-
1
-
-
0036187036
-
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
-
Acehan, D., Jiang, X., Morgan, D.G., Heuser, J.E., Wang, X., and Akey, C.W. (2002). Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell 9, 423-432.
-
(2002)
Mol. Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
Jiang, X.2
Morgan, D.G.3
Heuser, J.E.4
Wang, X.5
Akey, C.W.6
-
2
-
-
0033597923
-
Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
-
Adrain, C., Slee, E.A., Harte, M.T., and Martin, S.J. (1999). Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. J. Biol. Chem. 274, 20855-20860.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20855-20860
-
-
Adrain, C.1
Slee, E.A.2
Harte, M.T.3
Martin, S.J.4
-
3
-
-
1642285783
-
NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
-
Agostini, L., Martinon, F., Burns, K., McDermott, M.F., Hawkins, P.N., and Tschopp, J. (2004). NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319-325.
-
(2004)
Immunity
, vol.20
, pp. 319-325
-
-
Agostini, L.1
Martinon, F.2
Burns, K.3
McDermott, M.F.4
Hawkins, P.N.5
Tschopp, J.6
-
4
-
-
0031045588
-
CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP
-
Ahmad, M., Srinivasula, S.M., Wang, L., Talanian, R.V., Litwack, G., Fernandes-Alnemri, T., and Alnemri, E.S. (1997). CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57, 615-619.
-
(1997)
Cancer Res.
, vol.57
, pp. 615-619
-
-
Ahmad, M.1
Srinivasula, S.M.2
Wang, L.3
Talanian, R.V.4
Litwack, G.5
Fernandes-Alnemri, T.6
Alnemri, E.S.7
-
5
-
-
0038136890
-
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2
-
Baliga, B.C., Colussi, P.A., Read, S.H., Dias, M.M., Jans, D.A., and Kumar, S. (2003). Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. J. Biol. Chem. 278, 4899-4905.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4899-4905
-
-
Baliga, B.C.1
Colussi, P.A.2
Read, S.H.3
Dias, M.M.4
Jans, D.A.5
Kumar, S.6
-
6
-
-
8844224859
-
The biochemical mechanism of caspase-2 activation
-
Baliga, B.C., Read, S.H., and Kumar, S. (2004). The biochemical mechanism of caspase-2 activation. Cell Death Differ. 11, 1234-1241.
-
(2004)
Cell Death Differ.
, vol.11
, pp. 1234-1241
-
-
Baliga, B.C.1
Read, S.H.2
Kumar, S.3
-
7
-
-
25444473105
-
Structure of Apaf-1 in the auto-inhibited form: A critical role for ADP
-
Bao, Q., Riedl, S.J., and Shi, Y. (2005). Structure of Apaf-1 in the auto-inhibited form: a critical role for ADP. Cell Cycle 4, 1001-1003.
-
(2005)
Cell Cycle
, vol.4
, pp. 1001-1003
-
-
Bao, Q.1
Riedl, S.J.2
Shi, Y.3
-
8
-
-
0042303323
-
The CD95 type I/type II model
-
Barnhart, B.C., Alappat, E.C., and Peter, M.E. (2003). The CD95 type I/type II model. Semin. Immunol. 15, 185-193.
-
(2003)
Semin. Immunol.
, vol.15
, pp. 185-193
-
-
Barnhart, B.C.1
Alappat, E.C.2
Peter, M.E.3
-
9
-
-
4143093635
-
The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation
-
Beem, E., Holliday, L.S., and Segal, M.S. (2004). The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation. Am. J. Physiol. Cell Physiol. 287, C664-672.
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.287
-
-
Beem, E.1
Holliday, L.S.2
Segal, M.S.3
-
10
-
-
0032080197
-
Defects in regulation of apoptosis in caspase-2-deficient mice
-
Bergeron, L., Perez, G.I., MacDonald, G., Shi, L., Sun, Y., Jurisicova, A., Varmuza, S., Latham, K.E., Flaws, J.A., Salter, J.C., et al. (1998). Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12, 1304-1314.
-
(1998)
Genes Dev.
, vol.12
, pp. 1304-1314
-
-
Bergeron, L.1
Perez, G.I.2
MacDonald, G.3
Shi, L.4
Sun, Y.5
Jurisicova, A.6
Varmuza, S.7
Latham, K.E.8
Flaws, J.A.9
Salter, J.C.10
-
12
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright, K.M., Renatus, M., Scott, F.L., Sperandio, S., Shin, H., Pedersen, I.M., Ricci, J.E., Edris, W.A., Sutherlin, D.P., Green, D.R., and Salvesen, G.S. (2003). A unified model for apical caspase activation. Mol. Cell 11, 529-541.
-
(2003)
Mol. Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
Renatus, M.2
Scott, F.L.3
Sperandio, S.4
Shin, H.5
Pedersen, I.M.6
Ricci, J.E.7
Edris, W.A.8
Sutherlin, D.P.9
Green, D.R.10
Salvesen, G.S.11
-
13
-
-
4544288868
-
Activation of caspases-8 and -10 by FLIP(L)
-
Boatright, K.M., Deis, C., Denault, J.B., Sutherlin, D.P., and Salvesen, G.S. (2004). Activation of caspases-8 and -10 by FLIP(L). Biochem. J. 382, 651-657.
-
(2004)
Biochem. J.
, vol.382
, pp. 651-657
-
-
Boatright, K.M.1
Deis, C.2
Denault, J.B.3
Sutherlin, D.P.4
Salvesen, G.S.5
-
14
-
-
0035800827
-
Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein
-
Bonfoco, E., Li, E., Kolbinger, F., and Cooper, N.R. (2001). Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein. J. Biol. Chem. 276, 29242-29250.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29242-29250
-
-
Bonfoco, E.1
Li, E.2
Kolbinger, F.3
Cooper, N.R.4
-
15
-
-
0035283038
-
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes
-
Bratton, S.B., Walker, G., Srinivasula, S.M., Sun, X.M., Butterworth, M., Alnemri, E.S., and Cohen, G.M. (2001). Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J. 20, 998-1009.
-
(2001)
EMBO J.
, vol.20
, pp. 998-1009
-
-
Bratton, S.B.1
Walker, G.2
Srinivasula, S.M.3
Sun, X.M.4
Butterworth, M.5
Alnemri, E.S.6
Cohen, G.M.7
-
16
-
-
33344476184
-
cFLIP regulation of lymphocyte activation and development
-
Budd, R.C., Yeh, W.C., and Tschopp, J. (2006). cFLIP regulation of lymphocyte activation and development. Nat. Rev. Immunol. 6, 196-204.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 196-204
-
-
Budd, R.C.1
Yeh, W.C.2
Tschopp, J.3
-
17
-
-
0036478928
-
The Apaf-1 apoptosome: A large caspase-activating complex
-
Cain, K., Bratton, S.B., and Cohen, G.M. (2002). The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84, 203-214.
-
(2002)
Biochimie
, vol.84
, pp. 203-214
-
-
Cain, K.1
Bratton, S.B.2
Cohen, G.M.3
-
18
-
-
0026517239
-
Molecular cloning of the interleukin-1β converting enzyme
-
Cerretti, D.P., Kozlosky, C.J., Mosley, B., Nelson, N., Van Ness, K., Greenstreet, T.A., March, C.J., Kronheim, S.R., Druck, T., Cannizzaro, L.A., et al. (1992). Molecular cloning of the interleukin-1β converting enzyme. Science 256, 97-100.
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
Kozlosky, C.J.2
Mosley, B.3
Nelson, N.4
Van Ness, K.5
Greenstreet, T.A.6
March, C.J.7
Kronheim, S.R.8
Druck, T.9
Cannizzaro, L.A.10
-
19
-
-
0037099678
-
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
Chang, D.W., Xing, Z., Pan, Y., Algeciras-Schimnich, A., Barnhart, B.C., Yaish-Ohad, S., Peter, M.E., and Yang, X. (2002). c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21, 3704-3714.
-
(2002)
EMBO J.
, vol.21
, pp. 3704-3714
-
-
Chang, D.W.1
Xing, Z.2
Pan, Y.3
Algeciras-Schimnich, A.4
Barnhart, B.C.5
Yaish-Ohad, S.6
Peter, M.E.7
Yang, X.8
-
20
-
-
32044447161
-
The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover
-
Chang, L., Kamata, H., Solinas, G., Luo, J.L., Maeda, S., Venuprasad, K., Liu, Y.C., and Karin, M. (2006). The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover. Cell 124, 601-613.
-
(2006)
Cell
, vol.124
, pp. 601-613
-
-
Chang, L.1
Kamata, H.2
Solinas, G.3
Luo, J.L.4
Maeda, S.5
Venuprasad, K.6
Liu, Y.C.7
Karin, M.8
-
21
-
-
22744436580
-
Engineering a dimeric caspase-9: A reevaluation of the induced proximity model for caspase activation
-
Chao, Y., Shiozaki, E.N., Srinivasula, S.M., Rigotti, D.J., Fairman, R., and Shi, Y. (2005). Engineering a dimeric caspase-9: a reevaluation of the induced proximity model for caspase activation. PLoS Biol. 3, e183.
-
(2005)
PLoS Biol.
, vol.3
-
-
Chao, Y.1
Shiozaki, E.N.2
Srinivasula, S.M.3
Rigotti, D.J.4
Fairman, R.5
Shi, Y.6
-
22
-
-
0032563323
-
Solution structure of the RAIDD CARD and model for CARD/ CARD interaction in caspase-2 and caspase-9 recruitment
-
Chou, J.J., Matsuo, H., Duan, H., and Wagner, G. (1998). Solution structure of the RAIDD CARD and model for CARD/ CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94, 171-180.
-
(1998)
Cell
, vol.94
, pp. 171-180
-
-
Chou, J.J.1
Matsuo, H.2
Duan, H.3
Wagner, G.4
-
23
-
-
0027400726
-
Multiple defects of immune cell function in mice with disrupted interferon-γ genes
-
Dalton, D.K., Pitts-Meek, S., Keshav, S., Figari, I.S., Bradley, A., and Stewart, T.A. (1993). Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259, 1739-1742.
-
(1993)
Science
, vol.259
, pp. 1739-1742
-
-
Dalton, D.K.1
Pitts-Meek, S.2
Keshav, S.3
Figari, I.S.4
Bradley, A.5
Stewart, T.A.6
-
24
-
-
0033725155
-
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
-
Devin, A., Cook, A., Lin, Y., Rodriguez, Y., Kelliher, M., and Liu, Z. (2000). The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12, 419-429.
-
(2000)
Immunity
, vol.12
, pp. 419-429
-
-
Devin, A.1
Cook, A.2
Lin, Y.3
Rodriguez, Y.4
Kelliher, M.5
Liu, Z.6
-
25
-
-
0036398446
-
The IL-1 family and inflammatory diseases
-
Dinarello, C.A. (2002). The IL-1 family and inflammatory diseases. Clin. Exp. Rheumatol. 20, S1-13.
-
(2002)
Clin. Exp. Rheumatol.
, vol.20
-
-
Dinarello, C.A.1
-
27
-
-
0037291890
-
Insights into the regulatory mechanism for caspase-8 activation
-
Donepudi, M., MacSweeney, A., Briand, C., and Grutter, M.G. (2003). Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell 11, 543-549.
-
(2003)
Mol. Cell
, vol.11
, pp. 543-549
-
-
Donepudi, M.1
MacSweeney, A.2
Briand, C.3
Grutter, M.G.4
-
28
-
-
0035869463
-
Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells
-
Droin, N., Bichat, F., Rebe, C., Wotawa, A., Sordet, O., Hammann, A., Bertrand, R., and Solary, E. (2001). Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells. Blood 97, 1835-1844.
-
(2001)
Blood
, vol.97
, pp. 1835-1844
-
-
Droin, N.1
Bichat, F.2
Rebe, C.3
Wotawa, A.4
Sordet, O.5
Hammann, A.6
Bertrand, R.7
Solary, E.8
-
29
-
-
0034743434
-
Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
-
Druilhe, A., Srinivasula, S.M., Razmara, M., Ahmad, M., and Alnemri, E.S. (2001). Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ. 8, 649-657.
-
(2001)
Cell Death Differ.
, vol.8
, pp. 649-657
-
-
Druilhe, A.1
Srinivasula, S.M.2
Razmara, M.3
Ahmad, M.4
Alnemri, E.S.5
-
30
-
-
0031021356
-
RAIDD is a new 'death' adaptor molecule
-
Duan, H. and Dixit, V.M. (1997). RAIDD is a new 'death' adaptor molecule. Nature 385, 86-89.
-
(1997)
Nature
, vol.385
, pp. 86-89
-
-
Duan, H.1
Dixit, V.M.2
-
31
-
-
0032580153
-
NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
-
Eberstadt, M., Huang, B., Chen, Z., Meadows, R.P., Ng, S.C., Zheng, L., Lenardo, M.J., and Fesik, S.W. (1998). NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature 392, 941-945.
-
(1998)
Nature
, vol.392
, pp. 941-945
-
-
Eberstadt, M.1
Huang, B.2
Chen, Z.3
Meadows, R.P.4
Ng, S.C.5
Zheng, L.6
Lenardo, M.J.7
Fesik, S.W.8
-
32
-
-
9644307904
-
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
-
Enoksson, M., Robertson, J.D., Gogvadze, V., Bu, P., Kropotov, A., Zhivotovsky, B., and Orrenius, S. (2004). Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J. Biol. Chem. 279, 49575-49578.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49575-49578
-
-
Enoksson, M.1
Robertson, J.D.2
Gogvadze, V.3
Bu, P.4
Kropotov, A.5
Zhivotovsky, B.6
Orrenius, S.7
-
33
-
-
0026508561
-
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
-
Fadok, V.A., Voelker, D.R., Campbell, P.A., Cohen, J.J., Bratton, D.L., and Henson, P.M. (1992). Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148, 2207-2216.
-
(1992)
J. Immunol.
, vol.148
, pp. 2207-2216
-
-
Fadok, V.A.1
Voelker, D.R.2
Campbell, P.A.3
Cohen, J.J.4
Bratton, D.L.5
Henson, P.M.6
-
34
-
-
0037144586
-
A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β
-
Fiorentino, L., Stehlik, C., Oliveira, V., Ariza, M.E., Godzik, A., and Reed, J.C. (2002). A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β. J. Biol. Chem. 277, 35333-35340.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35333-35340
-
-
Fiorentino, L.1
Stehlik, C.2
Oliveira, V.3
Ariza, M.E.4
Godzik, A.5
Reed, J.C.6
-
35
-
-
0036294646
-
Human caspase 12 has acquired deleterious mutations
-
Fischer, H., Koenig, U., Eckhart, L., and Tschachler, E. (2002). Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293, 722-726.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 722-726
-
-
Fischer, H.1
Koenig, U.2
Eckhart, L.3
Tschachler, E.4
-
36
-
-
0032695108
-
Natural adjuvants: Endogenous activators of dendritic cells
-
Gallucci, S., Lolkema, M., and Matzinger, P. (1999). Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255.
-
(1999)
Nat. Med.
, vol.5
, pp. 1249-1255
-
-
Gallucci, S.1
Lolkema, M.2
Matzinger, P.3
-
37
-
-
33644663668
-
Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
-
Gao, Z., Shao, Y., and Jiang, X. (2005). Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. J. Biol. Chem. 280, 38271-38275.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 38271-38275
-
-
Gao, Z.1
Shao, Y.2
Jiang, X.3
-
38
-
-
0031004174
-
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
-
Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., et al. (1997). Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386, 619-623.
-
(1997)
Nature
, vol.386
, pp. 619-623
-
-
Ghayur, T.1
Banerjee, S.2
Hugunin, M.3
Butler, D.4
Herzog, L.5
Carter, A.6
Quintal, L.7
Sekut, L.8
Talanian, R.9
Paskind, M.10
-
39
-
-
0037310025
-
Interleukin-18
-
Gracie, J.A., Robertson, S.E., and McInnes, I.B. (2003). Interleukin-18. J. Leukoc. Biol. 73, 213-224.
-
(2003)
J. Leukoc. Biol.
, vol.73
, pp. 213-224
-
-
Gracie, J.A.1
Robertson, S.E.2
McInnes, I.B.3
-
40
-
-
0037134495
-
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
-
Guo, Y., Srinivasula, S.M., Druilhe, A., Fernandes-Alnemri, T., and Alnemri, E.S. (2002). Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. 277, 13430-13437.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13430-13437
-
-
Guo, Y.1
Srinivasula, S.M.2
Druilhe, A.3
Fernandes-Alnemri, T.4
Alnemri, E.S.5
-
41
-
-
0037815277
-
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
-
Harper, N., Hughes, M., MacFarlane, M., and Cohen, G.M. (2003). Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J. Biol. Chem. 278, 25534-25541.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25534-25541
-
-
Harper, N.1
Hughes, M.2
MacFarlane, M.3
Cohen, G.M.4
-
42
-
-
1042290321
-
Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra
-
Hawkins, P.N., Lachmann, H.J., Aganna, E., and McDermott, M.F. (2004). Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum. 50, 607-612.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 607-612
-
-
Hawkins, P.N.1
Lachmann, H.J.2
Aganna, E.3
McDermott, M.F.4
-
43
-
-
0035937775
-
Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins
-
Hlaing, T., Guo, R.F., Dilley, K.A., Loussia, J.M., Morrish, T.A., Shi, M.M., Vincenz, C., and Ward, P.A. (2001). Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem. 276, 9230-9238.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9230-9238
-
-
Hlaing, T.1
Guo, R.F.2
Dilley, K.A.3
Loussia, J.M.4
Morrish, T.A.5
Shi, M.M.6
Vincenz, C.7
Ward, P.A.8
-
44
-
-
0035179970
-
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
Hoffman, H.M., Mueller, J.L., Broide, D.H., Wanderer, A.A., and Kolodner, R.D. (2001). Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29, 301-305.
-
(2001)
Nat. Genet.
, vol.29
, pp. 301-305
-
-
Hoffman, H.M.1
Mueller, J.L.2
Broide, D.H.3
Wanderer, A.A.4
Kolodner, R.D.5
-
45
-
-
0029949257
-
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
-
Hsu, H., Huang, J., Shu, H.B., Baichwal, V., and Goeddel, D.V. (1996a). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396.
-
(1996)
Immunity
, vol.4
, pp. 387-396
-
-
Hsu, H.1
Huang, J.2
Shu, H.B.3
Baichwal, V.4
Goeddel, D.V.5
-
46
-
-
0030032106
-
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
-
Hsu, H., Shu, H.B., Pan, M.G., and Goeddel, D.V. (1996b). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308.
-
(1996)
Cell
, vol.84
, pp. 299-308
-
-
Hsu, H.1
Shu, H.B.2
Pan, M.G.3
Goeddel, D.V.4
-
47
-
-
0030465072
-
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
-
Huang, B., Eberstadt, M., Olejniczak, E.T., Meadows, R.P., and Fesik, S.W. (1996). NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature 384, 638-641.
-
(1996)
Nature
, vol.384
, pp. 638-641
-
-
Huang, B.1
Eberstadt, M.2
Olejniczak, E.T.3
Meadows, R.P.4
Fesik, S.W.5
-
48
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J.P., Chamaillard, M., Zouali, H., Lesage, S., Cezard, J.P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C.A., Gassull, M., et al. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
Lesage, S.4
Cezard, J.P.5
Belaiche, J.6
Almer, S.7
Tysk, C.8
O'Morain, C.A.9
Gassull, M.10
-
49
-
-
0037216780
-
The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations
-
Hull, K.M., Shoham, N., Chae, J.J., Aksentijevich, I., and Kastner, D.L. (2003). The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations. Curr. Opin. Rheumatol. 15, 61-69.
-
(2003)
Curr. Opin. Rheumatol.
, vol.15
, pp. 61-69
-
-
Hull, K.M.1
Shoham, N.2
Chae, J.J.3
Aksentijevich, I.4
Kastner, D.L.5
-
50
-
-
0034730325
-
ICEBERG: A novel inhibitor of interleukin-1β generation
-
Humke, E.W., Shriver, S.K., Starovasnik, M.A., Fairbrother, W.J., and Dixit, V.M. (2000). ICEBERG: a novel inhibitor of interleukin-1β generation. Cell 103, 99-111.
-
(2000)
Cell
, vol.103
, pp. 99-111
-
-
Humke, E.W.1
Shriver, S.K.2
Starovasnik, M.A.3
Fairbrother, W.J.4
Dixit, V.M.5
-
51
-
-
0037382303
-
The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activation
-
Hur, G.M., Lewis, J., Yang, Q., Lin, Y., Nakano, H., Nedospasov, S., and Liu, Z.G. (2003). The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activation. Genes Dev. 17, 873-882.
-
(2003)
Genes Dev.
, vol.17
, pp. 873-882
-
-
Hur, G.M.1
Lewis, J.2
Yang, Q.3
Lin, Y.4
Nakano, H.5
Nedospasov, S.6
Liu, Z.G.7
-
52
-
-
0033591330
-
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB
-
Inohara, N., Koseki, T., Del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., and Nunez, G. (1999). Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J. Biol. Chem. 274, 14560-14567.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14560-14567
-
-
Inohara, N.1
Koseki, T.2
Del Peso, L.3
Hu, Y.4
Yee, C.5
Chen, S.6
Carrio, R.7
Merino, J.8
Liu, D.9
Ni, J.10
Nunez, G.11
-
53
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.L., Schroter, M., Burns, K., Mattmann, C., et al. (1997). Inhibition of death receptor signals by cellular FLIP. Nature 388, 190-195.
-
(1997)
Nature
, vol.388
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
Bodmer, J.L.7
Schroter, M.8
Burns, K.9
Mattmann, C.10
-
55
-
-
28944447430
-
PIDD mediates NF-κB activation in response to DNA damage
-
Janssens, S., Tinel, A., Lippens, S., and Tschopp, J. (2005). PIDD mediates NF-κB activation in response to DNA damage. Cell 123, 1079-1092.
-
(2005)
Cell
, vol.123
, pp. 1079-1092
-
-
Janssens, S.1
Tinel, A.2
Lippens, S.3
Tschopp, J.4
-
56
-
-
0034658130
-
ATP-activated oligomerization as a mechanism for apoptosis regulation: Fold and mechanism prediction for CED-4
-
Jaroszewski, L., Rychlewski, L., Reed, J.C., and Godzik, A. (2000). ATP-activated oligomerization as a mechanism for apoptosis regulation: fold and mechanism prediction for CED-4. Proteins 39, 197-203.
-
(2000)
Proteins
, vol.39
, pp. 197-203
-
-
Jaroszewski, L.1
Rychlewski, L.2
Reed, J.C.3
Godzik, A.4
-
57
-
-
0034596826
-
Salmonella-induced caspase-2 activation in macrophages: A novel mechanism in pathogen-mediated apoptosis
-
Jesenberger, V., Procyk, K.J., Yuan, J., Reipert, S., and Baccarini, M. (2000). Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis. J. Exp. Med. 192, 1035-1046.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1035-1046
-
-
Jesenberger, V.1
Procyk, K.J.2
Yuan, J.3
Reipert, S.4
Baccarini, M.5
-
58
-
-
0037380598
-
Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells
-
Jiang, M. and Milner, J. (2003). Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. Genes Dev. 17, 832-837.
-
(2003)
Genes Dev.
, vol.17
, pp. 832-837
-
-
Jiang, M.1
Milner, J.2
-
59
-
-
0034613302
-
Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
-
Jiang, X. and Wang, X. (2000). Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J. Biol. Chem. 275, 31199-31203.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31199-31203
-
-
Jiang, X.1
Wang, X.2
-
60
-
-
28244459680
-
Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-κB-driven protein synthesis
-
Kahlenberg, J.M., Lundberg, K.C., Kertesy, S.B., Qu, Y., and Dubyak, G.R. (2005). Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-κB-driven protein synthesis. J. Immunol. 175, 7611-7622.
-
(2005)
J. Immunol.
, vol.175
, pp. 7611-7622
-
-
Kahlenberg, J.M.1
Lundberg, K.C.2
Kertesy, S.B.3
Qu, Y.4
Dubyak, G.R.5
-
61
-
-
32944462834
-
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
-
Kanneganti, T.D., Ozoren, N., Body-Malapel, M., Amer, A., Park, J.H., Franchi, L., Whitfield, J., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006). Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440, 233-236.
-
(2006)
Nature
, vol.440
, pp. 233-236
-
-
Kanneganti, T.D.1
Ozoren, N.2
Body-Malapel, M.3
Amer, A.4
Park, J.H.5
Franchi, L.6
Whitfield, J.7
Barchet, W.8
Colonna, M.9
Vandenabeele, P.10
-
62
-
-
1642386039
-
N-Terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway
-
Kataoka, T. and Tschopp, J. (2004). N-Terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway. Mol. Cell. Biol. 24, 2627-2636.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2627-2636
-
-
Kataoka, T.1
Tschopp, J.2
-
63
-
-
0033386808
-
Caspase activation is required for T cell proliferation
-
Kennedy, N.J., Kataoka, T., Tschopp, J., and Budd, R.C. (1999). Caspase activation is required for T cell proliferation. J. Exp. Med. 190, 1891-1896.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1891-1896
-
-
Kennedy, N.J.1
Kataoka, T.2
Tschopp, J.3
Budd, R.C.4
-
64
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr, J.F., Wyllie, A.H., and Currie, A.R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
-
(1972)
Br. J. Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
65
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel, F.C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P.H., and Peter, M.E. (1995). Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14, 5579-5588.
-
(1995)
EMBO J.
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
Hellbardt, S.2
Behrmann, I.3
Germer, M.4
Pawlita, M.5
Krammer, P.H.6
Peter, M.E.7
-
66
-
-
0037075551
-
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
-
Kobayashi, K., Inohara, N., Hernandez, L.D., Galan, J.E., Nunez, G., Janeway, C.A., Medzhitov, R., and Flavell, R.A. (2002). RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416, 194-199.
-
(2002)
Nature
, vol.416
, pp. 194-199
-
-
Kobayashi, K.1
Inohara, N.2
Hernandez, L.D.3
Galan, J.E.4
Nunez, G.5
Janeway, C.A.6
Medzhitov, R.7
Flavell, R.A.8
-
67
-
-
11144333066
-
Fire and death: The pyrin domain joins the death-domain superfamily
-
Kohl, A. and Grutter, M.G. (2004). Fire and death: the pyrin domain joins the death-domain superfamily. C. R. Biol. 327, 1077-1086.
-
(2004)
C. R. Biol.
, vol.327
, pp. 1077-1086
-
-
Kohl, A.1
Grutter, M.G.2
-
68
-
-
0032574745
-
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases
-
USA
-
Koseki, T., Inohara, N., Chen, S., and Nunez, G. (1998). ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc. Natl. Acad. Sci. USA 95, 5156-5160.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 5156-5160
-
-
Koseki, T.1
Inohara, N.2
Chen, S.3
Nunez, G.4
-
69
-
-
3543096349
-
NF-κB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
-
Kreuz, S., Siegmund, D., Rumpf, J.J., Samel, D., Leverkus, M., Janssen, O., Hacker, G., Dittrich-Breiholz, O., Kracht, M., Scheurich, P., and Wajant, H. (2004). NF-κB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J. Cell Biol. 166, 369-380.
-
(2004)
J. Cell Biol.
, vol.166
, pp. 369-380
-
-
Kreuz, S.1
Siegmund, D.2
Rumpf, J.J.3
Samel, D.4
Leverkus, M.5
Janssen, O.6
Hacker, G.7
Dittrich-Breiholz, O.8
Kracht, M.9
Scheurich, P.10
Wajant, H.11
-
70
-
-
0037791779
-
Humoral links between sleep and the immune system: Research issues
-
Krueger, J.M. and Majde, J.A. (2003). Humoral links between sleep and the immune system: research issues. Ann. NY Acad. Sci. 992, 9-20.
-
(2003)
Ann. NY Acad. Sci.
, vol.992
, pp. 9-20
-
-
Krueger, J.M.1
Majde, J.A.2
-
71
-
-
0027990778
-
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme
-
Kumar, S., Kinoshita, M., Noda, M., Copeland, N.G., and Jenkins, N.A. (1994). Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev. 8, 1613-1626.
-
(1994)
Genes Dev.
, vol.8
, pp. 1613-1626
-
-
Kumar, S.1
Kinoshita, M.2
Noda, M.3
Copeland, N.G.4
Jenkins, N.A.5
-
72
-
-
0036312069
-
Alice in caspase land. A phylogenetic analysis of caspases from worm to man
-
Lamkanfi, M., Declercq, W., Kalai, M., Saelens, X., and Vandenabeele, P. (2002). Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ. 9, 358-361.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 358-361
-
-
Lamkanfi, M.1
Declercq, W.2
Kalai, M.3
Saelens, X.4
Vandenabeele, P.5
-
73
-
-
10644270650
-
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1β generation
-
Lamkanfi, M., Denecker, G., Kalai, M., D'hondt, K., Meeus, A., Declercq, W., Saelens, X., and Vandenabeele, P. (2004a). INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1β generation. J. Biol. Chem. 279, 51729-51738.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51729-51738
-
-
Lamkanfi, M.1
Denecker, G.2
Kalai, M.3
D'hondt, K.4
Meeus, A.5
Declercq, W.6
Saelens, X.7
Vandenabeele, P.8
-
74
-
-
2642517305
-
Caspase-1 activates nuclear factor of the κ-enhancer in B cells independently of its enzymatic activity
-
Lamkanfi, M., Kalai, M., Saelens, X., Declercq, W., and Vandenabeele, P. (2004b). Caspase-1 activates nuclear factor of the κ-enhancer in B cells independently of its enzymatic activity. J. Biol. Chem. 279, 24785-24793.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24785-24793
-
-
Lamkanfi, M.1
Kalai, M.2
Saelens, X.3
Declercq, W.4
Vandenabeele, P.5
-
75
-
-
20044367651
-
A novel caspase-2 complex containing TRAF2 and RIP1
-
Lamkanfi, M., D'hondt, K., Vande Walle, L., Van Gurp, M., Denecker, G., Demeulemeester, J., Kalai, M., Declercq, W., Saelens, X., and Vandenabeele, P. (2005). A novel caspase-2 complex containing TRAF2 and RIP1. J. Biol. Chem. 280, 6923-6932.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 6923-6932
-
-
Lamkanfi, M.1
D'hondt, K.2
Vande Walle, L.3
Van Gurp, M.4
Denecker, G.5
Demeulemeester, J.6
Kalai, M.7
Declercq, W.8
Saelens, X.9
Vandenabeele, P.10
-
76
-
-
0037162833
-
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization
-
Lassus, P., Opitz-Araya, X., and Lazebnik, Y. (2002). Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297, 1352-1354.
-
(2002)
Science
, vol.297
, pp. 1352-1354
-
-
Lassus, P.1
Opitz-Araya, X.2
Lazebnik, Y.3
-
77
-
-
0035860780
-
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing
-
Lee, S.H., Stehlik, C., and Reed, J.C. (2001). Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. J. Biol. Chem. 276, 34495-34500.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34495-34500
-
-
Lee, S.H.1
Stehlik, C.2
Reed, J.C.3
-
78
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., and Wang, X. (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
79
-
-
21244441600
-
Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation
-
Lin, C.F., Chen, C.L., Chang, W.T., Jan, M.S., Hsu, L.J., Wu, R.H., Fang, Y.T., Tang, M.J., Chang, W.C., and Lin, Y.S. (2005). Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. J. Biol. Chem. 280, 23758-23765.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23758-23765
-
-
Lin, C.F.1
Chen, C.L.2
Chang, W.T.3
Jan, M.S.4
Hsu, L.J.5
Wu, R.H.6
Fang, Y.T.7
Tang, M.J.8
Chang, W.C.9
Lin, Y.S.10
-
80
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
-
Liu, X., Kim, C.N., Yang, J., Jemmerson, R., and Wang, X. (1996). Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147-157.
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
81
-
-
13244277880
-
Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing
-
Maeda, S., Hsu, L.C., Liu, H., Bankston, L.A., Iimura, M., Kagnoff, M.F., Eckmann, L., and Karin, M. (2005). Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing. Science 307, 734-738.
-
(2005)
Science
, vol.307
, pp. 734-738
-
-
Maeda, S.1
Hsu, L.C.2
Liu, H.3
Bankston, L.A.4
Iimura, M.5
Kagnoff, M.F.6
Eckmann, L.7
Karin, M.8
-
82
-
-
3142654767
-
Differential activation of the inflammasome by caspase-1 adaptors ASC and lpaf
-
Mariathasan, S., Newton, K., Monack, D.M., Vucic, D., French, D.M., Lee, W.P., Roose-Girma, M., Erickson, S., and Dixit, V.M. (2004). Differential activation of the inflammasome by caspase-1 adaptors ASC and lpaf. Nature 430, 213-218.
-
(2004)
Nature
, vol.430
, pp. 213-218
-
-
Mariathasan, S.1
Newton, K.2
Monack, D.M.3
Vucic, D.4
French, D.M.5
Lee, W.P.6
Roose-Girma, M.7
Erickson, S.8
Dixit, V.M.9
-
83
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan, S., Weiss, D.S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W.P., Weinrauch, Y., Monack, D.M., and Dixit, V.M. (2006). Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
Roose-Girma, M.6
Lee, W.P.7
Weinrauch, Y.8
Monack, D.M.9
Dixit, V.M.10
-
84
-
-
2542457495
-
Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
-
Martinon, F. and Tschopp, J. (2004). Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117, 561-574.
-
(2004)
Cell
, vol.117
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
85
-
-
22444433175
-
NLRs join TLRs as innate sensors of pathogens
-
Martinon, F. and Tschopp, J. (2005). NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26, 447-454.
-
(2005)
Trends Immunol.
, vol.26
, pp. 447-454
-
-
Martinon, F.1
Tschopp, J.2
-
86
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
Martinon, F., Burns, K., and Tschopp, J. (2002). The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426.
-
(2002)
Mol. Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
87
-
-
7944232105
-
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
-
Martinon, F., Agostini, L., Meylan, E., and Tschopp, J. (2004). Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14, 1929-1934.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1929-1934
-
-
Martinon, F.1
Agostini, L.2
Meylan, E.3
Tschopp, J.4
-
88
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon, F., Petrilli, V., Mayor, A., Tardivel, A., and Tschopp, J. (2006). Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
89
-
-
0037066427
-
The danger model: A renewed sense of self
-
Matzinger, P. (2002). The danger model: a renewed sense of self. Science 296, 301-305.
-
(2002)
Science
, vol.296
, pp. 301-305
-
-
Matzinger, P.1
-
90
-
-
0033696045
-
An autosomal dominant periodic fever associated with AA amyloidosis in a north Indian family maps to distal chromosome 1q
-
McDermott, M.F., Aganna, E., Hitman, G.A., Ogunkolade, B.W., Booth, D.R., and Hawkins, P.N. (2000). An autosomal dominant periodic fever associated with AA amyloidosis in a north Indian family maps to distal chromosome 1q. Arthritis Rheum. 43, 2034-2040.
-
(2000)
Arthritis Rheum.
, vol.43
, pp. 2034-2040
-
-
McDermott, M.F.1
Aganna, E.2
Hitman, G.A.3
Ogunkolade, B.W.4
Booth, D.R.5
Hawkins, P.N.6
-
91
-
-
0033975869
-
Innate immune recognition: Mechanisms and pathways
-
Medzhitov, R. and Janeway, C. Jr. (2000). Innate immune recognition: mechanisms and pathways. Immunol. Rev. 173, 89-97.
-
(2000)
Immunol. Rev.
, vol.173
, pp. 89-97
-
-
Medzhitov, R.1
Janeway Jr., C.2
-
92
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau, O. and Tschopp, J. (2003). Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
93
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
-
Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D.W., Briand, C., and Grutter, M.G. (2002). The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277, 45162-45171.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
Thome, M.2
Schneider, P.3
Holler, N.4
Tschopp, J.5
Nicholson, D.W.6
Briand, C.7
Grutter, M.G.8
-
94
-
-
33744517489
-
Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis
-
in press; doi: 10.1038/sj.cdd.4401855
-
Muppidi, J.R., Lobito, A.A., Ramaswamy, M., Yang, J.K., Wang, L., Wu, H., and Siegel, R.M. (2006). Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis. Cell Death Differ., in press; doi: 10.1038/sj.cdd.4401855.
-
(2006)
Cell Death Differ.
-
-
Muppidi, J.R.1
Lobito, A.A.2
Ramaswamy, M.3
Yang, J.K.4
Wang, L.5
Wu, H.6
Siegel, R.M.7
-
95
-
-
0032579490
-
An induced proximity model for caspase-8 activation
-
Muzio, M., Stockwell, B.R., Stennicke, H.R., Salvesen, G.S., and Dixit, V.M. (1998). An induced proximity model for caspase-8 activation. J. Biol. Chem. 273, 2926-2930.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2926-2930
-
-
Muzio, M.1
Stockwell, B.R.2
Stennicke, H.R.3
Salvesen, G.S.4
Dixit, V.M.5
-
96
-
-
0346350694
-
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 is an inducible inflammatory mediator with NF-κB suppressive properties
-
O'Connor, W. Jr., Harton, J.A., Zhu, X., Linhoff, M.W., and Ting, J.P. (2003). Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 is an inducible inflammatory mediator with NF-κB suppressive properties. J. Immunol. 171, 6329-6333.
-
(2003)
J. Immunol.
, vol.171
, pp. 6329-6333
-
-
O'Connor Jr., W.1
Harton, J.A.2
Zhu, X.3
Linhoff, M.W.4
Ting, J.P.5
-
97
-
-
0035895992
-
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
-
Ogura, Y., Inohara, N., Benito, A., Chen, F.F., Yamaoka, S., and Nunez, G. (2001). Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812-4818.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4812-4818
-
-
Ogura, Y.1
Inohara, N.2
Benito, A.3
Chen, F.F.4
Yamaoka, S.5
Nunez, G.6
-
98
-
-
0037605790
-
Caspase activity is required for stimulated B lymphocytes to enter the cell cycle
-
Olson, N.E., Graves, J.D., Shu, G.L., Ryan, E.J., and Clark, E.A. (2003). Caspase activity is required for stimulated B lymphocytes to enter the cell cycle. J. Immunol. 170, 6065-6072.
-
(2003)
J. Immunol.
, vol.170
, pp. 6065-6072
-
-
Olson, N.E.1
Graves, J.D.2
Shu, G.L.3
Ryan, E.J.4
Clark, E.A.5
-
99
-
-
0035877605
-
Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3
-
Paroni, G., Henderson, C., Schneider, C., and Brancolini, C. (2001). Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3. J. Biol. Chem. 276, 21907-21915.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21907-21915
-
-
Paroni, G.1
Henderson, C.2
Schneider, C.3
Brancolini, C.4
-
100
-
-
14644406398
-
The flip side of FLIP
-
Peter, M.E. (2004). The flip side of FLIP. Biochem. J. 382, e1-3.
-
(2004)
Biochem. J.
, vol.382
-
-
Peter, M.E.1
-
101
-
-
0037276437
-
The CD95(APO-1/Fas) DISC and beyond
-
Peter, M.E. and Krammer, P.H. (2003). The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10, 26-35.
-
(2003)
Cell Death Differ.
, vol.10
, pp. 26-35
-
-
Peter, M.E.1
Krammer, P.H.2
-
102
-
-
22844435414
-
Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail
-
Poukkula, M., Kaunisto, A., Hietakangas, V., Denessiouk, K., Katajamaki, T., Johnson, M.S., Sistonen, L., and Eriksson, J.E. (2005). Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail. J. Biol. Chem. 280, 27345-27355.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 27345-27355
-
-
Poukkula, M.1
Kaunisto, A.2
Hietakangas, V.3
Denessiouk, K.4
Katajamaki, T.5
Johnson, M.S.6
Sistonen, L.7
Eriksson, J.E.8
-
103
-
-
0033542482
-
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
-
Qin, H., Srinivasula, S.M., Wu, G., Fernandes-Alnemri, T., Alnemri, E.S., and Shi, Y. (1999). Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature 399, 549-557.
-
(1999)
Nature
, vol.399
, pp. 549-557
-
-
Qin, H.1
Srinivasula, S.M.2
Wu, G.3
Fernandes-Alnemri, T.4
Alnemri, E.S.5
Shi, Y.6
-
104
-
-
0037049549
-
A novel Apaf-1-independent putative caspase-2 activation complex
-
Read, S.H., Baliga, B.C., Ekert, P.G., Vaux, D.L., and Kumar, S. (2002). A novel Apaf-1-independent putative caspase-2 activation complex. J. Cell. Biol. 159, 739-745.
-
(2002)
J. Cell. Biol.
, vol.159
, pp. 739-745
-
-
Read, S.H.1
Baliga, B.C.2
Ekert, P.G.3
Vaux, D.L.4
Kumar, S.5
-
105
-
-
14144256097
-
The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development
-
USA
-
Ren, J., Shi, M., Liu, R., Yang, Q.H., Johnson, T., Skarnes, W.C., and Du, C. (2005). The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proc. Natl. Acad. Sci. USA 102, 565-570.
-
(2005)
Proc. Natl. Acad. Sci.
, vol.102
, pp. 565-570
-
-
Ren, J.1
Shi, M.2
Liu, R.3
Yang, Q.H.4
Johnson, T.5
Skarnes, W.C.6
Du, C.7
-
106
-
-
17244368276
-
Structure of the apoptotic protease-activating factor 1 bound to ADP
-
Riedl, S.J., Li, W., Chao, Y., Schwarzenbacher, R., and Shi, Y. (2005). Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 434, 926-933.
-
(2005)
Nature
, vol.434
, pp. 926-933
-
-
Riedl, S.J.1
Li, W.2
Chao, Y.3
Schwarzenbacher, R.4
Shi, Y.5
-
107
-
-
0034693227
-
Distinct pathways for stimulation of cytochrome c release by etoposide
-
Robertson, J.D., Gogvadze, V., Zhivotovsky, B., and Orrenius, S. (2000). Distinct pathways for stimulation of cytochrome c release by etoposide. J. Biol. Chem. 275, 32438-32443.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32438-32443
-
-
Robertson, J.D.1
Gogvadze, V.2
Zhivotovsky, B.3
Orrenius, S.4
-
108
-
-
0037119491
-
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
-
Robertson, J.D., Enoksson, M., Suomela, M., Zhivotovsky, B., and Orrenius, S. (2002). Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J. Biol. Chem. 277, 29803-29809.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29803-29809
-
-
Robertson, J.D.1
Enoksson, M.2
Suomela, M.3
Zhivotovsky, B.4
Orrenius, S.5
-
109
-
-
4344663051
-
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity
-
Robertson, J.D., Gogvadze, V., Kropotov, A., Vakifahmetoglu, H., Zhivotovsky, B., and Orrenius, S. (2004). Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep. 5, 643-648.
-
(2004)
EMBO Rep.
, vol.5
, pp. 643-648
-
-
Robertson, J.D.1
Gogvadze, V.2
Kropotov, A.3
Vakifahmetoglu, H.4
Zhivotovsky, B.5
Orrenius, S.6
-
110
-
-
0033573020
-
Caspase-9 and APAF-1 form an active holoenzyme
-
Rodriguez, J. and Lazebnik, Y. (1999). Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev. 13, 3179-3184.
-
(1999)
Genes Dev.
, vol.13
, pp. 3179-3184
-
-
Rodriguez, J.1
Lazebnik, Y.2
-
111
-
-
0031438499
-
The role of interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications
-
Rothwell, N., Allan, S., and Toulmond, S. (1997). The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. J. Clin. Invest. 100, 2648-2652.
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2648-2652
-
-
Rothwell, N.1
Allan, S.2
Toulmond, S.3
-
112
-
-
2342457148
-
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
-
Saleh, M., Vaillancourt, J.P., Graham, R.K., Huyck, M., Srinivasula, S.M., Alnemri, E.S., Steinberg, M.H., Nolan, V., Baldwin, C.T., Hotchkiss, R.S., et al. (2004). Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429, 75-79.
-
(2004)
Nature
, vol.429
, pp. 75-79
-
-
Saleh, M.1
Vaillancourt, J.P.2
Graham, R.K.3
Huyck, M.4
Srinivasula, S.M.5
Alnemri, E.S.6
Steinberg, M.H.7
Nolan, V.8
Baldwin, C.T.9
Hotchkiss, R.S.10
-
113
-
-
0033613143
-
Caspase activation: The induced-proximity model
-
USA
-
Salvesen, G.S. and Dixit, V.M. (1999). Caspase activation: the induced-proximity model. Proc. Natl. Acad. Sci. USA 96, 10964-10967.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 10964-10967
-
-
Salvesen, G.S.1
Dixit, V.M.2
-
114
-
-
0035932121
-
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
-
Samad, T.A., Moore, K.A., Sapirstein, A., Billet, S., Allchorne, A., Poole, S., Bonventre, J.V., and Woolf, C.J. (2001). Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410, 471-475.
-
(2001)
Nature
, vol.410
, pp. 471-475
-
-
Samad, T.A.1
Moore, K.A.2
Sapirstein, A.3
Billet, S.4
Allchorne, A.5
Poole, S.6
Bonventre, J.V.7
Woolf, C.J.8
-
115
-
-
2942744672
-
Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells
-
Sato, T., Machida, T., Takahashi, S., Iyama, S., Sato, Y., Kuribayashi, K., Takada, K., Oku, T., Kawano, Y., Okamoto, T., et al. (2004). Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells. J. Immunol. 173, 285-296.
-
(2004)
J. Immunol.
, vol.173
, pp. 285-296
-
-
Sato, T.1
Machida, T.2
Takahashi, S.3
Iyama, S.4
Sato, Y.5
Kuribayashi, K.6
Takada, K.7
Oku, T.8
Kawano, Y.9
Okamoto, T.10
-
116
-
-
0033529534
-
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
-
Scaffidi, C., Schmitz, I., Zha, J., Korsmeyer, S.J., Krammer, P.H., and Peter, M.E. (1999). Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem. 274, 22532-22538.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22532-22538
-
-
Scaffidi, C.1
Schmitz, I.2
Zha, J.3
Korsmeyer, S.J.4
Krammer, P.H.5
Peter, M.E.6
-
117
-
-
4444341939
-
Compartmentalization of TNF receptor 1 signaling: Internalized TNF receptosomes as death signaling vesicles
-
Schneider-Brachert, W., Tchikov, V., Neumeyer, J., Jakob, M., Winoto-Morbach, S., Held-Feindt, J., Heinrich, M., Merkel, O., Ehrenschwender, M., Adam, D., et al. (2004). Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415-428.
-
(2004)
Immunity
, vol.21
, pp. 415-428
-
-
Schneider-Brachert, W.1
Tchikov, V.2
Neumeyer, J.3
Jakob, M.4
Winoto-Morbach, S.5
Held-Feindt, J.6
Heinrich, M.7
Merkel, O.8
Ehrenschwender, M.9
Adam, D.10
-
118
-
-
0642314384
-
Non-apoptotic functions of caspases in cellular proliferation and differentiation
-
Schwerk, C. and Schulze-Osthoff, K. (2003). Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem. Pharmacol. 66, 1453-1458.
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 1453-1458
-
-
Schwerk, C.1
Schulze-Osthoff, K.2
-
119
-
-
24744451822
-
p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury
-
Seth, R., Yang, C., Kaushal, V., Shah, S.V., and Kaushal, G.P. (2005). p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. J. Biol. Chem. 280, 31230-31239.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31230-31239
-
-
Seth, R.1
Yang, C.2
Kaushal, V.3
Shah, S.V.4
Kaushal, G.P.5
-
120
-
-
0034097347
-
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD
-
Shearwin-Whyatt, L.M., Harvey, N.L., and Kumar, S. (2000). Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death Differ. 7, 155-165.
-
(2000)
Cell Death Differ.
, vol.7
, pp. 155-165
-
-
Shearwin-Whyatt, L.M.1
Harvey, N.L.2
Kumar, S.3
-
121
-
-
27144512715
-
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
-
Shin, S., Lee, Y., Kim, W., Ko, H., Choi, H., and Kim, K. (2005). Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J. 24, 4209-4210.
-
(2005)
EMBO J.
, vol.24
, pp. 4209-4210
-
-
Shin, S.1
Lee, Y.2
Kim, W.3
Ko, H.4
Choi, H.5
Kim, K.6
-
122
-
-
0033667778
-
FADD/ MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick, M.R., Weigand, M.A., Rieser, E., Rauch, C.T., Juo, P., Blenis, J., Krammer, P.H., and Walczak, H. (2000). FADD/ MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12, 599-609.
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
Rauch, C.T.4
Juo, P.5
Blenis, J.6
Krammer, P.H.7
Walczak, H.8
-
123
-
-
0037121940
-
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor κB activation pathways
-
Stehlik, C., Fiorentino, L., Dorfleutner, A., Bruey, J.M., Ariza, E.M., Sagara, J., and Reed, J.C. (2002). The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor κB activation pathways. J. Exp. Med. 196, 1605-1615.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1605-1615
-
-
Stehlik, C.1
Fiorentino, L.2
Dorfleutner, A.3
Bruey, J.M.4
Ariza, E.M.5
Sagara, J.6
Reed, J.C.7
-
124
-
-
0038682430
-
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-κB and pro-caspase-1 regulation
-
Stehlik, C., Krajewska, M., Welsh, K., Krajewski, S., Godzik, A., and Reed, J.C. (2003a). The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-κB and pro-caspase-1 regulation. Biochem. J. 373, 101-113.
-
(2003)
Biochem. J.
, vol.373
, pp. 101-113
-
-
Stehlik, C.1
Krajewska, M.2
Welsh, K.3
Krajewski, S.4
Godzik, A.5
Reed, J.C.6
-
125
-
-
0344585401
-
Apoptosis-associated specklike protein containing a caspase recruitment domain is a regulator of procaspase-1 activation
-
Stehlik, C., Lee, S.H., Dorfleutner, A., Stassinopoulos, A., Sagara, J., and Reed, J.C. (2003b). Apoptosis-associated specklike protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J. Immunol. 171, 6154-6163.
-
(2003)
J. Immunol.
, vol.171
, pp. 6154-6163
-
-
Stehlik, C.1
Lee, S.H.2
Dorfleutner, A.3
Stassinopoulos, A.4
Sagara, J.5
Reed, J.C.6
-
126
-
-
0028929328
-
Mechanisms and genes of cellular suicide
-
Steller, H. (1995). Mechanisms and genes of cellular suicide. Science 267, 1445-1449.
-
(1995)
Science
, vol.267
, pp. 1445-1449
-
-
Steller, H.1
-
127
-
-
0033605722
-
Caspase-9 can be activated without proteolytic processing
-
Stennicke, H.R., Deveraux, Q.L., Humke, E.W., Reed, J.C., Dixit, V.M., and Salvesen, G.S. (1999). Caspase-9 can be activated without proteolytic processing. J. Biol. Chem. 274, 8359-8362.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8359-8362
-
-
Stennicke, H.R.1
Deveraux, Q.L.2
Humke, E.W.3
Reed, J.C.4
Dixit, V.M.5
Salvesen, G.S.6
-
128
-
-
20044368626
-
Requirement for caspase-8 in NF-κB activation by antigen receptor
-
Su, H., Bidere, N., Zheng, L., Cubre, A., Sakai, K., Dale, J., Salmena, L., Hakem, R., Straus, S., and Lenardo, M. (2005). Requirement for caspase-8 in NF-κB activation by antigen receptor. Science 307, 1465-1468.
-
(2005)
Science
, vol.307
, pp. 1465-1468
-
-
Su, H.1
Bidere, N.2
Zheng, L.3
Cubre, A.4
Sakai, K.5
Dale, J.6
Salmena, L.7
Hakem, R.8
Straus, S.9
Lenardo, M.10
-
129
-
-
3543032779
-
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD
-
Thomas, L.R., Henson, A., Reed, J.C., Salsbury, F.R., and Thorburn, A. (2004). Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. J. Biol. Chem. 279, 32780-32785.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 32780-32785
-
-
Thomas, L.R.1
Henson, A.2
Reed, J.C.3
Salsbury, F.R.4
Thorburn, A.5
-
130
-
-
0035496099
-
Regulation of lymphocyte proliferation and death by FLIP
-
Thome, M. and Tschopp, J. (2001). Regulation of lymphocyte proliferation and death by FLIP. Nat. Rev. Immunol. 7, 50-58.
-
(2001)
Nat. Rev. Immunol.
, vol.7
, pp. 50-58
-
-
Thome, M.1
Tschopp, J.2
-
131
-
-
0030970013
-
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
-
Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.L., Schroter, M., et al. (1997). Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386, 517-521.
-
(1997)
Nature
, vol.386
, pp. 517-521
-
-
Thome, M.1
Schneider, P.2
Hofmann, K.3
Fickenscher, H.4
Meinl, E.5
Neipel, F.6
Mattmann, C.7
Burns, K.8
Bodmer, J.L.9
Schroter, M.10
-
132
-
-
0242656497
-
Death receptor-induced cell killing
-
Thorburn, A. (2004). Death receptor-induced cell killing. Cell Signal. 16, 139-144.
-
(2004)
Cell Signal.
, vol.16
, pp. 139-144
-
-
Thorburn, A.1
-
133
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes
-
Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., et al. (1992). A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356, 768-774.
-
(1992)
Nature
, vol.356
, pp. 768-774
-
-
Thornberry, N.A.1
Bull, H.G.2
Calaycay, J.R.3
Chapman, K.T.4
Howard, A.D.5
Kostura, M.J.6
Miller, D.K.7
Molineaux, S.M.8
Weidner, J.R.9
Aunins, J.10
-
134
-
-
2442453730
-
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
-
Tinel, A. and Tschopp, J. (2004). The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304, 843-846.
-
(2004)
Science
, vol.304
, pp. 843-846
-
-
Tinel, A.1
Tschopp, J.2
-
135
-
-
17644396670
-
CATERPILLER: A novel gene family important in immunity, cell death, and diseases
-
Ting, J.P. and Davis, B.K. (2005). CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu. Rev. Immunol. 23, 387-414.
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 387-414
-
-
Ting, J.P.1
Davis, B.K.2
-
136
-
-
0031726359
-
Inhibition of fas death signals by FLIPs
-
Tschopp, J., Irmler, M., and Thome, M. (1998). Inhibition of fas death signals by FLIPs. Curr. Opin. Immunol. 10, 552-558.
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 552-558
-
-
Tschopp, J.1
Irmler, M.2
Thome, M.3
-
137
-
-
30344459150
-
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
-
Tu, S., McStay, G.P., Boucher, L.M., Mak, T., Beere, H.M., and Green, D.R. (2006). In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat. Cell Biol. 8, 72-77.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 72-77
-
-
Tu, S.1
McStay, G.P.2
Boucher, L.M.3
Mak, T.4
Beere, H.M.5
Green, D.R.6
-
138
-
-
15844367093
-
Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
-
Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., et al. (1996). Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156, 4274-4279.
-
(1996)
J. Immunol.
, vol.156
, pp. 4274-4279
-
-
Ushio, S.1
Namba, M.2
Okura, T.3
Hattori, K.4
Nukada, Y.5
Akita, K.6
Tanabe, F.7
Konishi, K.8
Micallef, M.9
Fujii, M.10
-
139
-
-
1542289739
-
Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD
-
Vanden Berghe, T., Van Loo, G., Saelens, X., Van Gurp, M., Brouckaert, G., Kalai, M., Declercq, W., and Vandenabeele, P. (2004). Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J. Biol. Chem. 279, 7925-7933.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7925-7933
-
-
Vanden Berghe, T.1
Van Loo, G.2
Saelens, X.3
Van Gurp, M.4
Brouckaert, G.5
Kalai, M.6
Declercq, W.7
Vandenabeele, P.8
-
140
-
-
0035425256
-
The death domain superfamily: A tale of two interfaces?
-
Weber, C.H. and Vincenz, C. (2001). The death domain superfamily: a tale of two interfaces? Trends Biochem. Sci. 26, 475-481.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 475-481
-
-
Weber, C.H.1
Vincenz, C.2
-
141
-
-
3142581992
-
Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens
-
Werner, A.B., Tait, S.W., De Vries, E., Eldering, E., and Borst, J. (2004). Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. J. Biol. Chem. 279, 28771-28780.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 28771-28780
-
-
Werner, A.B.1
Tait, S.W.2
De Vries, E.3
Eldering, E.4
Borst, J.5
-
142
-
-
0032209361
-
Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel
-
Wiley, J.S., Gargett, C.E., Zhang, W., Snook, M.B., and Jamieson, G.P. (1998). Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel. Am. J. Physiol. 275, C1224-1231.
-
(1998)
Am. J. Physiol.
, vol.275
-
-
Wiley, J.S.1
Gargett, C.E.2
Zhang, W.3
Snook, M.B.4
Jamieson, G.P.5
-
143
-
-
7944231451
-
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
-
Yamamoto, M., Yaginuma, K., Tsutsui, H., Sagara, J., Guan, X., Seki, E., Yasuda, K., Akira, S., Nakanishi, K., Noda, T., and Taniguchi, S. (2004). ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 9, 1055-1067.
-
(2004)
Genes Cells
, vol.9
, pp. 1055-1067
-
-
Yamamoto, M.1
Yaginuma, K.2
Tsutsui, H.3
Sagara, J.4
Guan, X.5
Seki, E.6
Yasuda, K.7
Akira, S.8
Nakanishi, K.9
Noda, T.10
Taniguchi, S.11
-
144
-
-
29144463250
-
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition
-
Yang, J.K., Wang, L., Zheng, L., Wan, F., Ahmed, M., Lenardo, M.J., and Wu, H. (2005). Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol. Cell 20, 939-949.
-
(2005)
Mol. Cell
, vol.20
, pp. 939-949
-
-
Yang, J.K.1
Wang, L.2
Zheng, L.3
Wan, F.4
Ahmed, M.5
Lenardo, M.J.6
Wu, H.7
-
145
-
-
0036928158
-
Nod1, a CARD protein, enhances pro-interleukin-1β processing through the interaction with pro-caspase-1
-
Yoo, N.J., Park, W.S., Kim, S.Y., Reed, J.C., Son, S.G., Lee, J.Y., and Lee, S.H. (2002). Nod1, a CARD protein, enhances pro-interleukin-1β processing through the interaction with pro-caspase-1. Biochem. Biophys. Res. Commun. 299, 652-658.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 652-658
-
-
Yoo, N.J.1
Park, W.S.2
Kim, S.Y.3
Reed, J.C.4
Son, S.G.5
Lee, J.Y.6
Lee, S.H.7
-
146
-
-
27644483812
-
A structure of the human apoptosome at 12.8 Å resolution provides insights into this cell death platform
-
Camb.
-
Yu, X., Acehan, D., Menetret, J.F., Booth, C.R., Ludtke, S.J., Riedl, S.J., Shi, Y., Wang, X., and Akey, C.W. (2005). A structure of the human apoptosome at 12.8 Å resolution provides insights into this cell death platform. Structure (Camb.) 13, 1725-1735.
-
(2005)
Structure
, vol.13
, pp. 1725-1735
-
-
Yu, X.1
Acehan, D.2
Menetret, J.F.3
Booth, C.R.4
Ludtke, S.J.5
Riedl, S.J.6
Shi, Y.7
Wang, X.8
Akey, C.W.9
-
147
-
-
23744456144
-
An essential role for c-FLIP in the efficient development of mature T lymphocytes
-
Zhang, N. and He, Y.W. (2005). An essential role for c-FLIP in the efficient development of mature T lymphocytes. J. Exp. Med. 202, 395-404.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 395-404
-
-
Zhang, N.1
He, Y.W.2
-
148
-
-
0032576757
-
Injected cytochrome c induces apoptosis
-
Zhivotovsky, B., Orrenius, S., Brustugun, O.T., and Doskeland, S.O. (1998). Injected cytochrome c induces apoptosis. Nature 391, 449-450.
-
(1998)
Nature
, vol.391
, pp. 449-450
-
-
Zhivotovsky, B.1
Orrenius, S.2
Brustugun, O.T.3
Doskeland, S.O.4
-
149
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou, H., Henzel, W.J., Liu, X., Lutschg, A., and Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
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