The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Cell Death and Differentiation

Volumn 14, Issue 9, 2007, Pages 1590-1604

  Fernandes Alnemri, T ^a   Wu, J ^a   Yu, J W ^a   Datta, P ^a   Miller, B ^a   Jankowski, W ^a   Rosenberg, S ^a   Zhang, J ^a   Alnemri, E S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CYTOKINE; DIMER; ENZYME ACTIVATOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; POTASSIUM; PROTEIN ASC; PYROPTOSOME; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STIMULATION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DIMERIZATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; POTASSIUM DEPLETION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CASPASE 1; CYTOSKELETAL PROTEINS; DIMERIZATION; ENZYME ACTIVATION; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICROSCOPY, CONFOCAL; POTASSIUM; RECOMBINANT FUSION PROTEINS;

EID: 34548031870     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402194     Document Type: Article

References (42)

1. Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005; 26: 447-454.
2. Ting JP, Kastner DL, Hoffman HM. Caterpillars, pyrin and hereditary immunological disorders. Nat Rev Immunol 2006; 6: 183-195.
3. Delbridge LM, O'Riordan MX. Innate recognition of intracellular bacteria. Curr Opin Immunol 2007; 19: 10-16.
4. Dinarello CA. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann N Y Acad Sci 1998: 856: 1-11.
5. Martinon F, Burns K, Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proll-beta. Mol Cell 2002; 10: 417-426.
6. Mariathasan S, Monack DM. Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation. Nat Rev Immunol 2007; 7: 31-40.
7. Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S et al. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ 2006; 13: 236-249.
8. Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 2002; 277: 21119-21122. Epub 2002 Apr 19.
9. Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES. Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem 2001; 276: 28309-28313.
10. Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Mucide-Wells auto-inflammatory disorder. Immunity 2004; 20 319-325.
11. Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Beilly-Maitre B et al. Reconstituted NALP1 Inflammasome reveals two-step mechanism of cespase-1 activation. Mol Cell 2007; 25: 713-724.
12. Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 2006; 38: 240-244.
13. Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, Franchi L et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 2006: 440: 233-236.
14. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Ginna M et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440: 228-232.
15. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 Inflammasome. Nature 2006; 440: 237-241.
16. Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, Taraporewala ZF et al. Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006; 281: 36560-36568.
17. Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 2006; 24: 317-327.
18. Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 1999; 274 33835-33838.
19. Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004; 430: 213-218. Epub 2004 Jun 09.
20. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E et al. ASC is essential for LPS-Induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 2004; 9: 1055-1067.
21. Mariathasan S, Weiss DS, Dixit VM, Monack DM. Innate Immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 2005; 202: 1043-1049.
22. Swanson MS, Molofsky AB. Autophagy and inflammatory cell death, partners of innate immunity. Autophagy 2005; 1: 174-176.
23. Fink SL, Cookson BT. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 2006; 8: 1812-1825.
24. Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73: 1907-1916.
25. Cookson BT, Brennan MA. Pro-inflammatory programmed cell death. Trends Microbiol 2001; 9: 113-114.
26. Monack DM, Navarre WW, Falkow S. Salmonella-inducid macrophage death: the role of caspase-1 in death and inflammation. Microbes Infect 2001; 3: 1201-1212.
27. Wamy M, Kelly CP. Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases. Am J Physiol 1999; 276 C717-C724.
28. Perregaux D, Gabel CA. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 1994; 269: 15195-15203.
29. Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. Embo J 2000; 19: 3325-3336.
30. Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999; 285: 736-739.
31. Aliprantis AO, Weiss DS, Radolf JD, Zychlinsky A. Release of Toll-like receptol-2, activating bacterial lipoproteins in Shigella flexneri culture supematants. Infect Immun 2001; 69: 6248-6255.
32. Aliprantis AO, Weiss DS, Zychlinsky A. Toll-like receptor-2 transduces signals for NF-kappa B activation, apoptosis and reactive oxygen species production. J Endotoxin Res 2001; 7: 287-291.
33. Moriya M, Taniguchi S, Wu P, Liepinsh E, Otting G, Sagara J. Role of charged and hydrophobic residues in the oligomerizetion of the PYRIN domain of ASC. Biochemistry 2005; 44: 575-583.
34. Walev I, Reske K, Palmer M, Valeva A, Bhakdi S. Potassim-inhibited processing of IL-1 beta in human monocytes. EMBO J 1995; 14: 1607-1614.
35. Cain K, Langlais C, Sun XM, Brown DG, Cohen GM. Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome. J Biol Chem 2001; 276: 41985-41990.
36. Locovei S, Scemes E, Qiu F, Spray DC, Dahl G. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett 2007; 581: 483-488.
37. Pelegrin P, Surprenant A. Pannexin-1 couples to maitotoxin- and nigericin-induced inteleukin-1beta release through a dye uptake-independent pathway. J Biol Chem 2007; 282: 2386-2394.
38. Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 2006; 25: 5071-5082.
39. Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L et al. Pannexin-1-mediated recognition of bactarial molecules activates the cryopyrin inflammasome independent of toll-like receptor signaling. Immunity 2007; 26: 433-443.
40. Martinon F, Tschopp J. Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117: 561-574.
41. Andersson B, Behnam-Motlagh P, Henriksson R, Grankvist K. Pharmacological modulation of lung cancer cells for potassium ion depletion. Anticancer Res 2005; 25: 2609-2616.
42. Petsev DN, Thomas BR, Yau S, Vekilov PG. Interactions and aggregation of apoferritin molecules in solution: Effects of added electrolytes. Biophys J 2000; 78: 2060-2069.