-
1
-
-
0036855661
-
Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease
-
Selkoe, D. J. Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease. J. Clin. Invest. 110, 1375-1381 (2002).
-
(2002)
J. Clin. Invest
, vol.110
, pp. 1375-1381
-
-
Selkoe, D.J.1
-
2
-
-
33746310315
-
Alzheimer's disease
-
Blennow, K., de Leon, M. J. & Zetterberg, H. Alzheimer's disease. Lancet 368, 387-403 (2006).
-
(2006)
Lancet
, vol.368
, pp. 387-403
-
-
Blennow, K.1
de Leon, M.J.2
Zetterberg, H.3
-
3
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
4
-
-
0041355557
-
Notch and presenilin: Regulated intramembrane proteolysis links development and degeneration
-
Selkoe, D. & Kopan, R. Notch and presenilin: regulated intramembrane proteolysis links development and degeneration. Annu. Rev. Neurosci. 26, 565-597 (2003).
-
(2003)
Annu. Rev. Neurosci
, vol.26
, pp. 565-597
-
-
Selkoe, D.1
Kopan, R.2
-
5
-
-
33846282302
-
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
-
Shen, J. & Kelleher, R. J. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc. Natl Acad. Sci. USA 104, 403-409 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 403-409
-
-
Shen, J.1
Kelleher, R.J.2
-
6
-
-
0027407565
-
-
Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset Alzheimer disease, 1993
-
Strittmatter, W. J. et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset Alzheimer disease. Proc. Natl Acad. Sci. USA 90, 1977-1981 (1993).
-
(1977)
Proc. Natl Acad. Sci. USA
, vol.90
-
-
Strittmatter, W.J.1
-
7
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder, E. H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923 (1993).
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
-
8
-
-
0024299370
-
-
Mahley, R. W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622-630 (1988).
-
Mahley, R. W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622-630 (1988).
-
-
-
-
9
-
-
52449089987
-
Thirty years of Alzheimer's disease genetics: The implications of systematic meta-analyses
-
Bertram, L. & Tanzi, R. E. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nature Rev. Neurosci. 9, 768-778 (2008).
-
(2008)
Nature Rev. Neurosci
, vol.9
, pp. 768-778
-
-
Bertram, L.1
Tanzi, R.E.2
-
10
-
-
17744410836
-
ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative
-
Blacker, D. et al. ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology 48, 139-147 (1997).
-
(1997)
Neurology
, vol.48
, pp. 139-147
-
-
Blacker, D.1
-
11
-
-
47249138630
-
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression
-
Burt, T. D. et al. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression. Proc. Natl Acad. Sci. USA 105, 8718-8723 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8718-8723
-
-
Burt, T.D.1
-
12
-
-
0028991404
-
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy
-
Greenberg, S. M., Rebeck, G. W., Vonsattel, J. P., Gomez-Isla, T. & Hyman, B. T. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann. Neurol. 38, 254-259 (1995).
-
(1995)
Ann. Neurol
, vol.38
, pp. 254-259
-
-
Greenberg, S.M.1
Rebeck, G.W.2
Vonsattel, J.P.3
Gomez-Isla, T.4
Hyman, B.T.5
-
13
-
-
5344238183
-
Apolipoprotein E ε4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration
-
Josephs, K. A., Tsuboi, Y., Cookson, N., Watt, H. & Dickson, D. W. Apolipoprotein E ε4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration. Arch. Neurol. 61, 1579-1584 (2004).
-
(2004)
Arch. Neurol
, vol.61
, pp. 1579-1584
-
-
Josephs, K.A.1
Tsuboi, Y.2
Cookson, N.3
Watt, H.4
Dickson, D.W.5
-
14
-
-
21444443619
-
Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
-
Martinez, M. et al. Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 136B, 172-174 (2005).
-
(2005)
Am. J. Med. Genet. B Neuropsychiatr. Genet
, vol.136 B
, pp. 172-174
-
-
Martinez, M.1
-
15
-
-
2442593505
-
The telltale scan: APoE ε4 in multiple sclerosis
-
Masterman, T. & Hillert, J. The telltale scan: APoE ε4 in multiple sclerosis. Lancet Neurol. 3, 331 (2004).
-
(2004)
Lancet Neurol
, vol.3
, pp. 331
-
-
Masterman, T.1
Hillert, J.2
-
16
-
-
0035997373
-
Lipoprotein receptors in the nervous system
-
Herz, J. & Bock, H. H. Lipoprotein receptors in the nervous system. Annu. Rev. Biochem. 71, 405-434 (2002).
-
(2002)
Annu. Rev. Biochem
, vol.71
, pp. 405-434
-
-
Herz, J.1
Bock, H.H.2
-
17
-
-
33750333569
-
Reelin, lipoprotein receptors and synaptic plasticity
-
Herz, J. & Chen, Y. Reelin, lipoprotein receptors and synaptic plasticity. Nature Rev. Neurosci. 7, 850-859 (2006).
-
(2006)
Nature Rev. Neurosci
, vol.7
, pp. 850-859
-
-
Herz, J.1
Chen, Y.2
-
18
-
-
0023080585
-
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
-
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D. & Mahley, R. W. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim. Biophys. Acta 917, 148-161 (1987).
-
(1987)
Biochim. Biophys. Acta
, vol.917
, pp. 148-161
-
-
Pitas, R.E.1
Boyles, J.K.2
Lee, S.H.3
Foss, D.4
Mahley, R.W.5
-
19
-
-
0029097525
-
ApoE immunoreactivity and microglial cells in Alzheimer's disease brain
-
Uchihara, T. et al. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain. Neurosci. Lett. 195, 5-8 (1995).
-
(1995)
Neurosci. Lett
, vol.195
, pp. 5-8
-
-
Uchihara, T.1
-
20
-
-
0023280054
-
Lipoproteins and their receptors in the central nervous system
-
Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D. & Weisgraber, K. H. Lipoproteins and their receptors in the central nervous system. J. Biol. Chem. 262, 14352-14360 (1987).
-
(1987)
J. Biol. Chem
, vol.262
, pp. 14352-14360
-
-
Pitas, R.E.1
Boyles, J.K.2
Lee, S.H.3
Hui, D.4
Weisgraber, K.H.5
-
21
-
-
0031970198
-
Nascent astrocyte particles differ from lipoproteins in CSF
-
LaDu, M. J. et al. Nascent astrocyte particles differ from lipoproteins in CSF. J. Neurochem. 70, 2070-2081 (1998).
-
(1998)
J. Neurochem
, vol.70
, pp. 2070-2081
-
-
LaDu, M.J.1
-
22
-
-
4644295495
-
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
-
Hirsch-Reinshagen, V. et al. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J. Biol. Chem. 279, 41197-41207 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 41197-41207
-
-
Hirsch-Reinshagen, V.1
-
23
-
-
4644361588
-
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE
-
Wahrle, S. E. et al. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J. Biol. Chem. 279, 40987-40993 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 40987-40993
-
-
Wahrle, S.E.1
-
24
-
-
33746311471
-
Apolipoprotein E structure: Insights into function
-
Hatters, D. M., Peters-Libeu, C. A. & Weisgraber, K. H. Apolipoprotein E structure: insights into function. Trends Biochem. Sci. 31, 445-454 (2006).
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 445-454
-
-
Hatters, D.M.1
Peters-Libeu, C.A.2
Weisgraber, K.H.3
-
25
-
-
65249158083
-
Understanding the association of apolipoprotein E4 with Alzheimer's disease: Clues from its structure
-
Zhong, N. & Weisgraber, K. H. Understanding the association of apolipoprotein E4 with Alzheimer's disease: clues from its structure. J. Biol. Chem. 284, 6027-6031 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 6027-6031
-
-
Zhong, N.1
Weisgraber, K.H.2
-
26
-
-
0019783892
-
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms
-
Weisgraber, K. H., Rall, S. C. Jr & Mahley, R. W. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J. Biol. Chem. 256, 9077-9083 (1981).
-
(1981)
J. Biol. Chem
, vol.256
, pp. 9077-9083
-
-
Weisgraber, K.H.1
Rall Jr, S.C.2
Mahley, R.W.3
-
27
-
-
27944466636
-
Effect of domain interaction on apolipoprotein E levels in mouse brain
-
Ramaswamy, G., Xu, Q., Huang, Y. & Weisgraber, K. H. Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci. 25, 10658-10663 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 10658-10663
-
-
Ramaswamy, G.1
Xu, Q.2
Huang, Y.3
Weisgraber, K.H.4
-
28
-
-
0022168951
-
Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system
-
Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W. & Schneider, W. J. Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu. Rev. Cell Biol. 1, 1-39 (1985).
-
(1985)
Annu. Rev. Cell Biol
, vol.1
, pp. 1-39
-
-
Goldstein, J.L.1
Brown, M.S.2
Anderson, R.G.W.3
Russell, D.W.4
Schneider, W.J.5
-
29
-
-
22244478077
-
Structure and physiologic function of the low-density lipoprotein receptor
-
Jeon, H. & Blacklow, S. C. Structure and physiologic function of the low-density lipoprotein receptor. Annu. Rev. Biochem. 74, 535-562 (2005).
-
(2005)
Annu. Rev. Biochem
, vol.74
, pp. 535-562
-
-
Jeon, H.1
Blacklow, S.C.2
-
30
-
-
0001665337
-
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor
-
Herz, J. et al. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 7, 4119-4127 (1988).
-
(1988)
EMBO J
, vol.7
, pp. 4119-4127
-
-
Herz, J.1
-
31
-
-
0025369190
-
Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment
-
Herz, J., Kowal, R. C., Goldstein, J. L. & Brown, M. S. Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment. EMBO J. 9, 1769-1776 (1990).
-
(1990)
EMBO J
, vol.9
, pp. 1769-1776
-
-
Herz, J.1
Kowal, R.C.2
Goldstein, J.L.3
Brown, M.S.4
-
32
-
-
0035947646
-
Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
-
Li, Y., Lu, W., Marzolo, M. P. & Bu, G. Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J. Biol. Chem. 276, 18000-18006 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 18000-18006
-
-
Li, Y.1
Lu, W.2
Marzolo, M.P.3
Bu, G.4
-
33
-
-
0026439778
-
LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation
-
Herz, J., Clouthier, D. E. & Hammer, R. E. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell 71, 411-421 (1992).
-
(1992)
Cell
, vol.71
, pp. 411-421
-
-
Herz, J.1
Clouthier, D.E.2
Hammer, R.E.3
-
34
-
-
4744352010
-
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice
-
May, P. et al. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol. Cell. Biol. 24, 8872-8883 (2004).
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 8872-8883
-
-
May, P.1
-
35
-
-
0000063546
-
Lipoprotein receptors: New roles for ancient proteins
-
Willnow, T. E., Nykjaer, A. & Herz, J. Lipoprotein receptors: new roles for ancient proteins. Nature Cell Biol. 1, E157-E162 (1999).
-
(1999)
Nature Cell Biol
, vol.1
-
-
Willnow, T.E.1
Nykjaer, A.2
Herz, J.3
-
36
-
-
0035800742
-
The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein
-
Liu, C. X., Li, Y., obermoeller-McCormick, L. M., Schwartz, A. L. & Bu, G. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J. Biol. Chem. 276, 28889-28896 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 28889-28896
-
-
Liu, C.X.1
Li, Y.2
obermoeller-McCormick, L.M.3
Schwartz, A.L.4
Bu, G.5
-
37
-
-
0036829521
-
Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
-
Li, Y. et al. Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. J. Biol. Chem. 277, 42366-42371 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 42366-42371
-
-
Li, Y.1
-
38
-
-
3142717640
-
The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production
-
Cam, J. A. et al. The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production. J. Biol. Chem. 279, 29639-29646 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 29639-29646
-
-
Cam, J.A.1
-
39
-
-
0033003134
-
Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
-
Trommsdorff, M. et al. Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97, 689-701 (1999).
-
(1999)
Cell
, vol.97
, pp. 689-701
-
-
Trommsdorff, M.1
-
40
-
-
27944471018
-
Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice
-
Johnson, E. B., Hammer, R. E. & Herz, J. Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum. Mol. Genet. 14, 3523-3538 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 3523-3538
-
-
Johnson, E.B.1
Hammer, R.E.2
Herz, J.3
-
41
-
-
55049092996
-
Lrp4 is a receptor for agrin and forms a complex with MuSK
-
Kim, N. et al. Lrp4 is a receptor for agrin and forms a complex with MuSK. Cell 135, 334-342 (2008).
-
(2008)
Cell
, vol.135
, pp. 334-342
-
-
Kim, N.1
-
42
-
-
2342430345
-
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way
-
He, X., Semenov, M., Tamai, K. & Zeng, X. LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development 131, 1663-1677 (2004).
-
(2004)
Development
, vol.131
, pp. 1663-1677
-
-
He, X.1
Semenov, M.2
Tamai, K.3
Zeng, X.4
-
43
-
-
0038633228
-
LDL receptor-related proteins in neurodevelopment
-
May, P. & Herz, J. LDL receptor-related proteins in neurodevelopment. Traffic 4, 291-301 (2003).
-
(2003)
Traffic
, vol.4
, pp. 291-301
-
-
May, P.1
Herz, J.2
-
44
-
-
0031923160
-
Receptor-associated protein: A specialized chaperone and antagonist for members of the LDL receptor gene family
-
Bu, G. Receptor-associated protein: a specialized chaperone and antagonist for members of the LDL receptor gene family. Curr. Opin. Lipidol. 9, 149-155 (1998).
-
(1998)
Curr. Opin. Lipidol
, vol.9
, pp. 149-155
-
-
Bu, G.1
-
45
-
-
0034470157
-
Role of rap in the biogenesis of lipoprotein receptors
-
Bu, G. & Marzolo, M. P. Role of rap in the biogenesis of lipoprotein receptors. Trends Cardiovasc. Med. 10, 148-155 (2000).
-
(2000)
Trends Cardiovasc. Med
, vol.10
, pp. 148-155
-
-
Bu, G.1
Marzolo, M.P.2
-
46
-
-
21844432675
-
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice
-
Fryer, J. D. et al. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J. Biol. Chem. 280, 25754-25759 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 25754-25759
-
-
Fryer, J.D.1
-
47
-
-
34748897213
-
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
-
Liu, Q. et al. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56, 66-78 (2007).
-
(2007)
Neuron
, vol.56
, pp. 66-78
-
-
Liu, Q.1
-
48
-
-
33846021307
-
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice
-
Zerbinatti, C. V. et al. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice. J. Biol. Chem. 281, 36180-36186 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 36180-36186
-
-
Zerbinatti, C.V.1
-
49
-
-
0027374047
-
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
-
Rebeck, G. W., Reiter, J. S., Strickland, D. K. & Hyman, B. T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11, 575-580 (1993).
-
(1993)
Neuron
, vol.11
, pp. 575-580
-
-
Rebeck, G.W.1
Reiter, J.S.2
Strickland, D.K.3
Hyman, B.T.4
-
50
-
-
33744991531
-
Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes
-
Rapp, A., Gmeiner, B. & Huttinger, M. Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes. Biochimie 88, 473-483 (2006).
-
(2006)
Biochimie
, vol.88
, pp. 473-483
-
-
Rapp, A.1
Gmeiner, B.2
Huttinger, M.3
-
51
-
-
0141742030
-
Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein
-
Narita, M. et al. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. J. Biochem. 132, 743-749 (2002).
-
(2002)
J. Biochem
, vol.132
, pp. 743-749
-
-
Narita, M.1
-
52
-
-
0025302165
-
opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
-
Kowal, R. C. et al. opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J. Biol. Chem. 265, 10771-10779 (1990).
-
(1990)
J. Biol. Chem
, vol.265
, pp. 10771-10779
-
-
Kowal, R.C.1
-
53
-
-
0029958248
-
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
-
Fagan, A. M., Bu, G. J., Sun, Y. L., Daugherty, A. & Holtzman, D. M. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271, 30121-30125 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 30121-30125
-
-
Fagan, A.M.1
Bu, G.J.2
Sun, Y.L.3
Daugherty, A.4
Holtzman, D.M.5
-
54
-
-
55249114701
-
The reelin signaling pathway promotes dendritic spine development in hippocampal neurons
-
Niu, S., Yabut, o. & D'Arcangelo, G. The reelin signaling pathway promotes dendritic spine development in hippocampal neurons. J. Neurosci. 28, 10339-10348 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 10339-10348
-
-
Niu, S.1
Yabut, O.2
D'Arcangelo, G.3
-
55
-
-
1442300201
-
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission
-
Beffert, U. et al. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J. Neurosci. 24, 1897-1906 (2004).
-
(2004)
J. Neurosci
, vol.24
, pp. 1897-1906
-
-
Beffert, U.1
-
56
-
-
23744516021
-
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
-
Beffert, U. et al. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron 47, 567-579 (2005).
-
(2005)
Neuron
, vol.47
, pp. 567-579
-
-
Beffert, U.1
-
57
-
-
0033213256
-
Reelin is a ligand for lipoprotein receptors
-
D'Arcangelo, G. et al. Reelin is a ligand for lipoprotein receptors. Neuron 24, 471-479 (1999).
-
(1999)
Neuron
, vol.24
, pp. 471-479
-
-
D'Arcangelo, G.1
-
58
-
-
16244405249
-
Multiple pathways of apolipoprotein E signaling in primary neurons
-
Hoe, H. S., Harris, D. C. & Rebeck, G. W. Multiple pathways of apolipoprotein E signaling in primary neurons. J. Neurochem. 93, 145-155 (2005).
-
(2005)
J. Neurochem
, vol.93
, pp. 145-155
-
-
Hoe, H.S.1
Harris, D.C.2
Rebeck, G.W.3
-
59
-
-
0242570611
-
ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes
-
Qiu, Z., Crutcher, K. A., Hyman, B. T. & Rebeck, G. W. ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes. Neuroscience 122, 291-303 (2003).
-
(2003)
Neuroscience
, vol.122
, pp. 291-303
-
-
Qiu, Z.1
Crutcher, K.A.2
Hyman, B.T.3
Rebeck, G.W.4
-
60
-
-
33847240080
-
Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1
-
Hayashi, H., Campenot, R. B., Vance, D. E. & Vance, J. E. Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. J. Neurosci. 27, 1933-1941 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 1933-1941
-
-
Hayashi, H.1
Campenot, R.B.2
Vance, D.E.3
Vance, J.E.4
-
61
-
-
0029128232
-
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
-
Kounnas, M. Z. et al. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation. Cell 82, 331-340 (1995).
-
(1995)
Cell
, vol.82
, pp. 331-340
-
-
Kounnas, M.Z.1
-
62
-
-
0032509346
-
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
-
Trommsdorff, R., Borg, J. P. , Margolis, B. & Herz, J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273, 33556-33560 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 33556-33560
-
-
Trommsdorff, R.1
Borg, J.P.2
Margolis, B.3
Herz, J.4
-
63
-
-
2442498577
-
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
-
Pietrzik, C. U. et al. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J. Neurosci. 24, 4259-4265 (2004).
-
(2004)
J. Neurosci
, vol.24
, pp. 4259-4265
-
-
Pietrzik, C.U.1
-
64
-
-
0035503797
-
Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: Role of the intracellular adapter protein Fe65
-
Kinoshita, A. et al. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. J. Neurosci. 21, 8354-8361 (2001).
-
(2001)
J. Neurosci
, vol.21
, pp. 8354-8361
-
-
Kinoshita, A.1
-
65
-
-
0034629292
-
Modulation of β-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease
-
Ulery, P. G. et al. Modulation of β-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J. Biol. Chem. 275, 7410-7415 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 7410-7415
-
-
Ulery, P.G.1
-
66
-
-
17644421882
-
Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the β-amyloid precursor protein
-
Cam, J. A., Zerbinatti, C. V., Li, Y. & Bu, G. Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the β-amyloid precursor protein. J. Biol. Chem. 280, 15464-15470 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 15464-15470
-
-
Cam, J.A.1
Zerbinatti, C.V.2
Li, Y.3
Bu, G.4
-
67
-
-
38349107593
-
The Alzheimer's disease β-secretase enzyme, BACE1
-
Cole, S. L. & Vassar, R. The Alzheimer's disease β-secretase enzyme, BACE1. Mol. Neurodegener. 2, 22 (2007).
-
(2007)
Mol. Neurodegener
, vol.2
, pp. 22
-
-
Cole, S.L.1
Vassar, R.2
-
68
-
-
10744231924
-
Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
-
Zerbinatti, C. V. et al. Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc. Natl Acad. Sci. USA 101, 1075-1080 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 1075-1080
-
-
Zerbinatti, C.V.1
-
69
-
-
29444460533
-
Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
-
Ye, S. et al. Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc. Natl Acad. Sci. USA 102, 18700-18705 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18700-18705
-
-
Ye, S.1
-
70
-
-
27144504391
-
F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein
-
Hoe, H. S. et al. F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol. Cell. Biol. 25, 9259-9268 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9259-9268
-
-
Hoe, H.S.1
-
71
-
-
4043141580
-
Loss of apolipoprotein E receptor LR11 in Alzheimer disease
-
Scherzer, C. R. et al. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch. Neurol. 61, 1200-1205 (2004).
-
(2004)
Arch. Neurol
, vol.61
, pp. 1200-1205
-
-
Scherzer, C.R.1
-
72
-
-
26444607532
-
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
-
Andersen, o. M. et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl Acad. Sci. USA 102, 13461-13466 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13461-13466
-
-
Andersen, O.M.1
-
73
-
-
33846613222
-
The neuronal sortilin-related receptor SoRL1 is genetically associated with Alzheimer disease
-
Rogaeva, E. et al. The neuronal sortilin-related receptor SoRL1 is genetically associated with Alzheimer disease. Nature Genet. 39, 168-177 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
-
74
-
-
0141529993
-
-
Cirrito, J. R. et al. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque- associated changes in amyloid-β metabolism and half-life. J. Neurosci. 23, 8844-8853 (2003). This paper described an in vivo microdialysis technique to assess Aβ concentration in brain interstitial fluid. It also showed that Aβ's half-life in the mouse brain is 2-4 h.
-
Cirrito, J. R. et al. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque- associated changes in amyloid-β metabolism and half-life. J. Neurosci. 23, 8844-8853 (2003). This paper described an in vivo microdialysis technique to assess Aβ concentration in brain interstitial fluid. It also showed that Aβ's half-life in the mouse brain is 2-4 h.
-
-
-
-
75
-
-
33745920161
-
Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo
-
Bateman, R. J. et al. Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nature Med. 12, 856-861 (2006).
-
(2006)
Nature Med
, vol.12
, pp. 856-861
-
-
Bateman, R.J.1
-
76
-
-
4043061467
-
LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
-
Deane, R. et al. LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms. Neuron 43, 333-344 (2004).
-
(2004)
Neuron
, vol.43
, pp. 333-344
-
-
Deane, R.1
-
77
-
-
12044254746
-
-
Strittmatter, W. J. et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: i so form-specific effects and implications for late-onset Alzheimer's disease. Proc. Natl Acad. Sci. USA 90, 8098-8102 (1993).
-
Strittmatter, W. J. et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: i so form-specific effects and implications for late-onset Alzheimer's disease. Proc. Natl Acad. Sci. USA 90, 8098-8102 (1993).
-
-
-
-
78
-
-
42949168275
-
Interaction with amyloid β peptide compromises the lipid binding function of apolipoprotein E
-
Tamamizu-Kato, S. et al. Interaction with amyloid β peptide compromises the lipid binding function of apolipoprotein E. Biochemistry 47, 5225-5234 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 5225-5234
-
-
Tamamizu-Kato, S.1
-
79
-
-
0031882562
-
β-Amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons
-
Beffert, U. et al. β-Amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons. J. Neurochem. 70, 1458-1466 (1998).
-
(1998)
J. Neurochem
, vol.70
, pp. 1458-1466
-
-
Beffert, U.1
-
80
-
-
23944511140
-
Alzheimer's disease amyloid-β peptide modulates apolipoprotein E isoform specific receptor binding
-
Hone, E. et al. Alzheimer's disease amyloid-β peptide modulates apolipoprotein E isoform specific receptor binding. J. Alzheimers Dis. 7, 303-314 (2005).
-
(2005)
J. Alzheimers Dis
, vol.7
, pp. 303-314
-
-
Hone, E.1
-
81
-
-
0027931854
-
Isoform-specific binding of apolipoprotein E to β-amyloid
-
LaDu, M. J. et al. Isoform-specific binding of apolipoprotein E to β-amyloid. J. Biol. Chem. 269, 23403-23406 (1994).
-
(1994)
J. Biol. Chem
, vol.269
, pp. 23403-23406
-
-
LaDu, M.J.1
-
82
-
-
0033559412
-
Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease
-
Holtzman, D. M. et al. Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease. J. Clin. Invest. 103, R15-R21 (1999).
-
(1999)
J. Clin. Invest
, vol.103
-
-
Holtzman, D.M.1
-
83
-
-
4243215848
-
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
-
Holtzman, D. M. et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 97, 2892-2897 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2892-2897
-
-
Holtzman, D.M.1
-
84
-
-
9144224765
-
ApoE and clusterin cooperatively suppress Aβ levels and deposition: Evidence that ApoE regulates extracellular Aβ metabolism in vivo
-
DeMattos, R. B. et al. ApoE and clusterin cooperatively suppress Aβ levels and deposition: evidence that ApoE regulates extracellular Aβ metabolism in vivo. Neuron 41, 193-202 (2004).
-
(2004)
Neuron
, vol.41
, pp. 193-202
-
-
DeMattos, R.B.1
-
85
-
-
0027365822
-
-
Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
-
Schmechel, D. E. et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl Acad. Sci. USA 90, 9649-9653 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 9649-9653
-
-
Schmechel, D.E.1
-
86
-
-
0036545673
-
-
Bogdanovic, N., Corder, E., Lannfelt, L. & Winblad, B. APoE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late-onset Alzheimer's disease. J. Cell. Mol. Med. 6, 199-214 (2002).
-
Bogdanovic, N., Corder, E., Lannfelt, L. & Winblad, B. APoE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late-onset Alzheimer's disease. J. Cell. Mol. Med. 6, 199-214 (2002).
-
-
-
-
87
-
-
58149482094
-
Influence of cognitive status, age, and APoE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia
-
Small, G. W. et al. Influence of cognitive status, age, and APoE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Arch. Gen. Psychiatry 66, 81-87 (2009).
-
(2009)
Arch. Gen. Psychiatry
, vol.66
, pp. 81-87
-
-
Small, G.W.1
-
88
-
-
57449084208
-
apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain
-
Deane, R. et al. apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain. J. Clin. Invest. 118, 4002-4013 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 4002-4013
-
-
Deane, R.1
-
89
-
-
0036848549
-
Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein
-
Van Uden, E. et al. Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein. J. Neurosci. 22, 9298-9304 (2002).
-
(2002)
J. Neurosci
, vol.22
, pp. 9298-9304
-
-
Van Uden, E.1
-
90
-
-
0034521392
-
1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106, 1489-1499 (2000).
-
(2000)
J. Clin. Invest
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
-
91
-
-
14644442872
-
Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
-
Billings, L. M., oddo, S., Green, K. N., McGaugh, J. L. & Laferla, F. M. Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675-688 (2005).
-
(2005)
Neuron
, vol.45
, pp. 675-688
-
-
Billings, L.M.1
oddo, S.2
Green, K.N.3
McGaugh, J.L.4
Laferla, F.M.5
-
92
-
-
3142781310
-
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
-
Koistinaho, M. et al. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides. Nature Med. 10, 719-726 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 719-726
-
-
Koistinaho, M.1
-
93
-
-
56349166514
-
Mechanisms of microglia accumulation in Alzheimer's disease: Therapeutic implications
-
Khoury, J. E. & Luster, A. D. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol. Sci. 29, 626-632 (2008).
-
(2008)
Trends Pharmacol. Sci
, vol.29
, pp. 626-632
-
-
Khoury, J.E.1
Luster, A.D.2
-
94
-
-
3142612997
-
Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage
-
McCarron, M. o. & Nicoll, J. A. R. Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage. Lancet Neurol. 3, 484-492 (2004).
-
(2004)
Lancet Neurol
, vol.3
, pp. 484-492
-
-
McCarron, M.O.1
Nicoll, J.A.R.2
-
95
-
-
0027332081
-
β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease
-
Roher, A. E. et al. β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc. Natl Acad. Sci. USA 90, 10836-10840 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 10836-10840
-
-
Roher, A.E.1
-
96
-
-
15244340676
-
Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
-
Fryer, J. D. et al. Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J. Neurosci. 25, 2803-2810 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 2803-2810
-
-
Fryer, J.D.1
-
97
-
-
57649178322
-
The ABCs of Aβ-cleaving proteases
-
Leissring, M. A. The ABCs of Aβ-cleaving proteases. J. Biol. Chem. 283, 29645-29649 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 29645-29649
-
-
Leissring, M.A.1
-
98
-
-
4444276735
-
Clearance of Alzheimer's Aβ peptide: The many roads to perdition
-
Tanzi, R. E., Moir, R. D. & Wagner, S. L. Clearance of Alzheimer's Aβ peptide: the many roads to perdition. Neuron 43, 605-608 (2004).
-
(2004)
Neuron
, vol.43
, pp. 605-608
-
-
Tanzi, R.E.1
Moir, R.D.2
Wagner, S.L.3
-
99
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Aβ
-
Jiang, Q. et al. ApoE promotes the proteolytic degradation of Aβ. Neuron 58, 681-693 (2008).
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
-
100
-
-
0037200117
-
oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
-
Dahlgren, K. N. et al. oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J. Biol. Chem. 277, 32046-32053 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 32046-32053
-
-
Dahlgren, K.N.1
-
101
-
-
34249293987
-
Aβ42 neurotoxicity in primary co-cultures: Effect of apoE isoform and Aβ conformation
-
Manelli, A. M., Bulfinch, L. C., Sullivan, P. M. & LaDu, M. J. Aβ42 neurotoxicity in primary co-cultures: effect of apoE isoform and Aβ conformation. Neurobiol. Aging 28, 1139-1147 (2007).
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1139-1147
-
-
Manelli, A.M.1
Bulfinch, L.C.2
Sullivan, P.M.3
LaDu, M.J.4
-
102
-
-
49149124343
-
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar, G. M. et al. Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Med. 14, 837-842 (2008).
-
(2008)
Nature Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
-
103
-
-
33645038471
-
A specific amyloid-β protein assembly in the brain impairs memory
-
Lesne, S. et al. A specific amyloid-β protein assembly in the brain impairs memory. Nature 440, 352-357 (2006).
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
-
104
-
-
44649090171
-
Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits
-
Belinson, H., Lev, D., Masliah, E. & Michaelson, D. M. Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits. J. Neurosci. 28, 4690-4701 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 4690-4701
-
-
Belinson, H.1
Lev, D.2
Masliah, E.3
Michaelson, D.M.4
-
105
-
-
48349085043
-
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
-
Muller, T. , Meyer, H. E., Egensperger, R. & Marcus, K. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog. Neurobiol. 85, 393-406 (2008).
-
(2008)
Prog. Neurobiol
, vol.85
, pp. 393-406
-
-
Muller, T.1
Meyer, H.E.2
Egensperger, R.3
Marcus, K.4
-
106
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
Roberson, E. D. et al. Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754 (2007).
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
-
107
-
-
0033889344
-
Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
-
Tesseur, I. et al. Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am. J. Pathol. 156, 951-964 (2000).
-
(2000)
Am. J. Pathol
, vol.156
, pp. 951-964
-
-
Tesseur, I.1
-
108
-
-
12144290271
-
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
-
Brecht, W. J. et al. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J. Neurosci. 24, 2527-2534 (2004).
-
(2004)
J. Neurosci
, vol.24
, pp. 2527-2534
-
-
Brecht, W.J.1
-
109
-
-
0037385034
-
Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction
-
Aoki, K. et al. Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction. Stroke 34, 875-880 (2003).
-
(2003)
Stroke
, vol.34
, pp. 875-880
-
-
Aoki, K.1
-
110
-
-
33646911081
-
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus
-
Xu, Q. et al. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J. Neurosci. 26, 4985-4994 (2006).
-
(2006)
J. Neurosci
, vol.26
, pp. 4985-4994
-
-
Xu, Q.1
-
111
-
-
29444436680
-
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
-
Chang, S. et al. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc. Natl Acad. Sci. USA 102, 18694-18699 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18694-18699
-
-
Chang, S.1
-
112
-
-
33645808672
-
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
-
Mahley, R. W., Weisgraber, K. H. & Huang, Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl Acad. Sci. USA 103, 5644-5651 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 5644-5651
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
113
-
-
0037710127
-
Cholesterol homeostasis and function in neurons of the central nervous system
-
Pfrieger, F. W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60, 1158-1171 (2003).
-
(2003)
Cell. Mol. Life Sci
, vol.60
, pp. 1158-1171
-
-
Pfrieger, F.W.1
-
114
-
-
0035834416
-
CNS synaptogenesis promoted by glia-derived cholesterol
-
Mauch, D. H. et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science 294, 1354-1357 (2001).
-
(2001)
Science
, vol.294
, pp. 1354-1357
-
-
Mauch, D.H.1
-
115
-
-
27744602604
-
Cholesterol in Alzheimer's disease
-
Shobab, L. A., Hsiung, G.-Y. R. & Feldman, H. H. Cholesterol in Alzheimer's disease. Lancet Neurol. 4, 841-852 (2005).
-
(2005)
Lancet Neurol
, vol.4
, pp. 841-852
-
-
Shobab, L.A.1
Hsiung, G.-Y.R.2
Feldman, H.H.3
-
116
-
-
0345669752
-
Alzheimer's disease: The cholesterol connection
-
Puglielli, L., Tanzi, R. E. & Kovacs, D. M. Alzheimer's disease: the cholesterol connection. Nature Neurosci. 6, 345-351 (2003).
-
(2003)
Nature Neurosci
, vol.6
, pp. 345-351
-
-
Puglielli, L.1
Tanzi, R.E.2
Kovacs, D.M.3
-
117
-
-
10344226187
-
A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
-
Kaether, C. & Haass, C. A lipid boundary separates APP and secretases and limits amyloid β-peptide generation. J. Cell Biol. 167, 809-812 (2004).
-
(2004)
J. Cell Biol
, vol.167
, pp. 809-812
-
-
Kaether, C.1
Haass, C.2
-
118
-
-
34547315810
-
Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins
-
Reid, P. C., Urano, Y., Kodama, T. & Hamakubo, T. Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J. Cell. Mol. Med. 11, 383-392 (2007).
-
(2007)
J. Cell. Mol. Med
, vol.11
, pp. 383-392
-
-
Reid, P.C.1
Urano, Y.2
Kodama, T.3
Hamakubo, T.4
-
119
-
-
63949084694
-
Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
-
17 oct, doi:10.1016/j. semcdb.2008.10.005
-
Marzolo, M. P. & Bu, G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Semin. Cell Dev. Biol. 17 oct 2008 (doi:10.1016/j. semcdb.2008.10.005).
-
(2008)
Semin. Cell Dev. Biol
-
-
Marzolo, M.P.1
Bu, G.2
-
120
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran, G. & Koo, E. H. Amyloid precursor protein trafficking, processing, and function. J. Biol. Chem. 283, 29615-29619 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
121
-
-
0346463111
-
Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains
-
1190-1196
-
Ledesma, M. D. et al. Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains. EMBO Rep. 4, 1190-1196 (2003).
-
(2003)
EMBO Rep
, vol.4
-
-
Ledesma, M.D.1
-
122
-
-
33749045445
-
Amyloid excess in Alzheimer's disease: What is cholesterol to be blamed for?
-
Ledesma, M. D. & Dotti, C. G. Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for? FEBS Lett. 580, 5525-5532 (2006).
-
(2006)
FEBS Lett
, vol.580
, pp. 5525-5532
-
-
Ledesma, M.D.1
Dotti, C.G.2
-
123
-
-
0034639675
-
Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice
-
Hamanaka, H. et al. Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Hum. Mol. Genet. 9, 353-361 (2000).
-
(2000)
Hum. Mol. Genet
, vol.9
, pp. 353-361
-
-
Hamanaka, H.1
-
124
-
-
0033968648
-
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
-
Michikawa, M., Fan, Q. W., Isobe, I. & Yanagisawa, K. Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture. J. Neurochem. 74, 1008-1016 (2000).
-
(2000)
J. Neurochem
, vol.74
, pp. 1008-1016
-
-
Michikawa, M.1
Fan, Q.W.2
Isobe, I.3
Yanagisawa, K.4
-
125
-
-
0037119427
-
Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice
-
Gong, J. S. et al. Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J. Biol. Chem. 277, 29919-29926 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 29919-29926
-
-
Gong, J.S.1
-
126
-
-
38449103303
-
Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer's disease: A tale of shotgun lipidomics
-
Han, X. Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer's disease: a tale of shotgun lipidomics. J. Neurochem. 103, 171-179 (2007).
-
(2007)
J. Neurochem
, vol.103
, pp. 171-179
-
-
Han, X.1
-
127
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe, D. J. Alzheimer's disease is a synaptic failure. Science 298, 789-791 (2002).
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
128
-
-
15944410978
-
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
-
Wang, C. et al. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol. Dis. 18, 390-398 (2005).
-
(2005)
Neurobiol. Dis
, vol.18
, pp. 390-398
-
-
Wang, C.1
-
129
-
-
19944426892
-
ApoE isoform affects LTP in human targeted replacement mice
-
Trommer, B. L. et al. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport 15, 2655-2658 (2004).
-
(2004)
Neuroreport
, vol.15
, pp. 2655-2658
-
-
Trommer, B.L.1
-
130
-
-
33845388142
-
Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia
-
Hayashi, T. et al. Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia. Neurol. Res. 28, 822-825 (2006).
-
(2006)
Neurol. Res
, vol.28
, pp. 822-825
-
-
Hayashi, T.1
-
131
-
-
0028822219
-
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
-
Holtzman, D. M. et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl Acad. Sci. USA 92, 9480-9484 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 9480-9484
-
-
Holtzman, D.M.1
-
132
-
-
0028232662
-
Differential effects of apolipoprotein E3 and E4 on neuronal growth in vitro
-
Nathan, B. P. et al. Differential effects of apolipoprotein E3 and E4 on neuronal growth in vitro. Science 264, 850-852 (1994).
-
(1994)
Science
, vol.264
, pp. 850-852
-
-
Nathan, B.P.1
-
133
-
-
0242403213
-
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients
-
Ji, Y. et al. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience 122, 305-315 (2003).
-
(2003)
Neuroscience
, vol.122
, pp. 305-315
-
-
Ji, Y.1
-
134
-
-
0043095312
-
Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
-
Lanz, T. A., Carter, D. B. & Merchant, K. M. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol. Dis. 13, 246-253 (2003).
-
(2003)
Neurobiol. Dis
, vol.13
, pp. 246-253
-
-
Lanz, T.A.1
Carter, D.B.2
Merchant, K.M.3
-
135
-
-
39549091493
-
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons
-
Brodbeck, J. et al. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proc. Natl Acad. Sci. USA 105, 1343-1346 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 1343-1346
-
-
Brodbeck, J.1
-
136
-
-
0037345672
-
Expanding the association between the APOE gene and the risk of Alzheimer's disease: Possible roles for APOE promoter polymorphisms and alterations in APOE transcription
-
Laws, S. M., Hone, E., Gandy, S. & Martins, R. N. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. J. Neurochem. 84, 1215-1236 (2003).
-
(2003)
J. Neurochem
, vol.84
, pp. 1215-1236
-
-
Laws, S.M.1
Hone, E.2
Gandy, S.3
Martins, R.N.4
-
137
-
-
58149251844
-
Impact of apolipoprotein E (apoE) polymorphism on brain apoE levels
-
Riddell, D. R. et al. Impact of apolipoprotein E (apoE) polymorphism on brain apoE levels. J. Neurosci. 28, 11445-11453 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 11445-11453
-
-
Riddell, D.R.1
-
138
-
-
34548231638
-
oxysterols, cholesterol homeostasis, and Alzheimer disease
-
Vaya, J. & Schipper, H. M. oxysterols, cholesterol homeostasis, and Alzheimer disease. J. Neurochem. 102, 1727-1737 (2007).
-
(2007)
J. Neurochem
, vol.102
, pp. 1727-1737
-
-
Vaya, J.1
Schipper, H.M.2
-
139
-
-
33947610707
-
The LXR agonist To901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
-
Riddell, D. R. et al. The LXR agonist To901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol. Cell. Neurosci. 34, 621-628 (2007).
-
(2007)
Mol. Cell. Neurosci
, vol.34
, pp. 621-628
-
-
Riddell, D.R.1
-
140
-
-
34548706007
-
Apolipoprotein E and neurological disease: Therapeutic potential and pharmacogenomic interactions
-
Laskowitz, D. T. & Vitek, M. P. Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions. Pharmacogenomics 8, 959-969 (2007).
-
(2007)
Pharmacogenomics
, vol.8
, pp. 959-969
-
-
Laskowitz, D.T.1
Vitek, M.P.2
-
141
-
-
0037474046
-
Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures
-
Aono, M. et al. Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures. Neuroscience 116, 437-445 (2003).
-
(2003)
Neuroscience
, vol.116
, pp. 437-445
-
-
Aono, M.1
-
142
-
-
33745751979
-
Apolipoprotein E-derived peptides reduce CNS inflammation: Implications for therapy of neurological disease
-
Laskowitz, D. T. , Fillit, H., Yeung, N., Toku, K. & Vitek, M. P. Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. Acta Neurol. Scand. Suppl. 185, 15-20 (2006).
-
(2006)
Acta Neurol. Scand. Suppl
, vol.185
, pp. 15-20
-
-
Laskowitz, D.T.1
Fillit, H.2
Yeung, N.3
Toku, K.4
Vitek, M.P.5
-
143
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
-
Bales, K. R. et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genet. 17, 263-264 (1997).
-
(1997)
Nature Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
-
144
-
-
33845484383
-
Blocking the apolipoprotein E/ amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease
-
Sadowski, M. J. et al. Blocking the apolipoprotein E/ amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease. Proc. Natl Acad. Sci. USA 103, 18787-18792 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18787-18792
-
-
Sadowski, M.J.1
-
145
-
-
0033762062
-
Modulation of amyloid β-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway
-
Kang, D. E. et al. Modulation of amyloid β-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J. Clin. Invest. 106, 1159-1166 (2000).
-
(2000)
J. Clin. Invest
, vol.106
, pp. 1159-1166
-
-
Kang, D.E.1
-
146
-
-
0031673996
-
Soluble low-density lipoprotein receptor-related protein
-
Grimsley, P. G., Quinn, K. A. & owensby, D. A. Soluble low-density lipoprotein receptor-related protein. Trends Cardiovasc. Med. 8, 363-368 (1998).
-
(1998)
Trends Cardiovasc. Med
, vol.8
, pp. 363-368
-
-
Grimsley, P.G.1
Quinn, K.A.2
owensby, D.A.3
-
147
-
-
0033568616
-
-
Quinn, K. A., Pye, V. J., Dai, Y. P. , Chesterman, C. N. & owensby, D. A. Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP). Exp. Cell Res. 251, 433-441 (1999).
-
Quinn, K. A., Pye, V. J., Dai, Y. P. , Chesterman, C. N. & owensby, D. A. Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP). Exp. Cell Res. 251, 433-441 (1999).
-
-
-
-
148
-
-
34948888151
-
Clearance of amyloid-β by circulating lipoprotein receptors
-
Sagare, A. et al. Clearance of amyloid-β by circulating lipoprotein receptors. Nature Med. 13, 1029-1031 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 1029-1031
-
-
Sagare, A.1
-
149
-
-
24044497252
-
The low density lipoprotein receptor-related protein (LRP) is a novel β-secretase (BACE1) substrate
-
von Arnim, C. A. et al. The low density lipoprotein receptor-related protein (LRP) is a novel β-secretase (BACE1) substrate. J. Biol. Chem. 280, 17777-17785 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17777-17785
-
-
von Arnim, C.A.1
-
150
-
-
0141733204
-
Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase
-
May, P. , Bock, H. H., Nimpf, J. & Herz, J. Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase. J. Biol. Chem. 278, 37386-37392 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 37386-37392
-
-
May, P.1
Bock, H.H.2
Nimpf, J.3
Herz, J.4
-
151
-
-
0142103374
-
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65
-
Kinoshita, A., Shah, T. , Tangredi, M. M., Strickland, D. K. & Hyman, B. T. The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278, 41182-41188 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41182-41188
-
-
Kinoshita, A.1
Shah, T.2
Tangredi, M.M.3
Strickland, D.K.4
Hyman, B.T.5
-
152
-
-
58749110564
-
γ-Secretase limits the inflammatory response through the processing of LRP1
-
Zurhove, K., Nakajima, C., Herz, J., Bock, H. H. & May, P. γ-Secretase limits the inflammatory response through the processing of LRP1. Sci. Signal. 1, ra15 (2008).
-
(2008)
Sci. Signal
, vol.1
-
-
Zurhove, K.1
Nakajima, C.2
Herz, J.3
Bock, H.H.4
May, P.5
-
153
-
-
50349092478
-
Regulated proteolysis of APP and ApoE receptors
-
Hoe, H. S. & Rebeck, G. W. Regulated proteolysis of APP and ApoE receptors. Mol. Neurobiol. 37, 64-72 (2008).
-
(2008)
Mol. Neurobiol
, vol.37
, pp. 64-72
-
-
Hoe, H.S.1
Rebeck, G.W.2
|