Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 47, 2009, Pages 20057-20062

  Rhein, Virginie ^a   Song, Xiaomin ^b   Wiesner, Andreas ^c   Ittner, Lars M ^c   Baysang, Ginette ^a   Meier, Fides ^a   Ozmen, Laurence ^d   Bluethmann, Horst ^d   Dröse, Stefan ^e   Brandt, Ulrich ^e   Savaskan, Egemen ^a,f   Czech, Christian ^d   Götz, Jürgen ^c   Eckert, Anne ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MACQUARIE UNIVERSITY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e GOETHE UNIVERSITY   (Germany)

^f UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Amyloid beta peptide; Electron transport chain; Energy metabolism; Mitochondrial complexes; Tau protein

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; TAU PROTEIN;

AGE DISTRIBUTION; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; ENZYME SYNTHESIS; FEMALE; MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUANTITATIVE ANALYSIS; VALIDATION PROCESS; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; HUMANS; MASS SPECTROMETRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TAU PROTEINS;

MUS; MUS MUSCULUS;

EID: 73949142307     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905529106     Document Type: Article

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