Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 89-97

  DiNatale, Brett C ^a   Murray, Iain A ^a   Schroeder, Jennifer C ^a   Flaveny, Colin A ^a   Lahoti, Tejas S ^a   Laurenzana, Elizabeth M ^a   Omiecinski, Curtis J ^a   Perdew, Gary H ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Aryl hydrocarbon receptor; IDO; IL6; Kynurenic acid; TCDD

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DIOXIN; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KYNURENIC ACID; MESSENGER RNA; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AHR PROTEIN, HUMAN; AMINO ACID RECEPTOR BLOCKING AGENT; LIGAND;

ARTICLE; CANCER CELL; CARCINOGENESIS; CELL LINE; CELL METABOLISM; CYTOKINE PRODUCTION; ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; INTRACELLULAR SIGNALING; LIVER CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; ANIMAL; BIOSYNTHESIS; BREAST TUMOR; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; POLLUTANT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERLEUKIN-6; KYNURENIC ACID; LIGANDS; MICE; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACHLORODIBENZODIOXIN;

EID: 79551688725     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq024     Document Type: Article

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