The endogenous α7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells

Journal of the Neurological Sciences

Volumn 344, Issue 1-2, 2014, Pages 94-99

  Steiner, Levke ^a   Gold, Maike ^a   Mengel, David ^a   Dodel, Richard ^a   Bach, Jan Philipp ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Alzheimer disease; Inflammation; Kynurenic acid; Microglia; Phagocytosis; 7 nicotinic acetylcholine receptor

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; BUNGAROTOXIN RECEPTOR; INTERLEUKIN 6; KYNURENIC ACID; PROPIDIUM IODIDE; TUMOR NECROSIS FACTOR ALPHA; AMINO ACID RECEPTOR BLOCKING AGENT; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); NITRIC OXIDE; PEPTIDE FRAGMENT;

ANIMAL TISSUE; ARTICLE; CELL LYSATE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; FLUORESCENCE ACTIVATED CELL SORTING; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OLIGOMERIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; TRANSFORMED CELL LINE;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; AMYLOID BETA-PEPTIDES; ANIMALS; CELL LINE, TRANSFORMED; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID ANTAGONISTS; INTERLEUKIN-6; KYNURENIC ACID; MICE; MICE, INBRED C57BL; MICROGLIA; NITRIC OXIDE; PEPTIDE FRAGMENTS; PHAGOCYTOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84906939232     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.06.032     Document Type: Article

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