Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Nature Medicine

Volumn 14, Issue 10, 2008, Pages 1097-1105

  Du, Heng ^a   Guo, Lan ^a   Fang, Fang ^a   Chen, Doris ^a   A Sosunov, Alexander ^a   M McKhann, Guy ^a   Yan, Yilin ^b   Wang, Chunyu ^b   Zhang, Hong ^a   Molkentin, Jeffery D ^c   Gunn Moore, Frank J ^d   Vonsattel, Jean Paul ^a   Arancio, Ottavio ^a   Chen, John Xi ^e   Yan, Shi Du ^a  

^a Columbia University ^*  (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; CYCLOPHILIN D; OXYGEN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LEARNING; LONG TERM POTENTIATION; MEMORY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STRESS; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CALCIUM; CYCLOPHILINS; DISEASE MODELS, ANIMAL; HUMANS; LEARNING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMORY; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEURONS; REACTIVE OXYGEN SPECIES; SYNAPSES;

EID: 53549129483     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1868     Document Type: Article

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