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Volumn 7, Issue 6, 2007, Pages 429-442

Cytokines in the pathogenesis of rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

APRIL PROTEIN; CYTOKINE; CYTOKINE RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FC RECEPTOR; GAMMA INTERFERON; HLA DR4 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 7; ONCOSTATIN M; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ARGININE DEIMINASE; PROTEIN TYROSINE PHOSPHATASE; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNINDEXED DRUG;

EID: 34249720998     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2094     Document Type: Review
Times cited : (2104)

References (129)
  • 1
    • 0038011833 scopus 로고    scopus 로고
    • Firestein, G. S. Evolving concepts of rheumatoid arthritis. Nature 423, 356-361 (2003). This is an elegant overview of the pathogenesis of rheumatoid arthritis.
    • Firestein, G. S. Evolving concepts of rheumatoid arthritis. Nature 423, 356-361 (2003). This is an elegant overview of the pathogenesis of rheumatoid arthritis.
  • 2
    • 0034048349 scopus 로고    scopus 로고
    • Anti-cytokine therapy for rheumatoid arthritis
    • Maini, R. N. & Taylor, P. C. Anti-cytokine therapy for rheumatoid arthritis. Annu. Rev. Med. 51, 207-229 (2000).
    • (2000) Annu. Rev. Med , vol.51 , pp. 207-229
    • Maini, R.N.1    Taylor, P.C.2
  • 3
    • 33748997948 scopus 로고    scopus 로고
    • Cytokine networks - towards new therapies for rheumatoid arthritis
    • McInnes, I. B. & Liew, F. Y. Cytokine networks - towards new therapies for rheumatoid arthritis. Nature Clin. Pract. Rheumatol. 1, 31-39 (2005).
    • (2005) Nature Clin. Pract. Rheumatol , vol.1 , pp. 31-39
    • McInnes, I.B.1    Liew, F.Y.2
  • 5
    • 33845361515 scopus 로고    scopus 로고
    • Smoking as a trigger for inflammatory rheumatic diseases
    • Klareskog, L., Padyukov, L. & Alfredsson, L. Smoking as a trigger for inflammatory rheumatic diseases. Curr. Opin. Rheumatol. 19, 49-54 (2007).
    • (2007) Curr. Opin. Rheumatol , vol.19 , pp. 49-54
    • Klareskog, L.1    Padyukov, L.2    Alfredsson, L.3
  • 6
    • 23444449506 scopus 로고    scopus 로고
    • Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis
    • Jimenez-Boj, E. et al. Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis. J. Immunol. 175, 2579-2588 (2005).
    • (2005) J. Immunol , vol.175 , pp. 2579-2588
    • Jimenez-Boj, E.1
  • 8
    • 0346365086 scopus 로고    scopus 로고
    • Explaining how 'high-grade' systemic inflammation accelerates vascular risk in rheumatoid arthritis
    • Sattar, N., McCarey, D. W., Capell, H. & McInnes, I. B. Explaining how 'high-grade' systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108, 2957-2963 (2003).
    • (2003) Circulation , vol.108 , pp. 2957-2963
    • Sattar, N.1    McCarey, D.W.2    Capell, H.3    McInnes, I.B.4
  • 9
    • 32644436530 scopus 로고    scopus 로고
    • T-cell-directed trials have been of limited success, is there reason for optimism?
    • Panayi, G. S. Even though T-cell-directed trials have been of limited success, is there reason for optimism? Nature Clin. Pract. Rheumatol. 2, 58-59 (2006).
    • (2006) Nature Clin. Pract. Rheumatol , vol.2 , pp. 58-59
    • Panayi, G.1    Even though, S.2
  • 10
    • 0038746758 scopus 로고    scopus 로고
    • Abandoned therapies and unpublished trials in rheumatoid arthritis
    • Keystone, E. C. Abandoned therapies and unpublished trials in rheumatoid arthritis. Curr. Opin. Rheumatol. 15, 253-258 (2003).
    • (2003) Curr. Opin. Rheumatol , vol.15 , pp. 253-258
    • Keystone, E.C.1
  • 11
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
    • Genovese, M. C. et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N. Engl. J. Med. 353, 1114-1123 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1114-1123
    • Genovese, M.C.1
  • 12
    • 0031042456 scopus 로고    scopus 로고
    • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
    • McInnes, I. B., Leung, B. P., Sturrock, R. D., Field, M. & Liew, F. Y. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis. Nature Med. 3, 189-195 (1997).
    • (1997) Nature Med , vol.3 , pp. 189-195
    • McInnes, I.B.1    Leung, B.P.2    Sturrock, R.D.3    Field, M.4    Liew, F.Y.5
  • 13
  • 14
    • 13444256307 scopus 로고    scopus 로고
    • The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
    • Lubberts, E., Koenders, M. I. & van den Berg, W. B. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res. Ther. 7, 29-37 (2005).
    • (2005) Arthritis Res. Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    van den Berg, W.B.3
  • 15
    • 0031159108 scopus 로고    scopus 로고
    • High susceptibility to collagen-induced arthritis in mice lacking IFN-γ receptors
    • Manoury-Schwartz, B. et al. High susceptibility to collagen-induced arthritis in mice lacking IFN-γ receptors. J. Immunol. 158, 5501-5506 (1997).
    • (1997) J. Immunol , vol.158 , pp. 5501-5506
    • Manoury-Schwartz, B.1
  • 16
    • 0031156936 scopus 로고    scopus 로고
    • Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice
    • Vermeire, K. et al. Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice. J. Immunol. 158, 5507-5513 (1997).
    • (1997) J. Immunol , vol.158 , pp. 5507-5513
    • Vermeire, K.1
  • 17
    • 0346962972 scopus 로고    scopus 로고
    • H17 cells in CIA.
    • H17 cells in CIA.
  • 18
    • 32444448971 scopus 로고    scopus 로고
    • Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
    • Wang, J. et al. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J. Clin. Invest. 116, 414-421 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 414-421
    • Wang, J.1
  • 19
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi, T. et al. Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med. 187, 461-468 (1998).
    • (1998) J. Exp. Med , vol.187 , pp. 461-468
    • Alonzi, T.1
  • 20
    • 33846456970 scopus 로고    scopus 로고
    • + Th cells that cause autoimmune arthritis
    • + Th cells that cause autoimmune arthritis. J. Exp. Med. 204, 41-47 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 41-47
    • Hirota, K.1
  • 21
    • 0023205719 scopus 로고
    • Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that γ-interferon is not the primary macrophage activating factor
    • Firestein, G. S. & Zvaifler, N. J. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that γ-interferon is not the primary macrophage activating factor. Arthritis Rheum. 30, 864-871 (1987).
    • (1987) Arthritis Rheum , vol.30 , pp. 864-871
    • Firestein, G.S.1    Zvaifler, N.J.2
  • 22
    • 0031985926 scopus 로고    scopus 로고
    • Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis
    • Kanik, K. S. et al. Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis. J. Rheumatol. 25, 16-22 (1998).
    • (1998) J. Rheumatol , vol.25 , pp. 16-22
    • Kanik, K.S.1
  • 23
    • 0344157333 scopus 로고    scopus 로고
    • Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: Enhanced activity in synovial fluid compared to blood
    • Ronnelid, J. et al. Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood. Br. J. Rheumatol. 37, 7-14 (1998).
    • (1998) Br. J. Rheumatol , vol.37 , pp. 7-14
    • Ronnelid, J.1
  • 24
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum
    • 963-970
    • Chabaud, M. et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42, 963-970 (1999). This paper reports the first description of IL-17 in the rheumatoid arthritis synovium.
    • (1999) This paper reports the first description of IL-17 in the rheumatoid arthritis synovium , vol.42
    • Chabaud, M.1
  • 25
    • 3142719733 scopus 로고    scopus 로고
    • Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27
    • Goldberg, R., Wildbaum, G., Zohar, Y., Maor, G. & Karin, N. Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27. J. Immunol. 173, 1171-1178 (2004).
    • (2004) J. Immunol , vol.173 , pp. 1171-1178
    • Goldberg, R.1    Wildbaum, G.2    Zohar, Y.3    Maor, G.4    Karin, N.5
  • 26
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten, M. et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nature Immunol. 7, 929-936 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 929-936
    • Batten, M.1
  • 27
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer, J. S. et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunol. 7, 937-945 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 937-945
    • Stumhofer, J.S.1
  • 28
    • 33847206969 scopus 로고    scopus 로고
    • Weaver, C. T., Hatton, R. D., Mangan, P. R. & Harrington, L. E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821-852 (2007).
    • Weaver, C. T., Hatton, R. D., Mangan, P. R. & Harrington, L. E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821-852 (2007).
  • 29
    • 21644479222 scopus 로고    scopus 로고
    • Raza, K. et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res. Ther. 7, R784-R795 (2005). This is an important paper defining the early cytokine expression profile in synovial fluid.
    • Raza, K. et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res. Ther. 7, R784-R795 (2005). This is an important paper defining the early cytokine expression profile in synovial fluid.
  • 31
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
    • Ehrenstein, M. R. et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med. 200, 277-285 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1
  • 32
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β
    • Nadkarni, S., Mauri, C. & Ehrenstein, M. R. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J. Exp. Med. 204, 33-39 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 33
    • 33645700397 scopus 로고    scopus 로고
    • T-cell-targeted therapies in rheumatoid arthritis
    • Weyand, C. M. & Goronzy, J. J. T-cell-targeted therapies in rheumatoid arthritis. Nature Clin. Pract. Rheumatol. 2, 201-210 (2006).
    • (2006) Nature Clin. Pract. Rheumatol , vol.2 , pp. 201-210
    • Weyand, C.M.1    Goronzy, J.J.2
  • 34
    • 0030070295 scopus 로고    scopus 로고
    • Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
    • Schroder, A. E., Greiner, A., Seyfert, C. & Berek, C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 93, 221-225 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 221-225
    • Schroder, A.E.1    Greiner, A.2    Seyfert, C.3    Berek, C.4
  • 35
    • 0035340279 scopus 로고    scopus 로고
    • Prolonged exposure of T cells to TNF down-regulates TCRζ and expression of the TCR/CD3 complex at the cell surface
    • Isomaki, P. et al. Prolonged exposure of T cells to TNF down-regulates TCRζ and expression of the TCR/CD3 complex at the cell surface. J. Immunol. 166, 5495-5507 (2001).
    • (2001) J. Immunol , vol.166 , pp. 5495-5507
    • Isomaki, P.1
  • 36
    • 0031030787 scopus 로고    scopus 로고
    • A randomized, double-blind study comparing twenty-four-week treatment with recombinant interferon-γ versus placebo in the treatment of rheumatoid arthritis
    • Veys, E. M., Menkes, C. J. & Emery, P. A randomized, double-blind study comparing twenty-four-week treatment with recombinant interferon-γ versus placebo in the treatment of rheumatoid arthritis. Arthritis Rheum. 40, 62-68 (1997).
    • (1997) Arthritis Rheum , vol.40 , pp. 62-68
    • Veys, E.M.1    Menkes, C.J.2    Emery, P.3
  • 37
    • 0037333960 scopus 로고    scopus 로고
    • Interleukin-17 in rheumatoid arthritis: If T cells were to contribute to inflammation and destruction through synergy
    • Miossec, P. Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum. 48, 594-601 (2003).
    • (2003) Arthritis Rheum , vol.48 , pp. 594-601
    • Miossec, P.1
  • 38
    • 33846966636 scopus 로고    scopus 로고
    • H2 hypothesis of T cell-mediated tissue damage
    • H2 hypothesis of T cell-mediated tissue damage. Nature Med. 13, 139-145 (2007).
    • (2007) Nature Med , vol.13 , pp. 139-145
    • Steinman, L.1
  • 39
    • 33846906224 scopus 로고    scopus 로고
    • H17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • H17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651 (2007).
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1
  • 40
    • 17244381180 scopus 로고    scopus 로고
    • Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine
    • Ikeuchi, H. et al. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum. 52, 1037-1046 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1037-1046
    • Ikeuchi, H.1
  • 41
    • 0037007098 scopus 로고    scopus 로고
    • Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
    • Yumoto, K. et al. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Proc. Natl. Acad. Sci. USA 99, 4556-4561 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4556-4561
    • Yumoto, K.1
  • 42
    • 20144389023 scopus 로고    scopus 로고
    • Role of osteopontin in amplification and perpetuation of rheumatoid synovitis
    • Xu, G. et al. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J. Clin. Invest. 115, 1060-1067 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 1060-1067
    • Xu, G.1
  • 43
    • 0036164274 scopus 로고    scopus 로고
    • Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor κB pathways in tumor necrosis factor ? production in rheumatoid arthritis
    • Brennan, F. M. et al. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor κB pathways in tumor necrosis factor ? production in rheumatoid arthritis. Arthritis Rheum. 46, 31-41 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 31-41
    • Brennan, F.M.1
  • 44
    • 2942534513 scopus 로고    scopus 로고
    • Cell-cell interactions and tissue damage in rheumatoid arthritis
    • Dayer, J. M. & Burger, D. Cell-cell interactions and tissue damage in rheumatoid arthritis. Autoimmun. Rev. 3 (Suppl. 1), 14-16 (2004).
    • (2004) Autoimmun. Rev , vol.3 , Issue.SUPPL. 1 , pp. 14-16
    • Dayer, J.M.1    Burger, D.2
  • 45
    • 0034469236 scopus 로고    scopus 로고
    • Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells
    • McInnes, I. B., Leung, B. P. & Liew, F. Y. Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells. Arthritis Res. 2, 374-378 (2000).
    • (2000) Arthritis Res , vol.2 , pp. 374-378
    • McInnes, I.B.1    Leung, B.P.2    Liew, F.Y.3
  • 46
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards, J. C. et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350, 2572-2581 (2004).
    • (2004) N. Engl. J. Med , vol.350 , pp. 2572-2581
    • Edwards, J.C.1
  • 47
    • 0035888030 scopus 로고    scopus 로고
    • T cell activation in rheumatoid synovium is B cell dependent
    • Takemura, S., Klimiuk, P. A., Braun, A., Goronzy, J. J. & Weyand, C. M. T cell activation in rheumatoid synovium is B cell dependent. J. Immunol. 167, 4710-4718 (2001).
    • (2001) J. Immunol , vol.167 , pp. 4710-4718
    • Takemura, S.1    Klimiuk, P.A.2    Braun, A.3    Goronzy, J.J.4    Weyand, C.M.5
  • 48
    • 27644461904 scopus 로고    scopus 로고
    • BLyS and APRIL in rheumatoid arthritis
    • Seyler, T. M. et al. BLyS and APRIL in rheumatoid arthritis. J. Clin. Invest. 115, 3083-3092 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 3083-3092
    • Seyler, T.M.1
  • 49
    • 11844301640 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines
    • Ohata, J. et al. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J. Immunol. 174, 864-870 (2005).
    • (2005) J. Immunol , vol.174 , pp. 864-870
    • Ohata, J.1
  • 50
    • 33745010247 scopus 로고    scopus 로고
    • Signalling pathways in B cells: Implications for autoimmunity
    • Dorner, T. & Lipsky, P. E. Signalling pathways in B cells: implications for autoimmunity. Curr. Top. Microbiol. Immunol. 305, 213-240 (2006).
    • (2006) Curr. Top. Microbiol. Immunol , vol.305 , pp. 213-240
    • Dorner, T.1    Lipsky, P.E.2
  • 51
    • 0035879123 scopus 로고    scopus 로고
    • Lymphoid neogenesis in rheumatoid synovitis
    • Takemura, S. et al. Lymphoid neogenesis in rheumatoid synovitis. J. Immunol. 167, 1072-1080 (2001).
    • (2001) J. Immunol , vol.167 , pp. 1072-1080
    • Takemura, S.1
  • 52
    • 21044435315 scopus 로고    scopus 로고
    • Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis
    • Manzo, A. et al. Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur. J. Immunol. 35, 1347-1359 (2005).
    • (2005) Eur. J. Immunol , vol.35 , pp. 1347-1359
    • Manzo, A.1
  • 53
    • 0038240921 scopus 로고    scopus 로고
    • Ectopic germinal center formation in rheumatoid synovitis
    • Weyand, C. M. & Goronzy, J. J. Ectopic germinal center formation in rheumatoid synovitis. Ann. NY Acad. Sci. 987, 140-149 (2003).
    • (2003) Ann. NY Acad. Sci , vol.987 , pp. 140-149
    • Weyand, C.M.1    Goronzy, J.J.2
  • 54
    • 3142724043 scopus 로고    scopus 로고
    • Lymphotoxin β-mediated stimulation of synoviocytes in rheumatoid arthritis
    • Braun, A., Takemura, S., Vallejo, A. N., Goronzy, J. J. & Weyand, C. M. Lymphotoxin β-mediated stimulation of synoviocytes in rheumatoid arthritis. Arthritis Rheum. 50, 2140-2150 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 2140-2150
    • Braun, A.1    Takemura, S.2    Vallejo, A.N.3    Goronzy, J.J.4    Weyand, C.M.5
  • 55
    • 0033563249 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells
    • Lindhout, E. et al. Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells. J. Immunol. 162, 5949-5956 (1999).
    • (1999) J. Immunol , vol.162 , pp. 5949-5956
    • Lindhout, E.1
  • 56
    • 0037140551 scopus 로고    scopus 로고
    • CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis
    • Kang, Y. M. et al. CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J. Exp. Med. 195, 1325-1336 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 1325-1336
    • Kang, Y.M.1
  • 57
    • 23044494509 scopus 로고    scopus 로고
    • The role of Toll-like receptor signalling in the pathogenesis of arthritis
    • Brentano, F., Kyburz, D., Schorr, O., Gay, R. & Gay, S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol. 233, 90-96 (2005).
    • (2005) Cell Immunol , vol.233 , pp. 90-96
    • Brentano, F.1    Kyburz, D.2    Schorr, O.3    Gay, R.4    Gay, S.5
  • 58
    • 0037378466 scopus 로고    scopus 로고
    • Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium
    • Seibl, R. et al. Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am. J. Pathol. 162, 1221-1227 (2003).
    • (2003) Am. J. Pathol , vol.162 , pp. 1221-1227
    • Seibl, R.1
  • 59
    • 10744223444 scopus 로고    scopus 로고
    • Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: Critical role of myeloid differentiation factor 88
    • Joosten, L. A. et al. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J. Immunol. 171, 6145-6153 (2003).
    • (2003) J. Immunol , vol.171 , pp. 6145-6153
    • Joosten, L.A.1
  • 60
    • 33947545388 scopus 로고    scopus 로고
    • The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    • Sacre, S. M. et al. The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am. J. Pathol. 170, 518-525 (2007).
    • (2007) Am. J. Pathol , vol.170 , pp. 518-525
    • Sacre, S.M.1
  • 61
    • 33644783885 scopus 로고    scopus 로고
    • Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation
    • Kelso, E. B. et al. Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation. J. Pharmacol. Exp. Ther. 316, 1017-1024 (2006).
    • (2006) J. Pharmacol. Exp. Ther , vol.316 , pp. 1017-1024
    • Kelso, E.B.1
  • 62
    • 33947166333 scopus 로고    scopus 로고
    • Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: Ex vivo studies using a novel proteinase-activated receptor 2 antagonist
    • Kelso, E. B. et al. Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis Rheum. 56, 765-771 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 765-771
    • Kelso, E.B.1
  • 63
    • 0030003058 scopus 로고    scopus 로고
    • Feldmann, M., Brennan, F. M. & Maini, R. N. Rheumatoid arthritis. Cell 85, 307-310 (1996). This is a seminal review of the balance of cytokine activities in rheumatoid arthritis.
    • Feldmann, M., Brennan, F. M. & Maini, R. N. Rheumatoid arthritis. Cell 85, 307-310 (1996). This is a seminal review of the balance of cytokine activities in rheumatoid arthritis.
  • 65
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer, J. et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10, 4025-4031 (1991).
    • (1991) EMBO J , vol.10 , pp. 4025-4031
    • Keffer, J.1
  • 66
    • 19944431840 scopus 로고    scopus 로고
    • Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial
    • Quinn, M. A. et al. Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 52, 27-35 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 27-35
    • Quinn, M.A.1
  • 67
    • 6344269986 scopus 로고    scopus 로고
    • Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    • Ferrari-Lacraz, S. et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J. Immunol. 173, 5818-5826 (2004).
    • (2004) J. Immunol , vol.173 , pp. 5818-5826
    • Ferrari-Lacraz, S.1
  • 68
    • 25444519432 scopus 로고    scopus 로고
    • Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study
    • Baslund, B. et al. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum. 52, 2686-2692 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 2686-2692
    • Baslund, B.1
  • 69
    • 0036188765 scopus 로고    scopus 로고
    • Targeting interleukin-1 in the treatment of rheumatoid arthritis
    • Dayer, J. M. & Bresnihan, B. Targeting interleukin-1 in the treatment of rheumatoid arthritis. Arthritis Rheum. 46, 574-578 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 574-578
    • Dayer, J.M.1    Bresnihan, B.2
  • 70
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    • Horai, R. et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 191, 313-320 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 313-320
    • Horai, R.1
  • 71
    • 8444225132 scopus 로고    scopus 로고
    • Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    • Hoffman, H. M. et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364, 1779-1785 (2004).
    • (2004) Lancet , vol.364 , pp. 1779-1785
    • Hoffman, H.M.1
  • 72
    • 0037450737 scopus 로고    scopus 로고
    • Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling
    • Choe, J. Y., Crain, B., Wu, S. R. & Corr, M. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling. J. Exp. Med. 197, 537-542 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 537-542
    • Choe, J.Y.1    Crain, B.2    Wu, S.R.3    Corr, M.4
  • 73
    • 0032743708 scopus 로고    scopus 로고
    • A proinflammatory role for IL-18 in rheumatoid arthritis
    • Gracie, J. A. et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J. Clin. Invest. 104, 1393-1401 (1999).
    • (1999) J. Clin. Invest , vol.104 , pp. 1393-1401
    • Gracie, J.A.1
  • 74
    • 13444254086 scopus 로고    scopus 로고
    • Interleukin-18: A therapeutic target in rheumatoid arthritis?
    • McInnes, I. B., Liew, F. Y. & Gracie, J. A. Interleukin-18: a therapeutic target in rheumatoid arthritis? Arthritis Res. Ther. 7, 38-41 (2005).
    • (2005) Arthritis Res. Ther , vol.7 , pp. 38-41
    • McInnes, I.B.1    Liew, F.Y.2    Gracie, J.A.3
  • 75
    • 33644765841 scopus 로고    scopus 로고
    • IL-32, a proinflammatory cytokine in rheumatoid arthritis
    • Joosten, L. A. et al. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc. Natl Acad. Sci. USA 103, 3298-3303 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 3298-3303
    • Joosten, L.A.1
  • 76
    • 28044453314 scopus 로고    scopus 로고
    • IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1? and IL-6 production through a caspase 1-dependent mechanism
    • Netea, M. G. et al. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1? and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl Acad. Sci. USA 102, 16309-16314 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 16309-16314
    • Netea, M.G.1
  • 77
    • 0036822347 scopus 로고    scopus 로고
    • High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis
    • Kokkola, R. et al. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum. 46, 2598-2603 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 2598-2603
    • Kokkola, R.1
  • 78
    • 33745190762 scopus 로고    scopus 로고
    • Morand, E. F., Leech, M. & Bernhagen, J. MIF: a new cytokine link between rheumatoid arthritis and athero sclerosis. Nature Rev. Drug Discov. 5, 399-410 (2006).
    • Morand, E. F., Leech, M. & Bernhagen, J. MIF: a new cytokine link between rheumatoid arthritis and athero sclerosis. Nature Rev. Drug Discov. 5, 399-410 (2006).
  • 79
    • 34249712937 scopus 로고    scopus 로고
    • Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients
    • 18 January, doi:10.1136/ard.2006.063412
    • van der Pouw Kraan, T. C. et al. Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann. Rheum. Dis. 18 January 2007 (doi:10.1136/ard.2006.063412).
    • (2007) Ann. Rheum. Dis
    • van der Pouw Kraan, T.C.1
  • 80
    • 0030737716 scopus 로고    scopus 로고
    • Seeing the wood for the trees: The forgotten role of neutrophils in rheumatoid arthritis
    • Edwards, S. W. & Hallett, M. B. Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis. Immunol. Today 18, 320-324 (1997).
    • (1997) Immunol. Today , vol.18 , pp. 320-324
    • Edwards, S.W.1    Hallett, M.B.2
  • 81
    • 0037464519 scopus 로고    scopus 로고
    • The mast cell in inflammatory arthritis
    • Woolley, D. E. The mast cell in inflammatory arthritis. N. Engl. J. Med 348, 1709-1711 (2003).
    • (2003) N. Engl. J. Med , vol.348 , pp. 1709-1711
    • Woolley, D.E.1
  • 82
    • 0037031680 scopus 로고    scopus 로고
    • Mast cells: A cellular link between autoantibodies and inflammatory arthritis
    • Lee, D. M. et al. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297, 1689-1692 (2002).
    • (2002) Science , vol.297 , pp. 1689-1692
    • Lee, D.M.1
  • 83
    • 33749446861 scopus 로고    scopus 로고
    • Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
    • Paniagua, R. T. et al. Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. J. Clin. Invest. 116, 2633-2642 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 2633-2642
    • Paniagua, R.T.1
  • 84
    • 0036067610 scopus 로고    scopus 로고
    • A subset of natural killer cells is greatly expanded within inflamed joints
    • Dalbeth, N. & Callan, M. F. A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheum. 46, 1763-1772 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 1763-1772
    • Dalbeth, N.1    Callan, M.F.2
  • 85
    • 0035303568 scopus 로고    scopus 로고
    • The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis
    • Bresnihan, B. The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin. Arthritis Rheum. 30, 17-20 (2001).
    • (2001) Semin. Arthritis Rheum , vol.30 , pp. 17-20
    • Bresnihan, B.1
  • 86
    • 33845474273 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    • Schett, G. et al. High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study. Arch. Intern. Med. 166, 2495-2501 (2006).
    • (2006) Arch. Intern. Med , vol.166 , pp. 2495-2501
    • Schett, G.1
  • 87
    • 33748906063 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein and fracture risk in elderly women
    • Pasco, J. A. et al. High-sensitivity C-reactive protein and fracture risk in elderly women. JAMA 296, 1353-1355 (2006).
    • (2006) JAMA , vol.296 , pp. 1353-1355
    • Pasco, J.A.1
  • 88
    • 0042838281 scopus 로고    scopus 로고
    • Inflammatory mediators as essential elements in bone remodeling
    • Goldring, S. R. Inflammatory mediators as essential elements in bone remodeling. Calcif. Tissue Int. 73, 97-100 (2003).
    • (2003) Calcif. Tissue Int , vol.73 , pp. 97-100
    • Goldring, S.R.1
  • 89
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S. L. Bone resorption by osteoclasts. Science 289, 1504-1508 (2000).
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 90
    • 0036853902 scopus 로고    scopus 로고
    • Osteoclasts are essential for TNF-α-mediated joint destruction
    • Redlich, K. et al. Osteoclasts are essential for TNF-α-mediated joint destruction. J. Clin. Invest. 110, 1419-1427 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 1419-1427
    • Redlich, K.1
  • 91
    • 0034122050 scopus 로고    scopus 로고
    • Gravallese, E. M. et al. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 43, 250-258 (2000). This paper reports the important early description of the erosive potential in inflammatory synovitis.
    • Gravallese, E. M. et al. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 43, 250-258 (2000). This paper reports the important early description of the erosive potential in inflammatory synovitis.
  • 92
    • 0025332897 scopus 로고
    • The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
    • Yoshida, H. et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345, 442-444 (1990).
    • (1990) Nature , vol.345 , pp. 442-444
    • Yoshida, H.1
  • 93
    • 0028358343 scopus 로고
    • Constitutive mRNA and protein production of macrophage colony-stimulating factor but not of other cytokines by synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
    • Seitz, M., Loetscher, P., Fey, M. F. & Tobler, A. Constitutive mRNA and protein production of macrophage colony-stimulating factor but not of other cytokines by synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients. Br. J. Rheumatol. 33, 613-619 (1994).
    • (1994) Br. J. Rheumatol , vol.33 , pp. 613-619
    • Seitz, M.1    Loetscher, P.2    Fey, M.F.3    Tobler, A.4
  • 94
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey, D. L. et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 (1998).
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1
  • 95
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong, Y. Y. et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402, 304-309 (1999).
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.Y.1
  • 96
    • 0033768507 scopus 로고    scopus 로고
    • Expression of osteoclast differentiation factor in rheumatoid arthritis
    • Shigeyama, Y. et al. Expression of osteoclast differentiation factor in rheumatoid arthritis. Arthritis Rheum. 43, 2523-2530 (2000).
    • (2000) Arthritis Rheum , vol.43 , pp. 2523-2530
    • Shigeyama, Y.1
  • 97
    • 0031735152 scopus 로고    scopus 로고
    • Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells
    • Horwood, N. J., Elliott, J., Martin, T. J. & Gillespie, M. T. Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 139, 4743-4746 (1998).
    • (1998) Endocrinology , vol.139 , pp. 4743-4746
    • Horwood, N.J.1    Elliott, J.2    Martin, T.J.3    Gillespie, M.T.4
  • 98
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake, S. et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103, 1345-1352 (1999).
    • (1999) J. Clin. Invest , vol.103 , pp. 1345-1352
    • Kotake, S.1
  • 99
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet, W. S. et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309-319 (1997).
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1
  • 100
    • 0034523328 scopus 로고    scopus 로고
    • TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam, J. et al. TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J. Clin. Invest. 106, 1481-1488 (2000).
    • (2000) J. Clin. Invest , vol.106 , pp. 1481-1488
    • Lam, J.1
  • 101
    • 1642526641 scopus 로고    scopus 로고
    • hi osteoclast precursors but is essential for mature osteoclast formation in TNFα-mediated inflammatory arthritis
    • hi osteoclast precursors but is essential for mature osteoclast formation in TNFα-mediated inflammatory arthritis. J. Bone. Miner. Res. 19, 207-213 (2004).
    • (2004) J. Bone. Miner. Res , vol.19 , pp. 207-213
    • Li, P.1
  • 102
    • 0037364369 scopus 로고    scopus 로고
    • Mechanisms of TNF-α- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
    • Ritchlin, C. T., Haas-Smith, S. A., Li, P., Hicks, D. G. & Schwarz, E. M. Mechanisms of TNF-α- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J. Clin. Invest. 111, 821-831 (2003).
    • (2003) J. Clin. Invest , vol.111 , pp. 821-831
    • Ritchlin, C.T.1    Haas-Smith, S.A.2    Li, P.3    Hicks, D.G.4    Schwarz, E.M.5
  • 103
    • 14944371405 scopus 로고    scopus 로고
    • Wei, S., Kitaura, H., Zhou, P., Ross, F. P. & Teitelbaum, S. L. IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest. 115, 282-290 (2005).
    • Wei, S., Kitaura, H., Zhou, P., Ross, F. P. & Teitelbaum, S. L. IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest. 115, 282-290 (2005).
  • 104
    • 31044449633 scopus 로고    scopus 로고
    • Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis
    • Wong, P. K. et al. Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum. 54, 158-168 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 158-168
    • Wong, P.K.1
  • 105
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato, K. et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203, 2673-2682 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2673-2682
    • Sato, K.1
  • 106
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
    • Takayanagi, H. et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 408, 600-605 (2000).
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1
  • 107
    • 17544389276 scopus 로고    scopus 로고
    • Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation
    • Udagawa, N. et al. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation. J. Exp. Med. 185, 1005-1012 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 1005-1012
    • Udagawa, N.1
  • 108
    • 0022648104 scopus 로고
    • Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
    • Bertolini, D. R., Nedwin, G. E., Bringman, T. S., Smith, D. D. & Mundy, G. R. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319, 516-518 (1986).
    • (1986) Nature , vol.319 , pp. 516-518
    • Bertolini, D.R.1    Nedwin, G.E.2    Bringman, T.S.3    Smith, D.D.4    Mundy, G.R.5
  • 109
    • 33846949349 scopus 로고    scopus 로고
    • Dickkopf-1 is a master regulator of joint remodeling
    • Diarra, D. et al. Dickkopf-1 is a master regulator of joint remodeling. Nature Med. 13, 156-163 (2007).
    • (2007) Nature Med , vol.13 , pp. 156-163
    • Diarra, D.1
  • 110
    • 33748478814 scopus 로고    scopus 로고
    • The role of mesenchymal cells in the pathophysiology of inflammatory arthritis
    • Meyer, L. H., Franssen, L. & Pap, T. The role of mesenchymal cells in the pathophysiology of inflammatory arthritis. Best Pract. Res. Clin. Rheumatol. 20, 969-981 (2006).
    • (2006) Best Pract. Res. Clin. Rheumatol , vol.20 , pp. 969-981
    • Meyer, L.H.1    Franssen, L.2    Pap, T.3
  • 111
    • 33847133943 scopus 로고    scopus 로고
    • Cadherin-11 in synovial lining formation and pathology in arthritis
    • Lee, D. M. et al. Cadherin-11 in synovial lining formation and pathology in arthritis. Science 315, 1006-1010 (2007).
    • (2007) Science , vol.315 , pp. 1006-1010
    • Lee, D.M.1
  • 112
    • 0034469496 scopus 로고    scopus 로고
    • Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
    • Pap, T., Muller-Ladner, U., Gay, R. E. & Gay, S. Fibroblast biology: role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. 2, 361-367 (2000).
    • (2000) Arthritis Res , vol.2 , pp. 361-367
    • Pap, T.1    Muller-Ladner, U.2    Gay, R.E.3    Gay, S.4
  • 113
    • 0035132658 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism
    • Burger, J. A., Zvaifler, N. J., Tsukada, N., Firestein, G. S. & Kipps, T. J. Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism. J. Clin. Invest. 107, 305-315 (2001).
    • (2001) J. Clin. Invest , vol.107 , pp. 305-315
    • Burger, J.A.1    Zvaifler, N.J.2    Tsukada, N.3    Firestein, G.S.4    Kipps, T.J.5
  • 114
    • 13444252640 scopus 로고    scopus 로고
    • Direct interaction of immunoglobulins with synovial fibroblasts: A missing link in the pathogenesis of rheumatoid arthritis?
    • Pap, T. Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis? Arthritis Res. Ther. 7, 44-46 (2005).
    • (2005) Arthritis Res. Ther , vol.7 , pp. 44-46
    • Pap, T.1
  • 115
    • 0034669989 scopus 로고    scopus 로고
    • Amplification of IL-1β-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-κB and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways
    • Eberhardt, W., Huwiler, A., Beck, K. F., Walpen, S. & Pfeilschifter, J. Amplification of IL-1β-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-κB and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. J. Immunol. 165, 5788-5797 (2000).
    • (2000) J. Immunol , vol.165 , pp. 5788-5797
    • Eberhardt, W.1    Huwiler, A.2    Beck, K.F.3    Walpen, S.4    Pfeilschifter, J.5
  • 116
    • 0034761792 scopus 로고    scopus 로고
    • Synergistic induction of matrix metalloproteinase 1 by interleukin-1α and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism
    • Catterall, J. B. et al. Synergistic induction of matrix metalloproteinase 1 by interleukin-1α and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism. Arthritis Rheum. 44, 2296-2310 (2001).
    • (2001) Arthritis Rheum , vol.44 , pp. 2296-2310
    • Catterall, J.B.1
  • 117
    • 0036617187 scopus 로고    scopus 로고
    • Lessons from animal models of arthritis
    • Van den Berg, W. B. Lessons from animal models of arthritis. Curr. Rheumatol. Rep. 4, 232-239 (2002).
    • (2002) Curr. Rheumatol. Rep , vol.4 , pp. 232-239
    • Van den Berg, W.B.1
  • 118
    • 0000609002 scopus 로고
    • Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint
    • Pettipher, E. R., Higgs, G. A. & Henderson, B. Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc. Natl Acad. Sci. USA 83, 8749-8753 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 8749-8753
    • Pettipher, E.R.1    Higgs, G.A.2    Henderson, B.3
  • 119
    • 4344717421 scopus 로고    scopus 로고
    • Interleukin-18 Promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    • Joosten, L. A. B. et al. Interleukin-18 Promotes joint inflammation and induces interleukin-1-driven cartilage destruction. Am. J. Pathol. 165, 959-967 (2004).
    • (2004) Am. J. Pathol , vol.165 , pp. 959-967
    • Joosten, L.A.B.1
  • 120
    • 0033938870 scopus 로고    scopus 로고
    • Effect of interleukin 17 on proteoglycan degradation in murine knee joints
    • Dudler, J., Renggli-Zulliger, N., Busso, N., Lotz, M. & So, A. Effect of interleukin 17 on proteoglycan degradation in murine knee joints. Ann. Rheum. Dis. 59, 529-532 (2000).
    • (2000) Ann. Rheum. Dis , vol.59 , pp. 529-532
    • Dudler, J.1    Renggli-Zulliger, N.2    Busso, N.3    Lotz, M.4    So, A.5
  • 121
    • 0036192064 scopus 로고    scopus 로고
    • Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction
    • Lubberts, E. et al. Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflamm. Res. 51, 102-104 (2002).
    • (2002) Inflamm. Res , vol.51 , pp. 102-104
    • Lubberts, E.1
  • 122
    • 0035554955 scopus 로고    scopus 로고
    • Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo
    • Cai, L. et al. Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. Cytokine 16, 10-21 (2001).
    • (2001) Cytokine , vol.16 , pp. 10-21
    • Cai, L.1
  • 123
    • 33748499607 scopus 로고    scopus 로고
    • Inhibition of angiogenic pathways in rheumatoid arthritis: Potential for therapeutic targeting
    • Veale, D. J. & Fearon, U. Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting. Best Pract. Res. Clin. Rheumatol. 20, 941-947 (2006).
    • (2006) Best Pract. Res. Clin. Rheumatol , vol.20 , pp. 941-947
    • Veale, D.J.1    Fearon, U.2
  • 124
    • 34247568260 scopus 로고    scopus 로고
    • Angiogenesis in rheumatoid arthritis
    • Paleolog, E. M. Angiogenesis in rheumatoid arthritis. Arthritis Res. 4 (Suppl. 3), 81-90 (2002).
    • (2002) Arthritis Res , vol.4 , Issue.SUPPL. 3 , pp. 81-90
    • Paleolog, E.M.1
  • 125
    • 0009650526 scopus 로고    scopus 로고
    • CCR5 is characteristic of Th1 lymphocytes
    • Loetscher, P. et al. CCR5 is characteristic of Th1 lymphocytes. Nature 391, 344-345 (1998).
    • (1998) Nature , vol.391 , pp. 344-345
    • Loetscher, P.1
  • 126
    • 2942585608 scopus 로고    scopus 로고
    • Chemokine blockade: A new era in the treatment of rheumatoid arthritis?
    • Haringman, J. J. & Tak, P. P. Chemokine blockade: a new era in the treatment of rheumatoid arthritis? Arthritis Res. Ther. 6, 93-97 (2004).
    • (2004) Arthritis Res. Ther , vol.6 , pp. 93-97
    • Haringman, J.J.1    Tak, P.P.2
  • 127
    • 14944377754 scopus 로고    scopus 로고
    • Chemokines and their receptors in rheumatoid arthritis: Future targets?
    • Koch, A. E. Chemokines and their receptors in rheumatoid arthritis: future targets? Arthritis Rheum. 52, 710-721 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 710-721
    • Koch, A.E.1
  • 128
    • 27744514865 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
    • Goekoop-Ruiterman, Y. P. et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum. 52, 3381-3390 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 3381-3390
    • Goekoop-Ruiterman, Y.P.1
  • 129
    • 70349362651 scopus 로고    scopus 로고
    • Cytokines
    • 7th edn, eds Harris, E. D. Jr. et al, Ch. 15 Elsevier Saunders, Philadelphia
    • McInnes, I. B. Cytokines. In Kelley's Textbook of Rheumatology. 7th edn. (eds Harris, E. D. Jr. et al.) Ch. 15 (Elsevier Saunders, Philadelphia (2005).
    • (2005) Kelley's Textbook of Rheumatology
    • McInnes, I.B.1


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