Gout-associated uric acid crystals activate the NALP3 inflammasome

Nature

Volumn 440, Issue 7081, 2006, Pages 237-241

  Martinon, Fabio ^a   Pétrilli, Virginie ^a   Mayor, Annick ^a   Tardivel, Aubry ^a   Tschopp, Jürg ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; MATHEMATICAL MODELS; TISSUE;

AUTOINFLAMMATORY DISEASES; MONOSODIUM URATE (MSU); URIC ACID CRYSTALS;

CALCIUM COMPOUNDS;

CALCIUM PYROPHOSPHATE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN NALP3; UNCLASSIFIED DRUG; URATE; URIC ACID;

SCIENCE AND TECHNOLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOINFLAMMATORY DISEASE; CONTROLLED STUDY; GOUT; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NEUTROPHIL; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PSEUDOGOUT;

ANIMALS; CALCIUM PYROPHOSPHATE; CARRIER PROTEINS; CASPASE 1; CELL LINE; CELLS, CULTURED; CHONDROCALCINOSIS; COLCHICINE; DISEASE MODELS, ANIMAL; GOUT; HUMANS; INFLAMMATION; INTERLEUKIN-1; MACROPHAGES; MICE; NEUTROPHILS; PERITONITIS; RECEPTORS, INTERLEUKIN-1; URIC ACID;

ANIMALIA;

EID: 32944468985     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature04516     Document Type: Article

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