-
1
-
-
85027979996
-
Recent progress in Alzheimer's disease research, part 2: Genetics and epidemiology
-
Robinson M, Lee BY, Hane FT (2017) Recent progress in Alzheimer's disease research, part 2: Genetics and epidemiology. J Alzheimers Dis 57, 317-330.
-
(2017)
J Alzheimers Dis
, vol.57
, pp. 317-330
-
-
Robinson, M.1
Lee, B.Y.2
Hane, F.T.3
-
2
-
-
85015213312
-
Recent progress in Alzheimer's disease research, part 1: Pathology
-
Hane FT, Lee BY, Leonenko Z (2017) Recent progress in Alzheimer's disease research, part 1: Pathology. J Alzheimers Dis 57, 1-28.
-
(2017)
J Alzheimers Dis
, vol.57
, pp. 1-28
-
-
Hane, F.T.1
Lee, B.Y.2
Leonenko, Z.3
-
3
-
-
85017561826
-
Recent progress in Alzheimer's disease research, part 3: Diagnosis and treatment
-
Hane FT, Robinson M, Lee BY, Bai O, Leonenko Z, Albert MS (2017) Recent progress in Alzheimer's disease research, part 3: Diagnosis and treatment. J Alzheimers Dis 57, 645-665.
-
(2017)
J Alzheimers Dis
, vol.57
, pp. 645-665
-
-
Hane, F.T.1
Robinson, M.2
Lee, B.Y.3
Bai, O.4
Leonenko, Z.5
Albert, M.S.6
-
4
-
-
85021263676
-
Re-imagining Alzheimer's disease \-The diminishing importance of amyloid and a glimpse of what lies ahead
-
Tse KH, Herrup K (2017) Re-imagining Alzheimer's disease \-The diminishing importance of amyloid and a glimpse of what lies ahead. J Neurochem 143, 432-444.
-
(2017)
J Neurochem
, vol.143
, pp. 432-444
-
-
Tse, K.H.1
Herrup, K.2
-
5
-
-
84871925048
-
Kynurenines in the CNS: Recent advances and new questions
-
Vecsei L, Szalardy L, Fulop F, Toldi J (2013) Kynurenines in the CNS: Recent advances and new questions. Nat Rev Drug Discov 12, 64-82.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 64-82
-
-
Vecsei, L.1
Szalardy, L.2
Fulop, F.3
Toldi, J.4
-
6
-
-
84937019697
-
Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer's disease
-
Cabezas-Opazo FA, Vergara-Pulgar K, Perez MJ, Jara C, Osorio-Fuentealba C, Quintanilla RA (2015) Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer's disease. Oxid Med Cell Longev 2015, 509654.
-
(2015)
Oxid Med Cell Longev 2015
, pp. 509654
-
-
Cabezas-Opazo, F.A.1
Vergara-Pulgar, K.2
Perez, M.J.3
Jara, C.4
Osorio-Fuentealba, C.5
Quintanilla, R.A.6
-
7
-
-
84981731115
-
Mitochondrial regulatory pathways in the pathogenesis of Alzheimer's disease
-
Adiele RC, Adiele CA (2016) Mitochondrial regulatory pathways in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 53, 1257-1270.
-
(2016)
J Alzheimers Dis
, vol.53
, pp. 1257-1270
-
-
Adiele, R.C.1
Adiele, C.A.2
-
8
-
-
85018790060
-
Mitochondrial aspects of synaptic dysfunction in Alzheimer's disease
-
Cai Q, Tammineni P (2017) Mitochondrial aspects of synaptic dysfunction in Alzheimer's disease. J Alzheimers Dis 57, 1087-1103.
-
(2017)
J Alzheimers Dis
, vol.57
, pp. 1087-1103
-
-
Cai, Q.1
Tammineni, P.2
-
9
-
-
33750445482
-
Mitochondrial fusion and fission in mammals
-
ChanDC(2006) Mitochondrial fusion and fission in mammals. Annu Rev Cell Dev Biol 22, 79-99.
-
(2006)
Annu Rev Cell Dev Biol
, vol.22
, pp. 79-99
-
-
Chan, D.C.1
-
10
-
-
84879853173
-
Principles of the mitochondrial fusion and fission cycle in neurons
-
Cagalinec M, Safiulina D, Liiv M, Liiv J, Choubey V, Wareski P, Veksler V, Kaasik A (2013) Principles of the mitochondrial fusion and fission cycle in neurons. J Cell Sci 126, 2187-2197.
-
(2013)
J Cell Sci
, vol.126
, pp. 2187-2197
-
-
Cagalinec, M.1
Safiulina, D.2
Liiv, M.3
Liiv, J.4
Choubey, V.5
Wareski, P.6
Veksler, V.7
Kaasik, A.8
-
11
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, KressY,VintersHV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21, 3017-3023.
-
(2001)
J Neurosci
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
Shimohama, S.11
Cash, A.D.12
Siedlak, S.L.13
Harris, P.L.14
Jones, P.K.15
Petersen, R.B.16
Perry, G.17
Smith, M.A.18
-
12
-
-
58049218922
-
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
-
Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H,WangY, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105, 19318-19323.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19318-19323
-
-
Wang, X.1
Su, B.2
Siedlak, S.L.3
Moreira, P.I.4
Fujioka, H.5
Wang, Y.6
Casadesus, G.7
Zhu, X.8
-
13
-
-
67650732998
-
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
-
Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29, 9090-9103.
-
(2009)
J Neurosci
, vol.29
, pp. 9090-9103
-
-
Wang, X.1
Su, B.2
Lee, H.G.3
Li, X.4
Perry, G.5
Smith, M.A.6
Zhu, X.7
-
14
-
-
84924571507
-
Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells
-
Park J, Choi H, Min JS, Kim B, Lee SR, Yun JW, Choi MS, Chang KT, Lee DS (2015) Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells. J Neurochem 132, 687-702.
-
(2015)
J Neurochem
, vol.132
, pp. 687-702
-
-
Park, J.1
Choi, H.2
Min, J.S.3
Kim, B.4
Lee, S.R.5
Yun, J.W.6
Choi, M.S.7
Chang, K.T.8
Lee, D.S.9
-
15
-
-
81255190781
-
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
-
Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH (2011) Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum Mol Genet 20, 4515-4529.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 4515-4529
-
-
Calkins, M.J.1
Manczak, M.2
Mao, P.3
Shirendeb, U.4
Reddy, P.H.5
-
16
-
-
69749115919
-
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
-
Wang Z,Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H (2009) Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci 29, 10788-10801.
-
(2009)
J Neurosci
, vol.29
, pp. 10788-10801
-
-
Wang, Z.1
Wang, B.2
Yang, L.3
Guo, Q.4
Aithmitti, N.5
Songyang, Z.6
Zheng, H.7
-
17
-
-
76549123596
-
Amyloid-betaderived diffusible ligands cause impaired axonal transport of mitochondria in neurons
-
Wang X, Perry G, SmithMA,ZhuX(2010) Amyloid-betaderived diffusible ligands cause impaired axonal transport of mitochondria in neurons. Neurodegener Dis 7, 56-59.
-
(2010)
Neurodegener Dis
, vol.7
, pp. 56-59
-
-
Wang, X.1
Perry, G.2
Smith, M.A.3
Zhu, X.4
-
18
-
-
78649815388
-
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
-
Du H, Guo L, Yan S, Sosunov AA, McKhann GM, Yan SS (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A 107, 18670-18675.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 18670-18675
-
-
Du, H.1
Guo, L.2
Yan, S.3
Sosunov, A.A.4
McKhann, G.M.5
Yan, S.S.6
-
19
-
-
33646152108
-
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
-
Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH (2006) Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15, 1437-1449.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
Anekonda, T.S.2
Henson, E.3
Park, B.S.4
Quinn, J.5
Reddy, P.H.6
-
20
-
-
33748283747
-
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
-
Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci 26, 9057-9068.
-
(2006)
J Neurosci
, vol.26
, pp. 9057-9068
-
-
Devi, L.1
Prabhu, B.M.2
Galati, D.F.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
21
-
-
51349110166
-
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
-
Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, Leinonen V, Ito A, Winblad B, Glaser E, Ankarcrona M (2008) The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A 105, 13145-13150.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13145-13150
-
-
Hansson, P.C.A.1
Alikhani, N.2
Behbahani, H.3
Wiehager, B.4
Pavlov, P.F.5
Alafuzoff, I.6
Leinonen, V.7
Ito, A.8
Winblad, B.9
Glaser, E.10
Ankarcrona, M.11
-
22
-
-
77956197971
-
Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice
-
Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW, Bradshaw PC (2010) Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. J Alzheimers Dis 20(Suppl 2), S535-550.
-
(2010)
J Alzheimers Dis
, vol.20
, pp. S535-550
-
-
Dragicevic, N.1
Mamcarz, M.2
Zhu, Y.3
Buzzeo, R.4
Tan, J.5
Arendash, G.W.6
Bradshaw, P.C.7
-
23
-
-
79958721260
-
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
-
Manczak M, Calkins MJ, ReddyPH(2011) Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage. Hum Mol Genet 20, 2495-2509.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 2495-2509
-
-
Manczak, M.1
Calkins, M.J.2
Reddy, P.H.3
-
24
-
-
84865352799
-
Tau promotes neurodegeneration via DRP1 mislocalization 'in vivo
-
DuBoff B, Gotz J, Feany MB (2012) Tau promotes neurodegeneration via DRP1 mislocalization 'in vivo. Neuron 75, 618-632.
-
(2012)
Neuron
, vol.75
, pp. 618-632
-
-
DuBoff, B.1
Gotz, J.2
Feany, M.B.3
-
25
-
-
84868116461
-
A new link to mitochondrial impairment in tauopathies
-
Schulz KL, Eckert A, Rhein V, Mai S, Haase W, Reichert AS, Jendrach M, Muller WE, Leuner K (2012) A new link to mitochondrial impairment in tauopathies. Mol Neurobiol 46, 205-216.
-
(2012)
Mol Neurobiol
, vol.46
, pp. 205-216
-
-
Schulz, K.L.1
Eckert, A.2
Rhein, V.3
Mai, S.4
Haase, W.5
Reichert, A.S.6
Jendrach, M.7
Muller, W.E.8
Leuner, K.9
-
26
-
-
84861130196
-
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage
-
Manczak M, Reddy PH (2012) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21, 2538-2547.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 2538-2547
-
-
Manczak, M.1
Reddy, P.H.2
-
27
-
-
73949142307
-
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
-
RheinV, Song X,Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Drose S, Brandt U, Savaskan E, Czech C, Gotz J, Eckert A (2009) Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A 106, 20057-20062.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20057-20062
-
-
Rhein, V.1
Song, X.2
Wiesner, A.3
Ittner, L.M.4
Baysang, G.5
Meier, F.6
Ozmen, L.7
Bluethmann, H.8
Drose, S.9
Brandt, U.10
Savaskan, E.11
Czech, C.12
Gotz, J.13
Eckert, A.14
-
28
-
-
79951548587
-
Inhibition of amyloid-beta (Abeta) peptidebinding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease
-
Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS (2011) Inhibition of amyloid-beta (Abeta) peptidebinding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. J Neurosci 31, 2313-2320.
-
(2011)
J Neurosci
, vol.31
, pp. 2313-2320
-
-
Yao, J.1
Du, H.2
Yan, S.3
Fang, F.4
Wang, C.5
Lue, L.F.6
Guo, L.7
Chen, D.8
Stern, D.M.9
Gunn, M.F.J.10
Xi Chen, J.11
Arancio, O.12
Yan, S.S.13
-
29
-
-
0025024024
-
Cytochrome oxidase deficiency in Alzheimer's disease
-
Parker WD Jr, Filley CM, Parks JK (1990) Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40, 1302-1303.
-
(1990)
Neurology
, vol.40
, pp. 1302-1303
-
-
Parker, W.D.1
Filley, C.M.2
Parks, J.K.3
-
30
-
-
0028110234
-
Cortical cytochrome oxidase activity is reduced in Alzheimer's disease
-
Mutisya EM, Bowling AC, Beal MF (1994) Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem 63, 2179-2184.
-
(1994)
J Neurochem
, vol.63
, pp. 2179-2184
-
-
Mutisya, E.M.1
Bowling, A.C.2
Beal, M.F.3
-
31
-
-
0028869597
-
Human diseases with defects in oxidative phosphorylation 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis
-
Schagger H, Ohm TG (1995) Human diseases with defects in oxidative phosphorylation. 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis. Eur J Biochem 227, 916-921.
-
(1995)
Eur J Biochem
, vol.227
, pp. 916-921
-
-
Schagger, H.1
Ohm, T.G.2
-
32
-
-
0034612075
-
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
-
Maurer I, Zierz S, Moller HJ (2000) A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiol Aging 21, 455-462.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 455-462
-
-
Maurer, I.1
Zierz, S.2
Moller, H.J.3
-
33
-
-
2342628596
-
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
-
Manczak M, Park BS, Jung Y, Reddy PH (2004) Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med 5, 147-162.
-
(2004)
Neuromolecular Med
, vol.5
, pp. 147-162
-
-
Manczak, M.1
Park, B.S.2
Jung, Y.3
Reddy, P.H.4
-
34
-
-
0020685951
-
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
-
Sorbi S, Bird ED, Blass JP (1983) Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain. Ann Neurol 13, 72-78.
-
(1983)
Ann Neurol
, vol.13
, pp. 72-78
-
-
Sorbi, S.1
Bird, E.D.2
Blass, J.P.3
-
35
-
-
0021813419
-
An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain
-
Sheu KF, Kim YT, Blass JP, Weksler ME (1985) An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain. Ann Neurol 17, 444-449.
-
(1985)
Ann Neurol
, vol.17
, pp. 444-449
-
-
Sheu, K.F.1
Kim, Y.T.2
Blass, J.P.3
Weksler, M.E.4
-
36
-
-
0027332651
-
Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
-
Mastrogiacomo F, Bergeron C, Kish SJ (1993) Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J Neurochem 61, 2007-2014.
-
(1993)
J Neurochem
, vol.61
, pp. 2007-2014
-
-
Mastrogiacomo, F.1
Bergeron, C.2
Kish, S.J.3
-
37
-
-
0141707862
-
PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation
-
Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA (2003) PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J Neurosci 23, 8989-9003.
-
(2003)
J Neurosci
, vol.23
, pp. 8989-9003
-
-
Richards, J.G.1
Higgins, G.A.2
Ouagazzal, A.M.3
Ozmen, L.4
Kew, J.N.5
Bohrmann, B.6
Malherbe, P.7
Brockhaus, M.8
Loetscher, H.9
Czech, C.10
Huber, G.11
Bluethmann, H.12
Jacobsen, H.13
Kemp, J.A.14
-
38
-
-
9644272489
-
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
-
Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Muller-Spahn F, Haass C, Czech C, Pradier L, Muller WE, Eckert A (2004) Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem 279, 50310-50320.
-
(2004)
J Biol Chem
, vol.279
, pp. 50310-50320
-
-
Keil, U.1
Bonert, A.2
Marques, C.A.3
Scherping, I.4
Weyermann, J.5
Strosznajder, J.B.6
Muller-Spahn, F.7
Haass, C.8
Czech, C.9
Pradier, L.10
Muller, W.E.11
Eckert, A.12
-
39
-
-
19944433571
-
Copperdependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42
-
Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, Barnham KJ, Curtain CC, Cherny RA, Cappai R, Dyrks T, Masters CL, Trounce IA (2005) Copperdependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. J Neurosci 25, 672-679.
-
(2005)
J Neurosci
, vol.25
, pp. 672-679
-
-
Crouch, P.J.1
Blake, R.2
Duce, J.A.3
Ciccotosto, G.D.4
Li, Q.X.5
Barnham, K.J.6
Curtain, C.C.7
Cherny, R.A.8
Cappai, R.9
Dyrks, T.10
Masters, C.L.11
Trounce, I.A.12
-
40
-
-
33847686377
-
Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition
-
Gillardon F, RistW, Kussmaul L, Vogel J, BergM, Danzer K, Kraut N, Hengerer B (2007) Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition. Proteomics 7, 605-616.
-
(2007)
Proteomics
, vol.7
, pp. 605-616
-
-
Gillardon, F.1
Rist, W.2
Kussmaul, L.3
Vogel, J.4
Berg, M.5
Danzer, K.6
Kraut, N.7
Hengerer, B.8
-
41
-
-
54249137157
-
Oligomeric and fibrillar species of betaamyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice
-
Eckert A, Hauptmann S, Scherping I, Meinhardt J, Rhein V, Drose S, Brandt U, Fandrich M, Muller WE, Gotz J (2008) Oligomeric and fibrillar species of betaamyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. J Mol Med (Berl) 86, 1255-1267.
-
(2008)
J Mol Med (Berl)
, vol.86
, pp. 1255-1267
-
-
Eckert, A.1
Hauptmann, S.2
Scherping, I.3
Meinhardt, J.4
Rhein, V.5
Drose, S.6
Brandt, U.7
Fandrich, M.8
Muller, W.E.9
Gotz, J.10
-
42
-
-
69249211284
-
Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
-
Hauptmann S, Scherping I, Drose S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, Muller WE (2009) Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30, 1574-1586.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1574-1586
-
-
Hauptmann, S.1
Scherping, I.2
Drose, S.3
Brandt, U.4
Schulz, K.L.5
Jendrach, M.6
Leuner, K.7
Eckert, A.8
Muller, W.E.9
-
43
-
-
70149093436
-
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
-
Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, BrintonRD(2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad SciUS A 106, 14670-14675.
-
(2009)
Proc Natl Acad SciUS A
, vol.106
, pp. 14670-14675
-
-
Yao, J.1
Irwin, R.W.2
Zhao, L.3
Nilsen, J.4
Hamilton, R.T.5
Brinton, R.D.6
-
44
-
-
77956430510
-
The plasma membrane redox system is impaired by amyloid beta-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice
-
Hyun DH, Mughal MR, Yang H, Lee JH, Ko EJ, Hunt ND, de Cabo R, Mattson MP (2010) The plasma membrane redox system is impaired by amyloid beta-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice. Exp Neurol 225, 423-429.
-
(2010)
Exp Neurol
, vol.225
, pp. 423-429
-
-
Hyun, D.H.1
Mughal, M.R.2
Yang, H.3
Lee, J.H.4
Ko, E.J.5
Hunt, N.D.6
De Cabo, R.7
Mattson, M.P.8
-
45
-
-
84860198618
-
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
-
Leuner K, SchuttT,Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Drose S, Wittig I, Willem M, Haass C, Reichert AS, Muller WE (2012) Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 16, 1421-1433.
-
(2012)
Antioxid Redox Signal
, vol.16
, pp. 1421-1433
-
-
Leuner, K.1
Schutt, T.2
Kurz, C.3
Eckert, S.H.4
Schiller, C.5
Occhipinti, A.6
Mai, S.7
Jendrach, M.8
Eckert, G.P.9
Kruse, S.E.10
Palmiter, R.D.11
Brandt, U.12
Drose, S.13
Wittig, I.14
Willem, M.15
Haass, C.16
Reichert, A.S.17
Muller, W.E.18
-
46
-
-
84916892303
-
A cell model for the initial phase of sporadic Alzheimer's disease
-
Stockburger C, Gold VA, Pallas T, Kolesova N, Miano D, Leuner K, Muller WE (2014) A cell model for the initial phase of sporadic Alzheimer's disease. J Alzheimers Dis 42, 395-411.
-
(2014)
J Alzheimers Dis
, vol.42
, pp. 395-411
-
-
Stockburger, C.1
Gold, V.A.2
Pallas, T.3
Kolesova, N.4
Miano, D.5
Leuner, K.6
Muller, W.E.7
-
47
-
-
84952982461
-
Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-beta or hyperphosphorylated tau protein
-
Grimm A, Biliouris EE, Lang UE, Gotz J, Mensah-Nyagan AG, Eckert A (2016) Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-beta or hyperphosphorylated tau protein. Cell Mol Life Sci 73, 201-215.
-
(2016)
Cell Mol Life Sci
, vol.73
, pp. 201-215
-
-
Grimm, A.1
Biliouris, E.E.2
Lang, U.E.3
Gotz, J.4
Mensah-Nyagan, A.G.5
Eckert, A.6
-
48
-
-
0028152717
-
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
-
Mecocci P, MacGarvey U, BealMF(1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36, 747-751.
-
(1994)
Ann Neurol
, vol.36
, pp. 747-751
-
-
Mecocci, P.1
MacGarvey, U.2
Beal, M.F.3
-
49
-
-
0037081814
-
High aggregate burden of somatic mtDNApoint mutations in aging and Alzheimer's disease brain
-
Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF (2002) High aggregate burden of somatic mtDNApoint mutations in aging and Alzheimer's disease brain. Hum Mol Genet 11, 133-145.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 133-145
-
-
Lin, M.T.1
Simon, D.K.2
Ahn, C.H.3
Kim, L.M.4
Beal, M.F.5
-
50
-
-
85029538802
-
Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains
-
WeiW,Keogh MJ,Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF (2017) Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains. Acta Neuropathol Commun 5, 13.
-
(2017)
Acta Neuropathol Commun
, vol.5
, pp. 13
-
-
Wei, W.1
Keogh, M.J.2
Wilson, I.3
Coxhead, J.4
Ryan, S.5
Rollinson, S.6
Griffin, H.7
Kurzawa-Akanbi, M.8
Santibanez-Koref, M.9
Talbot, K.10
Turner, M.R.11
McKenzie, C.A.12
Troakes, C.13
Attems, J.14
Smith, C.15
Al Sarraj, S.16
Morris, C.M.17
Ansorge, O.18
Pickering-Brown, S.19
Ironside, J.W.20
Chinnery, P.F.21
more..
-
51
-
-
85043601066
-
Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains
-
WeiW,Keogh MJ,Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF (2017) Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains. Acta Neuropathol Commun 5, 17.
-
(2017)
Acta Neuropathol Commun
, vol.5
, pp. 17
-
-
Wei, W.1
Keogh, M.J.2
Wilson, I.3
Coxhead, J.4
Ryan, S.5
Rollinson, S.6
Griffin, H.7
Kurzawa-Akanbi, M.8
Santibanez-Koref, M.9
Talbot, K.10
Turner, M.R.11
McKenzie, C.A.12
Troakes, C.13
Attems, J.14
Smith, C.15
Al Sarraj, S.16
Morris, C.M.17
Ansorge, O.18
Pickering-Brown, S.19
Ironside, J.W.20
Chinnery, P.F.21
more..
-
52
-
-
0026486606
-
Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes
-
Yamaguchi H,Yamazaki T, Ishiguro K, Shoji M, Nakazato Y, Hirai S (1992) Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes. Acta Neuropathol 85, 15-22.
-
(1992)
Acta Neuropathol
, vol.85
, pp. 15-22
-
-
Yamaguchi, H.1
Yamazaki, T.2
Ishiguro, K.3
Shoji, M.4
Nakazato, Y.5
Hirai, S.6
-
53
-
-
0034745636
-
Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro
-
Parks JK, Smith TS, Trimmer PA, Bennett JP Jr, Parker WD Jr (2001) Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro. J Neurochem 76, 1050-1056.
-
(2001)
J Neurochem
, vol.76
, pp. 1050-1056
-
-
Parks, J.K.1
Smith, T.S.2
Trimmer, P.A.3
Bennett, J.P.4
Parker, W.D.5
-
54
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA (2002) Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80, 91-100.
-
(2002)
J Neurochem
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
55
-
-
0036403832
-
Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons
-
Casley CS, Land JM, Sharpe MA, Clark JB, Duchen MR, Canevari L (2002) Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis 10, 258-267.
-
(2002)
Neurobiol Dis
, vol.10
, pp. 258-267
-
-
Casley, C.S.1
Land, J.M.2
Sharpe, M.A.3
Clark, J.B.4
Duchen, M.R.5
Canevari, L.6
-
56
-
-
26444588771
-
Gradual alteration of mitochondrial structure and function by beta-amyloids: Importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release
-
Aleardi AM, Benard G, Augereau O, Malgat M, Talbot JC, Mazat JP, Letellier T, Dachary-Prigent J, Solaini GC, Rossignol R (2005) Gradual alteration of mitochondrial structure and function by beta-amyloids: Importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release. J Bioenerg Biomembr 37, 207-225.
-
(2005)
J Bioenerg Biomembr
, vol.37
, pp. 207-225
-
-
Aleardi, A.M.1
Benard, G.2
Augereau, O.3
Malgat, M.4
Talbot, J.C.5
Mazat, J.P.6
Letellier, T.7
Dachary-Prigent, J.8
Solaini, G.C.9
Rossignol, R.10
-
57
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader JW, Cirilli M, Lin C, XuHW, Takuma K,Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF,Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452.
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
Trinchese, F.11
Liu, S.12
Gunn-Moore, F.13
Lue, L.F.14
Walker, D.G.15
Kuppusamy, P.16
Zewier, Z.L.17
Arancio, O.18
Stern, D.19
Yan, S.S.20
Wu, H.21
more..
-
58
-
-
53549129483
-
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
-
Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14, 1097-1105.
-
(2008)
Nat Med
, vol.14
, pp. 1097-1105
-
-
Du, H.1
Guo, L.2
Fang, F.3
Chen, D.4
Sosunov, A.A.5
McKhann, G.M.6
Yan, Y.7
Wang, C.8
Zhang, H.9
Molkentin, J.D.10
Gunn-Moore, F.J.11
Vonsattel, J.P.12
Arancio, O.13
Chen, J.X.14
Yan, S.D.15
-
59
-
-
84869012777
-
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease
-
Manczak M, Reddy PH (2012) Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Hum Mol Genet 21, 5131-5146.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 5131-5146
-
-
Manczak, M.1
Reddy, P.H.2
-
60
-
-
0032487648
-
Amyloid betapeptide induces apoptosis-related events in synapses and dendrites
-
Mattson MP, Partin J, Begley JG (1998) Amyloid betapeptide induces apoptosis-related events in synapses and dendrites. Brain Res 807, 167-176.
-
(1998)
Brain Res
, vol.807
, pp. 167-176
-
-
Mattson, M.P.1
Partin, J.2
Begley, J.G.3
-
61
-
-
0036215321
-
Beta-Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine
-
Mungarro-Menchaca X, Ferrera P, Moran J, Arias C (2002) beta-Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine. J Neurosci Res 68, 89-96.
-
(2002)
J Neurosci Res
, vol.68
, pp. 89-96
-
-
Mungarro-Menchaca, X.1
Ferrera, P.2
Moran, J.3
Arias, C.4
-
62
-
-
78650659370
-
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
-
D'AmelioM,CavallucciV, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P, Battistini L, Moreno S, Bacci A, Ammassari-Teule M, Marie H, Cecconi F (2011) Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci 14, 69-76.
-
(2011)
Nat Neurosci
, vol.14
, pp. 69-76
-
-
D'Amelio, M.1
Cavallucci, V.2
Middei, S.3
Marchetti, C.4
Pacioni, S.5
Ferri, A.6
Diamantini, A.7
De Zio, D.8
Carrara, P.9
Battistini, L.10
Moreno, S.11
Bacci, A.12
Ammassari-Teule, M.13
Marie, H.14
Cecconi, F.15
-
63
-
-
84858046505
-
Overexpression of amyloid-beta protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade
-
Bartley MG, Marquardt K, Kirchhof D, Wilkins HM, Patterson D, Linseman DA (2012) Overexpression of amyloid-beta protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade. J Alzheimers Dis 28, 855-868.
-
(2012)
J Alzheimers Dis
, vol.28
, pp. 855-868
-
-
Bartley, M.G.1
Marquardt, K.2
Kirchhof, D.3
Wilkins, H.M.4
Patterson, D.5
Linseman, D.A.6
-
64
-
-
0028200649
-
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
-
Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269, 13623-13628.
-
(1994)
J Biol Chem
, vol.269
, pp. 13623-13628
-
-
Gabuzda, D.1
Busciglio, J.2
Chen, L.B.3
Matsudaira, P.4
Yankner, B.A.5
-
65
-
-
19944433845
-
Beta-siteAPPcleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
-
Tamagno E, Parola M, Bardini P, Piccini A, Borghi R, Guglielmotto M, Santoro G, Davit A, Danni O, Smith MA, Perry G,TabatonM(2005) Beta-siteAPPcleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. J Neurochem 92, 628-636.
-
(2005)
J Neurochem
, vol.92
, pp. 628-636
-
-
Tamagno, E.1
Parola, M.2
Bardini, P.3
Piccini, A.4
Borghi, R.5
Guglielmotto, M.6
Santoro, G.7
Davit, A.8
Danni, O.9
Smith, M.A.10
Perry, G.11
Tabaton, M.12
-
66
-
-
38049098793
-
Oxidative stress activates a positive feedback between the gammaand beta-secretase cleavages of the beta-amyloid precursor protein
-
Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, Muraca G, Danni O, Zhu X, Smith MA, Perry G, Jo DG, Mattson MP, TabatonM(2008) Oxidative stress activates a positive feedback between the gammaand beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem 104, 683-695.
-
(2008)
J Neurochem
, vol.104
, pp. 683-695
-
-
Tamagno, E.1
Guglielmotto, M.2
Aragno, M.3
Borghi, R.4
Autelli, R.5
Giliberto, L.6
Muraca, G.7
Danni, O.8
Zhu, X.9
Smith, M.A.10
Perry, G.11
Jo, D.G.12
Mattson, M.P.13
Tabaton, M.14
-
67
-
-
58549119790
-
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: Role of oxidative stress and HIF1alpha
-
Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M (2009) The up-regulation of BACE1 mediated by hypoxia and ischemic injury: Role of oxidative stress and HIF1alpha. J Neurochem 108, 1045-1056.
-
(2009)
J Neurochem
, vol.108
, pp. 1045-1056
-
-
Guglielmotto, M.1
Aragno, M.2
Autelli, R.3
Giliberto, L.4
Novo, E.5
Colombatto, S.6
Danni, O.7
Parola, M.8
Smith, M.A.9
Perry, G.10
Tamagno, E.11
Tabaton, M.12
-
68
-
-
80355148410
-
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice
-
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova NN, Yang L, Starkov AA, Beal F (2011) Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J 25, 4063-4072.
-
(2011)
FASEB J
, vol.25
, pp. 4063-4072
-
-
Dumont, M.1
Stack, C.2
Elipenahli, C.3
Jainuddin, S.4
Gerges, M.5
Starkova, N.N.6
Yang, L.7
Starkov, A.A.8
Beal, F.9
-
69
-
-
21244486781
-
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
-
David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Drose S, Brandt U, MullerWE,Eckert A, Gotz J (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem 280, 23802-23814.
-
(2005)
J Biol Chem
, vol.280
, pp. 23802-23814
-
-
David, D.C.1
Hauptmann, S.2
Scherping, I.3
Schuessel, K.4
Keil, U.5
Rizzu, P.6
Ravid, R.7
Drose, S.8
Brandt, U.9
Muller, W.E.10
Eckert, A.11
Gotz, J.12
-
70
-
-
67349270965
-
Apolipoprotein e and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
-
Bu G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy. Nat Rev Neurosci 10, 333-344.
-
(2009)
Nat Rev Neurosci
, vol.10
, pp. 333-344
-
-
Bu, G.1
-
71
-
-
84863504256
-
Apolipoprotein e and apolipoprotein e receptors: Normal biology and roles in Alzheimer disease
-
Holtzman DM, Herz J, Bu G (2012) Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med 2, a006312.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, pp. a006312
-
-
Holtzman, D.M.1
Herz, J.2
Bu, G.3
-
72
-
-
84873722367
-
Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy
-
Liu CC, Kanekiyo T, Xu H, Bu G (2013) Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy. Nat Rev Neurol 9, 106-118.
-
(2013)
Nat Rev Neurol
, vol.9
, pp. 106-118
-
-
Liu, C.C.1
Kanekiyo, T.2
Xu, H.3
Bu, G.4
-
73
-
-
84944537653
-
Mitochondrial dysfunction: The missing link between aging and sporadic Alzheimer's disease
-
Grimm A, Friedland K, Eckert A (2016) Mitochondrial dysfunction: The missing link between aging and sporadic Alzheimer's disease. Biogerontology 17, 281-296.
-
(2016)
Biogerontology
, vol.17
, pp. 281-296
-
-
Grimm, A.1
Friedland, K.2
Eckert, A.3
-
74
-
-
0033848159
-
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein e genotype
-
Gibson GE, Haroutunian V, Zhang H, Park LC, Shi Q, Lesser M, Mohs RC, Sheu RK, Blass JP (2000) Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. Ann Neurol 48, 297-303.
-
(2000)
Ann Neurol
, vol.48
, pp. 297-303
-
-
Gibson, G.E.1
Haroutunian, V.2
Zhang, H.3
Park, L.C.4
Shi, Q.5
Lesser, M.6
Mohs, R.C.7
Sheu, R.K.8
Blass, J.P.9
-
75
-
-
79953130715
-
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease
-
Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW(2011) Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem 286, 5215-5221.
-
(2011)
J Biol Chem
, vol.286
, pp. 5215-5221
-
-
Chen, H.K.1
Ji, Z.S.2
Dodson, S.E.3
Miranda, R.D.4
Rosenblum, C.I.5
Reynolds, I.J.6
Freedman, S.B.7
Weisgraber, K.H.8
Huang, Y.9
Mahley, R.W.10
-
76
-
-
70350668827
-
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
-
Nakamura T,Watanabe A, Fujino T, Hosono T, Michikawa M (2009) Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. Mol Neurodegener 4, 35.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 35
-
-
Nakamura, T.1
Watanabe, A.2
Fujino, T.3
Hosono, T.4
Michikawa, M.5
-
77
-
-
30544452263
-
The axonal transport of mitochondria
-
Hollenbeck PJ, Saxton WM (2005) The axonal transport of mitochondria. J Cell Sci 118, 5411-5419.
-
(2005)
J Cell Sci
, vol.118
, pp. 5411-5419
-
-
Hollenbeck, P.J.1
Saxton, W.M.2
-
78
-
-
84897567836
-
Mitochondrial trafficking and anchoring in neurons: New insight and implications
-
Sheng ZH (2014) Mitochondrial trafficking and anchoring in neurons: New insight and implications. J Cell Biol 204, 1087-1098.
-
(2014)
J Cell Biol
, vol.204
, pp. 1087-1098
-
-
Sheng, Z.H.1
-
79
-
-
0037032099
-
Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes
-
Dai J, Buijs RM, Kamphorst W, Swaab DF (2002) Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes. Brain Res 948, 138-144.
-
(2002)
Brain Res
, vol.948
, pp. 138-144
-
-
Dai, J.1
Buijs, R.M.2
Kamphorst, W.3
Swaab, D.F.4
-
80
-
-
0038118207
-
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
-
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci 23, 4499-4508.
-
(2003)
J Neurosci
, vol.23
, pp. 4499-4508
-
-
Pigino, G.1
Morfini, G.2
Pelsman, A.3
Mattson, M.P.4
Brady, S.T.5
Busciglio, J.6
-
81
-
-
20044385920
-
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
-
Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E,Williams DS, Goldstein LS (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288.
-
(2005)
Science
, vol.307
, pp. 1282-1288
-
-
Stokin, G.B.1
Lillo, C.2
Falzone, T.L.3
Brusch, R.G.4
Rockenstein, E.5
Mount, S.L.6
Raman, R.7
Davies, P.8
Masliah, E.9
Williams, D.S.10
Goldstein, L.S.11
-
82
-
-
33749854516
-
Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons
-
RuiY, Tiwari P, Xie Z, Zheng JQ (2006) Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons. J Neurosci 26, 10480-10487.
-
(2006)
J Neurosci
, vol.26
, pp. 10480-10487
-
-
Rui, Y.1
Tiwari, P.2
Xie, Z.3
Zheng, J.Q.4
-
83
-
-
34347353311
-
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
-
Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS (2007) Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci 27, 7011-7020.
-
(2007)
J Neurosci
, vol.27
, pp. 7011-7020
-
-
Lazarov, O.1
Morfini, G.A.2
Pigino, G.3
Gadadhar, A.4
Chen, X.5
Robinson, J.6
Ho, H.7
Brady, S.T.8
Sisodia, S.S.9
-
84
-
-
77957737750
-
Tau reduction prevents Abeta-induced defects in axonal transport
-
Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science 330, 198.
-
(2010)
Science
, vol.330
, pp. 198
-
-
Vossel, K.A.1
Zhang, K.2
Brodbeck, J.3
Daub, A.C.4
Sharma, P.5
Finkbeiner, S.6
Cui, B.7
Mucke, L.8
-
85
-
-
79751537405
-
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
-
Calkins MJ, Reddy PH (2011) Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons. Biochim Biophys Acta 1812, 507-513.
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 507-513
-
-
Calkins, M.J.1
Reddy, P.H.2
-
86
-
-
80052846665
-
Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
-
Reddy PH (2011) Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain Res 1415, 136-148.
-
(2011)
Brain Res
, vol.1415
, pp. 136-148
-
-
Reddy, P.H.1
-
87
-
-
84858281225
-
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics
-
Reddy PH, Tripathi R, Troung Q, Tirumala K, Reddy TP, Anekonda V, Shirendeb UP, Calkins MJ, Reddy AP, Mao P, Manczak M (2012) Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics. Biochim Biophys Acta 1822, 639-649.
-
(2012)
Biochim Biophys Acta
, vol.1822
, pp. 639-649
-
-
Reddy, P.H.1
Tripathi, R.2
Troung, Q.3
Tirumala, K.4
Reddy, T.P.5
Anekonda, V.6
Shirendeb, U.P.7
Calkins, M.J.8
Reddy, A.P.9
Mao, P.10
Manczak, M.11
-
88
-
-
84889596911
-
Beta-amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3
-
Deng Y, Xiong Z, Chen P, Wei J, Chen S, Yan Z (2014) Beta-amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3. Neurobiol Aging 35, 449-459.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 449-459
-
-
Deng, Y.1
Xiong, Z.2
Chen, P.3
Wei, J.4
Chen, S.5
Yan, Z.6
-
89
-
-
84936998627
-
Tau reduction prevents Abeta-induced axonal transport deficits by blocking activation of GSK3beta
-
Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L (2015) Tau reduction prevents Abeta-induced axonal transport deficits by blocking activation of GSK3beta. J Cell Biol 209, 419-433.
-
(2015)
J Cell Biol
, vol.209
, pp. 419-433
-
-
Vossel, K.A.1
Xu, J.C.2
Fomenko, V.3
Miyamoto, T.4
Suberbielle, E.5
Knox, J.A.6
Ho, K.7
Kim, D.H.8
Yu, G.Q.9
Mucke, L.10
-
90
-
-
62449166389
-
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
-
Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, Pasinetti GM (2009) PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol 66, 352-361.
-
(2009)
Arch Neurol
, vol.66
, pp. 352-361
-
-
Qin, W.1
Haroutunian, V.2
Katsel, P.3
Cardozo, C.P.4
Ho, L.5
Buxbaum, J.D.6
Pasinetti, G.M.7
-
91
-
-
84855687153
-
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
-
Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X (2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem 120, 419-429.
-
(2012)
J Neurochem
, vol.120
, pp. 419-429
-
-
Sheng, B.1
Wang, X.2
Su, B.3
Lee, H.G.4
Casadesus, G.5
Perry, G.6
Zhu, X.7
-
92
-
-
70549106846
-
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses
-
Abramov E, Dolev I, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci 12, 1567-1576.
-
(2009)
Nat Neurosci
, vol.12
, pp. 1567-1576
-
-
Abramov, E.1
Dolev, I.2
Fogel, H.3
Ciccotosto, G.D.4
Ruff, E.5
Slutsky, I.6
-
93
-
-
79955474315
-
Endogenous amyloidbeta is necessary for hippocampal synaptic plasticity and memory
-
Puzzo D, Privitera L, Fa M, Staniszewski A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O (2011) Endogenous amyloidbeta is necessary for hippocampal synaptic plasticity and memory. Ann Neurol 69, 819-830.
-
(2011)
Ann Neurol
, vol.69
, pp. 819-830
-
-
Puzzo, D.1
Privitera, L.2
Fa, M.3
Staniszewski, A.4
Hashimoto, G.5
Aziz, F.6
Sakurai, M.7
Ribe, E.M.8
Troy, C.M.9
Mercken, M.10
Jung, S.S.11
Palmeri, A.12
Arancio, O.13
-
95
-
-
0033562610
-
The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
-
Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19, 4180-4188.
-
(1999)
J Neurosci
, vol.19
, pp. 4180-4188
-
-
Tovar, K.R.1
Westbrook, G.L.2
-
96
-
-
0036241207
-
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
-
Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5, 405-414.
-
(2002)
Nat Neurosci
, vol.5
, pp. 405-414
-
-
Hardingham, G.E.1
Fukunaga, Y.2
Bading, H.3
-
97
-
-
33645837486
-
Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons
-
Ivanov A, Pellegrino C, Rama S, Dumalska I, Salyha Y, Ben-Ari Y, Medina I (2006) Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J Physiol 572, 789-798.
-
(2006)
J Physiol
, vol.572
, pp. 789-798
-
-
Ivanov, A.1
Pellegrino, C.2
Rama, S.3
Dumalska, I.4
Salyha, Y.5
Ben-Ari, Y.6
Medina, I.7
-
98
-
-
60349088785
-
Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices
-
Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD (2009) Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience 158, 1446-1459.
-
(2009)
Neuroscience
, vol.158
, pp. 1446-1459
-
-
Goebel-Goody, S.M.1
Davies, K.D.2
Alvestad, L.R.M.3
Freund, R.K.4
Browning, M.D.5
-
99
-
-
85017546835
-
Modulating the balance of synaptic and extrasynaptic NMDA receptors shows positive effects against amyloid-beta-induced neurotoxicity
-
Huang Y, Shen W, Su J, Cheng B, Li D, Liu G, Zhou WX,ZhangYX(2017) Modulating the balance of synaptic and extrasynaptic NMDA receptors shows positive effects against amyloid-beta-induced neurotoxicity. J Alzheimers Dis 57, 885-897.
-
(2017)
J Alzheimers Dis
, vol.57
, pp. 885-897
-
-
Huang, Y.1
Shen, W.2
Su, J.3
Cheng, B.4
Li, D.5
Liu, G.6
Zhou, W.X.7
Zhang, Y.X.8
-
100
-
-
84885174557
-
NMDA receptors in nervous system diseases
-
Zhou Q, Sheng M (2013) NMDA receptors in nervous system diseases. Neuropharmacology 74, 69-75.
-
(2013)
Neuropharmacology
, vol.74
, pp. 69-75
-
-
Zhou, Q.1
Sheng, M.2
-
101
-
-
0035866076
-
Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
-
Kim JH, Anwyl R, Suh YH, Djamgoz MB, Rowan MJ (2001) Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo. J Neurosci 21, 1327-1333.
-
(2001)
J Neurosci
, vol.21
, pp. 1327-1333
-
-
Kim, J.H.1
Anwyl, R.2
Suh, Y.H.3
Djamgoz, M.B.4
Rowan, M.J.5
-
102
-
-
0035658715
-
Remembrance of arguments past: How well is the glutamate receptor hypothesis of LTP holding up after 20 years
-
Baudry M, Lynch G (2001) Remembrance of arguments past: How well is the glutamate receptor hypothesis of LTP holding up after 20 years? Neurobiol Learn Mem 76, 284-297.
-
(2001)
Neurobiol Learn Mem
, vol.76
, pp. 284-297
-
-
Baudry, M.1
Lynch, G.2
-
103
-
-
0037059598
-
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
-
Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL (2002) Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res 924, 133-140.
-
(2002)
Brain Res
, vol.924
, pp. 133-140
-
-
Wang, H.W.1
Pasternak, J.F.2
Kuo, H.3
Ristic, H.4
Lambert, M.P.5
Chromy, B.6
Viola, K.L.7
Klein, W.L.8
Stine, W.B.9
Krafft, G.A.10
Trommer, B.L.11
-
104
-
-
80052172774
-
Long-term potentiation and depression as putative mechanisms for memory formation
-
Bermúdez-Rattoni F, ed. CRC Press, Boca Raton (FL
-
Escobar ML, DerrickB(2007) Long-term potentiation and depression as putative mechanisms for memory formation. In Neural Plasticity and Memory: From Genes to Brain Imaging, Bermúdez-Rattoni F, ed. CRC Press, Boca Raton (FL), pp. 15-45.
-
(2007)
Neural Plasticity and Memory: From Genes to Brain Imaging
, pp. 15-45
-
-
Escobar, M.L.1
Derrick, B.2
-
105
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, Greengard P (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8, 1051-1058.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
Paul, S.4
Moran, T.5
Choi, E.Y.6
Nairn, A.C.7
Salter, M.W.8
Lombroso, P.J.9
Gouras, G.K.10
Greengard, P.11
-
106
-
-
33845411954
-
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
-
Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R (2006) AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52, 831-843.
-
(2006)
Neuron
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
Boehm, J.2
Sato, C.3
Iwatsubo, T.4
Tomita, T.5
Sisodia, S.6
Malinow, R.7
-
107
-
-
84856958510
-
Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures
-
Ferreira IL, Bajouco LM, Mota SI, Auberson YP, Oliveira CR, Rego AC (2012) Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures. Cell Calcium 51, 95-106.
-
(2012)
Cell Calcium
, vol.51
, pp. 95-106
-
-
Ferreira, I.L.1
Bajouco, L.M.2
Mota, S.I.3
Auberson, Y.P.4
Oliveira, C.R.5
Rego, A.C.6
-
108
-
-
0033546347
-
Specific coupling ofNMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
-
Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, TymianskiM(1999) Specific coupling ofNMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284, 1845-1848.
-
(1999)
Science
, vol.284
, pp. 1845-1848
-
-
Sattler, R.1
Xiong, Z.2
Lu, W.Y.3
Hafner, M.4
MacDonald, J.F.5
Tymianski, M.6
-
109
-
-
33947331063
-
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
-
Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, Wu DC, Lu J, Tymianski M, Craig AM, Wang YT (2007) NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 27, 2846-2857.
-
(2007)
J Neurosci
, vol.27
, pp. 2846-2857
-
-
Liu, Y.1
Wong, T.P.2
Aarts, M.3
Rooyakkers, A.4
Liu, L.5
Lai, T.W.6
Wu, D.C.7
Lu, J.8
Tymianski, M.9
Craig, A.M.10
Wang, Y.T.11
-
110
-
-
33846633336
-
Abeta oligomerinduced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT,Wood M,Viola KL, KleinWL(2007) Abeta oligomerinduced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27, 796-807.
-
(2007)
J Neurosci
, vol.27
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
111
-
-
78649417803
-
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production
-
Bordji K, Becerril-Ortega J, Nicole O, Buisson A (2010) Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J Neurosci 30, 15927-15942.
-
(2010)
J Neurosci
, vol.30
, pp. 15927-15942
-
-
Bordji, K.1
Becerril-Ortega, J.2
Nicole, O.3
Buisson, A.4
-
112
-
-
84865405744
-
Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine-searching for the connections
-
Danysz W, Parsons CG (2012) Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine-searching for the connections. Br J Pharmacol 167, 324-352.
-
(2012)
Br J Pharmacol
, vol.167
, pp. 324-352
-
-
Danysz, W.1
Parsons, C.G.2
-
113
-
-
33644502516
-
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation
-
Amadoro G, Ciotti MT, Costanzi M, Cestari V, Calissano P, Canu N (2006) NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A 103, 2892-2897.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2892-2897
-
-
Amadoro, G.1
Ciotti, M.T.2
Costanzi, M.3
Cestari, V.4
Calissano, P.5
Canu, N.6
-
114
-
-
78651506630
-
Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
-
Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L (2011) Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci 31, 700-711.
-
(2011)
J Neurosci
, vol.31
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
Yao, J.4
Chin, J.5
Yan, F.6
Wu, T.7
Hamto, P.8
Devidze, N.9
Yu, G.Q.10
Palop, J.J.11
Noebels, J.L.12
Mucke, L.13
-
115
-
-
78751644048
-
Amyloid-beta and tau-A toxic pas de deux in Alzheimer's disease
-
Ittner LM, Gotz J (2011) Amyloid-beta and tau-A toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 12, 65-72.
-
(2011)
Nat Rev Neurosci
, vol.12
, pp. 65-72
-
-
Ittner, L.M.1
Gotz, J.2
-
116
-
-
0026570528
-
Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992) Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12, 376-389.
-
(1992)
J Neurosci
, vol.12
, pp. 376-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
117
-
-
0030894036
-
The inhibitory effects of beta-amyloid on glutamate and glucose uptakes by cultured astrocytes
-
Parpura-Gill A, Beitz D, Uemura E (1997) The inhibitory effects of beta-amyloid on glutamate and glucose uptakes by cultured astrocytes. Brain Res 754, 65-71.
-
(1997)
Brain Res
, vol.754
, pp. 65-71
-
-
Parpura-Gill, A.1
Beitz, D.2
Uemura, E.3
-
118
-
-
1842471972
-
Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: Modulation of uptake as a survival mechanism
-
Fernandez-Tome P, Brera B, Arevalo MA, de Ceballos ML (2004) Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: Modulation of uptake as a survival mechanism. Neurobiol Dis 15, 580-589.
-
(2004)
Neurobiol Dis
, vol.15
, pp. 580-589
-
-
Fernandez-Tome, P.1
Brera, B.2
Arevalo, M.A.3
De Ceballos, M.L.4
-
119
-
-
53949085542
-
Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades
-
Matos M, Augusto E, Oliveira CR, Agostinho P (2008) Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience 156, 898-910.
-
(2008)
Neuroscience
, vol.156
, pp. 898-910
-
-
Matos, M.1
Augusto, E.2
Oliveira, C.R.3
Agostinho, P.4
-
120
-
-
84877089562
-
Amyloid-beta1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1
-
Scimemi A, Meabon JS, Woltjer RL, Sullivan JM, Diamond JS, Cook DG (2013) Amyloid-beta1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1. J Neurosci 33, 5312-5318.
-
(2013)
J Neurosci
, vol.33
, pp. 5312-5318
-
-
Scimemi, A.1
Meabon, J.S.2
Woltjer, R.L.3
Sullivan, J.M.4
Diamond, J.S.5
Cook, D.G.6
-
121
-
-
84879732252
-
Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
-
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Pina-Crespo JC, Lipton SA (2013) Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A 110, E2518-2527.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E2518-2527
-
-
Talantova, M.1
Sanz-Blasco, S.2
Zhang, X.3
Xia, P.4
Akhtar, M.W.5
Okamoto, S.6
Dziewczapolski, G.7
Nakamura, T.8
Cao, G.9
Pratt, A.E.10
Kang, Y.J.11
Tu, S.12
Molokanova, E.13
McKercher, S.R.14
Hires, S.A.15
Sason, H.16
Stouffer, D.G.17
Buczynski, M.W.18
Solomon, J.P.19
Michael, S.20
Powers, E.T.21
Kelly, J.W.22
Roberts, A.23
Tong, G.24
Fang-Newmeyer, T.25
Parker, J.26
Holland, E.A.27
Zhang, D.28
Nakanishi, N.29
Chen, H.S.30
Wolosker, H.31
Wang, Y.32
Parsons, L.H.33
Ambasudhan, R.34
Masliah, E.35
Heinemann, S.F.36
Pina-Crespo, J.C.37
Lipton, S.A.38
more..
-
122
-
-
79955574336
-
Region-and age-specific changes in glutamate transport in the AbetaPP23 mouse model for Alzheimer's disease
-
Schallier A, Smolders I, Van Dam D, Loyens E, De Deyn PP, Michotte A, Michotte Y, Massie A (2011) Region-and age-specific changes in glutamate transport in the AbetaPP23 mouse model for Alzheimer's disease. J Alzheimers Dis 24, 287-300.
-
(2011)
J Alzheimers Dis
, vol.24
, pp. 287-300
-
-
Schallier, A.1
Smolders, I.2
Van Dam, D.3
Loyens, E.4
De Deyn, P.P.5
Michotte, A.6
Michotte, Y.7
Massie, A.8
-
123
-
-
84930082990
-
Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease
-
Zumkehr J, Rodriguez-Ortiz CJ, Cheng D, Kieu Z,Wai T, Hawkins C, Kilian J, Lim SL, Medeiros R, Kitazawa M (2015) Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiol Aging 36, 2260-2271.
-
(2015)
Neurobiol Aging
, vol.36
, pp. 2260-2271
-
-
Zumkehr, J.1
Rodriguez-Ortiz, C.J.2
Cheng, D.3
Kieu, Z.4
Wai, T.5
Hawkins, C.6
Kilian, J.7
Lim, S.L.8
Medeiros, R.9
Kitazawa, M.10
-
124
-
-
0030872412
-
Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
-
Li S, Mallory M, Alford M, Tanaka S, Masliah E (1997) Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. J Neuropathol Exp Neurol 56, 901-911.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 901-911
-
-
Li, S.1
Mallory, M.2
Alford, M.3
Tanaka, S.4
Masliah, E.5
-
125
-
-
0033556396
-
Interindividual differences in the levels of the glutamate transportersGLASTandGLT, but no clear correlation with Alzheimer's disease
-
Beckstrom H, Julsrud L, Haugeto O, Dewar D, Graham DI, Lehre KP, Storm-Mathisen J, Danbolt NC (1999) Interindividual differences in the levels of the glutamate transportersGLASTandGLT, but no clear correlation with Alzheimer's disease. J Neurosci Res 55, 218-229.
-
(1999)
J Neurosci Res
, vol.55
, pp. 218-229
-
-
Beckstrom, H.1
Julsrud, L.2
Haugeto, O.3
Dewar, D.4
Graham, D.I.5
Lehre, K.P.6
Storm-Mathisen, J.7
Danbolt, N.C.8
-
126
-
-
79952899104
-
Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
-
e1-11
-
Scott HA, Gebhardt FM, Mitrovic AD, Vandenberg RJ, Dodd PR (2011) Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease. Neurobiol Aging 32, 553.e1-11.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 553
-
-
Scott, H.A.1
Gebhardt, F.M.2
Mitrovic, A.D.3
Vandenberg, R.J.4
Dodd, P.R.5
-
127
-
-
84954470044
-
Chronic glutamate toxicity in neurodegenerative diseases-What is the evidence
-
Lewerenz J, Maher P (2015) Chronic glutamate toxicity in neurodegenerative diseases-What is the evidence? Front Neurosci 9, 469.
-
(2015)
Front Neurosci
, vol.9
, pp. 469
-
-
Lewerenz, J.1
Maher, P.2
-
128
-
-
33645217828
-
System Xc-and apolipoprotein e expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40
-
Qin S, Colin C, Hinners I, Gervais A, Cheret C, Mallat M (2006) System Xc-and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. J Neurosci 26, 3345-3356.
-
(2006)
J Neurosci
, vol.26
, pp. 3345-3356
-
-
Qin, S.1
Colin, C.2
Hinners, I.3
Gervais, A.4
Cheret, C.5
Mallat, M.6
-
129
-
-
0023895734
-
Glutamate becomes neurotoxic via the N-methyl-Daspartate receptor when intracellular energy levels are reduced
-
Novelli A, Reilly JA, Lysko PG, Henneberry RC (1988) Glutamate becomes neurotoxic via the N-methyl-Daspartate receptor when intracellular energy levels are reduced. Brain Res 451, 205-212.
-
(1988)
Brain Res
, vol.451
, pp. 205-212
-
-
Novelli, A.1
Reilly, J.A.2
Lysko, P.G.3
Henneberry, R.C.4
-
130
-
-
84926370173
-
Neuroinflammation in Alzheimer's disease
-
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP (2015) Neuroinflammation in Alzheimer's disease. Lancet Neurol 14, 388-405.
-
(2015)
Lancet Neurol
, vol.14
, pp. 388-405
-
-
Heneka, M.T.1
Carson, M.J.2
El Khoury, J.3
Landreth, G.E.4
Brosseron, F.5
Feinstein, D.L.6
Jacobs, A.H.7
Wyss-Coray, T.8
Vitorica, J.9
Ransohoff, R.M.10
Herrup, K.11
Frautschy, S.A.12
Finsen, B.13
Brown, G.C.14
Verkhratsky, A.15
Yamanaka, K.16
Koistinaho, J.17
Latz, E.18
Halle, A.19
Petzold, G.C.20
Town, T.21
Morgan, D.22
Shinohara, M.L.23
Perry, V.H.24
Holmes, C.25
Bazan, N.G.26
Brooks, D.J.27
Hunot, S.28
Joseph, B.29
Deigendesch, N.30
Garaschuk, O.31
Boddeke, E.32
Dinarello, C.A.33
Breitner, J.C.34
Cole, G.M.35
Golenbock, D.T.36
Kummer, M.P.37
more..
-
131
-
-
84929921146
-
Immune attack: The role of inflammation in Alzheimer disease
-
Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: The role of inflammation in Alzheimer disease. Nat Rev Neurosci 16, 358-372.
-
(2015)
Nat Rev Neurosci
, vol.16
, pp. 358-372
-
-
Heppner, F.L.1
Ransohoff, R.M.2
Becher, B.3
-
132
-
-
84900338300
-
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
-
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL (2014) Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 344, 519-523.
-
(2014)
Science
, vol.344
, pp. 519-523
-
-
Raj, T.1
Rothamel, K.2
Mostafavi, S.3
Ye, C.4
Lee, M.N.5
Replogle, J.M.6
Feng, T.7
Lee, M.8
Asinovski, N.9
Frohlich, I.10
Imboywa, S.11
Von Korff, A.12
Okada, Y.13
Patsopoulos, N.A.14
Davis, S.15
McCabe, C.16
Paik, H.I.17
Srivastava, G.P.18
Raychaudhuri, S.19
Hafler, D.A.20
Koller, D.21
Regev, A.22
Hacohen, N.23
Mathis, D.24
Benoist, C.25
Stranger, B.E.26
De Jager, P.L.27
more..
-
133
-
-
79955605102
-
Physiology of microglia
-
Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91, 461-553.
-
(2011)
Physiol Rev
, vol.91
, pp. 461-553
-
-
Kettenmann, H.1
Hanisch, U.K.2
Noda, M.3
Verkhratsky, A.4
-
134
-
-
84873497150
-
Microglia actively regulate the number of functional synapses
-
Ji K, Akgul G, Wollmuth LP, Tsirka SE (2013) Microglia actively regulate the number of functional synapses. PLoS One 8, e56293.
-
(2013)
PLoS One
, vol.8
, pp. e56293
-
-
Ji, K.1
Akgul, G.2
Wollmuth, L.P.3
Tsirka, S.E.4
-
135
-
-
84894574217
-
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
-
Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, 3rd, Lafaille JJ, Hempstead BL, Littman DR, Gan WB (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155, 1596-1609.
-
(2013)
Cell
, vol.155
, pp. 1596-1609
-
-
Parkhurst, C.N.1
Yang, G.2
Ninan, I.3
Savas, J.N.4
Yates, J.R.5
Lafaille, J.J.6
Hempstead, B.L.7
Littman, D.R.8
Gan, W.B.9
-
136
-
-
0026470167
-
MHC class II-positive microglia in human brain: Association with Alzheimer lesions
-
Perlmutter LS, Scott SA, Barron E, Chui HC (1992) MHC class II-positive microglia in human brain: Association with Alzheimer lesions. J Neurosci Res 33, 549-558.
-
(1992)
J Neurosci Res
, vol.33
, pp. 549-558
-
-
Perlmutter, L.S.1
Scott, S.A.2
Barron, E.3
Chui, H.C.4
-
137
-
-
84866291187
-
Increased binding of peripheral benzodiazepine receptor in mild cognitive impairmentdementia converters measured by positron emission tomography with(1)(1)C DAA1106
-
Yasuno F, Kosaka J, Ota M, Higuchi M, Ito H, Fujimura Y, Nozaki S, Takahashi S, Mizukami K, Asada T, Suhara T (2012) Increased binding of peripheral benzodiazepine receptor in mild cognitive impairmentdementia converters measured by positron emission tomography with (1)(1)C DAA1106. Psychiatry Res 203, 67-74.
-
(2012)
Psychiatry Res
, vol.203
, pp. 67-74
-
-
Yasuno, F.1
Kosaka, J.2
Ota, M.3
Higuchi, M.4
Ito, H.5
Fujimura, Y.6
Nozaki, S.7
Takahashi, S.8
Mizukami, K.9
Asada, T.10
Suhara, T.11
-
138
-
-
84868107574
-
Microglial activation in Alzheimer's disease: An (R)-(1)(1)C PK11195 positron emission tomography study
-
Schuitemaker A, Kropholler MA, Boellaard R, van der Flier WM, Kloet RW, van der Doef TF, Knol DL, Windhorst AD, Luurtsema G, Barkhof F, Jonker C, Lammertsma AA, Scheltens P, van Berckel BN (2013) Microglial activation in Alzheimer's disease: An (R)-(1)(1)C PK11195 positron emission tomography study. Neurobiol Aging 34, 128-136.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 128-136
-
-
Schuitemaker, A.1
Kropholler, M.A.2
Boellaard, R.3
Van Der Flier, W.M.4
Kloet, R.W.5
Van Der Doef, T.F.6
Knol, D.L.7
Windhorst, A.D.8
Luurtsema, G.9
Barkhof, F.10
Jonker, C.11
Lammertsma, A.A.12
Scheltens, P.13
Van Berckel, B.N.14
-
139
-
-
0034678024
-
Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta-and tumor necrosis factoralpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor-and NFkappaB-inducing kinase-dependent signaling mechanism
-
Akama KT, Van Eldik LJ (2000) Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta-and tumor necrosis factoralpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor-and NFkappaB-inducing kinase-dependent signaling mechanism. J Biol Chem 275, 7918-7924.
-
(2000)
J Biol Chem
, vol.275
, pp. 7918-7924
-
-
Akama, K.T.1
Van Eldik, L.J.2
-
140
-
-
0034948192
-
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
-
Lue LF, Rydel R, Brigham EF, Yang LB, Hampel H, Murphy GM Jr, Brachova L, Yan SD, Walker DG, Shen Y, Rogers J (2001) Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35, 72-79.
-
(2001)
Glia
, vol.35
, pp. 72-79
-
-
Lue, L.F.1
Rydel, R.2
Brigham, E.F.3
Yang, L.B.4
Hampel, H.5
Murphy, G.M.6
Brachova, L.7
Yan, S.D.8
Walker, D.G.9
Shen, Y.10
Rogers, J.11
-
141
-
-
33646089457
-
Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes
-
Walker DG, Link J, Lue LF, Dalsing-Hernandez JE, Boyes BE (2006) Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. J Leukoc Biol 79, 596-610.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 596-610
-
-
Walker, D.G.1
Link, J.2
Lue, L.F.3
Dalsing-Hernandez, J.E.4
Boyes, B.E.5
-
142
-
-
77956955758
-
The role of microglia in amyloid clearance from the AD brain
-
Lee CY, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna) 117, 949-960.
-
(2010)
J Neural Transm (Vienna)
, vol.117
, pp. 949-960
-
-
Lee, C.Y.1
Landreth, G.E.2
-
144
-
-
51149120624
-
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
-
Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28, 8354-8360.
-
(2008)
J Neurosci
, vol.28
, pp. 8354-8360
-
-
Hickman, S.E.1
Allison, E.K.2
El Khoury, J.3
-
145
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fievet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanche H, Dartigues JF, Tzourio C, Gut I,Van Broeckhoven C, Alperovitch A, Lathrop M, Amouyel P (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41, 1094-1099.
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
Campion, D.4
Sleegers, K.5
Hiltunen, M.6
Combarros, O.7
Zelenika, D.8
Bullido, M.J.9
Tavernier, B.10
Letenneur, L.11
Bettens, K.12
Berr, C.13
Pasquier, F.14
Fievet, N.15
Barberger-Gateau, P.16
Engelborghs, S.17
De Deyn, P.18
Mateo, I.19
Franck, A.20
Helisalmi, S.21
Porcellini, E.22
Hanon, O.23
De Pancorbo, M.M.24
Lendon, C.25
Dufouil, C.26
Jaillard, C.27
Leveillard, T.28
Alvarez, V.29
Bosco, P.30
Mancuso, M.31
Panza, F.32
Nacmias, B.33
Bossu, P.34
Piccardi, P.35
Annoni, G.36
Seripa, D.37
Galimberti, D.38
Hannequin, D.39
Licastro, F.40
Soininen, H.41
Ritchie, K.42
Blanche, H.43
Dartigues, J.F.44
Tzourio, C.45
Gut, I.46
Van Broeckhoven, C.47
Alperovitch, A.48
Lathrop, M.49
Amouyel, P.50
more..
-
146
-
-
79955484414
-
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H,Warden D,Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Ruther E, Schurmann B, Heun R, Kolsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frolich L, Hampel H, Gallacher J, Hull M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alperovitch A, Lathrop M, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Bjornsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossu P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 43, 429-435.
-
(2011)
Nat Genet
, vol.43
, pp. 429-435
-
-
Hollingworth, P.1
Harold, D.2
Sims, R.3
Gerrish, A.4
Lambert, J.C.5
Carrasquillo, M.M.6
Abraham, R.7
Hamshere, M.L.8
Pahwa, J.S.9
Moskvina, V.10
Dowzell, K.11
Jones, N.12
Stretton, A.13
Thomas, C.14
Richards, A.15
Ivanov, D.16
Widdowson, C.17
Chapman, J.18
Lovestone, S.19
Powell, J.20
Proitsi, P.21
Lupton, M.K.22
Brayne, C.23
Rubinsztein, D.C.24
Gill, M.25
Lawlor, B.26
Lynch, A.27
Brown, K.S.28
Passmore, P.A.29
Craig, D.30
McGuinness, B.31
Todd, S.32
Holmes, C.33
Mann, D.34
Smith, A.D.35
Beaumont, H.36
Warden, D.37
Wilcock, G.38
Love, S.39
Kehoe, P.G.40
Hooper, N.M.41
Vardy, E.R.42
Hardy, J.43
Mead, S.44
Fox, N.C.45
Rossor, M.46
Collinge, J.47
Maier, W.48
Jessen, F.49
Ruther, E.50
Schurmann, B.51
Heun, R.52
Kolsch, H.53
Van Den Bussche, H.54
Heuser, I.55
Kornhuber, J.56
Wiltfang, J.57
Dichgans, M.58
Frolich, L.59
Hampel, H.60
Gallacher, J.61
Hull, M.62
Rujescu, D.63
Giegling, I.64
Goate, A.M.65
Kauwe, J.S.66
Cruchaga, C.67
Nowotny, P.68
Morris, J.C.69
Mayo, K.70
Sleegers, K.71
Bettens, K.72
Engelborghs, S.73
De Deyn, P.P.74
Van Broeckhoven, C.75
Livingston, G.76
Bass, N.J.77
Gurling, H.78
McQuillin, A.79
Gwilliam, R.80
Deloukas, P.81
Al-Chalabi, A.82
Shaw, C.E.83
Tsolaki, M.84
Singleton, A.B.85
Guerreiro, R.86
Muhleisen, T.W.87
Nothen, M.M.88
Moebus, S.89
Jockel, K.H.90
Klopp, N.91
Wichmann, H.E.92
Pankratz, V.S.93
Sando, S.B.94
Aasly, J.O.95
Barcikowska, M.96
Wszolek, Z.K.97
Dickson, D.W.98
Graff-Radford, N.R.99
more..
-
147
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
-
Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, TsuangDW, Hakonarson H,Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 43, 436-441.
-
(2011)
Nat Genet
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
Jun, G.2
Beecham, G.W.3
Wang, L.S.4
Vardarajan, B.N.5
Buros, J.6
Gallins, P.J.7
Buxbaum, J.D.8
Jarvik, G.P.9
Crane, P.K.10
Larson, E.B.11
Bird, T.D.12
Boeve, B.F.13
Graff-Radford, N.R.14
De Jager, P.L.15
Evans, D.16
Schneider, J.A.17
Carrasquillo, M.M.18
Ertekin-Taner, N.19
Younkin, S.G.20
Cruchaga, C.21
Kauwe, J.S.22
Nowotny, P.23
Kramer, P.24
Hardy, J.25
Huentelman, M.J.26
Myers, A.J.27
Barmada, M.M.28
Demirci, F.Y.29
Baldwin, C.T.30
Green, R.C.31
Rogaeva, E.32
St George-Hyslop, P.33
Arnold, S.E.34
Barber, R.35
Beach, T.36
Bigio, E.H.37
Bowen, J.D.38
Boxer, A.39
Burke, J.R.40
Cairns, N.J.41
Carlson, C.S.42
Carney, R.M.43
Carroll, S.L.44
Chui, H.C.45
Clark, D.G.46
Corneveaux, J.47
Cotman, C.W.48
Cummings, J.L.49
DeCarli, C.50
DeKosky, S.T.51
Diaz-Arrastia, R.52
Dick, M.53
Dickson, D.W.54
Ellis, W.G.55
Faber, K.M.56
Fallon, K.B.57
Farlow, M.R.58
Ferris, S.59
Frosch, M.P.60
Galasko, D.R.61
Ganguli, M.62
Gearing, M.63
Geschwind, D.H.64
Ghetti, B.65
Gilbert, J.R.66
Gilman, S.67
Giordani, B.68
Glass, J.D.69
Growdon, J.H.70
Hamilton, R.L.71
Harrell, L.E.72
Head, E.73
Honig, L.S.74
Hulette, C.M.75
Hyman, B.T.76
Jicha, G.A.77
Jin, L.W.78
Johnson, N.79
Karlawish, J.80
Karydas, A.81
Kaye, J.A.82
Kim, R.83
Koo, E.H.84
Kowall, N.W.85
Lah, J.J.86
Levey, A.I.87
Lieberman, A.P.88
Lopez, O.L.89
Mack, W.J.90
Marson, D.C.91
Martiniuk, F.92
Mash, D.C.93
Masliah, E.94
McCormick, W.C.95
McCurry, S.M.96
McDavid, A.N.97
McKee, A.C.98
Mesulam, M.99
more..
-
148
-
-
84876006819
-
Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology
-
Krabbe G, Halle A, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, Miller KR, Prokop S, Kettenmann H, Heppner FL (2013) Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One 8, e60921.
-
(2013)
PLoS One
, vol.8
, pp. e60921
-
-
Krabbe, G.1
Halle, A.2
Matyash, V.3
Rinnenthal, J.L.4
Eom, G.D.5
Bernhardt, U.6
Miller, K.R.7
Prokop, S.8
Kettenmann, H.9
Heppner, F.L.10
-
149
-
-
84885761556
-
TREM2 and neurodegenerative disease
-
Guerreiro R, Hardy J (2013) TREM2 and neurodegenerative disease. N Engl J Med 369, 1569-1570.
-
(2013)
N Engl J Med
, vol.369
, pp. 1569-1570
-
-
Guerreiro, R.1
Hardy, J.2
-
150
-
-
84872088087
-
Variant of TREM2 associated with the risk of Alzheimer's disease
-
Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K (2013) Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 368, 107-116.
-
(2013)
N Engl J Med
, vol.368
, pp. 107-116
-
-
Jonsson, T.1
Stefansson, H.2
Steinberg, S.3
Jonsdottir, I.4
Jonsson, P.V.5
Snaedal, J.6
Bjornsson, S.7
Huttenlocher, J.8
Levey, A.I.9
Lah, J.J.10
Rujescu, D.11
Hampel, H.12
Giegling, I.13
Andreassen, O.A.14
Engedal, K.15
Ulstein, I.16
Djurovic, S.17
Ibrahim-Verbaas, C.18
Hofman, A.19
Ikram, M.A.20
Van Duijn, C.M.21
Thorsteinsdottir, U.22
Kong, A.23
Stefansson, K.24
more..
-
151
-
-
84891706947
-
CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology
-
Bradshaw EM, Chibnik LB, Keenan BT, Ottoboni L, Raj T, Tang A, Rosenkrantz LL, Imboywa S, Lee M, Von Korff A, Morris MC, Evans DA, Johnson K, Sperling RA, Schneider JA, Bennett DA, De Jager PL (2013) CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology. Nat Neurosci 16, 848-850.
-
(2013)
Nat Neurosci
, vol.16
, pp. 848-850
-
-
Bradshaw, E.M.1
Chibnik, L.B.2
Keenan, B.T.3
Ottoboni, L.4
Raj, T.5
Tang, A.6
Rosenkrantz, L.L.7
Imboywa, S.8
Lee, M.9
Von Korff, A.10
Morris, M.C.11
Evans, D.A.12
Johnson, K.13
Sperling, R.A.14
Schneider, J.A.15
Bennett, D.A.16
De Jager, P.L.17
-
152
-
-
84878433339
-
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE (2013) Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78, 631-643.
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
Lesinski, A.N.4
Asselin, C.N.5
Mullin, K.6
Hooli, B.7
Choi, S.H.8
Hyman, B.T.9
Tanzi, R.E.10
-
153
-
-
84873641792
-
Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
-
Thambisetty M, An Y, Nalls M, Sojkova J, Swaminathan S, Zhou Y, Singleton AB, Wong DF, Ferrucci L, Saykin AJ, Resnick SM (2013) Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype. Biol Psychiatry 73, 422-428.
-
(2013)
Biol Psychiatry
, vol.73
, pp. 422-428
-
-
Thambisetty, M.1
An, Y.2
Nalls, M.3
Sojkova, J.4
Swaminathan, S.5
Zhou, Y.6
Singleton, A.B.7
Wong, D.F.8
Ferrucci, L.9
Saykin, A.J.10
Resnick, S.M.11
-
154
-
-
84884185631
-
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
-
Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T (2013) Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79, 873-886.
-
(2013)
Neuron
, vol.79
, pp. 873-886
-
-
Lucin, K.M.1
O'Brien, C.E.2
Bieri, G.3
Czirr, E.4
Mosher, K.I.5
Abbey, R.J.6
Mastroeni, D.F.7
Rogers, J.8
Spencer, B.9
Masliah, E.10
Wyss-Coray, T.11
-
155
-
-
20444499367
-
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
-
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE (2005) Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128, 1442-1453.
-
(2005)
Brain
, vol.128
, pp. 1442-1453
-
-
Heneka, M.T.1
Sastre, M.2
Dumitrescu-Ozimek, L.3
Hanke, A.4
Dewachter, I.5
Kuiperi, C.6
O'Banion, K.7
Klockgether, T.8
Van Leuven, F.9
Landreth, G.E.10
-
156
-
-
82955220499
-
Impact and therapeutic potential of PPARs in Alzheimer's disease
-
HenekaMT,Reyes-Irisarri E, Hull M,KummerMP(2011) Impact and therapeutic potential of PPARs in Alzheimer's disease. Curr Neuropharmacol 9, 643-650.
-
(2011)
Curr Neuropharmacol
, vol.9
, pp. 643-650
-
-
Heneka, M.T.1
Reyes-Irisarri, E.2
Hull, M.3
Kummer, M.P.4
-
157
-
-
84870226700
-
PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
-
Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, HenekaMT(2012) PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci 32, 17321-17331.
-
(2012)
J Neurosci
, vol.32
, pp. 17321-17331
-
-
Yamanaka, M.1
Ishikawa, T.2
Griep, A.3
Axt, D.4
Kummer, M.P.5
Heneka, M.T.6
-
158
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
-
Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE (2012) ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506.
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
Lee, C.Y.4
Karlo, J.C.5
Zinn, A.E.6
Casali, B.T.7
Restivo, J.L.8
Goebel, W.D.9
James, M.J.10
Brunden, K.R.11
Wilson, D.A.12
Landreth, G.E.13
-
159
-
-
84884707790
-
Elevated levels of PPARgamma in the cerebrospinal fluid of patients with multiple sclerosis
-
Szalardy L, Zadori D, Tanczos E, Simu M, Bencsik K, Vecsei L, Klivenyi P (2013) Elevated levels of PPARgamma in the cerebrospinal fluid of patients with multiple sclerosis. Neurosci Lett 554, 131-134.
-
(2013)
Neurosci Lett
, vol.554
, pp. 131-134
-
-
Szalardy, L.1
Zadori, D.2
Tanczos, E.3
Simu, M.4
Bencsik, K.5
Vecsei, L.6
Klivenyi, P.7
-
160
-
-
85019126064
-
Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis
-
Szalardy L, Zadori D, Bencsik K, Vecsei L, Klivenyi P (2017) Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis. Neurosci Lett 651, 128-133.
-
(2017)
Neurosci Lett
, vol.651
, pp. 128-133
-
-
Szalardy, L.1
Zadori, D.2
Bencsik, K.3
Vecsei, L.4
Klivenyi, P.5
-
161
-
-
0025303784
-
Astrocytes and the plaques of Alzheimer's disease
-
Mandybur TI, Chuirazzi CC (1990) Astrocytes and the plaques of Alzheimer's disease. Neurology 40, 635-639.
-
(1990)
Neurology
, vol.40
, pp. 635-639
-
-
Mandybur, T.I.1
Chuirazzi, C.C.2
-
162
-
-
0027751737
-
Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease
-
Akiyama H,Tooyama I,KawamataT, Ikeda K, McGeerPL (1993) Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease. Brain Res 632, 249-259.
-
(1993)
Brain Res
, vol.632
, pp. 249-259
-
-
Akiyama, H.1
Tooyama, I.2
Kawamata, T.3
Ikeda, K.4
McGeer, P.L.5
-
163
-
-
0031927636
-
Confocal observation of senile plaques in Alzheimer's disease: Senile plaque morphology and relationship between senile plaques and astrocytes
-
Kato S, Gondo T, HoshiiY, Takahashi M,Yamada M, Ishihara T (1998) Confocal observation of senile plaques in Alzheimer's disease: Senile plaque morphology and relationship between senile plaques and astrocytes. Pathol Int 48, 332-340.
-
(1998)
Pathol Int
, vol.48
, pp. 332-340
-
-
Kato, S.1
Gondo, T.2
Hoshii, Y.3
Takahashi, M.4
Yamada, M.5
Ishihara, T.6
-
164
-
-
80052801105
-
Multiple cellular and molecular mechanisms are involved in human Abeta clearance by transplanted adult astrocytes
-
Pihlaja R, Koistinaho J, Kauppinen R, Sandholm J, Tanila H, Koistinaho M (2011) Multiple cellular and molecular mechanisms are involved in human Abeta clearance by transplanted adult astrocytes. Glia 59, 1643-1657.
-
(2011)
Glia
, vol.59
, pp. 1643-1657
-
-
Pihlaja, R.1
Koistinaho, J.2
Kauppinen, R.3
Sandholm, J.4
Tanila, H.5
Koistinaho, M.6
-
165
-
-
0037394788
-
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
-
Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J (2003) Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med 9, 453-457.
-
(2003)
Nat Med
, vol.9
, pp. 453-457
-
-
Wyss-Coray, T.1
Loike, J.D.2
Brionne, T.C.3
Lu, E.4
Anankov, R.5
Yan, F.6
Silverstein, S.C.7
Husemann, J.8
-
166
-
-
0037427384
-
Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
-
Nagele RG, D'Andrea MR, Lee H,VenkataramanV,Wang HY (2003) Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res 971, 197-209.
-
(2003)
Brain Res
, vol.971
, pp. 197-209
-
-
Nagele, R.G.1
D'Andrea, M.R.2
Lee, H.3
Venkataraman, V.4
Wang, H.Y.5
-
167
-
-
3142781310
-
Apolipoprotein e promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
-
KoistinahoM,Lin S,Wu X, EstermanM,Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR, Paul SM (2004) Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 10, 719-726.
-
(2004)
Nat Med
, vol.10
, pp. 719-726
-
-
Koistinaho, M.1
Lin, S.2
Wu, X.3
Esterman, M.4
Koger, D.5
Hanson, J.6
Higgs, R.7
Liu, F.8
Malkani, S.9
Bales, K.R.10
Paul, S.M.11
-
168
-
-
79956311751
-
Critical role of astroglial apolipoprotein e and liver X receptoralpha expression for microglial Abeta phagocytosis
-
Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JA, Holtzman DM, HenekaMT(2011) Critical role of astroglial apolipoprotein E and liver X receptoralpha expression for microglial Abeta phagocytosis. J Neurosci 31, 7049-7059.
-
(2011)
J Neurosci
, vol.31
, pp. 7049-7059
-
-
Terwel, D.1
Steffensen, K.R.2
Verghese, P.B.3
Kummer, M.P.4
Gustafsson, J.A.5
Holtzman, D.M.6
Heneka, M.T.7
-
169
-
-
84869016768
-
Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease
-
Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J Neurosci 32, 16129-16140.
-
(2012)
J Neurosci
, vol.32
, pp. 16129-16140
-
-
Furman, J.L.1
Sama, D.M.2
Gant, J.C.3
Beckett, T.L.4
Murphy, M.P.5
Bachstetter, A.D.6
Van Eldik, L.J.7
Norris, C.M.8
-
170
-
-
0001360461
-
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
-
Griffin WS, Stanley LC, Ling C, White L, MacLeodV, Perrot LJ, White CL 3rd, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86, 7611-7615.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7611-7615
-
-
Griffin, W.S.1
Stanley, L.C.2
Ling, C.3
White, L.4
MacLeod, V.5
Perrot, L.J.6
White, C.L.7
Araoz, C.8
-
171
-
-
0028178004
-
Brain interleukin-1 beta in Alzheimer's disease and vascular dementia
-
Cacabelos R, Alvarez XA, Fernandez-Novoa L, Franco A, Mangues R, Pellicer A, Nishimura T (1994) Brain interleukin-1 beta in Alzheimer's disease and vascular dementia. Methods Find Exp Clin Pharmacol 16, 141-151.
-
(1994)
Methods Find Exp Clin Pharmacol
, vol.16
, pp. 141-151
-
-
Cacabelos, R.1
Alvarez, X.A.2
Fernandez-Novoa, L.3
Franco, A.4
Mangues, R.5
Pellicer, A.6
Nishimura, T.7
-
172
-
-
0029986869
-
Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
-
Hull M, Berger M, Volk B, Bauer J (1996) Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques. Ann N Y Acad Sci 777, 205-212.
-
(1996)
Ann N y Acad Sci
, vol.777
, pp. 205-212
-
-
Hull, M.1
Berger, M.2
Volk, B.3
Bauer, J.4
-
173
-
-
0034237388
-
Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology
-
Mehlhorn G, Hollborn M, Schliebs R (2000) Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology. Int J Dev Neurosci 18, 423-431.
-
(2000)
J Dev Neurosci
, vol.18
, pp. 423-431
-
-
Mehlhorn, G.1
Hollborn, M.2
Schliebs, R.3
-
174
-
-
20244364226
-
Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice
-
Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Morris C, Winblad B, Nordberg A, Zhu J (2002) Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice. J Neuroimmunol 126, 50-57.
-
(2002)
J Neuroimmunol
, vol.126
, pp. 50-57
-
-
Abbas, N.1
Bednar, I.2
Mix, E.3
Marie, S.4
Paterson, D.5
Ljungberg, A.6
Morris, C.7
Winblad, B.8
Nordberg, A.9
Zhu, J.10
-
175
-
-
23944449670
-
Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain
-
Hampel H, Haslinger A, Scheloske M, Padberg F, Fischer P, Unger J, Teipel SJ, Neumann M, Rosenberg C, Oshida R, Hulette C, Pongratz D, Ewers M, Kretzschmar HA, Moller HJ (2005) Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain. Eur Arch Psychiatry Clin Neurosci 255, 269-278.
-
(2005)
Eur Arch Psychiatry Clin Neurosci
, vol.255
, pp. 269-278
-
-
Hampel, H.1
Haslinger, A.2
Scheloske, M.3
Padberg, F.4
Fischer, P.5
Unger, J.6
Teipel, S.J.7
Neumann, M.8
Rosenberg, C.9
Oshida, R.10
Hulette, C.11
Pongratz, D.12
Ewers, M.13
Kretzschmar, H.A.14
Moller, H.J.15
-
176
-
-
18144410635
-
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
-
Patel NS, Paris D, Mathura V, Quadros AN, Crawford FC, Mullan MJ (2005) Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease. J Neuroinflammation 2, 9.
-
(2005)
J Neuroinflammation
, vol.2
, pp. 9
-
-
Patel, N.S.1
Paris, D.2
Mathura, V.3
Quadros, A.N.4
Crawford, F.C.5
Mullan, M.J.6
-
177
-
-
77956064235
-
Inflammation in transgenic mouse models of neurodegenerative disorders
-
Schwab C, Klegeris A, McGeer PL (2010) Inflammation in transgenic mouse models of neurodegenerative disorders. Biochim Biophys Acta 1802, 889-902.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 889-902
-
-
Schwab, C.1
Klegeris, A.2
McGeer, P.L.3
-
178
-
-
79959669857
-
Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology
-
Morimoto K, Horio J, Satoh H, Sue L, Beach T, Arita S, Tooyama I, Konishi Y (2011) Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology. J Alzheimers Dis 25, 59-76.
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 59-76
-
-
Morimoto, K.1
Horio, J.2
Satoh, H.3
Sue, L.4
Beach, T.5
Arita, S.6
Tooyama, I.7
Konishi, Y.8
-
179
-
-
84870932482
-
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
-
Vom Berg J, Prokop S, Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL (2012) Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat Med 18, 1812-1819.
-
(2012)
Nat Med
, vol.18
, pp. 1812-1819
-
-
Vom Berg, J.1
Prokop, S.2
Miller, K.R.3
Obst, J.4
Kalin, R.E.5
Lopategui-Cabezas, I.6
Wegner, A.7
Mair, F.8
Schipke, C.G.9
Peters, O.10
Winter, Y.11
Becher, B.12
Heppner, F.L.13
-
180
-
-
84872337044
-
Neuroinflammatory phenotype in early Alzheimer's disease
-
Sudduth TL, Schmitt FA, Nelson PT,Wilcock DM (2013) Neuroinflammatory phenotype in early Alzheimer's disease. Neurobiol Aging 34, 1051-1059.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 1051-1059
-
-
Sudduth, T.L.1
Schmitt, F.A.2
Nelson, P.T.3
Wilcock, D.M.4
-
181
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493, 674-678.
-
(2013)
Nature
, vol.493
, pp. 674-678
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
Delekate, A.4
Schwartz, S.5
Vieira-Saecker, A.6
Griep, A.7
Axt, D.8
Remus, A.9
Tzeng, T.C.10
Gelpi, E.11
Halle, A.12
Korte, M.13
Latz, E.14
Golenbock, D.T.15
-
182
-
-
84911006075
-
Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: A comparative overview
-
Brosseron F, Krauthausen M, Kummer M, Heneka MT (2014) Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: A comparative overview. Mol Neurobiol 50, 534-544.
-
(2014)
Mol Neurobiol
, vol.50
, pp. 534-544
-
-
Brosseron, F.1
Krauthausen, M.2
Kummer, M.3
Heneka, M.T.4
-
183
-
-
0141740742
-
Intrathecal inflammation precedes development of Alzheimer's disease
-
Tarkowski E, Andreasen N, Tarkowski A, Blennow K (2003) Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry 74, 1200-1205.
-
(2003)
J Neurol Neurosurg Psychiatry
, vol.74
, pp. 1200-1205
-
-
Tarkowski, E.1
Andreasen, N.2
Tarkowski, A.3
Blennow, K.4
-
184
-
-
77956933314
-
Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment
-
Buchhave P, Zetterberg H, Blennow K, Minthon L, Janciauskiene S, Hansson O (2010) Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment. Neurobiol Aging 31, 1877-1884.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1877-1884
-
-
Buchhave, P.1
Zetterberg, H.2
Blennow, K.3
Minthon, L.4
Janciauskiene, S.5
Hansson, O.6
-
185
-
-
84979243361
-
The role of cerebrospinal fluid biomarkers in the evolution of diagnostic criteria in Alzheimer's disease: Shortcomings in prodromal diagnosis
-
Szalardy L, Zadori D, Klivenyi P, Vecsei L (2016) The role of cerebrospinal fluid biomarkers in the evolution of diagnostic criteria in Alzheimer's disease: Shortcomings in prodromal diagnosis. J Alzheimers Dis 53, 373-392.
-
(2016)
J Alzheimers Dis
, vol.53
, pp. 373-392
-
-
Szalardy, L.1
Zadori, D.2
Klivenyi, P.3
Vecsei, L.4
-
186
-
-
44949173099
-
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
-
Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA (2008) Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med 14, 681-687.
-
(2008)
Nat Med
, vol.14
, pp. 681-687
-
-
Town, T.1
Laouar, Y.2
Pittenger, C.3
Mori, T.4
Szekely, C.A.5
Tan, J.6
Duman, R.S.7
Flavell, R.A.8
-
187
-
-
76149092520
-
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition
-
Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, Zubair AC, Dickson D, Golde TE, Das P (2010) Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition. FASEB J 24, 548-559.
-
(2010)
FASEB J
, vol.24
, pp. 548-559
-
-
Chakrabarty, P.1
Jansen-West, K.2
Beccard, A.3
Ceballos-Diaz, C.4
Levites, Y.5
Verbeeck, C.6
Zubair, A.C.7
Dickson, D.8
Golde, T.E.9
Das, P.10
-
188
-
-
79951551206
-
Hippocampal expression of murine TNFalpha results in attenuation of amyloid deposition in vivo
-
Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE (2011) Hippocampal expression of murine TNFalpha results in attenuation of amyloid deposition in vivo. Mol Neurodegener 6, 16.
-
(2011)
Mol Neurodegener
, vol.6
, pp. 16
-
-
Chakrabarty, P.1
Herring, A.2
Ceballos-Diaz, C.3
Das, P.4
Golde, T.E.5
-
189
-
-
84864193530
-
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
-
Chakrabarty P, Tianbai L, Herring A, Ceballos-Diaz C, Das P, Golde TE (2012) Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition. Mol Neurodegener 7, 36.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 36
-
-
Chakrabarty, P.1
Tianbai, L.2
Herring, A.3
Ceballos-Diaz, C.4
Das, P.5
Golde, T.E.6
-
190
-
-
84922064574
-
IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior
-
Chakrabarty P, Li A, Ceballos-Diaz C, Eddy JA, Funk CC, Moore B, DiNunno N, Rosario AM, Cruz PE, Verbeeck C, Sacino A, Nix S, Janus C, Price ND, Das P, Golde TE (2015) IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. Neuron 85, 519-533.
-
(2015)
Neuron
, vol.85
, pp. 519-533
-
-
Chakrabarty, P.1
Li, A.2
Ceballos-Diaz, C.3
Eddy, J.A.4
Funk, C.C.5
Moore, B.6
DiNunno, N.7
Rosario, A.M.8
Cruz, P.E.9
Verbeeck, C.10
Sacino, A.11
Nix, S.12
Janus, C.13
Price, N.D.14
Das, P.15
Golde, T.E.16
-
191
-
-
21144447586
-
Arandomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
-
Thal LJ, Ferris SH, Kirby L, Block GA, Lines CR,Yuen E, Assaid C, Nessly ML, Norman BA, Baranak CC, Reines SA(2005)Arandomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology 30, 1204-1215.
-
(2005)
Neuropsychopharmacology
, vol.30
, pp. 1204-1215
-
-
Thal, L.J.1
Ferris, S.H.2
Kirby, L.3
Block, G.A.4
Lines, C.R.5
Yuen, E.6
Assaid, C.7
Nessly, M.L.8
Norman, B.A.9
Baranak, C.C.10
Reines, S.A.11
-
192
-
-
47549107705
-
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
-
Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, Evans D, Green R, Mullan M (2008) Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 65, 896-905.
-
(2008)
Arch Neurol
, vol.65
, pp. 896-905
-
-
Martin, B.K.1
Szekely, C.2
Brandt, J.3
Piantadosi, S.4
Breitner, J.C.5
Craft, S.6
Evans, D.7
Green, R.8
Mullan, M.9
-
193
-
-
80053383308
-
Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of preclinical Alzheimer disease: Findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial
-
Leoutsakos JM, Muthen BO, Breitner JC, Lyketsos CG (2012) Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of preclinical Alzheimer disease: Findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial. Int J Geriatr Psychiatry 27, 364-374.
-
(2012)
J Geriatr Psychiatry
, vol.27
, pp. 364-374
-
-
Leoutsakos, J.M.1
Muthen, B.O.2
Breitner, J.C.3
Lyketsos, C.G.4
-
194
-
-
84861314593
-
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
-
Jaturapatporn D, Isaac MG, McCleery J, Tabet N (2012) Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev, CD006378.
-
(2012)
Cochrane Database Syst Rev
, pp. CD006378
-
-
Jaturapatporn, D.1
Isaac, M.G.2
McCleery, J.3
Tabet, N.4
-
195
-
-
84933675711
-
Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Antiinflammatory Prevention Trial and its Follow-up Study
-
ADAPT-FS RG (2015) Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Antiinflammatory Prevention Trial and its Follow-up Study. Alzheimers Dement 11, 216-225.
-
(2015)
Alzheimers Dement
, vol.11
, pp. 216-225
-
-
Adapt-Fs, R.G.1
-
196
-
-
0032740467
-
Elevated CSF prostaglandin E2 levels in patients with probable AD
-
Montine TJ, Sidell KR, Crews BC, Markesbery WR,Marnett LJ, Roberts LJ 2nd, Morrow JD (1999) Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 53, 1495-1498.
-
(1999)
Neurology
, vol.53
, pp. 1495-1498
-
-
Montine, T.J.1
Sidell, K.R.2
Crews, B.C.3
Markesbery, W.R.4
Marnett, L.J.5
Roberts, I.I.L.J.6
Morrow, J.D.7
-
197
-
-
0041921071
-
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
-
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G (2003) Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci 23, 7504-7509.
-
(2003)
J Neurosci
, vol.23
, pp. 7504-7509
-
-
Yan, Q.1
Zhang, J.2
Liu, H.3
Babu-Khan, S.4
Vassar, R.5
Biere, A.L.6
Citron, M.7
Landreth, G.8
-
198
-
-
17144380506
-
Microglia lacking e Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity
-
Shie FS, Breyer RM, Montine TJ (2005) Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity. Am J Pathol 166, 1163-1172.
-
(2005)
Am J Pathol
, vol.166
, pp. 1163-1172
-
-
Shie, F.S.1
Breyer, R.M.2
Montine, T.J.3
-
199
-
-
29644438245
-
Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease
-
Combrinck M, Williams J, De Berardinis MA, Warden D, Puopolo M, Smith AD, Minghetti L (2006) Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease. J Neurol Neurosurg Psychiatry 77, 85-88.
-
(2006)
J Neurol Neurosurg Psychiatry
, vol.77
, pp. 85-88
-
-
Combrinck, M.1
Williams, J.2
De Berardinis, M.A.3
Warden, D.4
Puopolo, M.5
Smith, A.D.6
Minghetti, L.7
-
200
-
-
84920405563
-
Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
-
Johansson JU, Woodling NS, Wang Q, Panchal M, Liang X, Trueba-Saiz A, Brown HD, Mhatre SD, Loui T, Andreasson KI (2015) Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. J Clin Invest 125, 350-364.
-
(2015)
J Clin Invest
, vol.125
, pp. 350-364
-
-
Johansson, J.U.1
Woodling, N.S.2
Wang, Q.3
Panchal, M.4
Liang, X.5
Trueba-Saiz, A.6
Brown, H.D.7
Mhatre, S.D.8
Loui, T.9
Andreasson, K.I.10
-
201
-
-
0016007501
-
The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway
-
Wolf H (1974) The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway. Scand J Clin Lab Invest Suppl 136, 1-186.
-
(1974)
Scand J Clin Lab Invest Suppl
, vol.136
, pp. 1-186
-
-
Wolf, H.1
-
202
-
-
79955675748
-
Endogenous neuroprotection in chronic neurodegenerative disorders: With particular regard to the kynurenines
-
Zadori D, Klivenyi P, Plangar I, Toldi J, Vecsei L (2011) Endogenous neuroprotection in chronic neurodegenerative disorders: With particular regard to the kynurenines. J Cell Mol Med 15, 701-717.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 701-717
-
-
Zadori, D.1
Klivenyi, P.2
Plangar, I.3
Toldi, J.4
Vecsei, L.5
-
203
-
-
84997272182
-
Kynurenine pathway metabolites and enzymes involved in redox reactions
-
Gonzalez EsquivelD, Ramirez-Ortega D, Pineda B, Castro N, Rios C, Perez de la Cruz V (2017) Kynurenine pathway metabolites and enzymes involved in redox reactions. Neuropharmacology 112, 331-345.
-
(2017)
Neuropharmacology
, vol.112
, pp. 331-345
-
-
Gonzalez, E.D.1
Ramirez-Ortega, D.2
Pineda, B.3
Castro, N.4
Rios, C.5
Perez, V.6
-
204
-
-
0347024127
-
Kynurenines in neurodegenerative disorders: Therapeutic consideration
-
Klivenyi P, Toldi J, Vecsei L (2004) Kynurenines in neurodegenerative disorders: Therapeutic consideration. Adv Exp Med Biol 541, 169-183.
-
(2004)
Adv Exp Med Biol
, vol.541
, pp. 169-183
-
-
Klivenyi, P.1
Toldi, J.2
Vecsei, L.3
-
205
-
-
70449523216
-
Kynurenines in chronic neurodegenerative disorders: Future therapeutic strategies
-
Zadori D, Klivenyi P, Vamos E, Fulop F, Toldi J, Vecsei L (2009) Kynurenines in chronic neurodegenerative disorders: Future therapeutic strategies. J Neural Transm (Vienna) 116, 1403-1409.
-
(2009)
J Neural Transm (Vienna)
, vol.116
, pp. 1403-1409
-
-
Zadori, D.1
Klivenyi, P.2
Vamos, E.3
Fulop, F.4
Toldi, J.5
Vecsei, L.6
-
206
-
-
77957131120
-
Kynurenines, neurodegeneration and Alzheimer's disease
-
Kincses ZT, Toldi J, Vecsei L (2010) Kynurenines, neurodegeneration and Alzheimer's disease. J Cell Mol Med 14, 2045-2054.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 2045-2054
-
-
Kincses, Z.T.1
Toldi, J.2
Vecsei, L.3
-
207
-
-
79955643831
-
Targeting the kynurenine pathway-related alterations in Alzheimer's disease: A future therapeutic strategy
-
Plangar I, Zadori D, Klivenyi P, Toldi J, Vecsei L (2011) Targeting the kynurenine pathway-related alterations in Alzheimer's disease: A future therapeutic strategy. J Alzheimers Dis 24(Suppl 2), 199-209.
-
(2011)
J Alzheimers Dis
, vol.24
, pp. 199-209
-
-
Plangar, I.1
Zadori, D.2
Klivenyi, P.3
Toldi, J.4
Vecsei, L.5
-
208
-
-
0027486072
-
Neuropharmacology of quinolinic and kynurenic acids
-
Stone TW (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 45, 309-379.
-
(1993)
Pharmacol Rev
, vol.45
, pp. 309-379
-
-
Stone, T.W.1
-
209
-
-
71949108894
-
Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives
-
Fulop F, Szatmari I, Vamos E, Zadori D, Toldi J, Vecsei L (2009) Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives. Curr Med Chem 16, 4828-4842.
-
(2009)
Curr Med Chem
, vol.16
, pp. 4828-4842
-
-
Fulop, F.1
Szatmari, I.2
Vamos, E.3
Zadori, D.4
Toldi, J.5
Vecsei, L.6
-
210
-
-
84862603083
-
Kynurenines in the mammalian brain: When physiology meets pathology
-
Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012) Kynurenines in the mammalian brain: When physiology meets pathology. Nat Rev Neurosci 13, 465-477.
-
(2012)
Nat Rev Neurosci
, vol.13
, pp. 465-477
-
-
Schwarcz, R.1
Bruno, J.P.2
Muchowski, P.J.3
Wu, H.Q.4
-
211
-
-
84976576141
-
Inhibitors of the kynurenine pathway as neurotherapeutics: A patent review (2012-2015)
-
Zadori D,Veres G, Szalardy L, Klivenyi P, Fulop F, Toldi J, Vecsei L (2016) Inhibitors of the kynurenine pathway as neurotherapeutics: A patent review (2012-2015). Expert Opin Ther Pat 26, 815-832.
-
(2016)
Expert Opin Ther Pat
, vol.26
, pp. 815-832
-
-
Zadori, D.1
Veres, G.2
Szalardy, L.3
Klivenyi, P.4
Fulop, F.5
Toldi, J.6
Vecsei, L.7
-
212
-
-
0034466531
-
Degradation of tryptophan in neurodegenerative disorders
-
Widner B, Leblhuber F, Walli J, Tilz GP, Demel U, Fuchs D (1999) Degradation of tryptophan in neurodegenerative disorders. Adv Exp Med Biol 467, 133-138.
-
(1999)
Adv Exp Med Biol
, vol.467
, pp. 133-138
-
-
Widner, B.1
Leblhuber, F.2
Walli, J.3
Tilz, G.P.4
Demel, U.5
Fuchs, D.6
-
213
-
-
0034106148
-
Tryptophan degradation and immune activation in Alzheimer's disease
-
Widner B, Leblhuber F, Walli J, Tilz GP, Demel U, Fuchs D (2000) Tryptophan degradation and immune activation in Alzheimer's disease. J Neural Transm (Vienna) 107, 343-353.
-
(2000)
J Neural Transm (Vienna)
, vol.107
, pp. 343-353
-
-
Widner, B.1
Leblhuber, F.2
Walli, J.3
Tilz, G.P.4
Demel, U.5
Fuchs, D.6
-
214
-
-
23044462498
-
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus
-
Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM (2005) Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathol Appl Neurobiol 31, 395-404.
-
(2005)
Neuropathol Appl Neurobiol
, vol.31
, pp. 395-404
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Takikawa, O.4
Cullen, K.M.5
-
215
-
-
84876449074
-
Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain
-
WuW, Nicolazzo JA,Wen L, Chung R, Stankovic R, Bao SS, Lim CK, Brew BJ, Cullen KM, Guillemin GJ (2013) Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain. PLoS One 8, 9.
-
(2013)
PLoS One
, vol.8
, pp. 9
-
-
Wu, W.1
Nicolazzo, J.A.2
Wen, L.3
Chung, R.4
Stankovic, R.5
Bao, S.S.6
Lim, C.K.7
Brew, B.J.8
Cullen, K.M.9
Guillemin, G.J.10
-
216
-
-
77955069370
-
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease
-
Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, SmithMA(2010) Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep 15, 161-168.
-
(2010)
Redox Rep
, vol.15
, pp. 161-168
-
-
Bonda, D.J.1
Mailankot, M.2
Stone, J.G.3
Garrett, M.R.4
Staniszewska, M.5
Castellani, R.J.6
Siedlak, S.L.7
Zhu, X.8
Lee, H.G.9
Perry, G.10
Nagaraj, R.H.11
Smith, M.A.12
-
217
-
-
2342507918
-
A beta 1-42 induces production of quinolinic acid by human macrophages and microglia
-
Guillemin GJ, Smythe GA, Veas LA, Takikawa O, Brew BJ (2003) A beta 1-42 induces production of quinolinic acid by human macrophages and microglia. Neuroreport 14, 2311-2315.
-
(2003)
Neuroreport
, vol.14
, pp. 2311-2315
-
-
Guillemin, G.J.1
Smythe, G.A.2
Veas, L.A.3
Takikawa, O.4
Brew, B.J.5
-
218
-
-
0023095424
-
Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate
-
Dykens JA, Sullivan SG, SternA(1987) Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate. Biochem Pharmacol 36, 211-217.
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 211-217
-
-
Dykens, J.A.1
Sullivan, S.G.2
Stern, A.3
-
219
-
-
0025149531
-
Quinolinate-induced cortical cholinergic damage: Modulation by tryptophan metabolites
-
Jhamandas K, Boegman RJ, Beninger RJ, BialikM(1990) Quinolinate-induced cortical cholinergic damage: Modulation by tryptophan metabolites. Brain Res 529, 185-191.
-
(1990)
Brain Res
, vol.529
, pp. 185-191
-
-
Jhamandas, K.1
Boegman, R.J.2
Beninger, R.J.3
Bialik, M.4
-
220
-
-
0025672787
-
The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine
-
Eastman CL, GuilarteTR(1990) The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine. Neurochem Res 15, 1101-1107.
-
(1990)
Neurochem Res
, vol.15
, pp. 1101-1107
-
-
Eastman, C.L.1
Guilarte, T.R.2
-
221
-
-
0031972945
-
3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity
-
Okuda S, Nishiyama N, Saito H, Katsuki H (1998) 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem 70, 299-307.
-
(1998)
J Neurochem
, vol.70
, pp. 299-307
-
-
Okuda, S.1
Nishiyama, N.2
Saito, H.3
Katsuki, H.4
-
222
-
-
84871641982
-
3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the central nervous system
-
Colin-Gonzalez AL, Maldonado PD, SantamariaA(2013) 3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the central nervous system. Neurotoxicology 34, 189-204.
-
(2013)
Neurotoxicology
, vol.34
, pp. 189-204
-
-
Colin-Gonzalez, A.L.1
Maldonado, P.D.2
Santamaria, A.3
-
223
-
-
84910118539
-
The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum
-
Colin-Gonzalez AL, Maya-Lopez M, Pedraza-Chaverri J, Ali SF, Chavarria A, Santamaria A (2014) The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum. Brain Res 1589, 1-14.
-
(2014)
Brain Res
, vol.1589
, pp. 1-14
-
-
Colin-Gonzalez, A.L.1
Maya-Lopez, M.2
Pedraza-Chaverri, J.3
Ali, S.F.4
Chavarria, A.5
Santamaria, A.6
-
224
-
-
84862785742
-
Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain
-
Notarangelo FM, Wu HQ, Macherone A, Graham DR, Schwarcz R (2012) Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain. Anal Biochem 421, 573-581.
-
(2012)
Anal Biochem
, vol.421
, pp. 573-581
-
-
Notarangelo, F.M.1
Wu, H.Q.2
Macherone, A.3
Graham, D.R.4
Schwarcz, R.5
-
225
-
-
84939230085
-
Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production
-
Reyes-Ocampo J, Ramirez-Ortega D, Cervantes GI, Pineda B, Balderas PM, Gonzalez-Esquivel D, Sanchez-Chapul L, Lugo-Huitron R, Silva-Adaya D, Rios C, Jimenez-Anguiano A, Perez-de la Cruz V (2015) Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production. Neurotoxicology 50, 81-91.
-
(2015)
Neurotoxicology
, vol.50
, pp. 81-91
-
-
Reyes-Ocampo, J.1
Ramirez-Ortega, D.2
Cervantes, G.I.3
Pineda, B.4
Balderas, P.M.5
Gonzalez-Esquivel, D.6
Sanchez-Chapul, L.7
Lugo-Huitron, R.8
Silva-Adaya, D.9
Rios, C.10
Jimenez-Anguiano, A.11
Perez-De La Cruz, V.12
-
226
-
-
0029960647
-
Human microglia convert L-tryptophan into the neurotoxin quinolinic acid
-
Heyes MP, Achim CL, Wiley CA, Major EO, Saito K, Markey SP (1996) Human microglia convert L-tryptophan into the neurotoxin quinolinic acid. Biochem J 320, 595-597.
-
(1996)
Biochem J
, vol.320
, pp. 595-597
-
-
Heyes, M.P.1
Achim, C.L.2
Wiley, C.A.3
Major, E.O.4
Saito, K.5
Markey, S.P.6
-
227
-
-
0030887550
-
Activated human microglia produce the excitotoxin quinolinic acid
-
Espey MG, Chernyshev ON, Reinhard JF Jr, Namboodiri MA, Colton CA (1997) Activated human microglia produce the excitotoxin quinolinic acid. Neuroreport 8, 431-434.
-
(1997)
Neuroreport
, vol.8
, pp. 431-434
-
-
Espey, M.G.1
Chernyshev, O.N.2
Reinhard, J.F.3
Namboodiri, M.A.4
Colton, C.A.5
-
228
-
-
0034894035
-
Kynurenine pathway metabolism in human astrocytes: A paradox for neuronal protection
-
Guillemin GJ, Kerr SJ, Smythe GA, Smith DG, Kapoor V, Armati PJ, Croitoru J, Brew BJ (2001) Kynurenine pathway metabolism in human astrocytes: A paradox for neuronal protection. J Neurochem 78, 842-853.
-
(2001)
J Neurochem
, vol.78
, pp. 842-853
-
-
Guillemin, G.J.1
Kerr, S.J.2
Smythe, G.A.3
Smith, D.G.4
Kapoor, V.5
Armati, P.J.6
Croitoru, J.7
Brew, B.J.8
-
229
-
-
11144314849
-
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
-
Guillemin GJ, Smythe G, Takikawa O, Brew BJ (2005) Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia 49, 15-23.
-
(2005)
Glia
, vol.49
, pp. 15-23
-
-
Guillemin, G.J.1
Smythe, G.2
Takikawa, O.3
Brew, B.J.4
-
230
-
-
0026783169
-
Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease
-
Pearson SJ, Reynolds GP (1992) Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease. Neurosci Lett 144, 199-201.
-
(1992)
Neurosci Lett
, vol.144
, pp. 199-201
-
-
Pearson, S.J.1
Reynolds, G.P.2
-
232
-
-
84879097853
-
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls
-
Schwarz MJ, Guillemin GJ, Teipel SJ, Buerger K, Hampel H (2013) Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls. Eur Arch Psychiatry Clin Neurosci 263, 345-352.
-
(2013)
Eur Arch Psychiatry Clin Neurosci
, vol.263
, pp. 345-352
-
-
Schwarz, M.J.1
Guillemin, G.J.2
Teipel, S.J.3
Buerger, K.4
Hampel, H.5
-
233
-
-
77955950586
-
Circulating antibodies to IDO/THO pathway metabolites in Alzheimer's disease
-
Duleu S, Mangas A, Sevin F,Veyret B, Bessede A, Geffard M (2010) Circulating antibodies to IDO/THO pathway metabolites in Alzheimer's disease. Int J Alzheimers Dis 2010, 501541.
-
(2010)
J Alzheimers Dis 2010
, pp. 501541
-
-
Duleu, S.1
Mangas, A.2
Sevin, F.3
Veyret, B.4
Bessede, A.5
Geffard, M.6
-
234
-
-
78650477632
-
Kynurenine and its metabolites in Alzheimer's disease patients
-
Gulaj E, Pawlak K, Bien B, Pawlak D (2010) Kynurenine and its metabolites in Alzheimer's disease patients. Adv Med Sci 55, 204-211.
-
(2010)
Adv Med Sci
, vol.55
, pp. 204-211
-
-
Gulaj, E.1
Pawlak, K.2
Bien, B.3
Pawlak, D.4
-
235
-
-
0026740163
-
Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia
-
Tohgi H, Abe T, Takahashi S, Kimura M, Takahashi J, Kikuchi T (1992) Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neurosci Lett 141, 9-12.
-
(1992)
Neurosci Lett
, vol.141
, pp. 9-12
-
-
Tohgi, H.1
Abe, T.2
Takahashi, S.3
Kimura, M.4
Takahashi, J.5
Kikuchi, T.6
-
236
-
-
84874225589
-
IFN-gamma production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease
-
Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA (2013) IFN-gamma production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. J Immunol 190, 2241-2251.
-
(2013)
J Immunol
, vol.190
, pp. 2241-2251
-
-
Browne, T.C.1
McQuillan, K.2
McManus, R.M.3
O'Reilly, J.A.4
Mills, K.H.5
Lynch, M.A.6
-
237
-
-
20144366048
-
Abeta-related angiitis: Primary angiitis of the central nervous system associated with cerebral amyloid angiopathy
-
Scolding NJ, Joseph F, Kirby PA,Mazanti I, Gray F, Mikol J, Ellison D, Hilton DA, Williams TL, MacKenzie JM, Xuereb JH, Love S (2005) Abeta-related angiitis: Primary angiitis of the central nervous system associated with cerebral amyloid angiopathy. Brain 128, 500-515.
-
(2005)
Brain
, vol.128
, pp. 500-515
-
-
Scolding, N.J.1
Joseph, F.2
Kirby, P.A.3
Mazanti, I.4
Gray, F.5
Mikol, J.6
Ellison, D.7
Hilton, D.A.8
Williams, T.L.9
MacKenzie, J.M.10
Xuereb, J.H.11
Love, S.12
-
238
-
-
0342468278
-
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits
-
de Carvalho LP, Bochet P, Rossier J (1996) The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int 28, 445-452.
-
(1996)
Neurochem Int
, vol.28
, pp. 445-452
-
-
De Carvalho, L.P.1
Bochet, P.2
Rossier, J.3
-
239
-
-
0019440926
-
Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS
-
Stone TW, Perkins MN (1981) Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 72, 411-412.
-
(1981)
Eur J Pharmacol
, vol.72
, pp. 411-412
-
-
Stone, T.W.1
Perkins, M.N.2
-
240
-
-
0023876882
-
Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo
-
Connick JH, Stone TW (1988) Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo. Br J Pharmacol 93, 868-876.
-
(1988)
Br J Pharmacol
, vol.93
, pp. 868-876
-
-
Connick, J.H.1
Stone, T.W.2
-
241
-
-
0036128148
-
Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes
-
Tavares RG, Tasca CI, Santos CE, Alves LB, Porciuncula LO, Emanuelli T, Souza DO (2002) Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem Int 40, 621-627.
-
(2002)
Neurochem Int
, vol.40
, pp. 621-627
-
-
Tavares, R.G.1
Tasca, C.I.2
Santos, C.E.3
Alves, L.B.4
Porciuncula, L.O.5
Emanuelli, T.6
Souza, D.O.7
-
242
-
-
67651243648
-
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons
-
Rahman A, Ting K, Cullen KM, Braidy N, Brew BJ, Guillemin GJ (2009) The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS One 4, e6344.
-
(2009)
PLoS One
, vol.4
, pp. e6344
-
-
Rahman, A.1
Ting, K.2
Cullen, K.M.3
Braidy, N.4
Brew, B.J.5
Guillemin, G.J.6
-
243
-
-
0025936872
-
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
-
Rios C, Santamaria A (1991) Quinolinic acid is a potent lipid peroxidant in rat brain homogenates. Neurochem Res 16, 1139-1143.
-
(1991)
Neurochem Res
, vol.16
, pp. 1139-1143
-
-
Rios, C.1
Santamaria, A.2
-
244
-
-
0033406026
-
Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: Protection by melatonin and deprenyl
-
Behan WM, McDonald M, Darlington LG, Stone TW (1999) Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: Protection by melatonin and deprenyl. Br J Pharmacol 128, 1754-1760.
-
(1999)
Br J Pharmacol
, vol.128
, pp. 1754-1760
-
-
Behan, W.M.1
McDonald, M.2
Darlington, L.G.3
Stone, T.W.4
-
245
-
-
0036710931
-
Lipid peroxidation in aging brain and Alzheimer's disease
-
Montine TJ, Neely MD, Quinn JF, Beal MF, Markesbery WR, Roberts LJ, Morrow JD (2002) Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med 33, 620-626.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 620-626
-
-
Montine, T.J.1
Neely, M.D.2
Quinn, J.F.3
Beal, M.F.4
Markesbery, W.R.5
Roberts, L.J.6
Morrow, J.D.7
-
246
-
-
7744221544
-
Quinolinic acid induces NMDA receptormediated lipid peroxidation in rat brain microvessels
-
St'astny F, Lisy V, Mares V, Lisa V, Balcar VJ, Santamaria A (2004) Quinolinic acid induces NMDA receptormediated lipid peroxidation in rat brain microvessels. Redox Rep 9, 229-233.
-
(2004)
Redox Rep
, vol.9
, pp. 229-233
-
-
St'Astny, F.1
Lisy, V.2
Mares, V.3
Lisa, V.4
Balcar, V.J.5
Santamaria, A.6
-
247
-
-
0031024185
-
The effect of quinolinate on rat brain lipid peroxidation is dependent on iron
-
Stipek S, Stastny F, Platenik J, Crkovska J, Zima T (1997) The effect of quinolinate on rat brain lipid peroxidation is dependent on iron. Neurochem Int 30, 233-237.
-
(1997)
Neurochem Int
, vol.30
, pp. 233-237
-
-
Stipek, S.1
Stastny, F.2
Platenik, J.3
Crkovska, J.4
Zima, T.5
-
248
-
-
0343114486
-
Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum
-
Rodriguez-Martinez E, Camacho A, Maldonado PD, Pedraza-Chaverri J, Santamaria D, Galvan-Arzate S, Santamaria A (2000) Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum. Brain Res 858, 436-439.
-
(2000)
Brain Res
, vol.858
, pp. 436-439
-
-
Rodriguez-Martinez, E.1
Camacho, A.2
Maldonado, P.D.3
Pedraza-Chaverri, J.4
Santamaria, D.5
Galvan-Arzate, S.6
Santamaria, A.7
-
249
-
-
33744975232
-
Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
-
Ganzella M, Jardim FM, Boeck CR, Vendite D (2006) Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice. Neurosci Res 55, 397-402.
-
(2006)
Neurosci Res
, vol.55
, pp. 397-402
-
-
Ganzella, M.1
Jardim, F.M.2
Boeck, C.R.3
Vendite, D.4
-
250
-
-
74549166483
-
Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons
-
Braidy N, Grant R, Adams S, Guillemin GJ (2010) Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons. FEBS J 277, 368-382.
-
(2010)
FEBS J
, vol.277
, pp. 368-382
-
-
Braidy, N.1
Grant, R.2
Adams, S.3
Guillemin, G.J.4
-
251
-
-
77952293112
-
Time-course correlation of early toxic events in three models of striatal damage: Modulation by proteases inhibition
-
Perez-De La Cruz V, Elinos-Calderon D, Carrillo-Mora P, Silva-Adaya D, Konigsberg M, Moran J, Ali SF, Chanez-Cardenas ME, Perez-De La Cruz G, Santamaria A (2010) Time-course correlation of early toxic events in three models of striatal damage: Modulation by proteases inhibition. Neurochem Int 56, 834-842.
-
(2010)
Neurochem Int
, vol.56
, pp. 834-842
-
-
Perez-De La Cruz, V.1
Elinos-Calderon, D.2
Carrillo-Mora, P.3
Silva-Adaya, D.4
Konigsberg, M.5
Moran, J.6
Ali, S.F.7
Chanez-Cardenas, M.E.8
Perez-De La Cruz, G.9
Santamaria, A.10
-
252
-
-
84884856782
-
Quinolinic acid: An endogenous neurotoxin with multiple targets
-
Lugo-Huitron R, Ugalde Muniz P, Pineda B, Pedraza-Chaverri J, Rios C, Perez-de la Cruz V (2013) Quinolinic acid: An endogenous neurotoxin with multiple targets. Oxid Med Cell Longev 2013, 104024.
-
(2013)
Oxid Med Cell Longev 2013
, pp. 104024
-
-
Lugo-Huitron, R.1
Ugalde, M.P.2
Pineda, B.3
Pedraza-Chaverri, J.4
Rios, C.5
Perez-De La Cruz, V.6
-
253
-
-
0022970575
-
Senile dementia and Alzheimer's disease: Lack of changes of the cortical content of quinolinic acid
-
Moroni F, Lombardi G, Robitaille Y, Etienne P (1986) Senile dementia and Alzheimer's disease: Lack of changes of the cortical content of quinolinic acid. Neurobiol Aging 7, 249-253.
-
(1986)
Neurobiol Aging
, vol.7
, pp. 249-253
-
-
Moroni, F.1
Lombardi, G.2
Robitaille, Y.3
Etienne, P.4
-
254
-
-
0024818255
-
Brain quinolinic acid in Alzheimer's dementia
-
Sofic E, Halket J, Przyborowska A, Riederer P, Beckmann H, Sandler M, Jellinger K (1989) Brain quinolinic acid in Alzheimer's dementia. Eur Arch Psychiatry Neurol Sci 239, 177-179.
-
(1989)
Eur Arch Psychiatry Neurol Sci
, vol.239
, pp. 177-179
-
-
Sofic, E.1
Halket, J.2
Przyborowska, A.3
Riederer, P.4
Beckmann, H.5
Sandler, M.6
Jellinger, K.7
-
255
-
-
0024427596
-
No changes in central quinolinic acid levels in Alzheimer's disease
-
Mourdian MM, Heyes MP, Pan JB, Heuser IJ, Markey SP, Chase TN, MouradianMM(1989) No changes in central quinolinic acid levels in Alzheimer's disease. Neurosci Lett 105, 233-238.
-
(1989)
Neurosci Lett
, vol.105
, pp. 233-238
-
-
Mourdian, M.M.1
Heyes, M.P.2
Pan, J.B.3
Heuser, I.J.4
Markey, S.P.5
Chase, T.N.6
Mouradian, M.M.7
-
256
-
-
35948955851
-
Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques
-
Guillemin GJ, Brew BJ, Noonan CE, Knight TG, Smythe GA, Cullen KM (2007) Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques. Int Congr Ser 1304, 404-408.
-
(2007)
Congr ser
, vol.1304
, pp. 404-408
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Knight, T.G.4
Smythe, G.A.5
Cullen, K.M.6
-
257
-
-
0026539659
-
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease
-
Heyes MP, Saito K, Crowley JS, Davis LE, Demitrack MA, Der M, Dilling LA, Elia J, Kruesi MJ, Lackner A, et al. (1992) Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain 115, 1249-1273.
-
(1992)
Brain
, vol.115
, pp. 1249-1273
-
-
Heyes, M.P.1
Saito, K.2
Crowley, J.S.3
Davis, L.E.4
Demitrack, M.A.5
Der, M.6
Dilling, L.A.7
Elia, J.8
Kruesi, M.J.9
Lackner, A.10
-
258
-
-
0037136266
-
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: Mediation of suppression by tryptophan metabolites
-
Terness P, Bauer TM, Rose L, Dufter C,Watzlik A, Simon H, OpelzG(2002) Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: Mediation of suppression by tryptophan metabolites. J Exp Med 196, 447-457.
-
(2002)
J Exp Med
, vol.196
, pp. 447-457
-
-
Terness, P.1
Bauer, T.M.2
Rose, L.3
Dufter, C.4
Watzlik, A.5
Simon, H.6
Opelz, G.7
-
259
-
-
0036790338
-
T cell apoptosis by tryptophan catabolism
-
Fallarino F, Grohmann U,Vacca C, Bianchi R, Orabona C, Spreca A, Fioretti MC, Puccetti P (2002) T cell apoptosis by tryptophan catabolism. Cell Death Differ 9, 1069-1077.
-
(2002)
Cell Death Differ
, vol.9
, pp. 1069-1077
-
-
Fallarino, F.1
Grohmann, U.2
Vacca, C.3
Bianchi, R.4
Orabona, C.5
Spreca, A.6
Fioretti, M.C.7
Puccetti, P.8
-
260
-
-
21244487758
-
Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: Tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo
-
Bauer TM, Jiga LP, Chuang JJ, Randazzo M, Opelz G, Terness P (2005) Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: Tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo. Transpl Int 18, 95-100.
-
(2005)
Transpl Int
, vol.18
, pp. 95-100
-
-
Bauer, T.M.1
Jiga, L.P.2
Chuang, J.J.3
Randazzo, M.4
Opelz, G.5
Terness, P.6
-
261
-
-
0037337196
-
Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
-
Guillemin GJ, Croitoru-Lamoury J, Dormont D, Armati PJ, Brew BJ (2003) Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes. Glia 41, 371-381.
-
(2003)
Glia
, vol.41
, pp. 371-381
-
-
Guillemin, G.J.1
Croitoru-Lamoury, J.2
Dormont, D.3
Armati, P.J.4
Brew, B.J.5
-
262
-
-
27344457006
-
Quinolinic acid selectively induces apoptosis of human astrocytes: Potential role in AIDS dementia complex
-
Guillemin GJ, Wang L, Brew BJ (2005) Quinolinic acid selectively induces apoptosis of human astrocytes: Potential role in AIDS dementia complex. J Neuroinflammation 2, 16.
-
(2005)
J Neuroinflammation
, vol.2
, pp. 16
-
-
Guillemin, G.J.1
Wang, L.2
Brew, B.J.3
-
263
-
-
73249145672
-
Effect of quinolinic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease
-
Ting KK, Brew BJ, Guillemin GJ (2009) Effect of quinolinic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease. J Neuroinflammation 6, 36.
-
(2009)
J Neuroinflammation
, vol.6
, pp. 36
-
-
Ting, K.K.1
Brew, B.J.2
Guillemin, G.J.3
-
264
-
-
0034598966
-
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus
-
Wu HQ, Lee SC, Schwarcz R (2000) Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus. Eur J Pharmacol 390, 267-274.
-
(2000)
Eur J Pharmacol
, vol.390
, pp. 267-274
-
-
Wu, H.Q.1
Lee, S.C.2
Schwarcz, R.3
-
265
-
-
0019294951
-
Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: A potent inhibitor of 3-hydroxyanthranilic acid oxidase
-
Parli CJ, Krieter P, Schmidt B (1980) Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: A potent inhibitor of 3-hydroxyanthranilic acid oxidase. Arch Biochem Biophys 203, 161-166.
-
(1980)
Arch Biochem Biophys
, vol.203
, pp. 161-166
-
-
Parli, C.J.1
Krieter, P.2
Schmidt, B.3
-
266
-
-
0034024706
-
In situ produced 7-chlorokynurenate provides protection against quinolinateand malonate-induced neurotoxicity in the rat striatum
-
Guidetti P,Wu HQ, Schwarcz R (2000) In situ produced 7-chlorokynurenate provides protection against quinolinateand malonate-induced neurotoxicity in the rat striatum. Exp Neurol 163, 123-130.
-
(2000)
Exp Neurol
, vol.163
, pp. 123-130
-
-
Guidetti, P.1
Wu, H.Q.2
Schwarcz, R.3
-
267
-
-
84867582500
-
Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders
-
Zadori D, Klivenyi P, Szalardy L, Fulop F, Toldi J, Vecsei L (2012) Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders. J Neurol Sci 322, 187-191.
-
(2012)
J Neurol Sci
, vol.322
, pp. 187-191
-
-
Zadori, D.1
Klivenyi, P.2
Szalardy, L.3
Fulop, F.4
Toldi, J.5
Vecsei, L.6
-
268
-
-
84983783291
-
Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain
-
Heredi J, Berko AM, Jankovics F, Iwamori T, Iwamori N, Ono E, Horvath S, Kis Z, Toldi J, Vecsei L, Gellert L (2017) Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain. Brain Struct Funct 222, 1663-1672.
-
(2017)
Brain Struct Funct
, vol.222
, pp. 1663-1672
-
-
Heredi, J.1
Berko, A.M.2
Jankovics, F.3
Iwamori, T.4
Iwamori, N.5
Ono, E.6
Horvath, S.7
Kis, Z.8
Toldi, J.9
Vecsei, L.10
Gellert, L.11
-
269
-
-
0019967973
-
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
-
Perkins MN, Stone TW (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247, 184-187.
-
(1982)
Brain Res
, vol.247
, pp. 184-187
-
-
Perkins, M.N.1
Stone, T.W.2
-
270
-
-
0024564076
-
A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
-
Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists. J Neurochem 52, 1319-1328.
-
(1989)
J Neurochem
, vol.52
, pp. 1319-1328
-
-
Kessler, M.1
Terramani, T.2
Lynch, G.3
Baudry, M.4
-
271
-
-
0025482465
-
Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors
-
Swartz KJ, During MJ, Freese A, BealMF(1990) Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors. J Neurosci 10, 2965-2973.
-
(1990)
J Neurosci
, vol.10
, pp. 2965-2973
-
-
Swartz, K.J.1
During, M.J.2
Freese, A.3
Beal, M.F.4
-
272
-
-
78650177913
-
Role of the NMDA-receptor in prepulse inhibition in the rat
-
Linderholm K, Powell S, Olsson E, Holtze M, Snodgrass R, Erhardt S (2010) Role of the NMDA-receptor in prepulse inhibition in the rat. Int J Tryptophan Res 3, 1-12.
-
(2010)
J Tryptophan Res
, vol.3
, pp. 1-12
-
-
Linderholm, K.1
Powell, S.2
Olsson, E.3
Holtze, M.4
Snodgrass, R.5
Erhardt, S.6
-
273
-
-
33646780229
-
Kynurenic acid has a dual action on AMPA receptor responses
-
Prescott C, Weeks AM, Staley KJ, Partin KM (2006) Kynurenic acid has a dual action on AMPA receptor responses. Neurosci Lett 402, 108-112.
-
(2006)
Neurosci Lett
, vol.402
, pp. 108-112
-
-
Prescott, C.1
Weeks, A.M.2
Staley, K.J.3
Partin, K.M.4
-
274
-
-
49749101159
-
The Janusface kynurenic acid
-
Rozsa E, Robotka H, Vecsei L, Toldi J (2008) The Janusface kynurenic acid. J Neural Transm (Vienna) 115, 1087-1091.
-
(2008)
J Neural Transm (Vienna)
, vol.115
, pp. 1087-1091
-
-
Rozsa, E.1
Robotka, H.2
Vecsei, L.3
Toldi, J.4
-
275
-
-
0034466525
-
Radical scavenging properties of tryptophan metabolites Estimation of their radical reactivity
-
Goda K, HamaneY, Kishimoto R, OgishiY(1999) Radical scavenging properties of tryptophan metabolites. Estimation of their radical reactivity. Adv Exp Med Biol 467, 397-402.
-
(1999)
Adv Exp Med Biol
, vol.467
, pp. 397-402
-
-
Goda, K.1
Hamane, Y.2
Kishimoto, R.3
Ogishi, Y.4
-
276
-
-
0034466501
-
Indole-3-pyruvic and-propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers
-
Hardeland R, Zsizsik BK, Poeggeler B, Fuhrberg B, Holst S, Coto-Montes A (1999) Indole-3-pyruvic and-propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers. Adv Exp Med Biol 467, 389-395.
-
(1999)
Adv Exp Med Biol
, vol.467
, pp. 389-395
-
-
Hardeland, R.1
Zsizsik, B.K.2
Poeggeler, B.3
Fuhrberg, B.4
Holst, S.5
Coto-Montes, A.6
-
277
-
-
80053196130
-
On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress
-
Lugo-Huitron R, Blanco-Ayala T, Ugalde-Muniz P, Carrillo-Mora P, Pedraza-Chaverri J, Silva-Adaya D, Maldonado PD, Torres I, Pinzon E, Ortiz-Islas E, Lopez T, Garcia E, Pineda B, Torres-Ramos M, Santamaria A, La CruzVP(2011) On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress. Neurotoxicol Teratol 33, 538-547.
-
(2011)
Neurotoxicol Teratol
, vol.33
, pp. 538-547
-
-
Lugo-Huitron, R.1
Blanco-Ayala, T.2
Ugalde-Muniz, P.3
Carrillo-Mora, P.4
Pedraza-Chaverri, J.5
Silva-Adaya, D.6
Maldonado, P.D.7
Torres, I.8
Pinzon, E.9
Ortiz-Islas, E.10
Lopez, T.11
Garcia, E.12
Pineda, B.13
Torres-Ramos, M.14
Santamaria, A.15
La Cruz, V.P.16
-
278
-
-
0031936205
-
NMDA receptor-mediated differential laminar susceptibility to the intracellular Ca2+ accumulation induced by oxygen-glucose deprivation in rat neocortical slices
-
Fukuda A, Muramatsu K, Okabe A, Shimano Y, Hida H, Fujimoto I, Nishino H (1998) NMDA receptor-mediated differential laminar susceptibility to the intracellular Ca2+ accumulation induced by oxygen-glucose deprivation in rat neocortical slices. J Neurophysiol 79, 430-438.
-
(1998)
J Neurophysiol
, vol.79
, pp. 430-438
-
-
Fukuda, A.1
Muramatsu, K.2
Okabe, A.3
Shimano, Y.4
Hida, H.5
Fujimoto, I.6
Nishino, H.7
-
279
-
-
0036435648
-
Effect of 3-nitropropionic acid on kynurenine aminotransferase in the rat brain
-
Csillik A, Knyihar E, Okuno E, Krisztin-Peva B, Csillik B, Vecsei L (2002) Effect of 3-nitropropionic acid on kynurenine aminotransferase in the rat brain. Exp Neurol 177, 233-241.
-
(2002)
Exp Neurol
, vol.177
, pp. 233-241
-
-
Csillik, A.1
Knyihar, E.2
Okuno, E.3
Krisztin-Peva, B.4
Csillik, B.5
Vecsei, L.6
-
280
-
-
0037072547
-
1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats
-
Luchowski P, Luchowska E, Turski WA, Urbanska EM (2002) 1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats. Neurosci Lett 330, 49-52.
-
(2002)
Neurosci Lett
, vol.330
, pp. 49-52
-
-
Luchowski, P.1
Luchowska, E.2
Turski, W.A.3
Urbanska, E.M.4
-
281
-
-
33746823331
-
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
-
Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 281, 22021-22028.
-
(2006)
J Biol Chem
, vol.281
, pp. 22021-22028
-
-
Wang, J.1
Simonavicius, N.2
Wu, X.3
Swaminath, G.4
Reagan, J.5
Tian, H.6
Ling, L.7
-
282
-
-
84876966646
-
The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction
-
Klein C, Patte-Mensah C, Taleb O, Bourguignon JJ, Schmitt M, Bihel F, Maitre M, Mensah-NyaganAG(2013) The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction. Neuropharmacology 70, 254-260.
-
(2013)
Neuropharmacology
, vol.70
, pp. 254-260
-
-
Klein, C.1
Patte-Mensah, C.2
Taleb, O.3
Bourguignon, J.J.4
Schmitt, M.5
Bihel, F.6
Maitre, M.7
Mensah-Nyagan, A.G.8
-
283
-
-
84882733656
-
Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice
-
Park MH, Lee JK, Choi S, Ahn J, Jin HK, Park JS, Bae JS (2013) Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice. Brain Res 1529, 113-124.
-
(2013)
Brain Res
, vol.1529
, pp. 113-124
-
-
Park, M.H.1
Lee, J.K.2
Choi, S.3
Ahn, J.4
Jin, H.K.5
Park, J.S.6
Bae, J.S.7
-
284
-
-
84923315910
-
Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease
-
Huttenrauch M, Baches S, Gerth J, Bayer TA, Weggen S, Wirths O (2015) Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease. J Alzheimers Dis 44, 1291-1302.
-
(2015)
J Alzheimers Dis
, vol.44
, pp. 1291-1302
-
-
Huttenrauch, M.1
Baches, S.2
Gerth, J.3
Bayer, T.A.4
Weggen, S.5
Wirths, O.6
-
285
-
-
1042291136
-
Quinolinic acid in the pathogenesis of Alzheimer's disease
-
Guillemin GJ, Williams KR, Smith DG, Smythe GA, Croitoru-Lamoury J, Brew BJ (2003) Quinolinic acid in the pathogenesis of Alzheimer's disease. Adv Exp Med Biol 527, 167-176.
-
(2003)
Adv Exp Med Biol
, vol.527
, pp. 167-176
-
-
Guillemin, G.J.1
Williams, K.R.2
Smith, D.G.3
Smythe, G.A.4
Croitoru-Lamoury, J.5
Brew, B.J.6
-
286
-
-
84906939232
-
The endogenous alpha7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloidbeta-induced inflammation in BV-2 microglial cells
-
Steiner L, Gold M, Mengel D, Dodel R, Bach JP (2014) The endogenous alpha7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloidbeta-induced inflammation in BV-2 microglial cells. J Neurol Sci 344, 94-99.
-
(2014)
J Neurol Sci
, vol.344
, pp. 94-99
-
-
Steiner, L.1
Gold, M.2
Mengel, D.3
Dodel, R.4
Bach, J.P.5
-
287
-
-
84865337568
-
Aryl hydrocarbon receptor ligand effects in RBL2H3 cells
-
Maaetoft-Udsen K, Shimoda LM, Frokiaer H, Turner H (2012) Aryl hydrocarbon receptor ligand effects in RBL2H3 cells. J Immunotoxicol 9, 327-337.
-
(2012)
J Immunotoxicol
, vol.9
, pp. 327-337
-
-
Maaetoft-Udsen, K.1
Shimoda, L.M.2
Frokiaer, H.3
Turner, H.4
-
288
-
-
79551688725
-
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
-
DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH (2010) Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 115, 89-97.
-
(2010)
Toxicol Sci
, vol.115
, pp. 89-97
-
-
DiNatale, B.C.1
Murray, I.A.2
Schroeder, J.C.3
Flaveny, C.A.4
Lahoti, T.S.5
Laurenzana, E.M.6
Omiecinski, C.J.7
Perdew, G.H.8
-
289
-
-
0026554440
-
Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex
-
Beal MF, Matson WR, Storey E, Milbury P, Ryan EA, Ogawa T, Bird ED (1992) Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. J Neurol Sci 108, 80-87.
-
(1992)
J Neurol Sci
, vol.108
, pp. 80-87
-
-
Beal, M.F.1
Matson, W.R.2
Storey, E.3
Milbury, P.4
Ryan, E.A.5
Ogawa, T.6
Bird, E.D.7
-
290
-
-
0027269660
-
Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives
-
Francis PT, Sims NR, Procter AW, Bowen DM (1993) Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives. J Neurochem 60, 1589-1604.
-
(1993)
J Neurochem
, vol.60
, pp. 1589-1604
-
-
Francis, P.T.1
Sims, N.R.2
Procter, A.W.3
Bowen, D.M.4
-
291
-
-
0028029855
-
Selective increase of NMDAsensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/ Alzheimer's disease patients: An autoradiographic study
-
Ulas J, Weihmuller FB, Brunner LC, Joyce JN, Marshall JF, Cotman CW (1994) Selective increase of NMDAsensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/ Alzheimer's disease patients: An autoradiographic study. J Neurosci 14, 6317-6324.
-
(1994)
J Neurosci
, vol.14
, pp. 6317-6324
-
-
Ulas, J.1
Weihmuller, F.B.2
Brunner, L.C.3
Joyce, J.N.4
Marshall, J.F.5
Cotman, C.W.6
-
292
-
-
0032871187
-
Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain
-
Knyihar-Csillik E, Okuno E, Vecsei L (1999) Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain. Neuroscience 94, 269-277.
-
(1999)
Neuroscience
, vol.94
, pp. 269-277
-
-
Knyihar-Csillik, E.1
Okuno, E.2
Vecsei, L.3
-
293
-
-
33846228447
-
Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease
-
Hartai Z, Juhasz A, Rimanoczy A, Janaky T, Donko T, Dux L, Penke B, Toth GK, Janka Z, Kalman J (2007) Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease. Neurochem Int 50, 308-313.
-
(2007)
Neurochem Int
, vol.50
, pp. 308-313
-
-
Hartai, Z.1
Juhasz, A.2
Rimanoczy, A.3
Janaky, T.4
Donko, T.5
Dux, L.6
Penke, B.7
Toth, G.K.8
Janka, Z.9
Kalman, J.10
-
294
-
-
84900032495
-
Kynurenic acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with Lewy bodies
-
Wennstrom M, Nielsen HM, Orhan F, Londos E, Minthon L, Erhardt S (2014) Kynurenic acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with Lewy bodies. Int J Tryptophan Res 7, 1-7.
-
(2014)
J Tryptophan Res
, vol.7
, pp. 1-7
-
-
Wennstrom, M.1
Nielsen, H.M.2
Orhan, F.3
Londos, E.4
Minthon, L.5
Erhardt, S.6
-
295
-
-
0035399822
-
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
-
Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL, Seabrook GR (2001) Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J Neurosci 21, 4691-4698.
-
(2001)
J Neurosci
, vol.21
, pp. 4691-4698
-
-
Fitzjohn, S.M.1
Morton, R.A.2
Kuenzi, F.3
Rosahl, T.W.4
Shearman, M.5
Lewis, H.6
Smith, D.7
Reynolds, D.S.8
Davies, C.H.9
Collingridge, G.L.10
Seabrook, G.R.11
-
296
-
-
77952321612
-
Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus
-
Carrillo-Mora P, Mendez-Cuesta LA, Perez-De La Cruz V, Fortoul-van Der Goes TI, Santamaria A (2010) Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus. Behav Brain Res 210, 240-250.
-
(2010)
Behav Brain Res
, vol.210
, pp. 240-250
-
-
Carrillo-Mora, P.1
Mendez-Cuesta, L.A.2
Perez-De La Cruz, V.3
Van Der Goes, T.I.4
Santamaria, A.5
-
297
-
-
18844388707
-
Systemically administered glucosamine-kynurenic acid, but not pure kynurenic acid, is effective in decreasing the evoked activity in area CA1 of the rat hippocampus
-
Robotka H, Nemeth H, Somlai C, Vecsei L, Toldi J (2005) Systemically administered glucosamine-kynurenic acid, but not pure kynurenic acid, is effective in decreasing the evoked activity in area CA1 of the rat hippocampus. Eur J Pharmacol 513, 75-80.
-
(2005)
Eur J Pharmacol
, vol.513
, pp. 75-80
-
-
Robotka, H.1
Nemeth, H.2
Somlai, C.3
Vecsei, L.4
Toldi, J.5
-
298
-
-
85038602745
-
Multifunctional analogs of kynurenic acid for the treatment of Alzheimer's disease: Synthesis, pharmacology, and molecular modeling studies
-
Deora GS, Kantham S, Chan S, Dighe SN, Veliyath SK, McColl G, Parat MO, McGeary RP, Ross BP (2017) Multifunctional analogs of kynurenic acid for the treatment of Alzheimer's disease: Synthesis, pharmacology, and molecular modeling studies. ACS Chem Neurosci 8, 2667-2675.
-
(2017)
ACS Chem Neurosci
, vol.8
, pp. 2667-2675
-
-
Deora, G.S.1
Kantham, S.2
Chan, S.3
Dighe, S.N.4
Veliyath, S.K.5
McColl, G.6
Parat, M.O.7
McGeary, R.P.8
Ross, B.P.9
-
299
-
-
2442465965
-
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration
-
Li L, Sengupta A, Haque N, Grundke-Iqbal I, Iqbal K (2004) Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS Lett 566, 261-269.
-
(2004)
FEBS Lett
, vol.566
, pp. 261-269
-
-
Li, L.1
Sengupta, A.2
Haque, N.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
300
-
-
0025777901
-
Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats
-
Vecsei L, Beal MF (1991) Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats. Eur J Pharmacol 196, 239-246.
-
(1991)
Eur J Pharmacol
, vol.196
, pp. 239-246
-
-
Vecsei, L.1
Beal, M.F.2
-
301
-
-
0042887022
-
Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat
-
Shepard PD, Joy B, Clerkin L, Schwarcz R (2003) Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat. Neuropsychopharmacology 28, 1454-1462.
-
(2003)
Neuropsychopharmacology
, vol.28
, pp. 1454-1462
-
-
Shepard, P.D.1
Joy, B.2
Clerkin, L.3
Schwarcz, R.4
-
302
-
-
4143096940
-
Endogenous kynurenic acid disrupts prepulse inhibition
-
Erhardt S, Schwieler L, Emanuelsson C, Geyer M (2004) Endogenous kynurenic acid disrupts prepulse inhibition. Biol Psychiatry 56, 255-260.
-
(2004)
Biol Psychiatry
, vol.56
, pp. 255-260
-
-
Erhardt, S.1
Schwieler, L.2
Emanuelsson, C.3
Geyer, M.4
-
303
-
-
34248335693
-
Elevations of endogenous kynurenic acid produce spatial working memory deficits
-
Chess AC, Simoni MK, Alling TE, Bucci DJ (2007) Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr Bull 33, 797-804.
-
(2007)
Schizophr Bull
, vol.33
, pp. 797-804
-
-
Chess, A.C.1
Simoni, M.K.2
Alling, T.E.3
Bucci, D.J.4
-
304
-
-
67349279255
-
L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning
-
Chess AC, Landers AM, Bucci DJ (2009) L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning. Behav Brain Res 201, 325-331.
-
(2009)
Behav Brain Res
, vol.201
, pp. 325-331
-
-
Chess, A.C.1
Landers, A.M.2
Bucci, D.J.3
-
305
-
-
77953617514
-
Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior
-
Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R (2010) Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Neuropsychopharmacology 35, 1734-1742.
-
(2010)
Neuropsychopharmacology
, vol.35
, pp. 1734-1742
-
-
Potter, M.C.1
Elmer, G.I.2
Bergeron, R.3
Albuquerque, E.X.4
Guidetti, P.5
Wu, H.Q.6
Schwarcz, R.7
-
306
-
-
80052710746
-
Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory
-
Pocivavsek A,Wu HQ, Potter MC, Elmer GI, Pellicciari R, Schwarcz R (2011) Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology 36, 2357-2367.
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 2357-2367
-
-
Pocivavsek, A.1
Wu, H.Q.2
Potter, M.C.3
Elmer, G.I.4
Pellicciari, R.5
Schwarcz, R.6
-
307
-
-
70350324907
-
Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential
-
Mony L, Kew JN, Gunthorpe MJ, Paoletti P (2009) Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential. Br J Pharmacol 157, 1301-1317.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1301-1317
-
-
Mony, L.1
Kew, J.N.2
Gunthorpe, M.J.3
Paoletti, P.4
-
308
-
-
84871920238
-
Manipulating kynurenic acid levels in the brain-on the edge between neuroprotection and cognitive dysfunction
-
Szalardy L, Zadori D, Toldi J, Fulop F, Klivenyi P, Vecsei L (2012) Manipulating kynurenic acid levels in the brain-on the edge between neuroprotection and cognitive dysfunction. Curr Top Med Chem 12, 1797-1806.
-
(2012)
Curr Top Med Chem
, vol.12
, pp. 1797-1806
-
-
Szalardy, L.1
Zadori, D.2
Toldi, J.3
Fulop, F.4
Klivenyi, P.5
Vecsei, L.6
-
309
-
-
33846089855
-
Kynurenic acid amides as novelNR2BselectiveNMDAreceptor antagonists
-
Borza I, Kolok S, Galgoczy K, Gere A, Horvath C, Farkas S, Greiner I, Domany G (2007) Kynurenic acid amides as novelNR2BselectiveNMDAreceptor antagonists. Bioorg Med Chem Lett 17, 406-409.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 406-409
-
-
Borza, I.1
Kolok, S.2
Galgoczy, K.3
Gere, A.4
Horvath, C.5
Farkas, S.6
Greiner, I.7
Domany, G.8
-
310
-
-
79955661135
-
Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease
-
Zadori D, Nyiri G, Szonyi A, Szatmari I, Fulop F, Toldi J, Freund TF, Vecsei L, Klivenyi P (2011) Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease. J Neural Transm (Vienna) 118, 865-875.
-
(2011)
J Neural Transm (Vienna)
, vol.118
, pp. 865-875
-
-
Zadori, D.1
Nyiri, G.2
Szonyi, A.3
Szatmari, I.4
Fulop, F.5
Toldi, J.6
Freund, T.F.7
Vecsei, L.8
Klivenyi, P.9
-
311
-
-
80052036278
-
Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia
-
Gellert L, Fuzik J, Goblos A, Sarkozi K, Marosi M, Kis Z, Farkas T, Szatmari I, Fulop F, Vecsei L, Toldi J (2011) Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia. Eur J Pharmacol 667, 182-187.
-
(2011)
Eur J Pharmacol
, vol.667
, pp. 182-187
-
-
Gellert, L.1
Fuzik, J.2
Goblos, A.3
Sarkozi, K.4
Marosi, M.5
Kis, Z.6
Farkas, T.7
Szatmari, I.8
Fulop, F.9
Vecsei, L.10
Toldi, J.11
-
312
-
-
82255192967
-
Synthesis and biological effects of some kynurenic acid analogs
-
Nagy K, Plangar I, Tuka B, Gellert L, Varga D, Demeter I, Farkas T, Kis Z, Marosi M, Zadori D, Klivenyi P, Fulop F, Szatmari I, Vecsei L, Toldi J (2011) Synthesis and biological effects of some kynurenic acid analogs. Bioorg Med Chem 19, 7590-7596.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 7590-7596
-
-
Nagy, K.1
Plangar, I.2
Tuka, B.3
Gellert, L.4
Varga, D.5
Demeter, I.6
Farkas, T.7
Kis, Z.8
Marosi, M.9
Zadori, D.10
Klivenyi, P.11
Fulop, F.12
Szatmari, I.13
Vecsei, L.14
Toldi, J.15
-
313
-
-
84857630808
-
Behavioural studies with a newly developed neuroprotective KYNA-amide
-
Gellert L, Varga D, Ruszka M, Toldi J, Farkas T, Szatmari I, Fulop F, Vecsei L, Kis Z (2012) Behavioural studies with a newly developed neuroprotective KYNA-amide. J Neural Transm (Vienna) 119, 165-172.
-
(2012)
J Neural Transm (Vienna)
, vol.119
, pp. 165-172
-
-
Gellert, L.1
Varga, D.2
Ruszka, M.3
Toldi, J.4
Farkas, T.5
Szatmari, I.6
Fulop, F.7
Vecsei, L.8
Kis, Z.9
-
314
-
-
84935919312
-
Systemic L-kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice
-
Varga D, Heredi J, Kanvasi Z, Ruszka M, Kis Z, Ono E, Iwamori N, Iwamori T, Takakuwa H, Vecsei L, Toldi J, Gellert L (2015) Systemic L-kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice. Front Behav Neurosci 9, 157.
-
(2015)
Front Behav Neurosci
, vol.9
, pp. 157
-
-
Varga, D.1
Heredi, J.2
Kanvasi, Z.3
Ruszka, M.4
Kis, Z.5
Ono, E.6
Iwamori, N.7
Iwamori, T.8
Takakuwa, H.9
Vecsei, L.10
Toldi, J.11
Gellert, L.12
-
315
-
-
84884378069
-
Paradox effects of kynurenines on LTP induction in the Wistar rat An in vivo study
-
Demeter I, Nagy K, Farkas T, Kis Z, Kocsis K, Knapp L, Gellert L, Fulop F,Vecsei L, Toldi J (2013) Paradox effects of kynurenines on LTP induction in the Wistar rat. An in vivo study. Neurosci Lett 553, 138-141.
-
(2013)
Neurosci Lett
, vol.553
, pp. 138-141
-
-
Demeter, I.1
Nagy, K.2
Farkas, T.3
Kis, Z.4
Kocsis, K.5
Knapp, L.6
Gellert, L.7
Fulop, F.8
Vecsei, L.9
Toldi, J.10
-
316
-
-
34249788738
-
Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
-
Sas K, Robotka H, Toldi J, Vecsei L (2007) Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci 257, 221-239.
-
(2007)
J Neurol Sci
, vol.257
, pp. 221-239
-
-
Sas, K.1
Robotka, H.2
Toldi, J.3
Vecsei, L.4
-
317
-
-
84860523932
-
Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: Medicinal chemistry aspects
-
Szalardy L, Klivenyi P, Zadori D, Fulop F, Toldi J, Vecsei L (2012) Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: Medicinal chemistry aspects. Curr Med Chem 19, 1899-1920.
-
(2012)
Curr Med Chem
, vol.19
, pp. 1899-1920
-
-
Szalardy, L.1
Klivenyi, P.2
Zadori, D.3
Fulop, F.4
Toldi, J.5
Vecsei, L.6
-
318
-
-
84920607191
-
Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets
-
Zadori D, Veres G, Szalardy L, Klivenyi P, Toldi J, Vecsei L (2014) Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets. J Alzheimers Dis 42(Suppl 3), S177-187.
-
(2014)
J Alzheimers Dis
, vol.42
, pp. S177-187
-
-
Zadori, D.1
Veres, G.2
Szalardy, L.3
Klivenyi, P.4
Toldi, J.5
Vecsei, L.6
|