β-amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine

Journal of Neuroscience Research

Volumn 68, Issue 1, 2002, Pages 89-96

  Mungarro Menchaca, Xavier ^a   Morán, Patricia Ferrera Julio ^a   Clorinda, Arias ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Calcium; Ryanodine; Synaptosomes; amyloid protein

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACTIN; AMYLOID BETA PROTEIN; CALCIUM; CASPASE INHIBITOR; RYANODINE; RYANODINE RECEPTOR; SYNAPTOPHYSIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; BRAIN SYNAPTOSOME; CALCIUM BALANCE; CALCIUM MOBILIZATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; MALE; MITOCHONDRION SWELLING; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION STATE; PATHOPHYSIOLOGY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPSE VESICLE;

EID: 0036215321     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10193     Document Type: Article

References (30)

1. β-amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices
2. Lactic dehydrogenase
3. Caspase activation in dystrophic neurites in Alzheimer's disease and aged HuA-PPsw transgenic mice
4. Preseniline-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons
5. Structural correlates of cognition in dementia: Quantification and assessment of synapse change
6. 2+ entry, and spontaneous transmitter release
7. Depolarization-induced changes in cellular energy production
8. β-amyloid protein amplifies calcium signaling in central neurons from the adult mouse
9. Calcium mobilization evoked by amyloid β-protein involves inositol 1,4,5-triphosphate production in human platels
10. Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies
11. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P
12. Improved method for isolating synaptosomes from 11 regions of one rat brain: Electron microscopic and biochemical characterization and use in the study of drug effects on nerve terminal gamma-aminobutyric acid in vivo
13. Probing for calcium at presynaptic nerve terminals
14. 2+ channel activity by β-amyloid (1-40) in rat cortical synaptosomes and cultured cortical neurons
15. Caffeine-sensitive calcium stores in presynaptic nerve endings: A physiological role?
16. Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis
17. Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease
18. βamyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
19. 2+ homeostasis in Alzheimer's disease
20. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites
21. Evidence for synaptic apoptosis
22. Calcium signaling in the ER: Its role in neuronal plasticity and neurodegenerative disorders
23. 2+ release channel of sarcoplasmic reticulum
24. Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxicity
25. Subcellular localization of ryanodine receptors in rat brain
26. Susceptibility to β-amyloid-iduced toxicity is decreased in Goto-Kakizaki diabetic rats: Involvement of oxydative stress
27. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
28. Amyloid β protein (25-35) stimulation of phospholipase C in LA-N-2 cells
29. Anti-actin stain synapsis
30. Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides