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Volumn 117, Issue 3, 2007, Pages 514-521

The fundamental basis of inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

ABT 874; ALICAFORSEN; BASILIXIMAB; CASPASE RECRUITMENT DOMAIN PROTEIN 15; DACLIZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FONTOLIZUMAB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 12P40; INTERLEUKIN 12P40 ANTIBODY; INTERLEUKIN 6 ANTIBODY; MLN 02; NATALIZUMAB; UNCLASSIFIED DRUG; VISILIZUMAB;

EID: 33847381116     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI30587     Document Type: Article
Times cited : (1140)

References (83)
  • 1
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky, D. 2002. Inflammatory bowel disease. N. Engl. J. Med. 347:417-429.
    • (2002) N. Engl. J. Med , vol.347 , pp. 417-429
    • Podolsky, D.1
  • 2
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • doi:10.1172/JCI200419836
    • Fuss, I., et al. 2004. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113:1490-1497. doi:10.1172/JCI200419836.
    • (2004) J. Clin. Invest , vol.113 , pp. 1490-1497
    • Fuss, I.1
  • 3
    • 0242384062 scopus 로고    scopus 로고
    • Surgery for inflammatory bowel diseases
    • McLeod, R. 2003. Surgery for inflammatory bowel diseases. Dig. Dis. 21:168-179.
    • (2003) Dig. Dis , vol.21 , pp. 168-179
    • McLeod, R.1
  • 4
    • 0346785197 scopus 로고    scopus 로고
    • Maintenance therapy for inflammatory bowel disease
    • Feagan, B. 2003. Maintenance therapy for inflammatory bowel disease. Am. J. Gastroenterol. 98(Suppl. 12):S6-S17.
    • (2003) Am. J. Gastroenterol , vol.98 , Issue.SUPPL. 12
    • Feagan, B.1
  • 5
    • 33744817063 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with oral mesalamine: Advances in drug formulation, efficacy expectations and dose response, compliance, and chemoprevention
    • Sandborn, W. 2006. Treatment of ulcerative colitis with oral mesalamine: advances in drug formulation, efficacy expectations and dose response, compliance, and chemoprevention. Rev. Gastroenterol. Disord. 6:97-105.
    • (2006) Rev. Gastroenterol. Disord , vol.6 , pp. 97-105
    • Sandborn, W.1
  • 6
    • 21744455700 scopus 로고    scopus 로고
    • Practical management of inflammatory bowel disease patients taking immunomodulators
    • Siegel, C., and Sands, B. 2005. Practical management of inflammatory bowel disease patients taking immunomodulators. Aliment. Pharmacol. Ther. 22:1-16.
    • (2005) Aliment. Pharmacol. Ther , vol.22 , pp. 1-16
    • Siegel, C.1    Sands, B.2
  • 7
    • 33749038012 scopus 로고    scopus 로고
    • Current limitations of IBD treatment: Where do we go from here?
    • Targan, S. 2006. Current limitations of IBD treatment: where do we go from here? Ann. N. Y. Acad. Sci. 1072:1-8.
    • (2006) Ann. N. Y. Acad. Sci , vol.1072 , pp. 1-8
    • Targan, S.1
  • 8
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss, I., et al. 2006. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12:9-15.
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 9-15
    • Fuss, I.1
  • 9
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • doi:10.1172/JCI21404
    • Yen, D., et al. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116:1310-1316. doi:10.1172/JCI21404.
    • (2006) J. Clin. Invest , vol.116 , pp. 1310-1316
    • Yen, D.1
  • 10
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Mannon, P., et al. 2004. Anti-interleukin-12 antibody for active Crohn's disease. N. Engl. J. Med. 351:2069-2079.
    • (2004) N. Engl. J. Med , vol.351 , pp. 2069-2079
    • Mannon, P.1
  • 11
    • 0141501517 scopus 로고    scopus 로고
    • The nature of colitis in chronic granulomatous disease
    • Schappi, M., et al. 2003. The nature of colitis in chronic granulomatous disease. J. Pediatr. Gastroenterol. Nutr. 36:623-631.
    • (2003) J. Pediatr. Gastroenterol. Nutr , vol.36 , pp. 623-631
    • Schappi, M.1
  • 12
    • 33748106497 scopus 로고    scopus 로고
    • Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency
    • Mannon, P., et al. 2006. Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency. Gastroenterology. 131:748-756.
    • (2006) Gastroenterology , vol.131 , pp. 748-756
    • Mannon, P.1
  • 13
    • 31144475366 scopus 로고    scopus 로고
    • Intestinal disease in Hermansky-Pudlak syndrome: Occurrence of colitis and distribution with genotype
    • Hussain, N., et al. 2006. Intestinal disease in Hermansky-Pudlak syndrome: occurrence of colitis and distribution with genotype. Clin. Gastroenterol. Hepatol. 4:73-80.
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 73-80
    • Hussain, N.1
  • 14
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan, G., et al. 2003. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl. Acad. Sci. U. S. A. 100:8372-8377.
    • (2003) Proc. Natl. Acad. Sci. U. S. A , vol.100 , pp. 8372-8377
    • Phan, G.1
  • 15
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    • Duchmann, R., Herman, E., Mayet, W., Ewe, K., and Meyer zum Buschenfelde, K.H. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102:448-455.
    • (1995) Clin. Exp. Immunol , vol.102 , pp. 448-455
    • Duchmann, R.1    Herman, E.2    Mayet, W.3    Ewe, K.4    Meyer zum Buschenfelde, K.H.5
  • 16
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober, W., Fuss, I., and Blumberg, R. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495-549.
    • (2002) Annu. Rev. Immunol , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.2    Blumberg, R.3
  • 17
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • Hermiston, M., and Gordon, J. 1995. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science. 270:1203-1207.
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.1    Gordon, J.2
  • 18
    • 0038624558 scopus 로고    scopus 로고
    • NODS: Intracellular proteins involved in inflammation and apoptosis
    • Inohara, N., and Nunez, G. 2003. NODS: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3:371-382.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 19
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • Strober, W., Murray, P., Kitani, A., and Watanabe, T. 2006. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 6:9-20.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 9-20
    • Strober, W.1    Murray, P.2    Kitani, A.3    Watanabe, T.4
  • 20
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • doi:10.1172/JCI200317085
    • Kobayashi, M., et al. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111:1297-1308. doi:10.1172/JCI200317085.
    • (2003) J. Clin. Invest , vol.111 , pp. 1297-1308
    • Kobayashi, M.1
  • 21
    • 33747114270 scopus 로고    scopus 로고
    • Role of toll-like receptors in spontaneous commensal-dependent colitis
    • Rakoff-Nahoum, S., Hao, L., and Medzhitov, R. 2006. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity. 25:319-329.
    • (2006) Immunity , vol.25 , pp. 319-329
    • Rakoff-Nahoum, S.1    Hao, L.2    Medzhitov, R.3
  • 22
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot, J., et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.1
  • 23
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura, Y., et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1
  • 24
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor2-mediated T helper type 1 responses
    • Watanabe, T., Kitani, A., Murray, P., and Strober, W. 2004. NOD2 is a negative regulator of Toll-like receptor2-mediated T helper type 1 responses. Nat. Immunol. 5:800-808.
    • (2004) Nat. Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.3    Strober, W.4
  • 25
    • 0037075551 scopus 로고    scopus 로고
    • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    • Kobayashi, K., et al. 2002. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 416:194-199.
    • (2002) Nature , vol.416 , pp. 194-199
    • Kobayashi, K.1
  • 26
    • 11144289688 scopus 로고    scopus 로고
    • The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO
    • Abbott, D., Wilkins, A., Asara, J., and Cantley, L. 2004. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14:2217-2227.
    • (2004) Curr. Biol , vol.14 , pp. 2217-2227
    • Abbott, D.1    Wilkins, A.2    Asara, J.3    Cantley, L.4
  • 27
    • 12444259829 scopus 로고    scopus 로고
    • Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2 and NOD1-dependent manner, respectively, in human monocytic cells in culture
    • Uehara, A., et al. 2005. Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2 and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cell. Microbiol. 7:53-61.
    • (2005) Cell. Microbiol , vol.7 , pp. 53-61
    • Uehara, A.1
  • 28
    • 33244490747 scopus 로고    scopus 로고
    • Functional consequences of NOD2 deficiency in Crohn's disease patients peripheral blood blood monocytes derived dendritic cells
    • Zelinkova, Z., et al. 2005. Functional consequences of NOD2 deficiency in Crohn's disease patients peripheral blood blood monocytes derived dendritic cells. Gastroenterology. 128:A510.
    • (2005) Gastroenterology , vol.128
    • Zelinkova, Z.1
  • 29
    • 33748493563 scopus 로고    scopus 로고
    • Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis
    • Watanabe, T., et al. 2006. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity. 25:473-485.
    • (2006) Immunity , vol.25 , pp. 473-485
    • Watanabe, T.1
  • 30
    • 0037033434 scopus 로고    scopus 로고
    • T helper 1 and T helper 2 cells are pathogenic in an antigen specific model of colitis
    • Iqbal, N., et al. 2002. T helper 1 and T helper 2 cells are pathogenic in an antigen specific model of colitis. J. Exp. Med. 195:71-84.
    • (2002) J. Exp. Med , vol.195 , pp. 71-84
    • Iqbal, N.1
  • 31
    • 0035207279 scopus 로고    scopus 로고
    • CD4 T cells monospecific to ovalbumin produced by Eschericia coli can induce colitis upon transfer to BALB/c and SCID mice
    • Yoshida, M., et al. 2001. CD4 T cells monospecific to ovalbumin produced by Eschericia coli can induce colitis upon transfer to BALB/c and SCID mice. Int. Immunol. 13:1561-1570.
    • (2001) Int. Immunol , vol.13 , pp. 1561-1570
    • Yoshida, M.1
  • 32
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn's disease
    • doi:10.1172/JCI200420295
    • Lodes, M., et al. 2004. Bacterial flagellin is a dominant antigen in Crohn's disease. J. Clin. Invest. 113:1296-1306. doi:10.1172/JCI200420295.
    • (2004) J. Clin. Invest , vol.113 , pp. 1296-1306
    • Lodes, M.1
  • 33
    • 0036395918 scopus 로고    scopus 로고
    • Understanding immune-microbial homeostasis in intestine
    • Elson, C., and Cong, Y. 2002. Understanding immune-microbial homeostasis in intestine. Immunol. Res. 26:87-94.
    • (2002) Immunol. Res , vol.26 , pp. 87-94
    • Elson, C.1    Cong, Y.2
  • 34
    • 0031178798 scopus 로고    scopus 로고
    • Spontaneous colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora
    • Brandwein, S., et al. 1997. Spontaneous colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 159:44-52.
    • (1997) J. Immunol , vol.159 , pp. 44-52
    • Brandwein, S.1
  • 35
    • 0032536827 scopus 로고    scopus 로고
    • CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: Increased T helper cell type 1 response and ability to transfer disease
    • Cong, Y., et al. 1998. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J. Exp. Med. 187:855-864.
    • (1998) J. Exp. Med , vol.187 , pp. 855-864
    • Cong, Y.1
  • 36
    • 10744231057 scopus 로고    scopus 로고
    • Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalitis
    • Robinson, W., et al. 2003. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalitis. Nat. Biotechnol. 21:1017-1019.
    • (2003) Nat. Biotechnol , vol.21 , pp. 1017-1019
    • Robinson, W.1
  • 37
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBirt flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan, S., et al. 2005. Antibodies to CBirt flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 128:2020-2028.
    • (2005) Gastroenterology , vol.128 , pp. 2020-2028
    • Targan, S.1
  • 38
    • 27744533839 scopus 로고    scopus 로고
    • Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune responses to enteric bacterial antigens
    • Beckwith, J., Cong, Y., Sundberg, J., Elson, C., and Leiter, E. 2005. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune responses to enteric bacterial antigens. Gastroenterology. 129:1473-1484.
    • (2005) Gastroenterology , vol.129 , pp. 1473-1484
    • Beckwith, J.1    Cong, Y.2    Sundberg, J.3    Elson, C.4    Leiter, E.5
  • 39
    • 0036140777 scopus 로고    scopus 로고
    • Mucosal flora in inflammatory bowel disease
    • Swidsinski, A., et al. 2002. Mucosal flora in inflammatory bowel disease. Gastroenterology. 122:44-54.
    • (2002) Gastroenterology , vol.122 , pp. 44-54
    • Swidsinski, A.1
  • 40
    • 0031758230 scopus 로고    scopus 로고
    • Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohns' disease
    • Darfeuille-Michaud, A., et al. 1998. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohns' disease. Gastroenterology. 115:1405-1413.
    • (1998) Gastroenterology , vol.115 , pp. 1405-1413
    • Darfeuille-Michaud, A.1
  • 41
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Eschericia coli adherence and invasion in Crohn's disease and colon cancer
    • Martin, H., et al. 2004. Enhanced Eschericia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology. 127:80-93.
    • (2004) Gastroenterology , vol.127 , pp. 80-93
    • Martin, H.1
  • 42
    • 33747050143 scopus 로고    scopus 로고
    • The bacteriology of biopsies differs between newly diagnosed, untreated Crohn's disease and ulcerative colitis patients
    • Bibiloni, R., Mangold, M., Madsen, K., Fedorak, R., and Tannock, G. 2006. The bacteriology of biopsies differs between newly diagnosed, untreated Crohn's disease and ulcerative colitis patients. J. Med. Microbiol. 55:1141-1149.
    • (2006) J. Med. Microbiol , vol.55 , pp. 1141-1149
    • Bibiloni, R.1    Mangold, M.2    Madsen, K.3    Fedorak, R.4    Tannock, G.5
  • 43
    • 9144260143 scopus 로고    scopus 로고
    • Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease
    • Prindiville, T., Cantrell, M., and Wilson, K. 2004. Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease. Inflamm. Bowel Dis. 10:824-833.
    • (2004) Inflamm. Bowel Dis , vol.10 , pp. 824-833
    • Prindiville, T.1    Cantrell, M.2    Wilson, K.3
  • 44
    • 33748329408 scopus 로고    scopus 로고
    • Review article: The role of bacteria in onset and perpetuation of inflammatory bowel disease
    • Seksik, P., et al. 2006. Review article: the role of bacteria in onset and perpetuation of inflammatory bowel disease Aliment. Pharmacol. Ther. 24:11-18.
    • (2006) Aliment. Pharmacol. Ther , vol.24 , pp. 11-18
    • Seksik, P.1
  • 45
    • 33847385884 scopus 로고    scopus 로고
    • CD1d-dependent regulation of bacterial colonization in the intestine
    • Niewenhuis, E. 2006. CD1d-dependent regulation of bacterial colonization in the intestine. Gastroenterology. 130:A61.
    • (2006) Gastroenterology , vol.130
    • Niewenhuis, E.1
  • 46
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp, J., et al. 2005. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. U. S. A. 102:18129-18134.
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 18129-18134
    • Wehkamp, J.1
  • 47
    • 0142026070 scopus 로고    scopus 로고
    • Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis
    • Wehkamp, J., et al. 2003. Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm. Bowel Dis. 9:215-223.
    • (2003) Inflamm. Bowel Dis , vol.9 , pp. 215-223
    • Wehkamp, J.1
  • 48
    • 33748558056 scopus 로고    scopus 로고
    • A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn's disease in the colon
    • Fellerman, K., et al. 2006. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn's disease in the colon. Am. J. Hum. Genet. 79:439-448.
    • (2006) Am. J. Hum. Genet , vol.79 , pp. 439-448
    • Fellerman, K.1
  • 49
    • 33847340679 scopus 로고    scopus 로고
    • CARD15/NOD2 functions as an antibacterial factor in human epithelial cells
    • Hisamatsu, T., et al. 2003. CARD15/NOD2 functions as an antibacterial factor in human epithelial cells. Gastroenterology. 124:1145-1149.
    • (2003) Gastroenterology , vol.124 , pp. 1145-1149
    • Hisamatsu, T.1
  • 50
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K.S., et al. 2005. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 307:731-734.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 51
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess, J., et al. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 307:254-258.
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.1
  • 52
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno, M., et al. 2001. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2:361-367.
    • (2001) Nat. Immunol , vol.2 , pp. 361-367
    • Rescigno, M.1
  • 53
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A., and Uhr, T. 2004. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science. 303:1662-1665.
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.1    Uhr, T.2
  • 54
    • 0037103328 scopus 로고    scopus 로고
    • Selective adherence of IgA to murine Peyer's patch M cells: Evidence for a novel IgA receptor
    • Mantis, N., et al. 2002. Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. J. Immunol. 169:1844-1851.
    • (2002) J. Immunol , vol.169 , pp. 1844-1851
    • Mantis, N.1
  • 55
    • 14844349149 scopus 로고    scopus 로고
    • Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-β-bearing regulatory cells
    • DiGiacinto, C., Marinaro, M., Sanchez, M., Strober, W., and Boirivant, M. 2005. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-β-bearing regulatory cells. J. Immunol. 174:3237-3246.
    • (2005) J. Immunol , vol.174 , pp. 3237-3246
    • DiGiacinto, C.1    Marinaro, M.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 56
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson, C., et al. 1999. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 286:113-117.
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.1
  • 57
    • 4644246657 scopus 로고    scopus 로고
    • Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine
    • Norkina, O., Burnett, T., and Lisle, R.D. 2004. Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine. Infect. Immun. 72:6040-6049.
    • (2004) Infect. Immun , vol.72 , pp. 6040-6049
    • Norkina, O.1    Burnett, T.2    Lisle, R.D.3
  • 58
    • 33144478521 scopus 로고    scopus 로고
    • ABC1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: Discrimination of critical variants using a gene-wide haplotype tagging approach
    • Ho, G., et al. 2006. ABC1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach. Hum. Mol. Genet. 15:797-805.
    • (2006) Hum. Mol. Genet , vol.15 , pp. 797-805
    • Ho, G.1
  • 59
    • 14944356373 scopus 로고    scopus 로고
    • A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease
    • Newman, B., et al. 2005. A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. Gastroenterology. 128:260-269.
    • (2005) Gastroenterology , vol.128 , pp. 260-269
    • Newman, B.1
  • 60
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • Panwala, C., Jones, J., and Viney, J. 1998. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J. Immunol. 161:5733-5744.
    • (1998) J. Immunol , vol.161 , pp. 5733-5744
    • Panwala, C.1    Jones, J.2    Viney, J.3
  • 61
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn disease
    • Peltekova, V., et al. 2004. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat. Genet. 36:471-475.
    • (2004) Nat. Genet , vol.36 , pp. 471-475
    • Peltekova, V.1
  • 62
    • 22844446940 scopus 로고    scopus 로고
    • Natalizumab and progressive multifocal leukoencephalopathy
    • Adelman, B., Sandrock, A., and Panzara, M. 2005. Natalizumab and progressive multifocal leukoencephalopathy. N. Engl. J. Med. 353:432-433.
    • (2005) N. Engl. J. Med , vol.353 , pp. 432-433
    • Adelman, B.1    Sandrock, A.2    Panzara, M.3
  • 63
    • 33644829107 scopus 로고    scopus 로고
    • Complications of biological therapy for inflammatory bowel diseases
    • Blonski, W., and Lichtenstein, G. 2006. Complications of biological therapy for inflammatory bowel diseases. Curr. Opin. Gastroenterol. 22:30-43.
    • (2006) Curr. Opin. Gastroenterol , vol.22 , pp. 30-43
    • Blonski, W.1    Lichtenstein, G.2
  • 64
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • Feagan, B., et al. 2005. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N. Engl. J. Med. 352:2499-2507.
    • (2005) N. Engl. J. Med , vol.352 , pp. 2499-2507
    • Feagan, B.1
  • 65
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
    • Hanauer, S., et al. 2002. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet. 359:1541-1549.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.1
  • 66
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts, P., et al. 2005. Infliximab for induction and maintenance therapy for ulcerative colitis. N. Engl. J. Med. 353:2462-2476.
    • (2005) N. Engl. J. Med , vol.353 , pp. 2462-2476
    • Rutgeerts, P.1
  • 67
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn, W., et al. 2005. Natalizumab induction and maintenance therapy for Crohn's disease. N. Engl. J. Med. 353:1912-1925.
    • (2005) N. Engl. J. Med , vol.353 , pp. 1912-1925
    • Sandborn, W.1
  • 68
    • 33746176176 scopus 로고    scopus 로고
    • Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
    • Hommes, D., et al. 2006. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut. 55:1131-1137.
    • (2006) Gut , vol.55 , pp. 1131-1137
    • Hommes, D.1
  • 69
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • Ito, H., et al. 2004. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology. 126:989-996.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1
  • 70
    • 33744933432 scopus 로고    scopus 로고
    • A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease
    • Braat, H., et al. 2006. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin. Gastroenterol. Hepatol. 4:754-759.
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 754-759
    • Braat, H.1
  • 71
    • 33644666978 scopus 로고    scopus 로고
    • Leukocytapheresis therapy for steroid-naive patients with active ulcerative colitis: Its clinical efficacy and adverse effects compared with those of conventional steroid therapy
    • Nishioka, C., et al. 2005. Leukocytapheresis therapy for steroid-naive patients with active ulcerative colitis: its clinical efficacy and adverse effects compared with those of conventional steroid therapy. J. Gastroenterol. Hepatol. 20:1567-1571.
    • (2005) J. Gastroenterol. Hepatol , vol.20 , pp. 1567-1571
    • Nishioka, C.1
  • 72
    • 33748265673 scopus 로고    scopus 로고
    • Pilot feasibility studies of leukocytapheresis with the Adacolumn Apheresis System in patients with active ulcerative colitis or Crohn disease
    • Sands, B., et al. 2006. Pilot feasibility studies of leukocytapheresis with the Adacolumn Apheresis System in patients with active ulcerative colitis or Crohn disease. J. Clin. Gastroenterol. 40:482-489.
    • (2006) J. Clin. Gastroenterol , vol.40 , pp. 482-489
    • Sands, B.1
  • 73
    • 29144506331 scopus 로고    scopus 로고
    • A phase I-II Study: Multiple dose levels of visilizumab are well tolerated and produce rapid and sustained improvement in ulcerative colitis patients refractory to treatment with iv steroids (IVSR-UC)
    • Targan, S., et al. 2005. A phase I-II Study: multiple dose levels of visilizumab are well tolerated and produce rapid and sustained improvement in ulcerative colitis patients refractory to treatment with iv steroids (IVSR-UC). Gastroenterology. 128:A75.
    • (2005) Gastroenterology , vol.128
    • Targan, S.1
  • 74
    • 15744405106 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    • Oyama, Y., et al. 2005. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology. 128:552-563.
    • (2005) Gastroenterology , vol.128 , pp. 552-563
    • Oyama, Y.1
  • 75
    • 0034840260 scopus 로고    scopus 로고
    • Extracorporeal photochemotherapy in patients with steroid-dependent Crohn's disease: A prospective pilot study
    • Reinisch, W., et al. 2001. Extracorporeal photochemotherapy in patients with steroid-dependent Crohn's disease: a prospective pilot study. Aliment. Pharmacol. Ther. 15:1313-1322.
    • (2001) Aliment. Pharmacol. Ther , vol.15 , pp. 1313-1322
    • Reinisch, W.1
  • 76
    • 21644462655 scopus 로고    scopus 로고
    • A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation
    • Garcia-Olmo, D., et al. 2005. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis. Colon Rectum. 48:1416-1423.
    • (2005) Dis. Colon Rectum , vol.48 , pp. 1416-1423
    • Garcia-Olmo, D.1
  • 78
    • 33749013296 scopus 로고    scopus 로고
    • Helminths and mucosal immune modulation
    • Weinstock, J. 2006. Helminths and mucosal immune modulation. Ann. N. Y. Acad. Sci. 1072:356-364.
    • (2006) Ann. N. Y. Acad. Sci , vol.1072 , pp. 356-364
    • Weinstock, J.1
  • 79
    • 10744232542 scopus 로고    scopus 로고
    • Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
    • Creed, T., Norman, M., and Probert, C. 2003. Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment. Pharmacol. Ther. 18:65-75.
    • (2003) Aliment. Pharmacol. Ther , vol.18 , pp. 65-75
    • Creed, T.1    Norman, M.2    Probert, C.3
  • 80
    • 33750343050 scopus 로고    scopus 로고
    • Daclizumab, a humanized monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: A randomized, double blind, placebo controlled, dose ranging trial
    • Van Assche, G., et al. 2006. Daclizumab, a humanized monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomized, double blind, placebo controlled, dose ranging trial. Gut. 55:1568-1574.
    • (2006) Gut , vol.55 , pp. 1568-1574
    • Van Assche, G.1
  • 81
    • 25144515109 scopus 로고    scopus 로고
    • A phase 2 dose-ranging, double blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
    • Van Deventer, S., Volfova, M., and Flisiak, R. 2005. A phase 2 dose-ranging, double blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis. Gastroenterology. 128:A74.
    • (2005) Gastroenterology , vol.128
    • Van Deventer, S.1    Volfova, M.2    Flisiak, R.3
  • 82
    • 0037483705 scopus 로고    scopus 로고
    • Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-Sided ulcerative colitis or proctitis
    • Sinha, A., Nightingale, J., West, K., Berlanga-Acosta, J., and Playford, R. 2003. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-Sided ulcerative colitis or proctitis. N. Engl. J. Med. 349:350-357.
    • (2003) N. Engl. J. Med , vol.349 , pp. 350-357
    • Sinha, A.1    Nightingale, J.2    West, K.3    Berlanga-Acosta, J.4    Playford, R.5
  • 83
    • 17144402166 scopus 로고    scopus 로고
    • Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial
    • Summers, R., Elliott, D., and Urban, J. 2005. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology. 128:825-832.
    • (2005) Gastroenterology , vol.128 , pp. 825-832
    • Summers, R.1    Elliott, D.2    Urban, J.3


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