Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

Journal of Neurochemistry

Volumn 132, Issue 6, 2015, Pages 687-702

  Park, Junghyung ^a   Choi, Hoonsung ^b   Min, Ju Sik ^a   Kim, Bokyung ^a   Lee, Sang Rae ^b   Yun, Jong Won ^c   Choi, Myung Sook ^a   Chang, Kyu Tae ^b   Lee, Dong Seok ^a  

^a Kyungpook National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Daegu University   (South Korea)

Author keywords

Alzheimer's disease; Cdk5; mitochondrial fragmentation; mitofusin 2; oxidative stress; peroxiredoxin 2

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALLOGRAFT INFLAMMATORY FACTOR 1; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C; MITOFUSIN 1; MITOFUSIN 2; PEROXIREDOXIN 2; PROTEIN BAX; PROTEIN BCL 2; CDK5 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE; MFN2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; ANIMALS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 5; GTP PHOSPHOHYDROLASES; MICE; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS;

EID: 84924571507     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12984     Document Type: Article

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