Behavioural studies with a newly developed neuroprotective KYNA-amide

Journal of Neural Transmission

Volumn 119, Issue 2, 2012, Pages 165-172

  Gellért, Levente ^a   Varga, Dániel ^a   Ruszka, Marian ^a   Toldi, József ^a   Farkas, Tamás ^a   Szatmári, István ^b   Fülöp, Ferenc ^b   Vécsei, László ^a   Kis, Zsolt ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Behavioral studies; Mice; Open field; Radial maze; Rat; Water maze

Indexed keywords

KYNURENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; DRUG STRUCTURE; LOCOMOTION; MALE; MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REFERENCE MEMORY; WORKING MEMORY;

AMIDES; ANIMALS; KYNURENIC ACID; MALE; MAZE LEARNING; MICE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 84857630808     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-011-0692-8     Document Type: Article

References (33)

1. GA Ballinger 2004 Using generalized estimating equations for longitudinal data analysis Organ Res Methods 7 2 127 150 10.1177/1094428104263672 (Pubitemid 38597594)
2. TV Bliss GL Collingridge 1993 A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 6407 31 39 8421494 10.1038/361031a0 1:CAS:528:DyaK3sXntlOntw%3D%3D (Pubitemid 23020772)
3. ER Butelman 1989 A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task Pharmacol Biochem Behav 34 1 13 16 2696982 10.1016/0091-3057(89)90345-6 1:CAS:528:DyaK3cXjtVGhsQ%3D%3D (Pubitemid 20008876)
4. AC Chess MK Simoni, et al. 2007 Elevations of endogenous kynurenic acid produce spatial working memory deficits Schizophr Bull 33 3 797 804 16920787 10.1093/schbul/sbl033 (Pubitemid 47343705)
5. U Dirnagl C Iadecola, et al. 1999 Pathobiology of ischaemic stroke: an integrated view Trends Neurosci 22 9 391 397 10441299 10.1016/S0166-2236(99) 01401-0 1:CAS:528:DyaK1MXlsVygtrk%3D (Pubitemid 29453643)
6. M Endres U Dirnagl 2002 Ischemia and stroke Adv Exp Med Biol 513 455 473 12575832 10.1007/978-1-4615-0123-7-17 1:CAS:528:DC%2BD3sXotlymsbg%3D (Pubitemid 36332418)
7. S Erhardt L Schwieler, et al. 2004 Endogenous kynurenic acid disrupts prepulse inhibition Biol Psychiatry 56 4 255 260 15312813 10.1016/j.biopsych. 2004.06.006 1:CAS:528:DC%2BD2cXmslegtbg%3D (Pubitemid 39092940)
8. F Fulop I Szatmari, et al. 2009 Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives Curr Med Chem 16 36 4828 4842 19929784 10.2174/092986709789909602 1:CAS:528:DC%2BC3cXhsVSmtr8%3D
9. Gellért L, Fuzik J, Göblös A, Sárközi K, Marosi M, Kis Z, Farkas T, Szatmári I, Fülöp F, Vécsei L, Toldi J (2011) Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia. Eur J Pharmacol. doi: 10.1016/j.ejphar.2011.05.069
10. H Gunduz-Bruce 2009 The acute effects of NMDA antagonism: from the rodent to the human brain Brain Res Rev 60 2 279 286 18703087 10.1016/j.brainresrev. 2008.07.006 1:CAS:528:DC%2BD1MXls12jtr0%3D
11. C Hilmas EF Pereira, et al. 2001 The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications J Neurosci 21 19 7463 7473 11567036 1:CAS:528:DC%2BD3MXnsFCksrc%3D (Pubitemid 32904945)
12. JS Kenton, et al. 1990 Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors J Neurosci 10 9 2965 2973
13. E Knyihar-Csillik A Mihaly, et al. 2008 The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: comparative studies of the effects of SZR-72 and kynurenic acid Neurosci Res 61 4 429 432 18541319 10.1016/j.neures.2008.04.009 1:CAS:528:DC%2BD1cXnsF2ltb4%3D
14. M Marosi, et al. 2009 A novel kynurenic acid analogue: a comparison with kynurenic acid an in vitro electrophysiological study J Neural Transm 117 183 188 19953278 10.1007/s00702-009-0346-2
15. KW Muir 2006 Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists Curr Opin Pharmacol 6 1 53 60 16359918 10.1016/j.coph.2005.12. 002 1:CAS:528:DC%2BD28XmsVygtg%3D%3D (Pubitemid 43103819)
16. K Nakazawa TJ McHugh, et al. 2004 NMDA receptors, place cells and hippocampal spatial memory Nat Rev Neurosci 5 5 361 372 15100719 10.1038/nrn1385 1:CAS:528:DC%2BD2cXjt1ClsLg%3D (Pubitemid 38568497)
17. M Ohno T Yamamoto, et al. 1993 Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats Pharmacol Biochem Behav 45 1 89 93 8516378 10.1016/0091-3057(93)90091-7 1:CAS:528:DyaK3sXisVygs7w%3D
18. M Ohno T Yamamoto, et al. 1994 Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats Eur J Pharmacol 253 1-2 183 187 8013546 10.1016/0014-2999(94)90776-5 1:CAS:528:DyaK2cXitlKksb0%3D (Pubitemid 24063447)
19. Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R (2010) Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Neuropsychopharmacology 35(8):1734-1742
20. K Prass U Dirnagl 1998 Glutamate antagonists in therapy of stroke Restor Neurol Neurosci 13 1-2 3 10 12671283 1:CAS:528:DyaK1cXotFSnsrs%3D (Pubitemid 28526916)
21. C Prescott AM Weeks, et al. 2006 Kynurenic acid has a dual action on AMPA receptor responses Neurosci Lett 402 1-2 108 112 16644124 10.1016/j.neulet. 2006.03.051 1:CAS:528:DC%2BD28XltF2qtL4%3D (Pubitemid 43766458)
22. A Rassoulpour HQ Wu, et al. 2005 Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum J Neurochem 93 3 762 765 15836634 10.1111/j.1471-4159.2005.03134.x 1:CAS:528:DC%2BD2MXktFKgu7w%3D (Pubitemid 40617635)
23. R Schmidt-Kastner TF Freund 1991 Selective vulnerability of the hippocampus in brain ischemia Neuroscience 40 3 599 636 1676492 10.1016/0306-4522(91)90001-5 1:STN:280:DyaK3M3oslyruw%3D%3D
24. R Schwarcz R Pellicciari 2002 Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities J Pharmacol Exp Ther 303 1 1 10 12235226 10.1124/jpet.102.034439 1:CAS:528:DC%2BD38XnsV2ru7k%3D
25. TW Stone 2000 Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection Trends Pharmacol Sci 21 4 149 154 10740291 10.1016/S0165-6147(00)01451-6 1:CAS:528:DC%2BD3cXisFGgsL0%3D (Pubitemid 30190140)
26. TW Stone JI Addae 2002 The pharmacological manipulation of glutamate receptors and neuroprotection Eur J Pharmacol 447 2-3 285 296 12151020 10.1016/S0014-2999(02)01851-4 1:CAS:528:DC%2BD38XlvVWlur8%3D (Pubitemid 34874462)
27. DJ Surmeier J Plotkin, et al. 2009 Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection Curr Opin Neurobiol 19 6 621 628 19896832 10.1016/j.conb.2009.10.003 1:CAS:528:DC%2BC3cXps1Wh
28. E Vamos A Pardutz, et al. 2009 The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotection J Neurol Sci 283 1-2 21 27 19268309 10.1016/j.jns.2009.02.326 1:CAS:528:DC%2BD1MXoslSitr8%3D
29. E Vamos A Pardutz, et al. 2009 l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus Neuropharmacology 57 4 425 429 19580819 10.1016/j.neuropharm.2009.06.033 1:CAS:528:DC%2BD1MXhtVeis7vL
30. L Vecsei MF Beal 1990 Intracerebroventricular injection of kynurenic acid, but not kynurenine, induces ataxia and stereotyped behavior in rats Brain Res Bull 25 4 623 627 2271966 10.1016/0361-9230(90)90123-H 1:CAS:528: DyaK3MXpsFGmsg%3D%3D
31. HQ Wu P Guidetti, et al. 2000 Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo Neuroscience 97 2 243 251 10799756 10.1016/S0306-4522(00) 00030-0 1:CAS:528:DC%2BD3cXivVCqsrg%3D (Pubitemid 30224762)
32. T Yoshihara Y Ichitani 2004 Hippocampal N-methyl-d-aspartate receptor-mediated encoding and retrieval processes in spatial working memory: delay-interposed radial maze performance in rats Neuroscience 129 1 1 10 15489023 10.1016/j.neuroscience.2004.07.030 1:CAS:528:DC%2BD2cXos1yktb4%3D (Pubitemid 39360936)
33. D Zadori P Klivenyi, et al. 2009 Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies J Neural Transm 116 11 1403 1409 19618107 10.1007/s00702-009-0263-4 1:CAS:528:DC%2BD1MXhtlKhsbzL