Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Nature

Volumn 440, Issue 7081, 2006, Pages 233-236

  Kanneganti, Thirumala Devi ^a   Özören, Nesrin ^a   Body Malapel, Mathilde ^a   Amer, Amal ^a   Park, Jong Hwan ^a   Franchi, Luigi ^a   Whitfield, Joel ^a   Barchet, Winfried ^b   Colonna, Marco ^b   Vandenabeele, Peter ^c   Bertin, John ^d,f   Coyle, Anthony ^d,g   Grant, Ethan P ^d,f   Akira, Shizuo ^e   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GHENT UNIVERSITY   (Belgium)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e OSAKA UNIVERSITY   (Japan)

^f Synta Pharmaceuticals Corp   (United States)

^g MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; ENZYME IMMOBILIZATION; PROTEINS; RNA;

CRYOPYRIN; IMIDAZOQUINOLINE COMPOUNDS; MITOGEN-ACTIVATED PROTEIN KINASES (MAPK);

GENES;

BACTERIAL RNA; CELL PROTEIN; CRYOPYRIN; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPROTEIN COMPLEX; RESIQUIMOD; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

BACTERIUM;

ANIMAL CELL; ARTICLE; AUTOINFLAMMATORY DISEASE; CIAS1 GENE; CINCA SYNDROME; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; HOST RESISTANCE; MISSENSE MUTATION; MOUSE; MUCKLE WELLS SYNDROME; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 32944462834     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04517     Document Type: Article

References (27)

1. Stojanov, S. & Kastner, D. L. Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr. Opin. Rheumatol. 17, 586-599 (2005).
2. Inohara, N., Chamaillard, M., McDonald, C. & Nunez, G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu. Rev. Biochem. 74, 355-383 (2005).
3. Athman, R. & Philpott, D. Innate immunity via Toll-like receptors and Nod proteins. Curr. Opin. Microbiol. 7, 25-32 (2004).
4. Agostini, L. et al. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319-325 (2004).
5. Perregaux, D. G., McNiff, P., Laliberte, R., Conklyn, M. & Gabel, C. A. ATP acts as an agonist to promote stimulus-induced secretion of IL-1β and IL-18 in human blood. J. Immunol. 165, 4615-4623 (2000).
6. Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature Immunol. 3, 196-200 (2002).
7. Jurk, M. et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nature Immunol. 3, 499 (2002).
8. Dinarello, C. A. Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme. Ann. NY Acad. Sci. 856, 1-11 (1998).
9. Dowds, T. A., Masumoto, J., Zhu, L., Inohara, N. & Nunez, G. Cryopyrin-induced interleukin 1β secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J. Biol. Chem. 279, 21924-21928 (2004).
10. Dockrell, D. H. & Kinghorn, G. R. Imiquimod and resiquimod as novel immunomodulators. J. Antimicrob. Chemother. 48, 751-755 (2001).
11. Janssen, R., Verhard, E., Lankester, A., Ten Cate, R. & van Dissel, J. T. Enhanced interleukin-1β and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome. Arthritis Rheum. 50, 3329-3333 (2004).
12. O'Connor, W. Jr, Harton, J. A., Zhu, X., Linhoff, M. W. & Ting, J. P. Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-κB suppressive properties. J. Immunol. 171, 6329-6333 (2003).
13. Netea, M. G., Kullberg, B. J., Verschueren, I. & Van Der Meer, J. W. Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumour necrosis factor family and interleukin-1β. Eur. J. Immunol. 30, 3057-3060 (2000).
14. Martinon, F., Agostini, L., Meylan, E. & Tschopp, J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14, 1929-1934 (2004).
15. Kobayashi, K. S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
16. Heil, F. et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526-1529 (2004).
17. Lund, J. M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl Acad. Sci. USA 101, 5598-5603 (2004).
18. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
19. Kariko, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA recognition by toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175 (2005).
20. Koski, G. K. et al. Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells. J. Immunol. 172, 3989-3993 (2004).
21. Craft, N. et al. The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine. J. Immunol. 175, 1983-1990 (2005).
22. Harrison, C. J., Jenski, L., Voychehovski, T. & Bernstein, D. I. Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. Antiviral Res. 10, 209-223 (1988).
23. Tomai, M. A. et al. Immunomodulating and antiviral activities of the imidazoquinoline S-28463. Antiviral Res. 28, 253-264 (1995).
24. Marks, R. et al. Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. J. Am. Acad. Dermatol. 44, 807-813 (2001).
25. Özören, N. et al. Distinct roles of TLR2 and the adaptor ASC in IL-1β/IL-18 secretion and host defense against Listeria monocytogenes. J. Immunol. (submitted).
26. Lamkanfi, M., Kalai, M., Saelens, X., Declercq, W. & Vandenabeele, P. Caspase-1 activates nuclear factor of the κ-enhancer in B cells independently of its enzymatic activity. J. Biol. Chem. 279, 24785-24793 (2004).
27. Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218 (2004).