Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade

Journal of Alzheimer's Disease

Volumn 28, Issue 4, 2012, Pages 855-868

  Bartley, Matthew G ^a   Marquardt, Kristin ^a   Kirchhof, Danielle ^a   Wilkins, Heather M ^a   Patterson, David ^a   Linseman, Daniel A ^a,b,c  

^a UNIVERSITY OF DENVER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; amyloid protein precursor; apoptosis; Down syndrome; glutathione; oxidative stress

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; GLUTATHIONE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS FRAGMENTATION; CELLULAR PARAMETERS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ANALYSIS; GENE OVEREXPRESSION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MITOCHONDIRAL OXIDATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 84858046505     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-111172     Document Type: Article

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