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Volumn 11, Issue 4, 2004, Pages 379-389

Osteoarthritis gene therapy

Author keywords

Arthritis; Cartilage; Clinical trial; IL 1Ra; Joint; Synovium

Indexed keywords

ANALGESIC AGENT; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 2; FIBROBLAST GROWTH FACTOR; FRUCTOKINASE; HYALURONIC ACID; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 4; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; OSTEOGENIC PROTEIN 1; PARACETAMOL; PROTEIN BCL 2; SERINE PROTEINASE INHIBITOR; SMAD PROTEIN; SOMATOMEDIN C; STEROID; SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 1342285045     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302196     Document Type: Review
Times cited : (120)

References (134)
  • 1
    • 0036707745 scopus 로고    scopus 로고
    • Impact of osteoarthritis on individuals and society: How much disability? Social consequences and health economic implications
    • Brooks PM. Impact of osteoarthritis on individuals and society: how much disability? Social consequences and health economic implications. Curr Opin Rheumatol 2002; 14: 573-577.
    • (2002) Curr. Opin. Rheumatol. , vol.14 , pp. 573-577
    • Brooks, P.M.1
  • 3
    • 0034304209 scopus 로고    scopus 로고
    • The increasing impact of arthritis on public health
    • Elders MJ. The increasing impact of arthritis on public health. J Rheumatol Suppl 2000; 60: 6-8.
    • (2000) J. Rheumatol. Suppl. , vol.60 , pp. 6-8
    • Elders, M.J.1
  • 4
    • 0033036390 scopus 로고    scopus 로고
    • Potential treatment of osteoarthritis by gene therapy
    • Evans CH, Robbins PD. Potential treatment of osteoarthritis by gene therapy. Rheum Dis Clin North Am 1999; 25: 333-344.
    • (1999) Rheum. Dis. Clin. North Am. , vol.25 , pp. 333-344
    • Evans, C.H.1    Robbins, P.D.2
  • 5
    • 1342279178 scopus 로고    scopus 로고
    • Gene therapies for osteoarthritis
    • in press
    • Evans CH. Gene therapies for osteoarthritis. Curr Rheumatol Rep 2003, in press.
    • (2003) Curr. Rheumatol. Rep.
    • Evans, C.H.1
  • 6
    • 0036598716 scopus 로고    scopus 로고
    • Osteoarthritis
    • Dieppe P et al. Osteoarthritis. Clin Evid 2002; 7: 1071-1090.
    • (2002) Clin. Evid. , vol.7 , pp. 1071-1090
    • Dieppe, P.1
  • 7
    • 0036083985 scopus 로고    scopus 로고
    • Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects
    • Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002; 10: 432-463.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 432-463
    • Hunziker, E.B.1
  • 9
    • 0009835470 scopus 로고    scopus 로고
    • Catilage and synovium
    • Baratz ME, Watson AD, Imbriglia JE (eds). Thieme: New York
    • Evans CH. Catilage and synovium. In: Baratz ME, Watson AD, Imbriglia JE (eds). Orthopaedic Surgery. The Essentials. Thieme: New York, 1999, pp 33-46.
    • (1999) Orthopaedic Surgery. The Essentials , pp. 33-46
    • Evans, C.H.1
  • 12
    • 0033103091 scopus 로고    scopus 로고
    • Radiologic progression of hip and knee osteoarthritis
    • Ravaud F, Ayral X, Dougados M. Radiologic progression of hip and knee osteoarthritis. Osteoarthritis Cartilage 1999; 7: 222-229.
    • (1999) Osteoarthritis Cartilage , vol.7 , pp. 222-229
    • Ravaud, F.1    Ayral, X.2    Dougados, M.3
  • 13
    • 0020661113 scopus 로고
    • The nature and causes of osteoarthrosis
    • Gardner DL. The nature and causes of osteoarthrosis. BMJ (Clin Res Ed) 1983; 286: 418-424.
    • (1983) BMJ (Clin Res Ed) , vol.286 , pp. 418-424
    • Gardner, D.L.1
  • 15
    • 0034971296 scopus 로고    scopus 로고
    • Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets
    • Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001; 44: 1237-1247.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1237-1247
    • Pelletier, J.P.1    Martel-Pelletier, J.2    Abramson, S.B.3
  • 16
    • 0021320010 scopus 로고
    • Experimental arthritis induced by intraarticular injection of allogenic cartilaginous particles into rabbit knees
    • Evans CH et al. Experimental arthritis induced by intraarticular injection of allogenic cartilaginous particles into rabbit knees. Arthritis Rheum 1984; 27: 200-207.
    • (1984) Arthritis Rheum. , vol.27 , pp. 200-207
    • Evans, C.H.1
  • 17
    • 0033299421 scopus 로고    scopus 로고
    • Crystal-induced inflammation and cartilage degradation
    • McCarthy GM. Crystal-induced inflammation and cartilage degradation. Curr Rheumatol Rep 1999; 1: 101-106.
    • (1999) Curr. Rheumatol. Rep. , vol.1 , pp. 101-106
    • McCarthy, G.M.1
  • 19
    • 0032990777 scopus 로고    scopus 로고
    • The role of cytokines as inflammatory mediators in osteoarthritis: Lessons from animal models
    • Goldring MB. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res 1999; 40: 1-11.
    • (1999) Connect Tissue Res. , vol.40 , pp. 1-11
    • Goldring, M.B.1
  • 20
    • 0031047265 scopus 로고    scopus 로고
    • Synovial membrane inflammation and cytokine production in patients with early osteoarthritis
    • Smith MD et al. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 1997; 24: 365-371.
    • (1997) J. Rheumatol. , vol.24 , pp. 365-371
    • Smith, M.D.1
  • 21
    • 0033569188 scopus 로고    scopus 로고
    • An introduction to the pathophysiology of osteoarthritis
    • Poole AR. An introduction to the pathophysiology of osteoarthritis. Front Biosci 1999; 4: D662-670.
    • (1999) Front Biosci. , vol.4
    • Poole, A.R.1
  • 22
    • 0035076295 scopus 로고    scopus 로고
    • Articular cartilage and changes in arthritis. An introduction: Cell biology of osteoarthritis
    • Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 2001; 3: 107-113.
    • (2001) Arthritis Res. , vol.3 , pp. 107-113
    • Sandell, L.J.1    Aigner, T.2
  • 23
    • 0031886742 scopus 로고    scopus 로고
    • Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology
    • Blanco FJ et al. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 1998; 41: 284-289.
    • (1998) Arthritis Rheum. , vol.41 , pp. 284-289
    • Blanco, F.J.1
  • 24
    • 0034966785 scopus 로고    scopus 로고
    • Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: A study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage
    • Aigner T et al. Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 2001; 44: 1304-1312.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1304-1312
    • Aigner, T.1
  • 25
    • 0036675540 scopus 로고    scopus 로고
    • Apoptosis and cellular vitality: Issues in osteoarthritic cartilage degeneration
    • Aigner T, Kim HA. Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration. Arthritis Rheum 2002; 46: 1986-1996.
    • (2002) Arthritis Rheum. , vol.46 , pp. 1986-1996
    • Aigner, T.1    Kim, H.A.2
  • 26
    • 0036707739 scopus 로고    scopus 로고
    • Roles of chondrocytes in the pathogenesis of osteoarthritis
    • Aigner T et al. Roles of chondrocytes in the pathogenesis of osteoarthritis. Curr Opin Rheumatol 2002; 14: 578-584.
    • (2002) Curr. Opin. Rheumatol. , vol.14 , pp. 578-584
    • Aigner, T.1
  • 27
    • 0030936759 scopus 로고    scopus 로고
    • Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage
    • Aigner T et al. Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage. Arthritis Rheum 1997; 40: 562-569.
    • (1997) Arthritis Rheum. , vol.40 , pp. 562-569
    • Aigner, T.1
  • 28
    • 0025811018 scopus 로고
    • Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection
    • Adams ME, Brandt KD. Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J Rheumatol 1991; 18: 428-435.
    • (1991) J. Rheumatol. , vol.18 , pp. 428-435
    • Adams, M.E.1    Brandt, K.D.2
  • 29
    • 0036838547 scopus 로고    scopus 로고
    • Type II collagen degradation and its regulation in articular cartilage in osteoarthritis
    • Poole AR et al. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis 2002; 61 (Suppl 2): ii78-ii81.
    • (2002) Ann. Rheum. Dis. , vol.61 , Issue.SUPPL. 2
    • Poole, A.R.1
  • 30
    • 0027531738 scopus 로고
    • Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage
    • Aigner T et al. Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage. J Clin Invest 1993; 91: 829-837.
    • (1993) J. Clin. Invest. , vol.91 , pp. 829-837
    • Aigner, T.1
  • 31
    • 0000263201 scopus 로고    scopus 로고
    • Degradative enzymes in osteoarthritis
    • Smith RL. Degradative enzymes in osteoarthritis. Front Biosci 1999; 4: D704-12.
    • (1999) Front Biosci. , vol.4
    • Smith, R.L.1
  • 32
    • 0036516460 scopus 로고    scopus 로고
    • Matrix metalloproteinases: A tail of a frog that became a prince
    • Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002; 3: 207-214.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 207-214
    • Brinckerhoff, C.E.1    Matrisian, L.M.2
  • 33
    • 0036185667 scopus 로고    scopus 로고
    • Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding
    • Blobel CP. Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding. Inflamm Res 2002; 51: 83-84.
    • (2002) Inflamm. Res. , vol.51 , pp. 83-84
    • Blobel, C.P.1
  • 34
    • 0038639763 scopus 로고    scopus 로고
    • Aggrecanases and cartilage matrix degradation
    • Nagase H, Kashiwagi M. Aggrecanases and cartilage matrix degradation. Arthritis Res Ther 2003; 5: 94-103.
    • (2003) Arthritis Res. Ther. , vol.5 , pp. 94-103
    • Nagase, H.1    Kashiwagi, M.2
  • 36
    • 0033065891 scopus 로고    scopus 로고
    • Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants
    • Tiku ML, Gupta S, Deshmukh DR. Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants. Free Radic Res 1999; 30: 395-405.
    • (1999) Free Radic. Res. , vol.30 , pp. 395-405
    • Tiku, M.L.1    Gupta, S.2    Deshmukh, D.R.3
  • 37
    • 0035008314 scopus 로고    scopus 로고
    • Activation of stress-activated protein kinase in osteoarthritic cartilage: Evidence for nitric oxide dependence
    • Clancy R et al. Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence. Osteoarthritis Cartilage 2001; 9: 294-299.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 294-299
    • Clancy, R.1
  • 38
    • 0033166768 scopus 로고    scopus 로고
    • The role of COX-2 produced by cartilage in arthritis
    • Abramson SB. The role of COX-2 produced by cartilage in arthritis. Osteoarthritis Cartilage 1999; 7: 380-381.
    • (1999) Osteoarthritis Cartilage , vol.7 , pp. 380-381
    • Abramson, S.B.1
  • 40
    • 0035997484 scopus 로고    scopus 로고
    • Interleukin 17 induces cartilage collagen breakdown: Novel synergistic effects in combination with proinflammatory cytokines
    • Koshy PJ et al. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann Rheum Dis 2002; 61: 704-713.
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. 704-713
    • Koshy, P.J.1
  • 41
    • 0033556175 scopus 로고    scopus 로고
    • IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
    • Olee T et al. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J Immunol 1999; 162: 1096-1100.
    • (1999) J. Immunol. , vol.162 , pp. 1096-1100
    • Olee, T.1
  • 42
    • 0035025717 scopus 로고    scopus 로고
    • The role of C-C chemokines and their receptors in osteoarthritis
    • Yuan GH et al. The role of C-C chemokines and their receptors in osteoarthritis. Arthritis Rheum 2001; 44: 1056-1070.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1056-1070
    • Yuan, G.H.1
  • 43
    • 0033430364 scopus 로고    scopus 로고
    • Chemokine production by human chondrocytes
    • Pulsatelli L et al. Chemokine production by human chondrocytes. J Rheumatol 1999; 26: 1992-2001.
    • (1999) J. Rheumatol. , vol.26 , pp. 1992-2001
    • Pulsatelli, L.1
  • 44
    • 0032127059 scopus 로고    scopus 로고
    • Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid
    • Homandberg GA, Wen C, Hui F. Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid. Osteoarthritis Cartilage 1998; 6: 231-244.
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 231-244
    • Homandberg, G.A.1    Wen, C.2    Hui, F.3
  • 45
    • 0033297928 scopus 로고    scopus 로고
    • The role of crystals in articular tissue degeneration
    • Cheung HS. The role of crystals in articular tissue degeneration. Curr Rheumatol Rep 1999; 1: 128-131.
    • (1999) Curr. Rheumatol. Rep. , vol.1 , pp. 128-131
    • Cheung, H.S.1
  • 46
    • 0038622976 scopus 로고    scopus 로고
    • Advanced glycation endproducts and osteoarthritis
    • Saudek DM, Kay J. Advanced glycation endproducts and osteoarthritis. Curr Rheumatol Rep 2003; 5: 33-40.
    • (2003) Curr. Rheumatol. Rep. , vol.5 , pp. 33-40
    • Saudek, D.M.1    Kay, J.2
  • 47
    • 0034578147 scopus 로고    scopus 로고
    • Cartilage tissue remodeling in response to mechanical forces
    • Grodzinsky AJ et al. Cartilage tissue remodeling in response to mechanical forces. Annu Rev Biomed Eng 2000; 2: 691-713.
    • (2000) Annu. Rev. Biomed. Eng. , vol.2 , pp. 691-713
    • Grodzinsky, A.J.1
  • 48
    • 0037589854 scopus 로고    scopus 로고
    • Signal transduction by mechanical strain in chondrocytes
    • Deschner J et al. Signal transduction by mechanical strain in chondrocytes. Curr Opin Clin Nutr Metab Care 2003; 6: 289-293.
    • (2003) Curr. Opin. Clin. Nutr. Metab. Care , vol.6 , pp. 289-293
    • Deschner, J.1
  • 49
    • 0024338070 scopus 로고
    • Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines
    • Tyler JA. Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines. Biochem J 1989; 260: 543-548.
    • (1989) Biochem. J. , vol.260 , pp. 543-548
    • Tyler, J.A.1
  • 50
    • 0033948430 scopus 로고    scopus 로고
    • Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro
    • Loeser RF, Shanker G. Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro. Arthritis Rheum 2000; 43: 1552-1559.
    • (2000) Arthritis Rheum. , vol.43 , pp. 1552-1559
    • Loeser, R.F.1    Shanker, G.2
  • 51
    • 0036486699 scopus 로고    scopus 로고
    • Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1
    • Fortier LA, Nixon AJ, Lust G. Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1. Am J Vet Res 2002; 63: 301-305.
    • (2002) Am. J. Vet. Res. , vol.63 , pp. 301-305
    • Fortier, L.A.1    Nixon, A.J.2    Lust, G.3
  • 52
    • 0031918202 scopus 로고    scopus 로고
    • IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis
    • Martel-Pelletier J et al. IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis. Inflamm Res 1998; 47: 90-100.
    • (1998) Inflamm. Res. , vol.47 , pp. 90-100
    • Martel-Pelletier, J.1
  • 53
    • 0033680154 scopus 로고    scopus 로고
    • Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: Studies in a non-human primate model of naturally occurring disease
    • Loeser RF et al. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum 2000; 43: 2110-2120.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2110-2120
    • Loeser, R.F.1
  • 54
    • 0033712592 scopus 로고    scopus 로고
    • Nitric oxide inhibits chondrocyte response to IGF-1: Inhibition of IGF-IRbeta tyrosine phosphorylation
    • Studer RK et al. Nitric oxide inhibits chondrocyte response to IGF-1: inhibition of IGF-IRbeta tyrosine phosphorylation. Am J Physiol Cell Physiol 2000; 279: C961-C969.
    • (2000) Am. J. Physiol. Cell Physiol. , vol.279
    • Studer, R.K.1
  • 55
    • 0030947810 scopus 로고    scopus 로고
    • Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage
    • Lafeber FP et al. Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage. J Rheumatol 1997; 24: 536-542.
    • (1997) J. Rheumatol. , vol.24 , pp. 536-542
    • Lafeber, F.P.1
  • 56
    • 0041534377 scopus 로고    scopus 로고
    • Development of gene-based therapies for cartilage repair
    • Palmer G et al. Development of gene-based therapies for cartilage repair. Crit Rev Eukaryot Gene Expr 2002; 12: 259-273.
    • (2002) Crit. Rev. Eukaryot. Gene Expr. , vol.12 , pp. 259-273
    • Palmer, G.1
  • 57
    • 20244384369 scopus 로고    scopus 로고
    • Inhibition of cartilage degradation: A combined tissue engineering and gene therapy approach
    • Kafienah W et al. Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach. Arthritis Rheum 2003; 48: 709-718.
    • (2003) Arthritis Rheum. , vol.48 , pp. 709-718
    • Kafienah, W.1
  • 58
    • 0036285850 scopus 로고    scopus 로고
    • Animal models of osteoarthritis
    • Brandt KD. Animal models of osteoarthritis. Biorheology 2002; 39: 221-235.
    • (2002) Biorheology , vol.39 , pp. 221-235
    • Brandt, K.D.1
  • 59
    • 0034816099 scopus 로고    scopus 로고
    • Lessons from animal models of osteoarthritis
    • van den Berg WB. Lessons from animal models of osteoarthritis. Curr Opin Rheumatol 2001; 13: 452-456.
    • (2001) Curr. Opin. Rheumatol. , vol.13 , pp. 452-456
    • van den Berg, W.B.1
  • 60
    • 0017396851 scopus 로고
    • An experimental model of osteoarthritis; early morphological and biochemical changes
    • McDevitt C, Gilbertson E, Muir H. An experimental model of osteoarthritis; early morphological and biochemical changes. J Bone Joint Surg Br 1977; 59: 24-35.
    • (1977) J. Bone Joint Surg. Br. , vol.59 , pp. 24-35
    • McDevitt, C.1    Gilbertson, E.2    Muir, H.3
  • 61
    • 0028849234 scopus 로고
    • Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee
    • American College of Rheumatology
    • Hochberg MC et al. Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. American College of Rheumatology. Arthritis Rheum 1995; 38: 1541-1546.
    • (1995) Arthritis Rheum. , vol.38 , pp. 1541-1546
    • Hochberg, M.C.1
  • 62
    • 0028806589 scopus 로고
    • Guidelines for the medical management of osteoarthritis. Part I. Osteoarthritis of the hip
    • American College of Rheumatology
    • Hochberg MC et al. Guidelines for the medical management of osteoarthritis. Part I. Osteoarthritis of the hip. American College of Rheumatology. Arthritis Rheum 1995; 38: 1535-1540.
    • (1995) Arthritis Rheum. , vol.38 , pp. 1535-1540
    • Hochberg, M.C.1
  • 63
    • 0037114930 scopus 로고    scopus 로고
    • Update: Treatment of osteoarthritis
    • Chard J, Dieppe P. Update: treatment of osteoarthritis. Arthritis Rheum 2002; 47: 686-690.
    • (2002) Arthritis Rheum. , vol.47 , pp. 686-690
    • Chard, J.1    Dieppe, P.2
  • 64
    • 0037271861 scopus 로고    scopus 로고
    • Evaluation and treatment of the arthritic knee
    • Garrett Jr W. Evaluation and treatment of the arthritic knee. J Bone Joint Surg Am 2003; 85-A: 156-157.
    • (2003) J. Bone Joint Surg. Am. , vol.85 A , pp. 156-157
    • Garrett Jr., W.1
  • 65
    • 0038284089 scopus 로고    scopus 로고
    • Joint irrigation as treatment for osteoarthritis
    • Bradley JD. Joint irrigation as treatment for osteoarthritis. Curr Rheumatol Rep 2003; 5: 20-26.
    • (2003) Curr. Rheumatol. Rep. , vol.5 , pp. 20-26
    • Bradley, J.D.1
  • 66
    • 0037063133 scopus 로고    scopus 로고
    • A controlled trial of arthroscopic surgery for osteoarthritis of the knee
    • Moseley JB et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347: 81-88.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 81-88
    • Moseley, J.B.1
  • 67
    • 0028080841 scopus 로고
    • Operative treatment of osteoarthrosis. Current practice and future development
    • Buckwalter JA, Lohmander S. Operative treatment of osteoarthrosis. Current practice and future development. J Bone Joint Surg Am 1994; 76: 1405-1418.
    • (1994) J. Bone Joint Surg. Am. , vol.76 , pp. 1405-1418
    • Buckwalter, J.A.1    Lohmander, S.2
  • 68
    • 0038304589 scopus 로고    scopus 로고
    • Glucosamine and chondroitin sulfate are effective in the management of osteoarthritis
    • Hungerford DS, Jones LC. Glucosamine and chondroitin sulfate are effective in the management of osteoarthritis. J Arthroplasty 2003; 18 (3 Suppl 1): 5-9.
    • (2003) J. Arthroplasty , vol.18 , Issue.3 SUPPL. 1 , pp. 5-9
    • Hungerford, D.S.1    Jones, L.C.2
  • 69
    • 0034770450 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors in rheumatic diseases
    • Close DR. Matrix metalloproteinase inhibitors in rheumatic diseases. Ann Rheum Dis 2001; 60 (Suppl 3): iii62-iii67.
    • (2001) Ann. Rheum. Dis. , vol.60 , Issue.SUPPL. 3
    • Close, D.R.1
  • 70
    • 0035070770 scopus 로고    scopus 로고
    • Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders
    • Darlington LG, Stone TW. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. Br J Nutr 2001; 85: 251-269.
    • (2001) Br. J. Nutr. , vol.85 , pp. 251-269
    • Darlington, L.G.1    Stone, T.W.2
  • 71
    • 0035460852 scopus 로고    scopus 로고
    • Anticytokine therapy for osteoarthritis
    • Goldring MB. Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther 2001; 1: 817-829.
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 817-829
    • Goldring, M.B.1
  • 72
    • 0033768503 scopus 로고    scopus 로고
    • The genetic contribution to radiographic hip osteoarthritis in women: Results of a classic twin study
    • MacGregor AJ et al. The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 2000; 43: 2410-2416.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2410-2416
    • MacGregor, A.J.1
  • 73
    • 0029058932 scopus 로고
    • Genes and arthritis
    • Wordsworth P. Genes and arthritis. Br Med Bull 1995; 51: 249-266.
    • (1995) Br. Med. Bull. , vol.51 , pp. 249-266
    • Wordsworth, P.1
  • 74
    • 0025009766 scopus 로고
    • Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia
    • Ala-Kokko L et al. Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia. Proc Natl Acad Sci USA 1990; 87: 6565-6568.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6565-6568
    • Ala-Kokko, L.1
  • 75
    • 0026644221 scopus 로고
    • Gene transfer to synoviocytes: Prospects for gene treatment of arthritis
    • Bandara G et al. Gene transfer to synoviocytes: prospects for gene treatment of arthritis. DNA Cell Biol 1992; 11: 227-231.
    • (1992) DNA Cell Biol. , vol.11 , pp. 227-231
    • Bandara, G.1
  • 77
    • 0035260627 scopus 로고    scopus 로고
    • Gene therapy for rheumatoid arthritis
    • Gouze E et al. Gene therapy for rheumatoid arthritis. Curr Rheumatol Rep 2001; 3: 79-85.
    • (2001) Curr. Rheumatol. Rep. , vol.3 , pp. 79-85
    • Gouze, E.1
  • 79
    • 0032917794 scopus 로고    scopus 로고
    • Gene therapy for rheumatic diseases
    • Evans CH et al. Gene therapy for rheumatic diseases. Arthritis Rheum 1999; 42: 1-16.
    • (1999) Arthritis Rheum. , vol.42 , pp. 1-16
    • Evans, C.H.1
  • 80
    • 0033775224 scopus 로고    scopus 로고
    • Using gene therapy to protect and restore cartilage
    • Evans CH et al. Using gene therapy to protect and restore cartilage. Clin Orthop 2000 (Suppl 379): S214-S219.
    • (2000) Clin. Orthop. , Issue.SUPPL. 379
    • Evans, C.H.1
  • 81
    • 0001762706 scopus 로고    scopus 로고
    • Direct gene delivery strategies for the treatment of rheumatoid arthritis
    • Ghivizzani SC et al. Direct gene delivery strategies for the treatment of rheumatoid arthritis. Drug Discov Today 2001; 6: 259-267.
    • (2001) Drug Discov. Today , vol.6 , pp. 259-267
    • Ghivizzani, S.C.1
  • 82
    • 0033771094 scopus 로고    scopus 로고
    • Vector systems for gene transfer to joints
    • Oligino TJ et al. Vector systems for gene transfer to joints. Clin Orthop 2000 (Suppl 379): S17-30.
    • (2000) Clin. Orthop. , Issue.SUPPL. 379
    • Oligino, T.J.1
  • 83
    • 0029874283 scopus 로고    scopus 로고
    • Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo
    • Nita I et al. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996; 39: 820-828.
    • (1996) Arthritis Rheum. , vol.39 , pp. 820-828
    • Nita, I.1
  • 84
    • 0027435633 scopus 로고
    • Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer
    • Bandara G et al. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 1993; 90: 10764-10768.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10764-10768
    • Bandara, G.1
  • 85
    • 0036226899 scopus 로고    scopus 로고
    • In vivo gene delivery to synovium by lentiviral vectors
    • Gouze E et al. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 2002; 5: 397-404.
    • (2002) Mol. Ther. , vol.5 , pp. 397-404
    • Gouze, E.1
  • 86
    • 0033763544 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints
    • Mi Z et al. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum 2000; 43: 2563-2570.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2563-2570
    • Mi, Z.1
  • 87
    • 0042622575 scopus 로고    scopus 로고
    • Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees
    • Mi Z et al. Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther 2003; 5: R132-9.
    • (2003) Arthritis Res. Ther. , vol.5
    • Mi, Z.1
  • 88
    • 0035090484 scopus 로고    scopus 로고
    • Overexpression of active TGF-beta-1 in the murine knee joint: Evidence for synovial-layer-dependent chondro-osteophyte formation
    • Bakker AC et al. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. Osteoarthritis Cartilage 2001; 9: 128-136.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 128-136
    • Bakker, A.C.1
  • 89
    • 0034885826 scopus 로고    scopus 로고
    • Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer
    • Gelse K et al. Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer. Arthritis Rheum 2001; 44: 1943-1953.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1943-1953
    • Gelse, K.1
  • 90
    • 1342321515 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist
    • Thomson AW, Lotz MT (eds). Academic Press: London
    • Arend WP, Evans CH. Interleukin-1 receptor antagonist. In: Thomson AW, Lotz MT (eds). The Cytokine Handbook. Academic Press: London, 2003, pp 669-708.
    • (2003) The Cytokine Handbook , pp. 669-708
    • Arend, W.P.1    Evans, C.H.2
  • 91
    • 1342279175 scopus 로고    scopus 로고
    • Gene mediated restoration of cartilage matrix by combination insulin-like growth factor-1/interleukin-1 receptor antagonist therapy
    • in press
    • Nixon AJ et al. Gene mediated restoration of cartilage matrix by combination insulin-like growth factor-1/interleukin-1 receptor antagonist therapy. Gene Therapy 2003, in press.
    • (2003) Gene Therapy
    • Nixon, A.J.1
  • 92
    • 1342321513 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer to glutamine:fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1 beta on rat chondrocytes
    • in press
    • Gouze JN et al. Adenovirus-mediated gene transfer to glutamine:fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1 beta on rat chondrocytes. Osteoarthritis Cartilage 2003, in press.
    • (2003) Osteoarthritis Cartilage
    • Gouze, J.N.1
  • 93
    • 0038687289 scopus 로고    scopus 로고
    • Gene transfer to articular chondrocytes with recombinant adenovirus
    • Palmer GD et al. Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol 2003; 215: 235-246.
    • (2003) Methods Mol. Biol. , vol.215 , pp. 235-246
    • Palmer, G.D.1
  • 94
    • 0036247817 scopus 로고    scopus 로고
    • Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices
    • Samuel RE et al. Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices. Hum Gene Ther 2002; 13: 791-802.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 791-802
    • Samuel, R.E.1
  • 95
    • 0030893301 scopus 로고    scopus 로고
    • Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study
    • Kang R et al. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cartilage 1997; 5: 139-143.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 139-143
    • Kang, R.1
  • 96
    • 0036184684 scopus 로고    scopus 로고
    • Lipofection of rabbit chondrocytes and long lasting expression of a lacZ reporter system in alginate beads
    • Stove J et al. Lipofection of rabbit chondrocytes and long lasting expression of a lacZ reporter system in alginate beads. Osteoarthritis Cartilage 2002; 10: 212-217.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 212-217
    • Stove, J.1
  • 97
    • 0034782732 scopus 로고    scopus 로고
    • Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Zurakowski D, Trippel SB. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Therapy 2001; 8: 1443-1449.
    • (2001) Gene Therapy , vol.8 , pp. 1443-1449
    • Madry, H.1    Zurakowski, D.2    Trippel, S.B.3
  • 98
    • 0034232660 scopus 로고    scopus 로고
    • Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes
    • Shuler FD et al. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes. J Orthop Res 2000; 18: 585-592.
    • (2000) J. Orthop. Res. , vol.18 , pp. 585-592
    • Shuler, F.D.1
  • 99
    • 0035915777 scopus 로고    scopus 로고
    • Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function
    • Brower-Toland BD et al. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 2001; 12: 117-129.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 117-129
    • Brower-Toland, B.D.1
  • 100
    • 0034091315 scopus 로고    scopus 로고
    • Genetic enhancement of matrix synthesis by articular chondrocytes: Comparison of different growth factor genes in the presence and absence of interleukin-1
    • Smith P et al. Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 2000; 43: 1156-1164.
    • (2000) Arthritis Rheum. , vol.43 , pp. 1156-1164
    • Smith, P.1
  • 101
    • 0031786744 scopus 로고    scopus 로고
    • Adenovirus mediated gene delivery to the joints of guinea pigs
    • Ikeda T et al. Adenovirus mediated gene delivery to the joints of guinea pigs. J Rheumatol 1998; 25: 1666-1673.
    • (1998) J. Rheumatol. , vol.25 , pp. 1666-1673
    • Ikeda, T.1
  • 102
    • 0033771009 scopus 로고    scopus 로고
    • Potential applications of gene therapy to the treatment of intervertebral disc disorders
    • Nishida K et al. Potential applications of gene therapy to the treatment of intervertebral disc disorders. Clin Orthop 2000 (Suppl 379): 3795: S234-41.
    • (2000) Clin. Orthop. , vol.3795 , Issue.SUPPL. 379
    • Nishida, K.1
  • 103
    • 0030740745 scopus 로고    scopus 로고
    • Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
    • Baragi VM et al. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo. Osteoarthritis Cartilage 1997; 5: 275-282.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 275-282
    • Baragi, V.M.1
  • 104
    • 0034800546 scopus 로고    scopus 로고
    • Autologous chondrocytes used for articular cartilage repair: An update
    • Brittberg M et al. Autologous chondrocytes used for articular cartilage repair: an update. Clin Orthop 2001 (391 Suppl): S337-S348.
    • (2001) Clin. Orthop. , Issue.391 SUPPL.
    • Brittberg, M.1
  • 105
    • 0033925453 scopus 로고    scopus 로고
    • Adhesion of transplanted chondrocytes onto cartilage in vitro and in vivo
    • Doherty PJ et al. Adhesion of transplanted chondrocytes onto cartilage in vitro and in vivo. J Rheumatol 2000; 27: 1725-1731.
    • (2000) J. Rheumatol. , vol.27 , pp. 1725-1731
    • Doherty, P.J.1
  • 106
    • 0028799826 scopus 로고
    • Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation
    • Baragi VM et al. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest 1995; 96: 2454-2460.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2454-2460
    • Baragi, V.M.1
  • 107
    • 84942872625 scopus 로고    scopus 로고
    • Interleukin-1 family
    • Thomson AW, Lotz MT (eds). Academic Press: London
    • Dinarello CA. Interleukin-1 family. In: Thomson AW, Lotz MT (eds). The Cytokine Handbook. Academic Press: London, 2003, pp 643-668.
    • (2003) The Cytokine Handbook , pp. 643-668
    • Dinarello, C.A.1
  • 108
    • 0027389684 scopus 로고
    • Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis - An immunohistochemical study
    • Pelletier JP et al. Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis - an immunohistochemical study. Am J Pathol 1993; 142: 95-105.
    • (1993) Am. J. Pathol. , vol.142 , pp. 95-105
    • Pelletier, J.P.1
  • 109
    • 0029814957 scopus 로고    scopus 로고
    • Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression
    • Caron JP et al. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 1996; 39: 1535-1544.
    • (1996) Arthritis Rheum. , vol.39 , pp. 1535-1544
    • Caron, J.P.1
  • 110
    • 0037083347 scopus 로고    scopus 로고
    • Functional genomic analysis of type II IL-1beta decoy receptor: Potential for gene therapy in human arthritis and inflammation
    • Attur MG et al. Functional genomic analysis of type II IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation. J Immunol 2002; 168: 2001-2010.
    • (2002) J. Immunol. , vol.168 , pp. 2001-2010
    • Attur, M.G.1
  • 111
    • 0034704070 scopus 로고    scopus 로고
    • Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention
    • Attur MG et al. Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. J Biol Chem 2000; 275: 40307-40315.
    • (2000) J. Biol. Chem. , vol.275 , pp. 40307-40315
    • Attur, M.G.1
  • 112
    • 0031965384 scopus 로고    scopus 로고
    • Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8
    • Attur MG et al. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc Assoc Am Physicians 1998; 110: 65-72.
    • (1998) Proc. Assoc. Am. Physicians , vol.110 , pp. 65-72
    • Attur, M.G.1
  • 113
    • 0026725714 scopus 로고
    • The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function
    • Martel-Pelletier J et al. The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 1992; 35: 530-540.
    • (1992) Arthritis Rheum. , vol.35 , pp. 530-540
    • Martel-Pelletier, J.1
  • 114
    • 0032432868 scopus 로고    scopus 로고
    • Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
    • Melchiorri C et al. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 1998; 41: 2165-2174.
    • (1998) Arthritis Rheum. , vol.41 , pp. 2165-2174
    • Melchiorri, C.1
  • 115
    • 0030763495 scopus 로고    scopus 로고
    • Detection of interleukin-1 in the cartilage of patients with osteoarthritis: A possible autocrine/paracrine role in pathogenesis
    • Towle CA et al. Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthritis Cartilage 1997; 5: 293-300.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 293-300
    • Towle, C.A.1
  • 116
    • 0036233972 scopus 로고    scopus 로고
    • Human knee and ankle cartilage explants: Catabolic differences
    • Eger W et al. Human knee and ankle cartilage explants: catabolic differences. J Orthop Res 2002; 20: 526-534.
    • (2002) J. Orthop. Res. , vol.20 , pp. 526-534
    • Eger, W.1
  • 117
    • 0036159357 scopus 로고    scopus 로고
    • Molecular basis for differences between human joints
    • Cole AA, Kuettner KE. Molecular basis for differences between human joints. Cell Mol Life Sci 2002; 59: 19-26.
    • (2002) Cell Mol. Life Sci. , vol.59 , pp. 19-26
    • Cole, A.A.1    Kuettner, K.E.2
  • 118
    • 0037396896 scopus 로고    scopus 로고
    • Anakinra: The first interleukin-1 inhibitor in the treatment of rheumatoid arthritis
    • Kary S, Burmester GR. Anakinra: the first interleukin-1 inhibitor in the treatment of rheumatoid arthritis. Int J Clin Pract 2003; 57: 231-234.
    • (2003) Int. J. Clin. Pract. , vol.57 , pp. 231-234
    • Kary, S.1    Burmester, G.R.2
  • 119
    • 0035046629 scopus 로고    scopus 로고
    • The prospect of treating rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B. The prospect of treating rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. BioDrugs 2001; 15: 87-97.
    • (2001) BioDrugs , vol.15 , pp. 87-97
    • Bresnihan, B.1
  • 120
    • 18244420184 scopus 로고    scopus 로고
    • Addressing the safety of anakinra in patients with rheumatoid arthritis
    • Fleischmann RM. Addressing the safety of anakinra in patients with rheumatoid arthritis. Rheumatology (Oxford) 2003; 42 (Suppl 2): ii29-ii35.
    • (2003) Rheumatology (Oxford) , vol.42 , Issue.SUPPL. 2
    • Fleischmann, R.M.1
  • 121
    • 0035303568 scopus 로고    scopus 로고
    • The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis
    • Bresnihan B. The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin Arthritis Rheum 2001; 30 (5 Suppl 2): 17-20.
    • (2001) Semin. Arthritis Rheum. , vol.30 , Issue.5 SUPPL. 2 , pp. 17-20
    • Bresnihan, B.1
  • 122
    • 0033016267 scopus 로고    scopus 로고
    • Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: Comparison of efficacy in animal models with human clinical data
    • Bendele A et al. Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical data. Arthritis Rheum 1999; 42: 498-506.
    • (1999) Arthritis Rheum. , vol.42 , pp. 498-506
    • Bendele, A.1
  • 123
    • 0028390749 scopus 로고
    • The interleukin-1 receptor antagonist and its delivery by gene transfer
    • Evans CH, Robbins PD. The interleukin-1 receptor antagonist and its delivery by gene transfer. Receptor 1994; 4: 9-15.
    • (1994) Receptor , vol.4 , pp. 9-15
    • Evans, C.H.1    Robbins, P.D.2
  • 124
    • 0030961873 scopus 로고    scopus 로고
    • In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
    • Pelletier JP et al. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 1997; 40: 1012-1019.
    • (1997) Arthritis Rheum. , vol.40 , pp. 1012-1019
    • Pelletier, J.P.1
  • 125
    • 85047697321 scopus 로고    scopus 로고
    • Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene
    • Frisbie DD et al. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Therapy 2002; 9: 12-20.
    • (2002) Gene Therapy , vol.9 , pp. 12-20
    • Frisbie, D.D.1
  • 126
    • 0032924502 scopus 로고    scopus 로고
    • In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: Prevention of osteoarthritis progression
    • Fernandes J et al. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol 1999; 154: 1159-1169.
    • (1999) Am. J. Pathol. , vol.154 , pp. 1159-1169
    • Fernandes, J.1
  • 127
    • 0029967052 scopus 로고    scopus 로고
    • Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy
    • Otani K et al. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996; 156: 3558-3562.
    • (1996) J. Immunol. , vol.156 , pp. 3558-3562
    • Otani, K.1
  • 128
    • 19144364120 scopus 로고    scopus 로고
    • Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis
    • Evans CH et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996; 7: 1261-1280.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1261-1280
    • Evans, C.H.1
  • 129
    • 0028850009 scopus 로고
    • Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA
    • Boggs SS et al. Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA. Gene Therapy 1995; 2: 632-638.
    • (1995) Gene Therapy , vol.2 , pp. 632-638
    • Boggs, S.S.1
  • 130
    • 0033770975 scopus 로고    scopus 로고
    • Clinical trials in the gene therapy of arthritis
    • Evans CH et al. Clinical trials in the gene therapy of arthritis. Clin Orthop 2000 (Suppl 379): S300-S307.
    • (2000) Clin. Orthop. , Issue.SUPPL. 379
    • Evans, C.H.1
  • 131
    • 0037689517 scopus 로고    scopus 로고
    • Lentiviral-mediated gene delivery to synovium: Potent intra-articular expression with amplification by inflammation
    • Gouze E et al. Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther 2003; 7: 460-466.
    • (2003) Mol. Ther. , vol.7 , pp. 460-466
    • Gouze, E.1
  • 132
    • 0343618533 scopus 로고    scopus 로고
    • Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis
    • Goater J et al. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. J Rheumatol 2000; 27: 983-989.
    • (2000) J. Rheumatol. , vol.27 , pp. 983-989
    • Goater, J.1
  • 133
    • 0034130299 scopus 로고    scopus 로고
    • Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist
    • Pan RY et al. Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis Rheum 2000; 43: 289-297.
    • (2000) Arthritis Rheum. , vol.43 , pp. 289-297
    • Pan, R.Y.1
  • 134
    • 0034119863 scopus 로고    scopus 로고
    • Orthopaedic applications of gene therapy. From concept to clinic
    • The Marshall R. Urist Young Investigator Award
    • Kang R et al. The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic. Clin Orthop 2000: 324-337.
    • (2000) Clin. Orthop. , pp. 324-337
    • Kang, R.1


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