., Galan J.E., Nunez G., Janeway C.A., Medzhitov R., and Flavell R.A. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 (2002) 194-199
56. Kobayashi K.S., Chamaillard M., Ogura Y., Henegariu O., Inohara N., Nunez G., and Flavell R.A. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 (2005) 731-734
57. Lamkanfi M., Declercq W., Kalai M., Saelens X., and Vandenabeele P. Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ. 9 (2002) 358-361
58. Lamkanfi M., Am A., Kanneganti T.D., Munoz-Planillo R., Chen G., Vandenabeele P., Fortier A., Gros P., and Nunez G. The Nod-like receptor (NLR) family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J. Immunol. 178 (2007) 8022-8027
59. Leppla S.H., Arora N., and Varughese M. Anthrax toxin fusion proteins for intracellular delivery of macromolecules. J. Appl. Microbiol. 87 (1999) 284
60. Li J., Moran T., Swanson E., Julian C., Harris J., Bonen D.K., Hedl M., Nicolae D.L., Abraham C., and Cho J.H. Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum. Mol. Genet. 13 (2004) 1715-1725
61. Locovei S., Scemes E., Qiu F., Spray D.C., and Dahl G. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett. 581 (2007) 483-488
62. Mackey D., Holt III B.F., Wiig A., and Dangl J.L. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell 108 (2002) 743-754
63. Mackey D., Belkhadir Y., Alonso J.M., Ecker J.R., and Dangl J.L. Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance. Cell 112 (2003) 379-389
64. Maeda S., Hsu L.C., Liu H., Bankston L.A., Iimura M., Kagnoff M.F., Eckmann L., and Karin M. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307 (2005) 734-738
65. Mariathasan S., Newton K., Monack D.M., Vucic D., French D.M., Lee W.P., Roose-Girma M., Erickson S., and Dixit V.M. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 (2004) 213-218
66. Mariathasan S., Weiss D.S., Dixit V.M., and Monack D.M. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J. Exp. Med. 202 (2005) 1043-1049
67. Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K., Roose-Girma M., Lee W.P., Weinrauch Y., Monack D.M., and Dixit V.M. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440 (2006) 228-232
68. Martinon F., and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117 (2004) 561-574
69. Martinon F., Burns K., and Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10 (2002) 417-426
70. Martinon F., Petrilli V., Mayor A., Tardivel A., and Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006) 237-241
71. Masumoto J., Yang K., Varambally S., Hasegawa M., Tomlins S.A., Qiu S., Fujimoto Y., Kawasaki A., Foster S.J., Horie Y., et al. Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J. Exp. Med. 203 (2006) 203-213
72. Meylan E., and Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol. Cell 22 (2006) 561-569
73. Miao E.A., Alpuche-Aranda C.M., Dors M., Clark A.E., Bader M.W., Miller S.I., and Aderem A. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7 (2006) 569-575
74. Miceli-Richard C., Lesage S., Rybojad M., Prieur A.M., Manouvrier-Hanu S., Hafner R., Chamaillard M., Zouali H., Thomas G., and Hugot J.P. CARD15 mutations in Blau syndrome. Nat. Genet. 29 (2001) 19-20
75. Molofsky A.B., Byrne B.G., Whitfield N.N., Madigan C.A., Fuse E.T., Tateda K., and Swanson M.S. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J. Exp. Med. 203 (2006) 1093-1104
76. Nenci A., Becker C., Wullaert A., Gareus R., van Loo G., Danese S., Huth M., Nikolaev A., Neufert C., Madison B., et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446 (2007) 557-561
77. Netea M.G., Ferwerda G., de Jong D.J., Girardin S.E., Kullberg B.J., and van der Meer J.W. NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype. Neth. J. Med. 63 (2005) 305-308
78. Netea M.G., Ferwerda G., de Jong D.J., Jansen T., Jacobs L., Kramer M., Naber T.H., Drenth J.P., Girardin S.E., Kullberg B.J., et al. Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J. Immunol. 174 (2005) 6518-6523
79. Ogura Y., Bonen D.K., Inohara N., Nicolae D.L., Chen F.F., Ramos R., Britton H., Moran T., Karaliuskas R., Duerr R.H., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 (2001) 603-606
80. Ogura Y., Inohara N., Benito A., Chen F.F., Yamaoka S., and Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J. Biol. Chem. 276 (2001) 4812-4818
81. Opitz B., Forster S., Hocke A.C., Maass M., Schmeck B., Hippenstiel S., Suttorp N., and Krull M. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ. Res. 96 (2005) 319-326
82. Opitz B., Puschel A., Schmeck B., Hocke A.C., Rosseau S., Hammerschmidt S., Schumann R.R., Suttorp N., and Hippenstiel S. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J. Biol. Chem. 279 (2004) 36426-36432
83. Park J.H., Kim Y.G., McDonald C., Kanneganti T.D., Hasegawa M., Body-Malapel M., Inohara N., and Nunez G. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J. Immunol. 178 (2007) 2380-2386
84. Pauleau A.L., and Murray P.J. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol. Cell. Biol. 23 (2003) 7531-7539
85. Pelegrin P., and Surprenant A. Pannexin-1 couples to maitotoxin and nigericin-induced IL-1beta release through a dye-uptake independent pathway. J. Biol. Chem. 282 (2006) 2386-2394
86. Pelegrin P., and Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 25 (2006) 5071-5082
87. Petrilli V., Papin S., Dostert C., Mayor A., Martinon F., and Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14 (2007) 1583-1589
88. Ren T., Zamboni D.S., Roy C.R., Dietrich W.F., and Vance R.E. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog. 2 (2006) e18
89. Roberts J.E., Watters J.W., Ballard J.D., and Dietrich W.F. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol. Microbiol. 29 (1998) 581-591
90. Rosengren S., Mueller J.L., Anderson J.P., Niehaus B.L., Misaghi A., Anderson S., Boyle D.L., and Hoffman H.M. Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J. Allergy Clin. Immunol. 119 (2007) 991-996
91. Sutterwala F.S., Ogura Y., Szczepanik M., Lara-Tejero M., Lichtenberger G.S., Grant E.P., Bertin J., Coyle A.J., Galan J.E., Askenase P.W., and Flavell R.A. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24 (2006) 317-327
92. Tanabe T., Chamaillard M., Ogura Y., Zhu L., Qiu S., Masumoto J., Ghosh P., Moran A., Predergast M.M., Tromp G., et al. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J. 23 (2004) 1587-1597
93. Torres D., Barrier M., Bihl F., Quesniaux V.J., Maillet I., Akira S., Ryffel B., and Erard F. Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect. Immun. 72 (2004) 2131-2139
94. van Heel D.A., Ghosh S., Butler M., Hunt K.A., Lundberg A.M., Ahmad T., McGovern D.P., Onnie C., Negoro K., Goldthorpe S., et al. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 365 (2005) 1794-1796
95. Vazquez-Torres A., Vallance B.A., Bergman M.A., Finlay B.B., Cookson B.T., Jones-Carson J., and Fang F.C. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J. Immunol. 172 (2004) 6202-6208
96. Viala J., Chaput C., Boneca I.G., Cardona A., Girardin S.E., Moran A.P., Athman R., Memet S., Huerre M.R., Coyle A.J., et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat. Immunol. 5 (2004) 1166-1174
97. Watanabe T., Kitani A., Murray P.J., Wakatsuki Y., Fuss I.J., and Strober W. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25 (2006) 473-485
98. Wehkamp J., Salzman N.H., Porter E., Nuding S., Weichenthal M., Petras R.E., Shen B., Schaeffeler E., Schwab M., Linzmeier R., et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. USA 102 (2005) 18129-18134
99. Welter-Stahl L., Ojcius D.M., Viala J., Girardin S., Liu W., Delarbre C., Philpott D., Kelly K.A., and Darville T. Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum. Cell. Microbiol. 8 (2006) 1047-1057
100. Windheim M., Lang C., Peggie M., Plater L.A., and Cohen P. Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem. J. 404 (2007) 179-190
101. Wright E.K., Goodart S.A., Growney J.D., Hadinoto V., Endrizzi M.G., Long E.M., Sadigh K., Abney A.L., Bernstein-Hanley I., and Dietrich W.F. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13 (2003) 27-36
102. Yamamoto M., Yaginuma K., Tsutsui H., Sagara J., Guan X., Seki E., Yasuda K., Yamamoto M., Akira S., Nakanishi K., et al. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 9 (2004) 1055-1067
103. Zamboni D.S., Kobayashi K.S., Kohlsdorf T., Ogura Y., Long E.M., Vance R.E., Kuida K., Mariathasan S., Dixit V.M., Flavell R.A., et al. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat. Immunol. 7 (2006) 318-325
104. Zilbauer M., Dorrell N., Elmi A., Lindley K.J., Schuller S., Jones H.E., Klein N.J., Nunez G., Wren B.W., and Bajaj-Elliott M. A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni. Cell. Microbiol. 9 (2007) 2541-2548