NOD2 302oinsC mutation and the pathogenesis of Crohn's disease: Impaired IL-Iβ production points to a loss-of-function phenotype

Netherlands Journal of Medicine

Volumn 63, Issue 8, 2005, Pages 305-308

  Netea, M G ^a   Ferwerda, G ^a   de Jong, D J ^a   Girardin, S E ^b   Kullberg, B J ^a   van der Meer, J W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUT PASTEUR   (France)

Author keywords

Crohn's disease; Cytokine; IL I; NOD2

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; INTERLEUKIN 1BETA; MURAMYL DIPEPTIDE; PEPTIDOGLYCAN; CARD15 PROTEIN, HUMAN; INTERLEUKIN 1; MACROPHAGE STIMULATORY LIPOPEPTIDE 2; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; OLIGOPEPTIDE; SIGNAL PEPTIDE; TOLL LIKE RECEPTOR 2;

ANALYSIS OF VARIANCE; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FUNCTION; RADIOIMMUNOASSAY; WILD TYPE; ALLELE; BIOSYNTHESIS; BLOOD; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HOMOZYGOTE; IMMUNOLOGY; METABOLISM; MUTATION; SIGNAL TRANSDUCTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ALLELES; CASE-CONTROL STUDIES; CROHN DISEASE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HOMOZYGOTE; HUMANS; INTERLEUKIN-1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; OLIGOPEPTIDES; PEPTIDOGLYCAN; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

EID: 26044460479     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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