메뉴 건너뛰기




Volumn 42, Issue , 2014, Pages S177-S187

Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets

Author keywords

Alzheimer's disease; glutamate excitotoxicity; kynurenic acid amides; memantine; neurodegeneration; neuroprotection; therapy

Indexed keywords

AMYLOID BETA PROTEIN; GLYCINE; IFENPRODIL; ION CHANNEL; KYNURENIC ACID; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POLYAMINE; TAU PROTEIN; AMINO ACID RECEPTOR BLOCKING AGENT; GLUTAMIC ACID; NR2B NMDA RECEPTOR;

EID: 84920607191     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132621     Document Type: Conference Paper
Times cited : (72)

References (123)
  • 2
    • 38749107038 scopus 로고    scopus 로고
    • The role of chronic brain hypoperfusion in the pathogenesis of Alzheimer's disease-facts and hypotheses
    • Zadori D, Datki Z, PenkeB(2007) [The role of chronic brain hypoperfusion in the pathogenesis of Alzheimer's disease-facts and hypotheses]. Ideggyogy Sz 60, 428-437.
    • (2007) Ideggyogy Sz , vol.60 , pp. 428-437
    • Zadori, D.1    Datki, Z.2    Penke, B.3
  • 3
    • 34247204182 scopus 로고    scopus 로고
    • Dementia syndromes: Evaluation and treatment
    • Scott KR, Barrett AM (2007) Dementia syndromes: Evaluation and treatment. Expert Rev Neurother 7, 407-422.
    • (2007) Expert Rev Neurother , vol.7 , pp. 407-422
    • Scott, K.R.1    Barrett, A.M.2
  • 4
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: Prevalence estimates using the 2000 census
    • Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: Prevalence estimates using the 2000 census. Arch Neurol 60, 1119-1122.
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 5
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82, 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 7
    • 0029010832 scopus 로고
    • Alzheimer's disease: Maladaptive synaptoplasticity hypothesis
    • Neill D (1995) Alzheimer's disease: Maladaptive synaptoplasticity hypothesis. Neurodegeneration 4, 217-232.
    • (1995) Neurodegeneration , vol.4 , pp. 217-232
    • Neill, D.1
  • 9
    • 28444448358 scopus 로고    scopus 로고
    • Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression
    • Mortimer JA, Borenstein AR, Gosche KM, Snowdon DA (2005) Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression. J Geriatr Psychiatry Neurol 18, 218-223.
    • (2005) J Geriatr Psychiatry Neurol , vol.18 , pp. 218-223
    • Mortimer, J.A.1    Borenstein, A.R.2    Gosche, K.M.3    Snowdon, D.A.4
  • 10
    • 0030660087 scopus 로고    scopus 로고
    • Proposal to revise the morphologic criteria for the diagnosis of Alzheimer's disease
    • Perl DP, Purohit DP (1997) Proposal to revise the morphologic criteria for the diagnosis of Alzheimer's disease. Neurobiol Aging 18, S81-S84.
    • (1997) Neurobiol Aging , vol.18 , pp. S81-S84
    • Perl, D.P.1    Purohit, D.P.2
  • 11
    • 0016775401 scopus 로고
    • Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey I. Temporal lobe afferents
    • Van Hoesen G, Pandya DN (1975) Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. I. Temporal lobe afferents. Brain Res 95, 1-24.
    • (1975) Brain Res , vol.95 , pp. 1-24
    • Van Hoesen, G.1    Pandya, D.N.2
  • 12
    • 0016830420 scopus 로고
    • Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents
    • Van Hoesen G, Pandya DN, Butters N (1975) Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents. Brain Res 95, 25-38.
    • (1975) Brain Res , vol.95 , pp. 25-38
    • Van Hoesen, G.1    Pandya, D.N.2    Butters, N.3
  • 13
    • 0016829574 scopus 로고
    • Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections
    • Van Hoesen GW, Pandya DN (1975) Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections. Brain Res 95, 39-59.
    • (1975) Brain Res , vol.95 , pp. 39-59
    • Van Hoesen, G.W.1    Pandya, D.N.2
  • 15
  • 16
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42, 631-639.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 17
    • 0017139133 scopus 로고
    • The limbic system in Alzheimer's disease
    • Hooper WM, Vogel FS (1976) The limbic system in Alzheimer's disease. Am J Pathol 85, 1-19.
    • (1976) Am J Pathol , vol.85 , pp. 1-19
    • Hooper, W.M.1    Vogel, F.S.2
  • 19
    • 33747760358 scopus 로고    scopus 로고
    • Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
    • Scheff SW, Price DA, Schmitt FA, Mufson EJ (2006) Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 27, 1372-1384.
    • (2006) Neurobiol Aging , vol.27 , pp. 1372-1384
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    Mufson, E.J.4
  • 21
    • 34247611481 scopus 로고    scopus 로고
    • Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    • Scheff SW, Price DA, Schmitt FA, DeKosky ST, Mufson EJ (2007) Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 68, 1501-1508.
    • (2007) Neurology , vol.68 , pp. 1501-1508
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    Dekosky, S.T.4    Mufson, E.J.5
  • 22
    • 0029680160 scopus 로고    scopus 로고
    • Functional anatomy of human hippocampal formation and related structures
    • Braak H, Braak E, Yilmazer D, Bohl J (1996) Functional anatomy of human hippocampal formation and related structures. J Child Neurol 11, 265-275.
    • (1996) J Child Neurol , vol.11 , pp. 265-275
    • Braak, H.1    Braak, E.2    Yilmazer, D.3    Bohl, J.4
  • 23
    • 84856216329 scopus 로고    scopus 로고
    • Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques
    • Shah A, Jhawar SS, Goel A (2012) Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques. J Clin Neurosci 19, 289-298.
    • (2012) J Clin Neurosci , vol.19 , pp. 289-298
    • Shah, A.1    Jhawar, S.S.2    Goel, A.3
  • 24
    • 0021847008 scopus 로고
    • Intrinsic projections of the retrohippocampal region in the rat brain. I. the subicular complex
    • Kohler C (1985) Intrinsic projections of the retrohippocampal region in the rat brain. I. The subicular complex. J Comp Neurol 236, 504-522.
    • (1985) J Comp Neurol , vol.236 , pp. 504-522
    • Kohler, C.1
  • 26
    • 0031814748 scopus 로고    scopus 로고
    • Cortical pathways to the mammalian amygdala
    • McDonald AJ (1998) Cortical pathways to the mammalian amygdala. Prog Neurobiol 55, 257-332.
    • (1998) Prog Neurobiol , vol.55 , pp. 257-332
    • McDonald, A.J.1
  • 27
    • 0032032006 scopus 로고    scopus 로고
    • Cognitive neuroscience and the study of memory
    • Milner B, Squire LR, Kandel ER (1998) Cognitive neuroscience and the study of memory. Neuron 20, 445-468.
    • (1998) Neuron , vol.20 , pp. 445-468
    • Milner, B.1    Squire, L.R.2    Kandel, E.R.3
  • 28
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42, 1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 29
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 30
    • 33745920510 scopus 로고    scopus 로고
    • Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease
    • Kirvell SL, Esiri M, Francis PT (2006) Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease. J Neurochem 98, 939-950.
    • (2006) J Neurochem , vol.98 , pp. 939-950
    • Kirvell, S.L.1    Esiri, M.2    Francis, P.T.3
  • 32
    • 84879879175 scopus 로고    scopus 로고
    • Altered synapses and gliotransmission in Alzheimer's disease and AD model mice
    • Mitew S, Kirkcaldie MT, Dickson TC, Vickers JC (2013) Altered synapses and gliotransmission in Alzheimer's disease and AD model mice. Neurobiol Aging 34, 2341-2351.
    • (2013) Neurobiol Aging , vol.34 , pp. 2341-2351
    • Mitew, S.1    Kirkcaldie, M.T.2    Dickson, T.C.3    Vickers, J.C.4
  • 34
    • 84886592954 scopus 로고    scopus 로고
    • Predominant loss of glutamatergic terminal markers in a beta-amyloid peptide model of Alzheimer's disease
    • Canas PM, Simoes AP, Rodrigues RJ, Cunha RA (2014) Predominant loss of glutamatergic terminal markers in a beta-amyloid peptide model of Alzheimer's disease. Neuropharmacology 76(Pt A), 51-56.
    • (2014) Neuropharmacology , vol.76 , pp. 51-56
    • Canas, P.M.1    Simoes, A.P.2    Rodrigues, R.J.3    Cunha, R.A.4
  • 35
    • 84857032482 scopus 로고    scopus 로고
    • Neuropathological subtypes of Alzheimer's disease
    • Jellinger KA (2012) Neuropathological subtypes of Alzheimer's disease. Acta Neuropathol 123, 153-154.
    • (2012) Acta Neuropathol , vol.123 , pp. 153-154
    • Jellinger, K.A.1
  • 36
    • 84886641553 scopus 로고    scopus 로고
    • Dysfunctional synapse in Alzheimer's disease-A focus on NMDA receptors
    • Mota SI, Ferreira IL, Rego AC (2014) Dysfunctional synapse in Alzheimer's disease-A focus on NMDA receptors. Neuropharmacology 76(Pt A), 16-26.
    • (2014) Neuropharmacology , vol.76 , pp. 16-26
    • Mota, S.I.1    Ferreira, I.L.2    Rego, A.C.3
  • 37
    • 0037070606 scopus 로고    scopus 로고
    • Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II
    • Rank KB, Pauley AM, Bhattacharya K,Wang Z, Evans DB, Fleck TJ, Johnston JA, Sharma SK (2002) Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II. FEBS Lett 514, 263-268.
    • (2002) FEBS Lett , vol.514 , pp. 263-268
    • Rank, K.B.1    Pauley, A.M.2    Bhattacharya Kwang, Z.3    Evans, D.B.4    Fleck, T.J.5    Johnston, J.A.6    Sharma, S.K.7
  • 38
    • 84881546833 scopus 로고    scopus 로고
    • The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease
    • Crimins JL, Pooler A, Polydoro M, Luebke JI, Spires-Jones TL (2013) The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing Res Rev 12, 757-763.
    • (2013) Ageing Res Rev , vol.12 , pp. 757-763
    • Crimins, J.L.1    Pooler, A.2    Polydoro, M.3    Luebke, J.I.4    Spires-Jones, T.L.5
  • 40
    • 70549106846 scopus 로고    scopus 로고
    • Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses
    • Abramov E, Dolev I, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci 12, 1567-1576.
    • (2009) Nat Neurosci , vol.12 , pp. 1567-1576
    • Abramov, E.1    Dolev, I.2    Fogel, H.3    Ciccotosto, G.D.4    Ruff, E.5    Slutsky, I.6
  • 41
    • 81955164774 scopus 로고    scopus 로고
    • Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex
    • Sokolow S, Luu SH, Nandy K, Miller CA, Vinters HV, Poon WW, Gylys KH (2012) Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiol Dis 45, 381-387.
    • (2012) Neurobiol Dis , vol.45 , pp. 381-387
    • Sokolow, S.1    Luu, S.H.2    Nandy, K.3    Miller, C.A.4    Vinters, H.V.5    Poon, W.W.6    Gylys, K.H.7
  • 42
    • 33846633336 scopus 로고    scopus 로고
    • Abeta oligomerinduced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Abeta oligomerinduced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27, 796-807.
    • (2007) J Neurosci , vol.27 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 43
    • 84858204150 scopus 로고    scopus 로고
    • Synapses and dendritic spines as pathogenic targets in Alzheimer's disease
    • Yu W, Lu B (2012) Synapses and dendritic spines as pathogenic targets in Alzheimer's disease. Neural Plast 2012, 247150.
    • (2012) Neural Plast , pp. 247150
    • Yu, W.1    Lu, B.2
  • 45
    • 0033562610 scopus 로고    scopus 로고
    • The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
    • Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19, 4180-4188.
    • (1999) J Neurosci , vol.19 , pp. 4180-4188
    • Tovar, K.R.1    Westbrook, G.L.2
  • 46
    • 60349088785 scopus 로고    scopus 로고
    • Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices
    • Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD (2009) Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience 158, 1446-1459.
    • (2009) Neuroscience , vol.158 , pp. 1446-1459
    • Goebel-Goody, S.M.1    Davies, K.D.2    Alvestad Linger, R.M.3    Freund, R.K.4    Browning, M.D.5
  • 49
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5, 405-414.
    • (2002) Nat Neurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 50
    • 84885174557 scopus 로고    scopus 로고
    • NMDA receptors in nervous system diseases
    • Zhou Q, Sheng M (2013) NMDA receptors in nervous system diseases. Neuropharmacology 74, 69-75.
    • (2013) Neuropharmacology , vol.74 , pp. 69-75
    • Zhou, Q.1    Sheng, M.2
  • 51
    • 0035658715 scopus 로고    scopus 로고
    • Remembrance of arguments past: How well is the glutamate receptor hypothesis of LTP holding up after 20 years?
    • Baudry M, Lynch G (2001) Remembrance of arguments past: How well is the glutamate receptor hypothesis of LTP holding up after 20 years? Neurobiol Learn Mem 76, 284-297.
    • (2001) Neurobiol Learn Mem , vol.76 , pp. 284-297
    • Baudry, M.1    Lynch, G.2
  • 52
    • 80052172774 scopus 로고    scopus 로고
    • Long-term potentiation and depression as putative mechanisms for memory formation
    • Bermudez-Rattoni F, ed CRC Press, Boca Raton (FL)
    • Escobar ML, Derrick B (2007) Long-term potentiation and depression as putative mechanisms for memory formation. In Neural Plasticity and Memory: From Genes to Brain Imaging, Bermudez-Rattoni F, ed. CRC Press, Boca Raton (FL), pp. 15-45.
    • (2007) Neural Plasticity and Memory: From Genes to Brain Imaging , pp. 15-45
    • Escobar, M.L.1    Derrick, B.2
  • 54
    • 0035866076 scopus 로고    scopus 로고
    • Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
    • Kim JH, Anwyl R, Suh YH, Djamgoz MB, Rowan MJ (2001) Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo. J Neurosci 21, 1327-1333.
    • (2001) J Neurosci , vol.21 , pp. 1327-1333
    • Kim, J.H.1    Anwyl, R.2    Suh, Y.H.3    Djamgoz, M.B.4    Rowan, M.J.5
  • 55
    • 33845411954 scopus 로고    scopus 로고
    • AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
    • Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R (2006) AMPAR removal underlies Abeta-induced synaptic depress d dendritic spine loss. Neuron 52, 831-843.
    • (2006) Neuron , vol.52 , pp. 831-843
    • Hsieh, H.1    Boehm, J.2    Sato, C.3    Iwatsubo, T.4    Tomita, T.5    Sisodia, S.6    Malinow, R.7
  • 59
    • 84874629526 scopus 로고    scopus 로고
    • Metabotropic NMDA receptor function is required for beta-amyloidinduced synaptic depression
    • Kessels HW, Nabavi S, Malinow R (2013) Metabotropic NMDA receptor function is required for beta-amyloidinduced synaptic depression. Proc Natl Acad Sci USA 110, 4033-4038.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4033-4038
    • Kessels, H.W.1    Nabavi, S.2    Malinow, R.3
  • 62
    • 34548631724 scopus 로고    scopus 로고
    • Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression
    • Corlew R, Wang Y, Ghermazien H, Erisir A, Philpot BD (2007) Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression. J Neurosci 27, 9835-9845.
    • (2007) J Neurosci , vol.27 , pp. 9835-9845
    • Corlew, R.1    Wang, Y.2    Ghermazien, H.3    Erisir, A.4    Philpot, B.D.5
  • 63
    • 70350133699 scopus 로고    scopus 로고
    • Increased levels of NMDA receptor NR2A subunits at preand postsynaptic sites of the hippocampal CA1: An early response to conditional double knockout of presenilin 1 and 2
    • Aoki C, Lee J, Nedelescu H, Ahmed T, Ho A, Shen J (2009) Increased levels of NMDA receptor NR2A subunits at preand postsynaptic sites of the hippocampal CA1: An early response to conditional double knockout of presenilin 1 and 2. J Comp Neurol 517, 512-523.
    • (2009) J Comp Neurol , vol.517 , pp. 512-523
    • Aoki, C.1    Lee, J.2    Nedelescu, H.3    Ahmed, T.4    Ho, A.5    Shen, J.6
  • 64
    • 0042837889 scopus 로고    scopus 로고
    • Caspase activation in the limbic cortex of subjects with early Alzheimer's disease
    • Gastard MC, Troncoso JC, Koliatsos VE (2003) Caspase activation in the limbic cortex of subjects with early Alzheimer's disease. Ann Neurol 54, 393-398.
    • (2003) Ann Neurol , vol.54 , pp. 393-398
    • Gastard, M.C.1    Troncoso, J.C.2    Koliatsos, V.E.3
  • 65
    • 39149117756 scopus 로고    scopus 로고
    • Amyloid beta peptides and glutamatergic synaptic dysregulation
    • Parameshwaran K, Dhanasekaran M, Suppiramaniam V (2008) Amyloid beta peptides and glutamatergic synaptic dysregulation. Exp Neurol 210, 7-13.
    • (2008) Exp Neurol , vol.210 , pp. 7-13
    • Parameshwaran, K.1    Dhanasekaran, M.2    Suppiramaniam, V.3
  • 66
    • 84856958510 scopus 로고    scopus 로고
    • Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures
    • Ferreira IL, Bajouco LM, Mota SI, Auberson YP, Oliveira CR, Rego AC (2012) Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures. Cell Calcium 51, 95-106.
    • (2012) Cell Calcium , vol.51 , pp. 95-106
    • Ferreira, I.L.1    Bajouco, L.M.2    Mota, S.I.3    Auberson, Y.P.4    Oliveira, C.R.5    Rego, A.C.6
  • 67
    • 0033546347 scopus 로고    scopus 로고
    • Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
    • Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M (1999) Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284, 1845-1848.
    • (1999) Science , vol.284 , pp. 1845-1848
    • Sattler, R.1    Xiong, Z.2    Lu, W.Y.3    Hafner, M.4    MacDonald, J.F.5    Tymianski, M.6
  • 69
    • 78649417803 scopus 로고    scopus 로고
    • Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production
    • Bordji K, Becerril-Ortega J, Nicole O, Buisson A (2010) Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J Neurosci 30, 15927-15942.
    • (2010) J Neurosci , vol.30 , pp. 15927-15942
    • Bordji, K.1    Becerril-Ortega, J.2    Nicole, O.3    Buisson, A.4
  • 70
    • 84865405744 scopus 로고    scopus 로고
    • Alzheimer's disease, beta-amyloid, glutamate,NMDAreceptors and memantine-searching for the connections
    • Danysz W, Parsons CG (2012) Alzheimer's disease, beta-amyloid, glutamate,NMDAreceptors and memantine-searching for the connections. Br J Pharmacol 167, 324-352.
    • (2012) Br J Pharmacol , vol.167 , pp. 324-352
    • Danysz, W.1    Parsons, C.G.2
  • 74
    • 53949085542 scopus 로고    scopus 로고
    • Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades
    • Matos M, Augusto E, Oliveira CR, Agostinho P (2008) Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience 156, 898-910.
    • (2008) Neuroscience , vol.156 , pp. 898-910
    • Matos, M.1    Augusto, E.2    Oliveira, C.R.3    Agostinho, P.4
  • 75
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli A, Reilly JA, Lysko PG, HenneberryRC(1988) Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res 451, 205-212.
    • (1988) Brain Res , vol.451 , pp. 205-212
    • Novelli, A.1    Reilly, J.A.2    Henneberryrc, L.P.G.3
  • 76
    • 84867521251 scopus 로고    scopus 로고
    • NMDA neurotransmission dysfunction in behavioral and psychological symptoms of Alzheimer's disease
    • Huang YJ, Lin CH, Lane HY, Tsai GE (2012) NMDA neurotransmission dysfunction in behavioral and psychological symptoms of Alzheimer's disease. Curr Neuropharmacol 10, 272-285.
    • (2012) Curr Neuropharmacol , vol.10 , pp. 272-285
    • Huang, Y.J.1    Lin, C.H.2    Lane, H.Y.3    Tsai, G.E.4
  • 77
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • Muir KW, Lees KR (1995) Clinical experience with excitatory amino acid antagonist drugs. Stroke 26, 503-513.
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 78
    • 30844439634 scopus 로고    scopus 로고
    • Glutamate-based therapeutic approaches: Clinical trials with NMDA antagonists
    • Muir KW (2006) Glutamate-based therapeutic approaches: Clinical trials with NMDA antagonists. Curr Opin Pharmacol 6, 53-60.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 53-60
    • Muir, K.W.1
  • 79
    • 13444291406 scopus 로고    scopus 로고
    • Paradigm shift in NMDA receptor antagonist drug development: Molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders
    • Lipton SA (2004) Paradigm shift in NMDA receptor antagonist drug development: Molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. J Alzheimers Dis 6, S61-S74.
    • (2004) J Alzheimers Dis , vol.6 , pp. S61-S74
    • Lipton, S.A.1
  • 80
    • 77955855654 scopus 로고    scopus 로고
    • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    • Xia P, Chen HS, Zhang D, Lipton SA (2010) Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J Neurosci 30, 11246-11250.
    • (2010) J Neurosci , vol.30 , pp. 11246-11250
    • Xia, P.1    Chen, H.S.2    Zhang, D.3    Lipton, S.A.4
  • 81
    • 0029664442 scopus 로고    scopus 로고
    • Modulation of 45Ca2+influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites
    • Grimwood S, Gilbert E, Ragan CI, Hutson PH (1996) Modulation of 45Ca2+influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites. J Neurochem 66, 2589-2595.
    • (1996) J Neurochem , vol.66 , pp. 2589-2595
    • Grimwood, S.1    Gilbert, E.2    Ragan, C.I.3    Hutson, P.H.4
  • 82
    • 74149089703 scopus 로고    scopus 로고
    • Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cells
    • Ray B, Banerjee PK, Greig NH, Lahiri DK (2010) Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cells. Neurosci Lett 470, 1-5.
    • (2010) Neurosci Lett , vol.470 , pp. 1-5
    • Ray, B.1    Banerjee, P.K.2    Greig, N.H.3    Lahiri, D.K.4
  • 83
    • 84863717143 scopus 로고    scopus 로고
    • A review of the effects of memantine on clinical progression in Alzheimer's disease
    • Wilkinson D (2012) A review of the effects of memantine on clinical progression in Alzheimer's disease. Int J Geriatr Psychiatry 27, 769-776.
    • (2012) Int J Geriatr Psychiatry , vol.27 , pp. 769-776
    • Wilkinson, D.1
  • 84
    • 84881445612 scopus 로고    scopus 로고
    • Effectiveness and safety of memantine treatment for Alzheimer's disease
    • Yang Z, Zhou X, ZhangQ(2013) Effectiveness and safety of memantine treatment for Alzheimer's disease. J Alzheimers Dis 36, 445-458.
    • (2013) J Alzheimers Dis , vol.36 , pp. 445-458
    • Yang, Z.1    Zhou, X.2    Zhang, Q.3
  • 85
    • 34948842904 scopus 로고    scopus 로고
    • Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse
    • Parsons CG, Stoffler A, Danysz W (2007) Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse. Neuropharmacology 53, 699-723.
    • (2007) Neuropharmacology , vol.53 , pp. 699-723
    • Parsons, C.G.1    Stoffler, A.2    Danysz, W.3
  • 86
    • 79955675748 scopus 로고    scopus 로고
    • Endogenous neuroprotection in chronic neurodegenerative disorders: With particular regard to the kynurenines
    • Zadori D, Klivenyi P, Plangar I, Toldi J, Vecsei L (2011) Endogenous neuroprotection in chronic neurodegenerative disorders: With particular regard to the kynurenines. J Cell Mol Med 15, 701-717.
    • (2011) J Cell Mol Med , vol.15 , pp. 701-717
    • Zadori, D.1    Klivenyi, P.2    Plangar, I.3    Toldi, J.4    Vecsei, L.5
  • 87
    • 84867582500 scopus 로고    scopus 로고
    • Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders
    • Zadori D, Klivenyi P, Szalardy L, Fulop F, Toldi J, Vecsei L (2012) Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders. J Neurol Sci 322, 187-191.
    • (2012) J Neurol Sci , vol.322 , pp. 187-191
    • Zadori, D.1    Klivenyi, P.2    Szalardy, L.3    Fulop, F.4    Toldi, J.5    Vecsei, L.6
  • 88
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012) Kynurenines in the mammalian brain: When physiology meets pathology. Nat Rev Neurosci 13, 465-477.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 89
  • 90
    • 79955643831 scopus 로고    scopus 로고
    • Targeting the kynurenine pathway-related alterations in Alzheimer's disease: A future therapeutic strategy
    • Plangar I, Zadori D, Klivenyi P, Toldi J, Vecsei L (2011) Targeting the kynurenine pathway-related alterations in Alzheimer's disease: A future therapeutic strategy. J Alzheimers Dis 24(Suppl 2), 199-209.
    • (2011) J Alzheimers Dis , vol.24 , pp. 199-209
    • Plangar, I.1    Zadori, D.2    Klivenyi, P.3    Toldi, J.4    Vecsei, L.5
  • 91
    • 0019967973 scopus 로고
    • An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
    • Perkins MN, Stone TW (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247, 184-187.
    • (1982) Brain Res , vol.247 , pp. 184-187
    • Perkins, M.N.1    Stone, T.W.2
  • 92
    • 0024564076 scopus 로고
    • A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
    • Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists. J Neurochem 52, 1319-1328.
    • (1989) J Neurochem , vol.52 , pp. 1319-1328
    • Kessler, M.1    Terramani, T.2    Lynch, G.3    Baudry, M.4
  • 93
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone TW (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 45, 309-379.
    • (1993) Pharmacol Rev , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 94
    • 0025482465 scopus 로고
    • Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors
    • Swartz KJ, During MJ, Freese A, Beal MF (1990) Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors. J Neurosci 10, 2965-2973.
    • (1990) J Neurosci , vol.10 , pp. 2965-2973
    • Swartz, K.J.1    During, M.J.2    Freese, A.3    Beal, M.F.4
  • 96
    • 0025777901 scopus 로고
    • Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats
    • Vecsei L, BealMF(1991) Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats. Eur J Pharmacol 196, 239-246.
    • (1991) Eur J Pharmacol , vol.196 , pp. 239-246
    • Vecsei, L.1    Beal, M.F.2
  • 97
    • 0033058001 scopus 로고    scopus 로고
    • Kynurenine metabolism in Alzheimer's disease
    • Baran H, Jellinger K, Deecke L (1999) Kynurenine metabolism in Alzheimer's disease. J Neural Transm 106, 165-181.
    • (1999) J Neural Transm , vol.106 , pp. 165-181
    • Baran, H.1    Jellinger, K.2    Deecke, L.3
  • 98
    • 77953617514 scopus 로고    scopus 로고
    • Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior
    • Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R (2010) Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Neuropsychopharmacology 35, 1734-1742.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1734-1742
    • Potter, M.C.1    Elmer, G.I.2    Bergeron, R.3    Albuquerque, E.X.4    Guidetti, P.5    Wu, H.Q.6    Schwarcz, R.7
  • 99
    • 0035478066 scopus 로고    scopus 로고
    • The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: Physiopathological implications
    • Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX (2001) The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: Physiopathological implications. J Neurosci 21, 7463-7473.
    • (2001) J Neurosci , vol.21 , pp. 7463-7473
    • Hilmas, C.1    Pereira, E.F.2    Alkondon, M.3    Rassoulpour, A.4    Schwarcz, R.5    Albuquerque, E.X.6
  • 100
    • 0036325889 scopus 로고    scopus 로고
    • Direct evidence that release-stimulating alpha7∗ nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals
    • Marchi M, Risso F, Viola C, Cavazzani P, Raiteri M (2002) Direct evidence that release-stimulating alpha7∗ nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals. J Neurochem 80, 1071-1078.
    • (2002) J Neurochem , vol.80 , pp. 1071-1078
    • Marchi, M.1    Risso, F.2    Viola, C.3    Cavazzani, P.4    Raiteri, M.5
  • 102
    • 33646780229 scopus 로고    scopus 로고
    • Kynurenic acid has a dual action on AMPA receptor responses
    • Prescott C, Weeks AM, Staley KJ, Partin KM (2006) Kynurenic acid has a dual action on AMPA receptor responses. Neurosci Lett 402, 108-112.
    • (2006) Neurosci Lett , vol.402 , pp. 108-112
    • Prescott, C.1    Weeks, A.M.2    Staley, K.J.3    Partin, K.M.4
  • 104
    • 70350324907 scopus 로고    scopus 로고
    • Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential
    • Mony L, Kew JN, Gunthorpe MJ, Paoletti P (2009) Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential. Br J Pharmacol 157, 1301-1317.
    • (2009) Br J Pharmacol , vol.157 , pp. 1301-1317
    • Mony, L.1    Kew, J.N.2    Gunthorpe, M.J.3    Paoletti, P.4
  • 105
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams K (1993) Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol 44, 851-859.
    • (1993) Mol Pharmacol , vol.44 , pp. 851-859
    • Williams, K.1
  • 106
    • 0032190650 scopus 로고    scopus 로고
    • An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones
    • Kew JN, Kemp JA (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J Physiol 512(Pt 1), 17-28.
    • (1998) J Physiol , vol.512 , pp. 17-28
    • Kew, J.N.1    Kemp, J.A.2
  • 108
    • 84866452758 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-beta oligomers
    • Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, RegoAC, PereiraCM(2012) Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-beta oligomers. Aging Cell 11, 823-833.
    • (2012) Aging Cell , vol.11 , pp. 823-833
    • Costa, R.O.1    Lacor, P.N.2    Ferreira, I.L.3    Resende, R.4    Auberson, Y.P.5    Klein, W.L.6    Oliveira, C.R.7    Rego, A.C.8    Pereira, C.M.9
  • 109
    • 73949133583 scopus 로고    scopus 로고
    • GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
    • Hu NW, Klyubin I, Anwyl R, Rowan MJ (2009) GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo. Proc Natl Acad Sci USA 106, 20504-20509.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20504-20509
    • Hu, N.W.1    Klyubin, I.2    Anwyl, R.3    Rowan, M.J.4
  • 111
    • 79955769953 scopus 로고    scopus 로고
    • Soluble Abeta oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containingNMDA receptors
    • Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ (2011) Soluble Abeta oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containingNMDA receptors. J Neurosci 31, 6627-6638.
    • (2011) J Neurosci , vol.31 , pp. 6627-6638
    • Li, S.1    Jin, M.2    Koeglsperger, T.3    Shepardson, N.E.4    Shankar, G.M.5    Selkoe, D.J.6
  • 112
    • 79952454330 scopus 로고    scopus 로고
    • Therapeutic significance of NR2Bcontaining NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of beta-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices
    • Rammes G, Hasenjager A, Sroka-Saidi K, Deussing JM, Parsons CG (2011) Therapeutic significance of NR2Bcontaining NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of beta-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. Neuropharmacology 60, 982-990.
    • (2011) Neuropharmacology , vol.60 , pp. 982-990
    • Rammes, G.1    Hasenjager, A.2    Sroka-Saidi, K.3    Deussing, J.M.4    Parsons, C.G.5
  • 114
    • 71949108894 scopus 로고    scopus 로고
    • Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives
    • Fulop F, Szatmari I, Vamos E, Zadori D, Toldi J, Vecsei L (2009) Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives. Curr Med Chem 16, 4828-4842.
    • (2009) Curr Med Chem , vol.16 , pp. 4828-4842
    • Fulop, F.1    Szatmari, I.2    Vamos, E.3    Zadori, D.4    Toldi, J.5    Vecsei, L.6
  • 120
    • 38449097509 scopus 로고    scopus 로고
    • Adenosine receptor antagonists for cognitive dysfunction: A review of animal studies
    • Takahashi RN, Pamplona FA, Prediger RD (2008) Adenosine receptor antagonists for cognitive dysfunction: A review of animal studies. Front Biosci 13, 2614-2632.
    • (2008) Front Biosci , vol.13 , pp. 2614-2632
    • Takahashi, R.N.1    Pamplona, F.A.2    Prediger, R.D.3
  • 121
    • 70349653486 scopus 로고    scopus 로고
    • The role of adenosine in Alzheimer's disease
    • Rahman A (2009) The role of adenosine in Alzheimer's disease. Curr Neuropharmacol 7, 207-216.
    • (2009) Curr Neuropharmacol , vol.7 , pp. 207-216
    • Rahman, A.1
  • 122
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 123
    • 5344272541 scopus 로고    scopus 로고
    • A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
    • Coleman P, Federoff H, Kurlan R (2004) A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology 63, 1155-1162.
    • (2004) Neurology , vol.63 , pp. 1155-1162
    • Coleman, P.1    Federoff, H.2    Kurlan, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.